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  1. Book: Hemodialysis vascular access

    Conlon, Peter J.

    practice and problems

    (Oxford clinical nephrology series)

    2000  

    Author's details ed. by Peter J. Conlon
    Series title Oxford clinical nephrology series
    Keywords Hämodialyse ; Shunt
    Subject Nebenschluss ; Blutdialyse ; Blutwäsche
    Language English
    Size XII, 290 S. : Ill., graph. Darst.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT012739437
    ISBN 0-19-262942-5 ; 978-0-19-262942-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2000 A 2195 order for loan Magazin

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  2. Article ; Online: Variant renal artery anatomy in first degree relatives on MDCT angiography.

    Reid, Conor / Kelly, Dearbhla / Briody, Hayley / Lawless, Philip / Little, Dilly / Conlon, Peter J / Morrin, Martina

    Clinical transplantation

    2023  Volume 37, Issue 8, Page(s) e14980

    MeSH term(s) Humans ; Renal Artery/diagnostic imaging ; Angiography ; Multidetector Computed Tomography ; Abdomen ; Coronary Angiography ; Sensitivity and Specificity
    Language English
    Publishing date 2023-03-27
    Publishing country Denmark
    Document type Letter
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.14980
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  3. Article ; Online: Long-term renal function following radical cystectomy and ileal conduit creation.

    Chevarria, Julio / Ebad, Chaudhry A / Hamill, Mairead / Constandache, Catalin / Cowhig, Cliona / Little, Dilly M / Conlon, Peter J

    Irish journal of medical science

    2023  Volume 193, Issue 2, Page(s) 639–644

    Abstract: Background: Treatment for bladder cancer includes radical cystectomy (RC) and urinary diversion; RC is associated with long-term morbidity, kidney impairment and mortality.: Aim: To identify risk factors associated with postoperative long-term kidney ...

    Abstract Background: Treatment for bladder cancer includes radical cystectomy (RC) and urinary diversion; RC is associated with long-term morbidity, kidney impairment and mortality.
    Aim: To identify risk factors associated with postoperative long-term kidney function and mortality.
    Methods: Retrospective study of patients with RC and urinary diversion in Beaumont Hospital from 1996 to 2016. We included patients who had follow-up at least 2 years post-procedure. We assessed estimated glomerular filtration rate (eGFR) preoperatively and yearly post-procedure, dialysis commencement and mortality. Cox and Fine-Gray regression analyses were applied; p-value < 0.05 was considered significant.
    Results: We included 264 patients, median age 68.3 years, 73.7% males. The most common diagnosis was bladder cancer 93.3%, TNM stages T ≥ 2 75.9%, N ≥ 1 47.6% and M1 28%. The median eGFR preoperative was 65.8 ml/min/1.73m
    Conclusions: Patients with RC are at risk of progressive kidney function deterioration and elevated mortality and the main risk factors associated were age and preoperative eGFR. Regular monitoring of kidney function will permit early diagnosis and treatment.
    MeSH term(s) Male ; Humans ; Aged ; Female ; Cystectomy/adverse effects ; Cystectomy/methods ; Retrospective Studies ; Early Detection of Cancer ; Urinary Diversion/adverse effects ; Urinary Diversion/methods ; Urinary Bladder Neoplasms/surgery ; Urinary Bladder Neoplasms/pathology ; Kidney/surgery ; Kidney/pathology
    Language English
    Publishing date 2023-09-24
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 390895-1
    ISSN 1863-4362 ; 0021-1265
    ISSN (online) 1863-4362
    ISSN 0021-1265
    DOI 10.1007/s11845-023-03524-1
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  4. Article ; Online: The relationship between donor-recipient genetic distance and long-term kidney transplant outcome.

    Stapleton, Caragh P / Lord, Graham M / Conlon, Peter J / Cavalleri, Gianpiero L

    HRB open research

    2020  Volume 3, Page(s) 47

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2020-07-29
    Publishing country Ireland
    Document type Journal Article
    ISSN 2515-4826
    ISSN (online) 2515-4826
    DOI 10.12688/hrbopenres.13021.1
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  5. Article ; Online: Using omics to explore complications of kidney transplantation.

    Stapleton, Caragh P / Conlon, Peter J / Phelan, Paul J

    Transplant international : official journal of the European Society for Organ Transplantation

    2017  Volume 31, Issue 3, Page(s) 251–262

    Abstract: The importance of genetic and biochemical variation in renal transplant outcomes has been clear since the discovery of the HLA in the 1950s. Since that time, there have been huge advancements in both transplantation and omics. In recent years, there has ... ...

    Abstract The importance of genetic and biochemical variation in renal transplant outcomes has been clear since the discovery of the HLA in the 1950s. Since that time, there have been huge advancements in both transplantation and omics. In recent years, there has seen an increased number of genome-, proteome- and transcriptome-wide studies in the field of transplantation moving away from the earlier candidate gene/protein approaches. These areas have the potential to lead to the development of personalized treatment depending on individual molecular risk profiles. Here, we discuss recent progress and the current literature surrounding omics and renal transplant complications.
    MeSH term(s) Allografts/physiology ; Diabetes Mellitus/genetics ; Genomics ; Humans ; Immune Tolerance ; Kidney Transplantation/adverse effects ; Neoplasms/genetics ; Postoperative Complications/genetics
    Language English
    Publishing date 2017-10-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.13067
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  6. Article ; Online: Integration of genetic and histopathology data in interpretation of kidney disease.

    Murray, Susan L / Fennelly, Neil K / Doyle, Brendan / Lynch, Sally Ann / Conlon, Peter J

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2020  Volume 35, Issue 7, Page(s) 1113–1132

    Abstract: For many years renal biopsy has been the gold standard for diagnosis in many forms of kidney disease. It provides rapid, accurate and clinically useful information in most individuals with kidney disease. However, in recent years, other diagnostic ... ...

    Abstract For many years renal biopsy has been the gold standard for diagnosis in many forms of kidney disease. It provides rapid, accurate and clinically useful information in most individuals with kidney disease. However, in recent years, other diagnostic modalities have become available that may provide more detailed and specific diagnostic information in addition to, or instead of, renal biopsy. Genomics is one of these modalities. Previously prohibitively expensive and time consuming, it is now increasingly available and practical in a clinical setting for the diagnosis of inherited kidney disease. Inherited kidney disease is a significant cause of kidney disease, in both the adult and paediatric populations. While individual inherited kidney diseases are rare, together they represent a significant burden of disease. Because of the heterogenicity of inherited kidney disease, diagnosis and management can be a challenge and often multiple diagnostic modalities are needed to arrive at a diagnosis. We present updates in genomic medicine for renal disease, how genetic testing integrates with our knowledge of renal histopathology and how the two modalities may interact to enhance patient care.
    MeSH term(s) Adult ; Child ; Genetic Testing/methods ; Humans ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Patient Care/standards
    Language English
    Publishing date 2020-08-10
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gfaa176
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    Zs.MO 329: Show issues

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  7. Article ; Online: Polygenic risk score of non-melanoma skin cancer predicts post-transplant skin cancer across multiple organ types.

    Stapleton, Caragh P / Chang, Bao-Li / Keating, Brendan J / Conlon, Peter J / Cavalleri, Gianpiero L

    Clinical transplantation

    2020  Volume 34, Issue 8, Page(s) e13904

    Abstract: Polygenic risk scores (PRSs) calculated from genome-wide association studies (GWASs) of non-melanoma skin cancer (NMSC) in a general, non-transplant setting have recently been shown to predict risk of and time to post-renal transplant skin cancer. In ... ...

    Abstract Polygenic risk scores (PRSs) calculated from genome-wide association studies (GWASs) of non-melanoma skin cancer (NMSC) in a general, non-transplant setting have recently been shown to predict risk of and time to post-renal transplant skin cancer. In this study, we set out to test these findings in a cohort of heart, lung, and liver transplant patients to see whether these scores could be applied across different organ transplant types. Using the PRS from Stapleton et al (2018), PRS was calculated for each sample across a European ancestry heart, lung, and liver transplant cohorts (n = 523) and tested as predictor of time to NMSC post-transplant. The top PRS, squamous cell carcinoma (SCC) pT1 x 10
    MeSH term(s) Carcinoma, Basal Cell/etiology ; Carcinoma, Basal Cell/genetics ; Carcinoma, Squamous Cell/genetics ; Genome-Wide Association Study ; Humans ; Incidence ; Risk Factors ; Skin Neoplasms/genetics
    Language English
    Publishing date 2020-05-31
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639001-8
    ISSN 1399-0012 ; 0902-0063
    ISSN (online) 1399-0012
    ISSN 0902-0063
    DOI 10.1111/ctr.13904
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  8. Article ; Online: Familial Variability of Disease Severity in Adult Patients With ADPKD.

    Elhassan, Elhussein A E / O'Kelly, Patrick / Collins, Kane E / Teltsh, Omri / Ciurli, Francesca / Murray, Susan L / Kennedy, Claire / Madden, Stephen F / Benson, Katherine A / Cavalleri, Gianpiero L / Conlon, Peter J

    Kidney international reports

    2023  Volume 9, Issue 3, Page(s) 649–660

    Abstract: Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic nephropathy and has striking familial variability of disease severity.: Methods: To better comprehend familial phenotypic variability, we analyzed ... ...

    Abstract Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic nephropathy and has striking familial variability of disease severity.
    Methods: To better comprehend familial phenotypic variability, we analyzed clinical and pedigree data on 92 unrelated ADPKD kindreds with ≥2 affected individuals (
    Results: Marked intrafamilial variability was observed in at least 13% of the 92 families, with a higher proportion of families carrying
    Conclusion: Using objective measures, we quantified marked intrafamilial variability in ADPKD disease phenotype in at least 13% of families. Our findings indicate that intrafamilial phenotypic variability remains incompletely understood and necessitates a more thorough identification of relevant clinical and genotypic factors.
    Language English
    Publishing date 2023-12-12
    Publishing country United States
    Document type Journal Article
    ISSN 2468-0249
    ISSN (online) 2468-0249
    DOI 10.1016/j.ekir.2023.12.002
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  9. Article: Kidney injury in COVID-19.

    Ahmed, Adeel Rafi / Ebad, Chaudhry Adeel / Stoneman, Sinead / Satti, Muniza Manshad / Conlon, Peter J

    World journal of nephrology

    2020  Volume 9, Issue 2, Page(s) 18–32

    Abstract: Coronavirus disease 2019 (COVID-19) continues to affect millions of people around the globe. As data emerge, it is becoming more evident that extrapulmonary organ involvement, particularly the kidneys, highly influence mortality. The incidence of acute ... ...

    Abstract Coronavirus disease 2019 (COVID-19) continues to affect millions of people around the globe. As data emerge, it is becoming more evident that extrapulmonary organ involvement, particularly the kidneys, highly influence mortality. The incidence of acute kidney injury has been estimated to be 30% in COVID-19 non-survivors. Current evidence suggests four broad mechanisms of renal injury: Hypovolaemia, acute respiratory distress syndrome related, cytokine storm and direct viral invasion as seen on renal autopsy findings. We look to critically assess the epidemiology, pathophysiology and management of kidney injury in COVID-19.
    Language English
    Publishing date 2020-11-29
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2220-6124
    ISSN 2220-6124
    DOI 10.5527/wjn.v9.i2.18
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  10. Article ; Online: Very long-term survivors of kidney transplantation.

    Traynor, Carol / Conlon, Peter J

    Transplant international : official journal of the European Society for Organ Transplantation

    2013  Volume 26, Issue 2, Page(s) e8–9

    MeSH term(s) Female ; Humans ; Kidney Transplantation/physiology ; Male
    Language English
    Publishing date 2013-02
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.12028
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