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  1. Article ; Online: Designing lightweight neutron absorbing composites using a comprehensive absorber areal density metric.

    O'Connor, Andrew / Park, Cheol / Bolch, Wesley E / Enqvist, Andreas / Manuel, Michele V

    Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

    2024  Volume 206, Page(s) 111227

    Abstract: Efforts to lightweight neutron absorbing composites are limited by incomplete understandings of the interaction between absorbing particles and their matrices. In this study, analytical models and a more physically representative simulation evaluated the ...

    Abstract Efforts to lightweight neutron absorbing composites are limited by incomplete understandings of the interaction between absorbing particles and their matrices. In this study, analytical models and a more physically representative simulation evaluated the penalty to neutron absorbing performance due to neutron channeling between large absorbing particles. Models and simulation agreed that B
    Language English
    Publishing date 2024-02-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1142596-9
    ISSN 1872-9800 ; 0883-2889 ; 0969-8043
    ISSN (online) 1872-9800
    ISSN 0883-2889 ; 0969-8043
    DOI 10.1016/j.apradiso.2024.111227
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    Ue I Zs.279: Show issues Location:
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  2. Article: An extended-temperature, volumetric source model for betavoltaic power generation.

    O'Connor, Andrew / Manuel, Michele V / Shaw, Harry

    Transactions of the American Nuclear Society

    2021  Volume 121, Page(s) 542–545

    Language English
    Publishing date 2021-07-03
    Publishing country United States
    Document type Journal Article
    ISSN 0003-018X
    ISSN 0003-018X
    DOI 10.13182/T30591
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: An external validation of the Kidney Donor Risk Index in the UK transplant population in the presence of semi-competing events.

    Riley, Stephanie / Tam, Kimberly / Tse, Wai-Yee / Connor, Andrew / Wei, Yinghui

    Diagnostic and prognostic research

    2023  Volume 7, Issue 1, Page(s) 20

    Abstract: Background: Transplantation represents the optimal treatment for many patients with end-stage kidney disease. When a donor kidney is available to a waitlisted patient, clinicians responsible for the care of the potential recipient must make the decision ...

    Abstract Background: Transplantation represents the optimal treatment for many patients with end-stage kidney disease. When a donor kidney is available to a waitlisted patient, clinicians responsible for the care of the potential recipient must make the decision to accept or decline the offer based upon complex and variable information about the donor, the recipient and the transplant process. A clinical prediction model may be able to support clinicians in their decision-making. The Kidney Donor Risk Index (KDRI) was developed in the United States to predict graft failure following kidney transplantation. The survival process following transplantation consists of semi-competing events where death precludes graft failure, but not vice-versa.
    Methods: We externally validated the KDRI in the UK kidney transplant population and assessed whether validation under a semi-competing risks framework impacted predictive performance. Additionally, we explored whether the KDRI requires updating. We included 20,035 adult recipients of first, deceased donor, single, kidney-only transplants between January 1, 2004, and December 31, 2018, collected by the UK Transplant Registry and held by NHS Blood and Transplant. The outcomes of interest were 1- and 5-year graft failure following transplantation. In light of the semi-competing events, recipient death was handled in two ways: censoring patients at the time of death and modelling death as a competing event. Cox proportional hazard models were used to validate the KDRI when censoring graft failure by death, and cause-specific Cox models were used to account for death as a competing event.
    Results: The KDRI underestimated event probabilities for those at higher risk of graft failure. For 5-year graft failure, discrimination was poorer in the semi-competing risks model (0.625, 95% CI 0.611 to 0.640;0.611, 95% CI 0.597 to 0.625), but predictions were more accurate (Brier score 0.117, 95% CI 0.112 to 0.121; 0.114, 95% CI 0.109 to 0.118). Calibration plots were similar regardless of whether the death was modelled as a competing event or not. Updating the KDRI worsened calibration, but marginally improved discrimination.
    Conclusions: Predictive performance for 1-year graft failure was similar between death-censored and competing event graft failure, but differences appeared when predicting 5-year graft failure. The updated index did not have superior performance and we conclude that updating the KDRI in the present form is not required.
    Language English
    Publishing date 2023-11-21
    Publishing country England
    Document type Journal Article
    ISSN 2397-7523
    ISSN (online) 2397-7523
    DOI 10.1186/s41512-023-00159-9
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  4. Article ; Online: Who made what? The Ross renal biopsy needle.

    Connor, Henry / Connor, Andrew

    Journal of medical biography

    2019  Volume 27, Issue 4, Page(s) 244–245

    MeSH term(s) Biopsy, Needle/history ; Biopsy, Needle/instrumentation ; England ; History, 20th Century
    Language English
    Publishing date 2019-01-15
    Publishing country England
    Document type Historical Article ; Journal Article
    ZDB-ID 1159267-9
    ISSN 1758-1087 ; 0967-7720
    ISSN (online) 1758-1087
    ISSN 0967-7720
    DOI 10.1177/0967772018818051
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    Zs.A 3995: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Delayed Presentation of Urinoma Following Renal Transplant Biopsy: A Case Report.

    Powell, Richard / Edney, Naomi / Aroori, Somaiah / Connor, Andrew

    Transplantation proceedings

    2020  Volume 52, Issue 2, Page(s) 619–621

    Abstract: A urinoma is an unusual complication following renal transplant biopsy that can easily be missed or mistaken for a hematoma. In addition to trauma to the renal collecting system, a degree of urinary tract obstruction is required for urine to leak into ... ...

    Abstract A urinoma is an unusual complication following renal transplant biopsy that can easily be missed or mistaken for a hematoma. In addition to trauma to the renal collecting system, a degree of urinary tract obstruction is required for urine to leak into the surrounding tissues and form a urinoma, which can in turn cause pressure on surrounding structures. This case report describes a patient who developed ipsilateral leg swelling several months after a renal transplant biopsy. Imaging demonstrated a perirenal transplant fluid collection, which biochemical analysis confirmed to be urine. This was successfully managed with percutaneous nephrostomy and antegrade ureteric stent insertion. The fluid collection persisted as a seroma however, and the patient proceeded to have peritoneal fenestration and marsupialization surgery. To our knowledge, this is the first reported case of urinoma complicating a renal transplant biopsy. This case highlights a diagnosis that can be easily missed and is therefore a potential pitfall for clinicians.
    MeSH term(s) Female ; Humans ; Kidney Transplantation/adverse effects ; Middle Aged ; Ureteral Obstruction/etiology ; Urinoma/etiology ; Urinoma/surgery
    Language English
    Publishing date 2020-03-07
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2019.09.016
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    Zs.A 835: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: Using Information Available at the Time of Donor Offer to Predict Kidney Transplant Survival Outcomes: A Systematic Review of Prediction Models.

    Riley, Stephanie / Zhang, Qing / Tse, Wai-Yee / Connor, Andrew / Wei, Yinghui

    Transplant international : official journal of the European Society for Organ Transplantation

    2022  Volume 35, Page(s) 10397

    Abstract: Statistical models that can predict graft and patient survival outcomes following kidney transplantation could be of great clinical utility. We sought to appraise existing clinical prediction models for kidney transplant survival outcomes that could ... ...

    Abstract Statistical models that can predict graft and patient survival outcomes following kidney transplantation could be of great clinical utility. We sought to appraise existing clinical prediction models for kidney transplant survival outcomes that could guide kidney donor acceptance decision-making. We searched for clinical prediction models for survival outcomes in adult recipients with single kidney-only transplants. Models that require information anticipated to become available only after the time of transplantation were excluded as, by that time, the kidney donor acceptance decision would have already been made. The outcomes of interest were all-cause and death-censored graft failure, and death. We summarised the methodological characteristics of the prediction models, predictive performance and risk of bias. We retrieved 4,026 citations from which 23 articles describing 74 models met the inclusion criteria. Discrimination was moderate for all-cause graft failure (C-statistic: 0.570-0.652; Harrell's C: 0.580-0.660; AUC: 0.530-0.742), death-censored graft failure (C-statistic: 0.540-0.660; Harrell's C: 0.590-0.700; AUC: 0.450-0.810) and death (C-statistic: 0.637-0.770; Harrell's C: 0.570-0.735). Calibration was seldom reported. Risk of bias was high in 49 of the 74 models, primarily due to methods for handling missing data. The currently available prediction models using pre-transplantation information show moderate discrimination and varied calibration. Further model development is needed to improve predictions for the purpose of clinical decision-making.
    MeSH term(s) Adult ; Clinical Decision-Making ; Graft Survival ; Humans ; Kidney Transplantation ; Models, Statistical ; Tissue Donors
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.3389/ti.2022.10397
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    Zs.A 2358: Show issues Location:
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  7. Article: Renal Transplantation in Pure Autonomic Failure.

    Ul Abideen, Zain / Rixon, Anna / Gunatillake, Nirosha D / Househam, Elizabeth / Mathias, Christopher J / Connor, Andrew

    Transplantation direct

    2022  Volume 8, Issue 9, Page(s) e1358

    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article
    ISSN 2373-8731
    ISSN 2373-8731
    DOI 10.1097/TXD.0000000000001358
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  8. Article: Catastrophic Fibromuscular Dysplasia Presenting with Concomitant Bilateral Renal Infarction, Vertebral Artery Dissection, and Mesenteric Ischaemia.

    Gourd, Nicholas Martin / Jenkins, Hannah Elizabeth / Miles, Richard / Lee, Adrienne / Mason, Justin / Connor, Andrew

    Case reports in nephrology and dialysis

    2022  Volume 12, Issue 3, Page(s) 255–261

    Abstract: Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disorder of the arterial wall muscular layer which can lead to arterial stenosis, occlusion, and dissection. Clinical presentations of FMD vary depending on the arterial territories ...

    Abstract Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disorder of the arterial wall muscular layer which can lead to arterial stenosis, occlusion, and dissection. Clinical presentations of FMD vary depending on the arterial territories involved, often leading to diagnostic challenges. This case report describes an exceptionally unusual presentation of FMD, not previously described, affecting a previously fit and well 37-year-old female presenting with bilateral renal infarction, sequential vertebral artery dissections, mesenteric ischaemia, and the requirement for continued renal replacement. This report highlights how unusual presentations of FMD can mask the underlying diagnosis. Early consideration of FMD in a differential diagnosis can guide an effective management strategy, including appropriate imaging and multi-speciality involvement.
    Language English
    Publishing date 2022-11-30
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2809879-1
    ISSN 2296-9705
    ISSN 2296-9705
    DOI 10.1159/000527438
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  9. Article ; Online: Selective Serotonin Reuptake Inhibitors and Tardive Dyskinesia: A Case Report of Escitalopram Use in a Cardiac and Liver Transplant Patient.

    Fischer, Avital / Connor, Andrew T / Machenzie, Katherine M / Shaw, Richard J

    Journal of clinical psychopharmacology

    2020  Volume 40, Issue 6, Page(s) 626–627

    MeSH term(s) Citalopram/adverse effects ; Heart Transplantation ; Humans ; Liver Transplantation ; Male ; Motor Activity/drug effects ; Recovery of Function ; Risk Factors ; Serotonin Uptake Inhibitors/adverse effects ; Tardive Dyskinesia/chemically induced ; Tardive Dyskinesia/diagnosis ; Tardive Dyskinesia/physiopathology ; Treatment Outcome ; Young Adult
    Chemical Substances Serotonin Uptake Inhibitors ; Citalopram (0DHU5B8D6V)
    Language English
    Publishing date 2020-10-31
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001285
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    Zs.A 1664: Show issues Location:
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  10. Article ; Online: BAI1 localizes AMPA receptors at the cochlear afferent post-synaptic density and is essential for hearing.

    Carlton, Adam J / Jeng, Jing-Yi / Grandi, Fiorella C / De Faveri, Francesca / Amariutei, Ana E / De Tomasi, Lara / O'Connor, Andrew / Johnson, Stuart L / Furness, David N / Brown, Steve D M / Ceriani, Federico / Bowl, Michael R / Mustapha, Mirna / Marcotti, Walter

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114025

    Abstract: Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic density (PSD) ...

    Abstract Type I spiral ganglion neurons (SGNs) convey sound information to the central auditory pathway by forming synapses with inner hair cells (IHCs) in the mammalian cochlea. The molecular mechanisms regulating the formation of the post-synaptic density (PSD) in the SGN afferent terminals are still unclear. Here, we demonstrate that brain-specific angiogenesis inhibitor 1 (BAI1) is required for the clustering of AMPA receptors GluR2-4 (glutamate receptors 2-4) at the PSD. Adult Bai1-deficient mice have functional IHCs but fail to transmit information to the SGNs, leading to highly raised hearing thresholds. Despite the almost complete absence of AMPA receptor subunits, the SGN fibers innervating the IHCs do not degenerate. Furthermore, we show that AMPA receptors are still expressed in the cochlea of Bai1-deficient mice, highlighting a role for BAI1 in trafficking or anchoring GluR2-4 to the PSDs. These findings identify molecular and functional mechanisms required for sound encoding at cochlear ribbon synapses.
    MeSH term(s) Animals ; Receptors, AMPA/metabolism ; Mice ; Spiral Ganglion/metabolism ; Hearing/physiology ; Cochlea/metabolism ; Post-Synaptic Density/metabolism ; Mice, Knockout ; Hair Cells, Auditory, Inner/metabolism ; Mice, Inbred C57BL ; Synapses/metabolism ; Receptors, G-Protein-Coupled
    Chemical Substances Receptors, AMPA ; Adgrv1 protein, mouse ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114025
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