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  1. Book: The first green wave

    O'Connor, Ryan

    pollution probe and the origins of environmental activism in Ontario

    (Nature, history, society)

    2015  

    Author's details Ryan O'Connor
    Series title Nature, history, society
    Language English
    Size XXV, 231 S. : Ill.
    Publisher Univ. of British Columbia Press
    Publishing place Vancouver
    Publishing country Canada
    Document type Book
    HBZ-ID HT018504755
    ISBN 978-0-7748-2808-6 ; 9780774828109 ; 9780774828116 ; 0-7748-2808-0 ; 0774828102 ; 0774828110
    Database Catalogue ZB MED Nutrition, Environment, Agriculture

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    Shelf markLoan statusLocation
    158/26 available for loan (reading room) Freihandmagazin (U1)

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  2. Article ; Online: Aziridination via Nitrogen-Atom Transfer to Olefins from Photoexcited Azoxy-Triazenes.

    Mitchell, Joshua K / Hussain, Waseem A / Bansode, Ajay H / O'Connor, Ryan M / Parasram, Marvin

    Journal of the American Chemical Society

    2024  Volume 146, Issue 14, Page(s) 9499–9505

    Abstract: Herein, we report that readily accessible azoxy-triazenes can serve as nitrogen atom sources under visible light excitation for the phthalimido-protected aziridination of alkenes. This approach eliminates the need for external oxidants, precious ... ...

    Abstract Herein, we report that readily accessible azoxy-triazenes can serve as nitrogen atom sources under visible light excitation for the phthalimido-protected aziridination of alkenes. This approach eliminates the need for external oxidants, precious transition metals, and photocatalysts, marking a departure from conventional methods. The versatility of this transformation extends to the selective aziridination of both activated and unactivated multisubstituted alkenes of varying electronic profiles. Notably, this process avoids the formation of competing C-H insertion products. The described protocol is operationally simple, scalable, and adaptable to photoflow conditions. Mechanistic studies support the idea that the photofragmentation of azoxy-triazenes results in the generation of a free singlet nitrene. Furthermore, a mild photoredox-catalyzed N-N cleavage of the protecting group to furnish the free aziridines is reported. Our findings contribute to the advancement of sustainable and practical methodologies for the synthesis of nitrogen-containing compounds, showcasing the potential for broader applications in synthetic chemistry.
    Language English
    Publishing date 2024-03-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c14713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

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  3. Article ; Online: Singlet Oxygen's Potential Role as a Nonoxidative Facilitator of Disulfide S-S Bond Rotation

    Turque, Oliver / O'Connor, Ryan M / Greer, Alexander

    Photochemistry and photobiology

    2022  Volume 99, Issue 2, Page(s) 652–660

    Abstract: The role of singlet oxygen potentially mediating increased conformational flexibility of a disulfide was investigated. Density functional theory (DFT) calculations indicate that the singlet oxygenation of 1,2-dimethyldisulfane produces a peroxy ... ...

    Abstract The role of singlet oxygen potentially mediating increased conformational flexibility of a disulfide was investigated. Density functional theory (DFT) calculations indicate that the singlet oxygenation of 1,2-dimethyldisulfane produces a peroxy intermediate. This intermediate adopts a structure with a longer S-S bond distance and a more planar torsional angle θ (C-S-S-C) compared with the nonoxygenated 1,2-dimethyldisulfane. The lengthened S-S bond enables a facile rotation about the torsional angle in the semicircle region 0° < θ < 210°, that is ~5 kcal mol
    Language English
    Publishing date 2022-10-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.13727
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  4. Article ; Online: Systemic Inflammatory Response Syndrome from Nitrofurantoin: A Case Report.

    O'Connor, Ryan A / Patel, Vaidahi / Lang, Valerie / Brima, Wunnie

    The American journal of case reports

    2022  Volume 23, Page(s) e935113

    Abstract: BACKGROUND Nitrofurantoin is an antibiotic that is commonly used and preferred to treat lower urinary tract infections due to its relatively safe adverse effects profile. However, with the increased emphasis on antibiotic stewardship, it is important to ... ...

    Abstract BACKGROUND Nitrofurantoin is an antibiotic that is commonly used and preferred to treat lower urinary tract infections due to its relatively safe adverse effects profile. However, with the increased emphasis on antibiotic stewardship, it is important to recognize the rare, yet serious adverse effects profile of this medication. One of the rare adverse reactions is the development of systemic inflammatory response syndrome from nitrofurantoin. CASE REPORT We present a case of a 66-year-old woman who developed a classic systemic inflammatory response syndrome, including leukocytosis and fevers, after 2 repeated exposures to nitrofurantoin after a urological procedure. The patient had an initial infectious workup which was negative. A suspected adverse reaction to nitrofurantoin was suspected and the patient was found to have complete resolution of symptoms with discontinuation of the drug and with supportive treatment. CONCLUSIONS This case demonstrates that although nitrofurantoin is known to be relatively well tolerated, clinicians should still be aware of the adverse reactions, including a potential systemic inflammatory response, from nitrofurantoin use. This information should be used to educate patients going forward on potential adverse effects to be aware of.
    MeSH term(s) Aged ; Anti-Bacterial Agents/adverse effects ; Female ; Fever/chemically induced ; Humans ; Leukocytosis ; Nitrofurantoin/adverse effects ; Systemic Inflammatory Response Syndrome/chemically induced
    Chemical Substances Anti-Bacterial Agents ; Nitrofurantoin (927AH8112L)
    Language English
    Publishing date 2022-03-16
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.935113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: How Tryptophan Oxidation Arises by "Dark" Photoreactions from Chemiexcited Triplet Acetone.

    O'Connor, Ryan M / Greer, Alexander

    Photochemistry and photobiology

    2021  Volume 97, Issue 2, Page(s) 456–459

    Abstract: Dioxetane intermediates readily decompose to chemiluminescent triplet carbonyls, giving rise to what has been paradoxically called photochemistry in the dark. In this issue of Photochemistry and Photobiology, Bechara et al. report on mechanistic advances ...

    Abstract Dioxetane intermediates readily decompose to chemiluminescent triplet carbonyls, giving rise to what has been paradoxically called photochemistry in the dark. In this issue of Photochemistry and Photobiology, Bechara et al. report on mechanistic advances in such a reaction. With the use of horseradish peroxidase for isobutyraldehyde-derived triplet acetone, light emission from acetone and singlet oxygen can be quenched. The experiments reveal that the reaction depends on oxygen and the amino acid. The analysis reveals that free tryptophan is a target of this form of "carbonyl stress," with the efficient formation of mono-, bi- and tricyclic compounds (N-formylkynurenine, indoline, 1λ
    MeSH term(s) Acetone/chemistry ; Chromatography, High Pressure Liquid/methods ; Horseradish Peroxidase/chemistry ; Oxidation-Reduction ; Photochemical Processes ; Singlet Oxygen/chemistry ; Tandem Mass Spectrometry ; Tryptophan/chemistry
    Chemical Substances Acetone (1364PS73AF) ; Singlet Oxygen (17778-80-2) ; Tryptophan (8DUH1N11BX) ; Horseradish Peroxidase (EC 1.11.1.-)
    Language English
    Publishing date 2021-01-21
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 123540-0
    ISSN 1751-1097 ; 0031-8655
    ISSN (online) 1751-1097
    ISSN 0031-8655
    DOI 10.1111/php.13375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1686: Show issues Location:
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  6. Article ; Online: Epidemiology and clinical manifestations of cardiac amyloidosis.

    Bajwa, Farhan / O'Connor, Ryan / Ananthasubramaniam, Karthikeyan

    Heart failure reviews

    2021  Volume 27, Issue 5, Page(s) 1471–1484

    Abstract: Cardiac amyloidosis, once considered a rare disease, has garnered significant attention over the last few years due to three key reasons: first, increased recognition of this disease in conjunction with various common cardiac conditions such as heart ... ...

    Abstract Cardiac amyloidosis, once considered a rare disease, has garnered significant attention over the last few years due to three key reasons: first, increased recognition of this disease in conjunction with various common cardiac conditions such as heart failure with preserved ejection fraction and aortic stenosis; second, due to the advent of promising new therapies for light chain disease (AL), transthyretin (ATTR) cardiomyopathy, and amyloid neuropathy; finally, the advancements in cardiac imaging including echocardiography, magnetic resonance imaging, and nuclear cardiac scintigraphy aid in non-biopsy diagnosis of ATTR cardiac amyloidosis. The hereditary forms of ATTR have further come into importance with the availability of genetic testing and increased prevalence of certain mutations in African Americans. Recognition of non-cardiac clues to this disease has gained importance and reiterates that high clinical suspicion, detailed patient history, and examination with appropriate use of imaging are vital to confirm the diagnosis.
    MeSH term(s) Amyloid Neuropathies, Familial/complications ; Amyloid Neuropathies, Familial/diagnosis ; Amyloid Neuropathies, Familial/epidemiology ; Amyloidosis/diagnosis ; Amyloidosis/epidemiology ; Amyloidosis/genetics ; Aortic Valve Stenosis ; Cardiomyopathies/diagnosis ; Cardiomyopathies/epidemiology ; Cardiomyopathies/genetics ; Echocardiography ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Heart Failure/etiology ; Humans
    Language English
    Publishing date 2021-10-25
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1336499-6
    ISSN 1573-7322 ; 1382-4147
    ISSN (online) 1573-7322
    ISSN 1382-4147
    DOI 10.1007/s10741-021-10162-1
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    Zs.A 5212: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Photoinduced Nitroarenes as Versatile Anaerobic Oxidants for Accessing Carbonyl and Imine Derivatives.

    Mitchell, Joshua K / Hussain, Waseem A / Bansode, Ajay H / O'Connor, Ryan M / Wise, Dan E / Choe, Michael H / Parasram, Marvin

    Organic letters

    2023  Volume 25, Issue 35, Page(s) 6517–6521

    Abstract: Herein, we report a protocol for the anaerobic oxidation of alcohols, amines, aldehydes, and imines promoted by photoexcited nitroarenes. Mechanistic studies support the idea that photoexcited nitroarenes undergo double hydrogen atom transfer (HAT) steps ...

    Abstract Herein, we report a protocol for the anaerobic oxidation of alcohols, amines, aldehydes, and imines promoted by photoexcited nitroarenes. Mechanistic studies support the idea that photoexcited nitroarenes undergo double hydrogen atom transfer (HAT) steps with alcohols and amines to provide the respective ketone and imine products. In the presence of aldehydes and imines, successive HAT and oxygen atom transfer (OAT) events occur to yield carboxylic acids and amides, respectively. This transformation is amenable to a continuous-photoflow setup, which led to reduced reaction times.
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02292
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Born in the cold: contrasted thermal exchanges and maintenance costs in juvenile and adult snow buntings on their breeding and wintering grounds.

    Demers, Rachel / O'Connor, Ryan S / Le Pogam, Audrey / Young, Kevin G / Berteaux, Dominique / Tam, Andrew / Vézina, François

    Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology

    2023  Volume 193, Issue 5, Page(s) 557–568

    Abstract: Several species of passerines leave their nest with unfinished feather growth, resulting in lower feather insulation and increased thermoregulatory demands compared to adults. However, feather insulation is essential for avian species breeding at ... ...

    Abstract Several species of passerines leave their nest with unfinished feather growth, resulting in lower feather insulation and increased thermoregulatory demands compared to adults. However, feather insulation is essential for avian species breeding at northern latitudes, where cold conditions or even snowstorms can occur during the breeding season. In altricial arctic species, increased heat loss caused by poor feather insulation during growth could be counter-adaptative as it creates additional energy demands for thermoregulation. Using flow-through respirometry, we compared resting metabolic rate at thermoneutrality (RMRt), summit metabolic rate (M
    Language English
    Publishing date 2023-06-29
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 231245-1
    ISSN 1432-136X ; 0174-1578
    ISSN (online) 1432-136X
    ISSN 0174-1578
    DOI 10.1007/s00360-023-01502-8
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  9. Article ; Online: Effect of a Comprehensive School-Based Health Center on Academic Growth in K-8th Grade Students.

    Connor, Katherine A / Spin, Paul / Smith, Brandon M / Marshall, Beth R / Calderon, Gabriela V / Prichett, Laura / Jones, Vanya C / Connor, Ryan / Cheng, Tina L / Klein, Lauren M / Johnson, Sara B

    Academic pediatrics

    2024  

    Abstract: Objective: School-based health centers (SBHCs) improve health care access, but associations with educational outcomes are mixed and limited for elementary and middle school students. We investigated whether students enrolled in a comprehensive SBHC ... ...

    Abstract Objective: School-based health centers (SBHCs) improve health care access, but associations with educational outcomes are mixed and limited for elementary and middle school students. We investigated whether students enrolled in a comprehensive SBHC demonstrated more growth in standardized math and reading assessments over 4 school years versus nonenrolled students. We also explored changes in absenteeism.
    Methods: Participants were students enrolled in 2 co-located Title I schools from 2015-19 (1 elementary, 1 middle, n = 2480). Analysis of math and reading was limited to students with baseline and postbaseline scores (math n = 1622; reading n = 1607). Longitudinal regression models accounting for within-subject clustering were used to estimate the association of SBHC enrollment with academic scores and daily absenteeism, adjusting for grade, sex, body mass index category, health conditions, baseline outcomes (scores or absenteeism), and outcome pretrends.
    Results: More than 70% of SBHC-enrolled students had math (1194 [73.6%]) and reading 1186 [73.8%]) scores. Enrollees were more likely than nonenrollees to have asthma (39.7% vs 19.6%) and overweight/obesity (42.4% vs 33.6%). Adjusted baseline scores were significantly lower in math and reading for enrollees. Mean change from baseline for enrollees exceeded nonenrollees by 3.5 points (95% confidence interval [CI]: 2.2, 4.8) in math and 2.1 points (95% CI: 0.9, 3.3) in reading. The adjusted rate of decrease in daily absenteeism was 10.8% greater for enrollees (incident rate ratio 0.772 [95% CI: 0.623, 0.956]) than nonenrollees (incident rate ratio 0.865 [95% CI: 0.696, 1.076]).
    Conclusions: SBHC enrollees had greater health and educational risk but demonstrated more growth in math and reading and less absenteeism than nonenrollees.
    Language English
    Publishing date 2024-04-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2483385-X
    ISSN 1876-2867 ; 1876-2859
    ISSN (online) 1876-2867
    ISSN 1876-2859
    DOI 10.1016/j.acap.2024.03.018
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  10. Article ; Online: Regio- and Diastereoselective Rhodium-Catalyzed Allylic Substitution with Unstabilized Benzyl Nucleophiles.

    Pal, Debasis / Wright, Timothy B / O'Connor, Ryan / Evans, P Andrew

    Angewandte Chemie (International ed. in English)

    2020  Volume 60, Issue 6, Page(s) 2987–2992

    Abstract: We have developed a highly regio- and diastereoselective rhodium-catalyzed allylic substitution of challenging alkyl-substituted secondary allylic carbonates with benzylzinc reagents, which are prepared from widely available benzyl halides. This process ... ...

    Abstract We have developed a highly regio- and diastereoselective rhodium-catalyzed allylic substitution of challenging alkyl-substituted secondary allylic carbonates with benzylzinc reagents, which are prepared from widely available benzyl halides. This process utilizes rhodium(III) chloride as a commercially available, high-oxidation state and bench-stable pre-catalyst to provide a rare example of a regio- and diastereoselective allylic substitution in the absence of an exogenous ligand. This reaction tolerates electronically diverse benzylzinc nucleophiles and an array of functionalized and/or challenging aliphatic allylic electrophiles. Finally, the configurational fluxionality of the rhodium-allyl intermediate is exploited to develop a novel diastereoselective process for the construction of vicinal acyclic ternary/ternary stereogenic centers, in addition to a cyclic ternary/quaternary derivative.
    Language English
    Publishing date 2020-12-03
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202008071
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