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  1. Article ; Online: Immunologic Control of HIV-1: What Have We Learned and Can We Induce It?

    Rogan, Daniel C / Connors, Mark

    Current HIV/AIDS reports

    2021  Volume 18, Issue 3, Page(s) 211–220

    Abstract: Purpose of review: A large amount of data now exists on the virus-specific immune response associated with spontaneous or induced immunologic control of lentiviruses. This review focuses on how the current understanding of HIV-specific immunity might be ...

    Abstract Purpose of review: A large amount of data now exists on the virus-specific immune response associated with spontaneous or induced immunologic control of lentiviruses. This review focuses on how the current understanding of HIV-specific immunity might be leveraged into induction of immunologic control and what further research is needed to accomplish this goal.
    Recent findings: During chronic infection, the function most robustly associated with immunologic control of HIV-1 is CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes ; HIV Infections/drug therapy ; HIV Seropositivity ; HIV-1 ; Humans
    Language English
    Publishing date 2021-03-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2151206-1
    ISSN 1548-3576 ; 1548-3568
    ISSN (online) 1548-3576
    ISSN 1548-3568
    DOI 10.1007/s11904-021-00545-2
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    Zs.A 5920: Show issues Location:
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  2. Article ; Online: Bringing nature into CAMHS inpatient services: reflections for the implementation and integration of training into practice.

    Hunt, David Francis / Morgan, Mia / Connors, Michéal / Mellor, Catriona

    International review of psychiatry (Abingdon, England)

    2022  Volume 34, Issue 5, Page(s) 546–552

    Abstract: Poor mental health is a global concern and is exacerbated by recent challenges concerning COVID-19 and the climate emergency, with significant consequences to individuals and to society. Increasing evidence demonstrates that nature-based approaches (NBAs) ...

    Abstract Poor mental health is a global concern and is exacerbated by recent challenges concerning COVID-19 and the climate emergency, with significant consequences to individuals and to society. Increasing evidence demonstrates that nature-based approaches (NBAs) have numerous benefits to mental health services and the people they support with mental health needs. Despite these benefits, understanding how to integrate these approaches into practice is challenging. In this paper, we report our findings from a recent qualitative study with staff from a CAMHS inpatient unit who had recently undergone NatureWell Facilitator training. This is a particular approach to working with people in nature developed by The Natural Academy. Participants identified the importance of implementation of discreet, novel NBAs, as well as integrating nature into current practice, the benefits when fostering psychologically safe and therapeutic relationships with staff, and the clinical and operational factors when carrying out NBAs in these settings.
    MeSH term(s) COVID-19 ; Humans ; Inpatients ; Mental Health ; Mental Health Services ; Qualitative Research
    Language English
    Publishing date 2022-06-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1018090-4
    ISSN 1369-1627 ; 0954-0261
    ISSN (online) 1369-1627
    ISSN 0954-0261
    DOI 10.1080/09540261.2022.2080530
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  3. Article: Who Participates in Quality Rating and Improvement Systems?

    Jenkins, Jade Marcus / Duer, Jennifer K / Connors, Maia

    Early childhood research quarterly

    2020  Volume 54, Page(s) 219–227

    Abstract: Even with rapid and widespread expansion of states' quality rating and improvement systems (QRIS)-tiered frameworks that assess, communicate, and improve early childhood education (ECE) quality-there exists no population-level information regarding which ...

    Abstract Even with rapid and widespread expansion of states' quality rating and improvement systems (QRIS)-tiered frameworks that assess, communicate, and improve early childhood education (ECE) quality-there exists no population-level information regarding which providers choose to participate in these primarily voluntary systems. We use a nationally representative survey of ECE centers to examine how the characteristics of ECE centers and the communities in which they are located predict participation in QRIS to understand the scope of QRIS policy implementation and the extent to which QRIS may be equity enhancing. We find that approximately one-third of centers nationwide participated in QRIS in 2012. Selection model results reveal that participation is more likely among centers that blend multiple funding sources and who are NAEYC accredited, and in communities with high poverty rates. However, QRIS participation is less likely in communities with relatively higher proportions of Black residents. Findings raise questions about how QRISs can equitably engage programs in all communities.
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article
    ISSN 0885-2006
    ISSN 0885-2006
    DOI 10.1016/j.ecresq.2020.09.005
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  4. Article ; Online: SARS-CoV-2 Vaccines: Much Accomplished, Much to Learn.

    Connors, Mark / Graham, Barney S / Lane, H Clifford / Fauci, Anthony S

    Annals of internal medicine

    2021  Volume 174, Issue 5, Page(s) 687–690

    MeSH term(s) COVID-19/immunology ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Clinical Trials as Topic ; Humans ; Immunogenicity, Vaccine ; Pandemics/prevention & control ; Patient Safety ; Pneumonia, Viral/immunology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/virology ; SARS-CoV-2/immunology ; United States ; United States Food and Drug Administration ; Vaccines, Synthetic/immunology ; Viral Vaccines/immunology ; mRNA Vaccines
    Chemical Substances COVID-19 Vaccines ; Vaccines, Synthetic ; Viral Vaccines
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/M21-0111
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  5. Book ; Online: Statistics of Large Impulsive Magnetic Events in the Auroral Zone

    Reiter, Kyle / Guillon, Sébastien / Connors, Martin / Jackel, Brian

    2021  

    Abstract: Impulsive geomagnetic variations, latitudinally localized to the auroral zone, have been observed over the period from 2015-2020. These impulsive events have been observed mostly in the pre-midnight sector as upward vertical perturbations. Diurnal ... ...

    Abstract Impulsive geomagnetic variations, latitudinally localized to the auroral zone, have been observed over the period from 2015-2020. These impulsive events have been observed mostly in the pre-midnight sector as upward vertical perturbations. Diurnal variations in geomagnetically-triggered harmonic distortion events observed in Hydro-Qu\'ebec's Syst\`eme de Mesure de D\'ecalage Angulaire (SMDA) synchrophasor measurement system have been found to have a peak in the number of events around midnight. This was similar to diurnal rates of occurrence of negative $B_z$ geomagnetic impulsive events, observed at nearby auroral zone magnetometers. Superposed epoch analysis demonstrates the impulses are regularly associated with increases in harmonic distortion observed at a nearby substation transformer. These large impulsive vertical geomagnetic perturbations appear to be local vortical ionospheric disturbances.

    Comment: This manuscript has been accepted for publication in the Journal of Space Weather and Space Climate (JSWSC)
    Keywords Physics - Space Physics
    Subject code 551
    Publishing date 2021-07-12
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Class II-Restricted CD8s: New Lessons Violate Old Paradigms.

    Migueles, Stephen A / Connors, Mark

    Immunity

    2016  Volume 45, Issue 4, Page(s) 712–714

    Abstract: ... ...

    Abstract CD8
    MeSH term(s) Animals ; CD8-Positive T-Lymphocytes/immunology ; Histocompatibility Antigens Class II/immunology ; Humans ; SAIDS Vaccines/immunology ; Simian Acquired Immunodeficiency Syndrome/immunology ; Simian Immunodeficiency Virus/immunology
    Chemical Substances Histocompatibility Antigens Class II ; SAIDS Vaccines
    Language English
    Publishing date 2016-10-19
    Publishing country United States
    Document type Journal Article ; Review ; Comment
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2016.10.004
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    Zs.A 4227: Show issues Location:
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  7. Article ; Online: Success and failure of the cellular immune response against HIV-1.

    Migueles, Stephen A / Connors, Mark

    Nature immunology

    2015  Volume 16, Issue 6, Page(s) 563–570

    Abstract: The cellular immune response to HIV-1 has now been studied in extraordinary detail. A very large body of data provides the most likely reasons that the HIV-specific cellular immune response succeeds in a small number of people but fails in most. ... ...

    Abstract The cellular immune response to HIV-1 has now been studied in extraordinary detail. A very large body of data provides the most likely reasons that the HIV-specific cellular immune response succeeds in a small number of people but fails in most. Understanding the success and failure of the HIV-specific cellular immune response has implications that extend not only to immunotherapies and vaccines for HIV-1 but also to the cellular immune response in other disease states. This Review focuses on the mechanisms that are most likely responsible for durable and potent immunologic control of HIV-1. Although we now have a detailed picture of the cellular immune responses to HIV-1, important questions remain regarding the nature of these responses and how they arise.
    MeSH term(s) AIDS Vaccines/immunology ; Animals ; Antigens, Viral/immunology ; Asymptomatic Diseases ; Cytotoxicity, Immunologic/genetics ; Disease Progression ; Epitopes, T-Lymphocyte/immunology ; HIV Infections/immunology ; HIV Infections/therapy ; HIV Long-Term Survivors ; HIV-1/immunology ; HLA Antigens/genetics ; Humans ; Immunity, Cellular ; Immunotherapy ; Polymorphism, Genetic ; nef Gene Products, Human Immunodeficiency Virus/genetics
    Chemical Substances AIDS Vaccines ; Antigens, Viral ; Epitopes, T-Lymphocyte ; HLA Antigens ; nef Gene Products, Human Immunodeficiency Virus ; nef protein, Human immunodeficiency virus 1
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2016987-5
    ISSN 1529-2916 ; 1529-2908
    ISSN (online) 1529-2916
    ISSN 1529-2908
    DOI 10.1038/ni.3161
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  8. Article ; Online: Indirect task instructions better reveal theory-of-mind impairment, independent of executive dysfunction, in schizophrenia.

    Langdon, Robyn / Connors, Michael / Connaughton, Emily

    Psychiatry research

    2017  Volume 256, Page(s) 342–344

    Abstract: Theory of mind (TOM) impairments associate significantly with executive deficits in schizophrenia, consistent with the proposal that executive abilities can limit TOM task performance, and confounding identification of those patients who would benefit ... ...

    Abstract Theory of mind (TOM) impairments associate significantly with executive deficits in schizophrenia, consistent with the proposal that executive abilities can limit TOM task performance, and confounding identification of those patients who would benefit most from targeted mentalising interventions. 50 schizophrenia patients and 30 healthy controls completed an executive battery and four TOM tasks that were alike with regards generating overt measures of causal false-belief reasoning, but differed with regards using indirect (vs. more direct) instructions. Only the TOM tasks that used indirect instructions to elicit spontaneous false-belief inferences revealed impairment, independent of executive dysfunction, in the schizophrenia patients.
    Language English
    Publishing date 2017-10
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 445361-x
    ISSN 1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
    ISSN (online) 1872-7123 ; 1872-7506
    ISSN 0925-4927 ; 0165-1781
    DOI 10.1016/j.psychres.2017.06.064
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  9. Article ; Online: Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling.

    Palsamy, Kanagaraj / Chen, Jessica Y / Skaggs, Kaia / Qadeer, Yusuf / Connors, Meghan / Cutler, Noah / Richmond, Joshua / Kommidi, Vineeth / Poles, Allison / Affrunti, Danielle / Powell, Curtis / Goldman, Daniel / Parent, Jack M

    Glia

    2023  Volume 71, Issue 11, Page(s) 2642–2663

    Abstract: The adult zebrafish brain, unlike mammals, has a remarkable regenerative capacity. Although inflammation in part hinders regeneration in mammals, it is necessary for zebrafish brain repair. Microglia are resident brain immune cells that regulate the ... ...

    Abstract The adult zebrafish brain, unlike mammals, has a remarkable regenerative capacity. Although inflammation in part hinders regeneration in mammals, it is necessary for zebrafish brain repair. Microglia are resident brain immune cells that regulate the inflammatory response. To explore the microglial role in repair, we used liposomal clodronate or colony stimulating factor-1 receptor (csf1r) inhibitor to suppress microglia after brain injury, and also examined regeneration in two genetic mutant lines that lack microglia. We found that microglial ablation impaired telencephalic regeneration after injury. Microglial suppression attenuated cell proliferation at the intermediate progenitor cell amplification stage of neurogenesis. Notably, the loss of microglia impaired phospho-Stat3 (signal transducer and activator of transcription 3) and ß-Catenin signaling after injury. Furthermore, the ectopic activation of Stat3 and ß-Catenin rescued neurogenesis defects caused by microglial loss. Microglial suppression also prolonged the post-injury inflammatory phase characterized by neutrophil accumulation, likely hindering the resolution of inflammation. These findings reveal specific roles of microglia and inflammatory signaling during zebrafish telencephalic regeneration that should advance strategies to improve mammalian brain repair.
    MeSH term(s) Animals ; Microglia ; Zebrafish ; Brain ; Brain Injuries ; Neurogenesis ; Inflammation ; Catenins ; Mammals
    Chemical Substances Catenins
    Language English
    Publishing date 2023-07-14
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 639414-0
    ISSN 1098-1136 ; 0894-1491
    ISSN (online) 1098-1136
    ISSN 0894-1491
    DOI 10.1002/glia.24444
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  10. Article ; Online: A retrograde co-orbital asteroid of Jupiter.

    Wiegert, Paul / Connors, Martin / Veillet, Christian

    Nature

    2017  Volume 543, Issue 7647, Page(s) 687–689

    Abstract: Recent theoretical work in celestial mechanics has revealed that an asteroid may orbit stably in the same region as a planet, despite revolving around the Sun in the sense opposite to that of the planet itself. Asteroid 2015 ... ...

    Abstract Recent theoretical work in celestial mechanics has revealed that an asteroid may orbit stably in the same region as a planet, despite revolving around the Sun in the sense opposite to that of the planet itself. Asteroid 2015 BZ
    Language English
    Publishing date 2017--29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/nature22029
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