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  1. Article ; Online: 2019 novel coronavirus (COVID-19) pneumonia complications: the importance of lung ultrasound.

    Consoli, Letizia / Bendotti, Vittorio / Cicchinelli, Sara / Gaioni, Federico / Prandolini, Paola / Bettonagli, Monica / Terragnoli, Paolo

    Journal of ultrasound

    2020  Volume 25, Issue 1, Page(s) 107–110

    Abstract: In December 2019, a novel coronavirus (SARS-Cov-2) was first reported in Wuhan, China, and rapidly spread around the world, leading to an international emerging public health emergency. As reported from Chinese experiences, approximately 20% of patients ... ...

    Abstract In December 2019, a novel coronavirus (SARS-Cov-2) was first reported in Wuhan, China, and rapidly spread around the world, leading to an international emerging public health emergency. As reported from Chinese experiences, approximately 20% of patients had a severe course, requiring intensive care, with an overall case fatality rate of 2.3%. In diagnosis, chest computed tomography most commonly showed ground-glass opacity with or without consolidative patterns.Herein, we report a case of a patient affected by COVID-19 pneumonia referred in the emergency department of our institution on April 4, 2020, with peculiar lung ultrasound findings.
    MeSH term(s) COVID-19 ; Humans ; Lung/diagnostic imaging ; SARS-CoV-2 ; Tomography, X-Ray Computed ; Ultrasonography
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2365426-0
    ISSN 1876-7931 ; 1971-3495
    ISSN (online) 1876-7931
    ISSN 1971-3495
    DOI 10.1007/s40477-020-00494-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The "Black Pattern", a Simplified Ultrasound Approach to Non-Traumatic Abdominal Emergencies.

    Tamburrini, Stefania / Consoli, Letizia / Garrone, Marco / Sfuncia, Giuseppe / Lugarà, Marina / Coppola, Maria Gabriella / Piccirillo, Miryam / Toto, Roberta / Stella, Salvatore Massimo / Sofia, Soccorsa / Scuderi, Mario / Catalano, Orlando

    Tomography (Ann Arbor, Mich.)

    2022  Volume 8, Issue 2, Page(s) 798–814

    Abstract: Background: A key issue in abdominal US is the assessment of fluid, which is usually anechoic, thus appearing "black". Our approach focuses on searching for fluid in non-traumatic patients, providing a new, simplified method for point-of-care US (POCUS). ...

    Abstract Background: A key issue in abdominal US is the assessment of fluid, which is usually anechoic, thus appearing "black". Our approach focuses on searching for fluid in non-traumatic patients, providing a new, simplified method for point-of-care US (POCUS).
    Objective: Fluid assessment is based on a three-step analysis that we can thus summarize. 1. Look for black where it should not be. This means searching for effusions or collections. 2. Check if black is too much. This means evaluating anatomical landmarks where fluid should normally be present but may be abnormally abundant. 3. Look for black that is not clearly black. This means evaluating fluid aspects, whether wholly anechoic or not (suggesting heterogeneous or corpusculated fluid).
    Discussion: Using this simple method focused on US fluid presence and appearance should help clinicians to make a timely diagnosis. Although our simplified, systematic algorithm of POCUS may identify abnormalities; this usually entails a second-level imaging. An accurate knowledge of the physio-pathological and anatomical ultrasound bases remains essential in applying this algorithm.
    Conclusion: The black pattern approach in non -traumatic emergencies may be applied to a broad spectrum of abnormalities. It may represent a valuable aid for emergency physicians, especially if inexperienced, involved in a variety of non-traumatic scenarios. It may also be a simple and effective teaching aid for US beginners.
    MeSH term(s) Abdomen/diagnostic imaging ; Algorithms ; Emergencies ; Humans ; Point-of-Care Systems ; Ultrasonography/methods
    Language English
    Publishing date 2022-03-15
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography8020066
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  3. Article: 2019 novel coronavirus (COVID-19) pneumonia complications: the importance of lung ultrasound

    Consoli, Letizia / Bendotti, Vittorio / Cicchinelli, Sara / Gaioni, Federico / Prandolini, Paola / Bettonagli, Monica / Terragnoli, Paolo

    Abstract: In December 2019, a novel coronavirus (SARS-Cov-2) was first reported in Wuhan, China, and rapidly spread around the world, leading to an international emerging public health emergency. As reported from Chinese experiences, approximately 20% of patients ... ...

    Abstract In December 2019, a novel coronavirus (SARS-Cov-2) was first reported in Wuhan, China, and rapidly spread around the world, leading to an international emerging public health emergency. As reported from Chinese experiences, approximately 20% of patients had a severe course, requiring intensive care, with an overall case fatality rate of 2.3%. In diagnosis, chest computed tomography most commonly showed ground-glass opacity with or without consolidative patterns.Herein, we report a case of a patient affected by COVID-19 pneumonia referred in the emergency department of our institution on April 4, 2020, with peculiar lung ultrasound findings.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32562109
    Database COVID19

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  4. Article ; Online: 2019 novel coronavirus (COVID-19) pneumonia complications

    Consoli, Letizia / Bendotti, Vittorio / Cicchinelli, Sara / Gaioni, Federico / Prandolini, Paola / Bettonagli, Monica / Terragnoli, Paolo

    Journal of Ultrasound ; ISSN 1876-7931

    the importance of lung ultrasound

    2020  

    Keywords covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    DOI 10.1007/s40477-020-00494-3
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Major cardiovascular events in patients with Coronavirus Disease 2019: Experience of a cardiovascular department of Northern Italy.

    Bellosta, Raffaello / Pegorer, Matteo Alberto / Bettari, Luca / Luzzani, Luca / Attisani, Luca / Fossati, Alessandro / Consoli, Letizia / Maffeo, Diego / Cuccia, Claudio / Terragnoli, Paolo / Bush, Ruth L / Piffaretti, Gabriele

    Thrombosis research

    2020  Volume 197, Page(s) 202–204

    MeSH term(s) Anticoagulants ; COVID-19 ; Cardiovascular Diseases/epidemiology ; Humans ; Italy/epidemiology ; SARS-CoV-2
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2020-11-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 121852-9
    ISSN 1879-2472 ; 0049-3848
    ISSN (online) 1879-2472
    ISSN 0049-3848
    DOI 10.1016/j.thromres.2020.10.038
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 863: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Major cardiovascular events in patients with Coronavirus Disease 2019: experience of a cardiovascular Department of Northern Italy

    Bellosta, Raffaello Pegorer Matteo Alberto Bettari Luca Luzzani Luca Attisani Luca Fossati Alessandro Consoli Letizia Maffeo Diego Cuccia Claudio Terragnoli Paolo Bush Ruth L. / Piffaretti, Gabriele

    Thrombosis Research

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #912639
    Database COVID19

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  7. Article: A 'desaturase hypothesis' for atherosclerosis: Janus-faced enzymes in omega-6 and omega-3 polyunsaturated fatty acid metabolism.

    Martinelli, Nicola / Consoli, Letizia / Olivieri, Oliviero

    Journal of nutrigenetics and nutrigenomics

    2009  Volume 2, Issue 3, Page(s) 129–139

    Abstract: The delta-5 and delta-6 desaturases are key enzymes in the metabolism of omega-3 (omega-3) and omega-6 (omega-6) polyunsaturated fatty acids (PUFA), which in turn influence cellular functions by regulating several metabolic pathways with well-known ... ...

    Abstract The delta-5 and delta-6 desaturases are key enzymes in the metabolism of omega-3 (omega-3) and omega-6 (omega-6) polyunsaturated fatty acids (PUFA), which in turn influence cellular functions by regulating several metabolic pathways with well-known effects on the cardiovascular system. At present, data about desaturase activity and cardiovascular risk remain inconclusive. In this short review we propose a 'desaturase hypothesis' of atherosclerosis, providing suggestions for the Janus-faced role of desaturases, with both more favorable (mainly related to omega-3 long-chain fatty acids) and more harmful (mainly related to omega-6 long-chain fatty acids) cardiovascular effects than those obtained in subjects with lower desaturase activity. In particular in populations eating a Western diet rich in omega-6 PUFA, a high desaturase activity may promote an increased bioavailability of arachidonic acid with prevailing synthesis of arachidonic acid-derived proinflammatory eicosanoids, finally favoring atherosclerotic vascular damage. In contrast, high desaturase activity in subjects consuming a diet rich in omega-3 PUFA or receiving omega-3 PUFA supplementation could result in the opposite situation with a preferential synthesis of anti-inflammatory eicosanoids. For these reasons, carriers of specific FADS haplotypes may be predisposed to more pronounced vascular inflammatory damage, but also to an increased beneficial effect with omega-3 PUFA supplementation.
    MeSH term(s) Atherosclerosis/enzymology ; Atherosclerosis/genetics ; Atherosclerosis/prevention & control ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/prevention & control ; Diet ; Environment ; Fatty Acid Desaturases/genetics ; Fatty Acid Desaturases/metabolism ; Fatty Acids, Omega-3/metabolism ; Fatty Acids, Omega-3/therapeutic use ; Fatty Acids, Omega-6/metabolism ; Humans ; Linoleoyl-CoA Desaturase/genetics ; Linoleoyl-CoA Desaturase/metabolism ; Models, Biological
    Chemical Substances Fatty Acids, Omega-3 ; Fatty Acids, Omega-6 ; Fatty Acid Desaturases (EC 1.14.19.-) ; Linoleoyl-CoA Desaturase (EC 1.14.19.3) ; delta-5 fatty acid desaturase (EC 1.14.99.-)
    Language English
    Publishing date 2009
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2253668-1
    ISSN 1661-6758 ; 1661-6499
    ISSN (online) 1661-6758
    ISSN 1661-6499
    DOI 10.1159/000238177
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7783: Show issues

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  8. Article: Paraoxonases: ancient substrate hunters and their evolving role in ischemic heart disease.

    Martinelli, Nicola / Consoli, Letizia / Girelli, Domenico / Grison, Elisa / Corrocher, Roberto / Olivieri, Oliviero

    Advances in clinical chemistry

    2013  Volume 59, Page(s) 65–100

    Abstract: Interest in the role of paraoxonases (PON) in cardiovascular research has increased substantially over the past two decades. These multifaceted and pleiotropic enzymes are encoded by three highly conserved genes (PON1, PON2, and PON3) located on ... ...

    Abstract Interest in the role of paraoxonases (PON) in cardiovascular research has increased substantially over the past two decades. These multifaceted and pleiotropic enzymes are encoded by three highly conserved genes (PON1, PON2, and PON3) located on chromosome 7q21.3-22.1. Phylogenetic analysis suggests that PON2 is the ancient gene from which PON1 and PON3 arose via gene duplication. Although PON are primarily lactonases with overlapping, but distinct specificities, their physiologic substrates remain poorly characterized. The most interesting characteristic of PON, however, is their multifunctional roles in various biochemical pathways. These include protection against oxidative damage and lipid peroxidation, contribution to innate immunity, detoxification of reactive molecules, bioactivation of drugs, modulation of endoplasmic reticulum stress, and regulation of cell proliferation/apoptosis. In general, PON appear as "hunters" of old and new substrates often involved in athero- and thrombogenesis. Although reduced PON activity appears associated with increased cardiovascular risk, the correlation between PON genotype and ischemic heart disease remains controversial. In this review, we examine the biochemical pathways impacted by these unique enzymes and investigate the potential use of PON as diagnostic tools and their impact on development of future therapeutic strategies.
    MeSH term(s) Animals ; Aryldialkylphosphatase/blood ; Aryldialkylphosphatase/genetics ; Aryldialkylphosphatase/physiology ; Atherosclerosis/etiology ; Genotype ; Humans ; Myocardial Ischemia/enzymology ; Myocardial Ischemia/etiology
    Chemical Substances Aryldialkylphosphatase (EC 3.1.8.1)
    Language English
    Publishing date 2013-03-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 210505-6
    ISSN 0065-2423
    ISSN 0065-2423
    DOI 10.1016/b978-0-12-405211-6.00003-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.182: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Major cardiovascular events in patients with Coronavirus Disease 2019: experience of a cardiovascular Department of Northern Italy

    Bellosta, Raffaello / Pegorer, Matteo Alberto / Bettari, Luca / Luzzani, Luca / Attisani, Luca / Fossati, Alessandro / Consoli, Letizia / Maffeo, Diego / Cuccia, Claudio / Terragnoli, Paolo / Bush, Ruth L. / Piffaretti, Gabriele

    Thromb Res

    Abstract: Although small with short-term data, our series reports a translational experience of a cardiovascular department facing MACE in COVID-19 patients being acute arterial events the new insight into this COVID-19 pandemic. • COVID-19 infection may trigger ...

    Abstract • Although small with short-term data, our series reports a translational experience of a cardiovascular department facing MACE in COVID-19 patients being acute arterial events the new insight into this COVID-19 pandemic. • COVID-19 infection may trigger a hypercoagulable status leading to challenging MACE and is associated with high mortality rate. • COVID-19 patient with MACE should be treated with both ventilator support, extensive operative cardiac and peripheral revascularization, and the adjunct of heparin which provides better survival chance independently of the infection-related drug treatment.
    Keywords covid19
    Publisher Elsevier; PMC
    Document type Article ; Online
    DOI 10.1016/j.thromres.2020.10.038
    Database COVID19

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  10. Article ; Online: Major Cardiovascular Events in Patients with COVID-19

    Bellosta, Raffaello / Pegorer, Matteo Alberto / Bettari, Luca / Luzzani, Luca / Attisani, Luca / Fossati, Alessandro / Consoli, Letizia / Maffeo, Diego / Cuccia, Claudio / Terragnoli, Paolo / Bush, Ruth L / Piffaretti, Gabriele

    SSRN Electronic Journal ; ISSN 1556-5068

    Experience of a Cardiovascular Department in the Lombardia Region of Northern Italy

    2020  

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    DOI 10.2139/ssrn.3605117
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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