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Article ; Online: Clinical Characterization of [

Constantinescu, Cristian C / Brown, Terry / Wang, Shining / Yin, Wei / Barret, Olivier / Jennings, Danna / Tauscher, Johannes

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2023 Volume 64, Issue 12, Page(s) 1972–1979

Abstract: This series of studies characterized [ ...

Abstract	This series of studies characterized [
MeSH term(s)	Humans ; Male ; Cholesterol 24-Hydroxylase ; Ligands ; Positron-Emission Tomography/methods ; Radiometry ; Female
Chemical Substances	Cholesterol 24-Hydroxylase (EC 1.14.14.25) ; Ligands ; soticlestat (1766MU795L)
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.123.265912
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Article ; Online: Design and synthesis of aryl-piperidine derivatives as potent and selective PET tracers for cholesterol 24-hydroxylase (CH24H).

Ikeda, Shuhei / Kajita, Yuichi / Miyamoto, Maki / Matsumiya, Kouta / Ishii, Tsuyoshi / Nishi, Toshiya / Gay, Sean C / Lane, Weston / Constantinescu, Cristian C / Alagille, David / Papin, Caroline / Tamagnan, Gilles / Kuroita, Takanobu / Koike, Tatsuki

European journal of medicinal chemistry

2022 Volume 240, Page(s) 114612

Abstract: Cholesterol 24-hydroxylase (CH24H, CYP46A1) is a cytochrome P450 family enzyme that maintains the homeostasis of brain cholesterol. Soticlestat, a potent and selective CH24H inhibitor, is in development as a therapeutic agent for Dravet syndrome and ... ...

Abstract	Cholesterol 24-hydroxylase (CH24H, CYP46A1) is a cytochrome P450 family enzyme that maintains the homeostasis of brain cholesterol. Soticlestat, a potent and selective CH24H inhibitor, is in development as a therapeutic agent for Dravet syndrome and Lennox-Gastaut syndrome. Herein, we report the discovery of aryl-piperidine derivatives as potent and selective CH24H positron emission tomography (PET) tracers which can be used for dose guidance of a clinical CH24H inhibitor and as a diagnostic tool for CH24H-related pathology. Starting from compound 1 (IC
MeSH term(s)	Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Cholesterol 24-Hydroxylase/metabolism ; Mice ; Piperidines/metabolism ; Piperidines/pharmacology ; Positron-Emission Tomography/methods ; Pyridines/metabolism
Chemical Substances	Piperidines ; Pyridines ; soticlestat (1766MU795L) ; Cholesterol 24-Hydroxylase (EC 1.14.14.25)
Language	English
Publishing date	2022-07-14
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2022.114612
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Article ; Online: The rate of dasotraline brain entry is slow following intravenous administration.

Lew, Robert / Constantinescu, Cristian C / Holden, Daniel / Carson, Richard E / Carroll, Vincent / Galluppi, Gerald / Koblan, Kenneth S / Hopkins, Seth C

Psychopharmacology

2020 Volume 237, Issue 11, Page(s) 3435–3446

Abstract: Rationale: Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear ...

Abstract	Rationale: Drugs that rapidly increase dopamine levels have an increased risk of abuse. Dasotraline (DAS) is a dopamine and norepinephrine reuptake inhibitor characterized by slow oral absorption with low potential for abuse. However, it remains unclear whether intravenous (i.v.) administration would facilitate the rapid elevation of dopamine levels associated with stimulant drugs. Objective: To assess the kinetics of DAS across the blood-brain barrier and time to onset of dopamine transporters (DAT) inhibition. Methods: We compared the onset of DAT occupancy and the associated elevation of synaptic dopamine levels in rhesus monkey following i.v. administration of DAS or methylphenidate (MPH) using positron emission tomography (PET). Brain entry times were estimated by reductions in [ Results: Intravenous administration of DAS (0.1 and 0.2 mg/kg) resulted in striatal DAT occupancies of 54% and 68%, respectively; i.v. administered MPH (0.1 and 0.5 mg/kg) achieved occupancies of 69% and 88% respectively. Brain entry times of DAS (22 and 15 min, respectively) were longer than for MPH (3 and 2 min). Elevations in synaptic dopamine were similar for both DAS and MPH however the time for half-maximal displacement by MPH (t = 23 min) was 4-fold more rapid than for DAS (t = 88 min). Conclusions: These results demonstrate that the pharmacodynamics effects of DAS on DAT occupancy and synaptic dopamine levels are more gradual in onset than those of MPH even with i.v. administration that is favored by recreational drug abusers.
MeSH term(s)	1-Naphthylamine/administration & dosage ; 1-Naphthylamine/analogs & derivatives ; 1-Naphthylamine/metabolism ; Administration, Intravenous ; Animals ; Brain/drug effects ; Brain/metabolism ; Dopamine/metabolism ; Dopamine Plasma Membrane Transport Proteins/antagonists & inhibitors ; Dopamine Plasma Membrane Transport Proteins/metabolism ; Dopamine Uptake Inhibitors/administration & dosage ; Dopamine Uptake Inhibitors/metabolism ; Female ; Macaca mulatta ; Male ; Methylphenidate/administration & dosage ; Methylphenidate/metabolism ; Positron-Emission Tomography/methods ; Receptors, Dopamine D2/metabolism
Chemical Substances	Dopamine Plasma Membrane Transport Proteins ; Dopamine Uptake Inhibitors ; Receptors, Dopamine D2 ; Methylphenidate (207ZZ9QZ49) ; 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine (4D28EY0L5T) ; 1-Naphthylamine (9753I242R5) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2020-08-19
Publishing country	Germany
Document type	Journal Article
ZDB-ID	130601-7
ISSN	1432-2072 ; 0033-3158
ISSN (online)	1432-2072
ISSN	0033-3158
DOI	10.1007/s00213-020-05623-8
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Article ; Online: Preclinical characterization of [

Koike, Tatsuki / Constantinescu, Cristian C / Ikeda, Shuhei / Nishi, Toshiya / Sunahara, Eiji / Miyamoto, Maki / Cole, Patricia / Barret, Olivier / Alagille, David / Papin, Caroline / Morley, Thomas / Fowles, Krista / Seibyl, John / Tamagnan, Gilles / Kuroita, Takanobu

European journal of nuclear medicine and molecular imaging

2021 Volume 49, Issue 4, Page(s) 1148–1156

Abstract: Purpose: Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting cholesterol into 24S-hydroxycholesterol. The selective CH24H inhibitor soticlestat (TAK-935) is being pursued ... ...

Abstract	Purpose: Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that plays a major role in brain cholesterol homeostasis by converting cholesterol into 24S-hydroxycholesterol. The selective CH24H inhibitor soticlestat (TAK-935) is being pursued as a drug for treatment of seizures in developmental and epileptic encephalopathies. Herein, we describe the successful discovery and the preclinical validation of the novel radiolabeled CH24H ligand (3-[ Methods: In vitro autoradiography (ARG) studies in the CH24H wild-type (WT) and knockout (KO) mouse brain sections were conducted using [ Results: In ARG studies, binding of [ Conclusion: The preclinical in vitro and in vivo evaluation of labeled T-008 demonstrates that [
MeSH term(s)	Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Cholesterol 24-Hydroxylase/metabolism ; Humans ; Macaca mulatta/metabolism ; Mice ; Piperidines ; Positron-Emission Tomography/methods ; Pyridines
Chemical Substances	Piperidines ; Pyridines ; soticlestat (1766MU795L) ; Cholesterol 24-Hydroxylase (EC 1.14.14.25)
Language	English
Publishing date	2021-10-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-021-05565-z
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Article: Performance evaluation of an Inveon PET preclinical scanner.

Constantinescu, Cristian C / Mukherjee, Jogeshwar

Physics in medicine and biology

2009 Volume 54, Issue 9, Page(s) 2885–2899

Abstract: We evaluated the performance of an Inveon preclinical PET scanner (Siemens Medical Solutions), the latest MicroPET system. Spatial resolution was measured with a glass capillary tube (0.26 mm inside diameter, 0.29 mm wall thickness) filled with (18)F ... ...

Abstract	We evaluated the performance of an Inveon preclinical PET scanner (Siemens Medical Solutions), the latest MicroPET system. Spatial resolution was measured with a glass capillary tube (0.26 mm inside diameter, 0.29 mm wall thickness) filled with (18)F solution. Transaxial and axial resolutions were measured with the source placed parallel and perpendicular to the axis of the scanner. The sensitivity of the scanner was measured with a (22)Na point source, placed on the animal bed and positioned at different offsets from the center of the field of view (FOV), as well as at different energy and coincidence windows. The noise equivalent count rates (NECR) and the system scatter fraction were measured using rat-like (Phi = 60, L = 150 mm) and mouse-like (Phi = 25 mm, L = 70 mm) cylindrical phantoms. Line sources filled with high activity (18)F (>250 MBq) were inserted parallel to the axes of the phantoms (13.5 and 10 mm offset). For each phantom, list-mode data were collected over 24 h at 350-650 keV and 250-750 keV energy windows and 3.4 ns coincidence window. System scatter fraction was measured when the random event rates were below 1%. Performance phantoms consisting of cylinders with hot rod inserts filled with (18)F were imaged. In addition, we performed imaging studies that show the suitability of the Inveon scanner for imaging small structures such as those in mice with a variety of tracers. The radial, tangential and axial resolutions at the center of FOV were 1.46 mm, 1.49 and 1.15 mm, respectively. At a radial offset of 2 cm, the FWHM values were 1.73, 2.20 and 1.47 mm, respectively. At a coincidence window of 3.4 ns, the sensitivity was 5.75% for EW = 350-650 keV and 7.4% for EW = 250-750 keV. For an energy window of 350-650 keV, the peak NECR was 538 kcps at 131.4 MBq for the rat-like phantom, and 1734 kcps at 147.4 MBq for the mouse-like phantom. The system scatter fraction values were 0.22 for the rat phantom and 0.06 for the mouse phantom. The Inveon system presents high image resolution, low scatter fraction values and improved sensitivity and count rate performance.
MeSH term(s)	Animals ; Image Processing, Computer-Assisted ; Mice ; Positron-Emission Tomography/instrumentation ; Positron-Emission Tomography/methods ; Rats ; Scattering, Radiation ; Sensitivity and Specificity ; Universities
Language	English
Publishing date	2009-04-21
Publishing country	England
Document type	Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	208857-5
ISSN	1361-6560 ; 0031-9155
ISSN (online)	1361-6560
ISSN	0031-9155
DOI	10.1088/0031-9155/54/9/020
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Article ; Online: Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain.

Hattori, Yasushi / Matsuda, Satoru / Baba, Rina / Matsumiya, Kouta / Iwasaki, Shinji / Constantinescu, Cristian C / Morley, Thomas J / Carroll, Vincent M / Papin, Caroline / Gouasmat, Alexandra / Alagille, David / Tamagnan, Gilles / Koike, Tatsuki

Journal of medicinal chemistry

2021 Volume 64, Issue 7, Page(s) 3780–3793

Abstract: Dysregulation of histone H3 lysine 4 (H3K4) methylation is implicated in the pathogenesis of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediated ... ...

Abstract	Dysregulation of histone H3 lysine 4 (H3K4) methylation is implicated in the pathogenesis of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediated histone demethylation. Therefore, LSD1 inhibition in the brain can be a novel therapeutic option for treating these disorders. Positron emission tomography (PET) imaging of LSD1 allows for investigating LSD1 expression levels under normal and disease conditions and validating target engagement of therapeutic LSD1 inhibitors. This study designed and synthesized (2-aminocyclopropyl)phenyl derivatives with irreversible binding to LSD1 as PET imaging agents for LSD1 in the brain. We optimized lipophilicity of the lead compound to minimize the risk of nonspecific binding and identified
MeSH term(s)	Animals ; Brain/metabolism ; Cell Line ; Contrast Media/chemical synthesis ; Contrast Media/metabolism ; Cyclopropanes/chemical synthesis ; Cyclopropanes/metabolism ; Drug Design ; Histone Demethylases/metabolism ; Humans ; Macaca mulatta ; Male ; Positron-Emission Tomography ; Protein Binding ; Rats ; Swine
Chemical Substances	Contrast Media ; Cyclopropanes ; Histone Demethylases (EC 1.14.11.-)
Language	English
Publishing date	2021-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.0c01937
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Article ; Online: Clinical evaluation of [

Schmidt, Mark E / Janssens, Luc / Moechars, Diederik / Rombouts, Frederik J R / Timmers, Maarten / Barret, Olivier / Constantinescu, Cristian C / Madonia, Jennifer / Russell, David S / Sandiego, Christine M / Kolb, Hartmuth

European journal of nuclear medicine and molecular imaging

2020 Volume 47, Issue 13, Page(s) 3176–3185

Abstract: Purpose: The accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with Alzheimer's disease (AD) being the most common. Earlier we identified JNJ-64326067, a novel isoquinoline derivative with high affinity and ... ...

Abstract	Purpose: The accumulation of misfolded tau is a common feature of several neurodegenerative disorders, with Alzheimer's disease (AD) being the most common. Earlier we identified JNJ-64326067, a novel isoquinoline derivative with high affinity and selectivity for tau aggregates from human AD brain. We report the dosimetry of [ Methods: [ Results: One of the healthy controls had focal areas of PET signal in occipital and parietal cortex underlying the site of a gunshot injury as an adolescent; the other four healthy subjects had no tau brain signal. Four of the 5 AD participants had visually apparent retention of [ Conclusions: [
MeSH term(s)	Adolescent ; Alzheimer Disease/diagnostic imaging ; Aniline Compounds ; Brain/diagnostic imaging ; Brain/metabolism ; Female ; Fluorine Radioisotopes ; Humans ; Isoquinolines ; Kinetics ; Male ; Positron-Emission Tomography ; Pyridines ; Radiopharmaceuticals ; tau Proteins/metabolism
Chemical Substances	Aniline Compounds ; Fluorine Radioisotopes ; Isoquinolines ; JNJ-64326067 ; Pyridines ; Radiopharmaceuticals ; tau Proteins
Language	English
Publishing date	2020-06-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8236-3
ISSN	1619-7089 ; 0340-6997 ; 1619-7070
ISSN (online)	1619-7089
ISSN	0340-6997 ; 1619-7070
DOI	10.1007/s00259-020-04880-1
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Article ; Online: Dopamine D

Barret, Olivier / Zhang, Lei / Alagille, David / Constantinescu, Cristian C / Sandiego, Christine / Papin, Caroline / Sullivan, Jenna M / Morley, Thomas / Carroll, Vincent M / Seibyl, John / Chen, Jianqing / Lee, Chewah / Villalobos, Anabella / Gray, David / McCarthy, Timothy J / Tamagnan, Gilles

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

2021 Volume 62, Issue 9, Page(s) 1307–1313

Abstract: Non-catechol-based high-affinity selective dopamine ... ...

Abstract	Non-catechol-based high-affinity selective dopamine D
MeSH term(s)	Animals ; Dopamine ; Macaca mulatta ; Positron-Emission Tomography ; Whole Body Imaging
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2021-02-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80272-4
ISSN	1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
ISSN (online)	1535-5667
ISSN	0097-9058 ; 0161-5505 ; 0022-3123
DOI	10.2967/jnumed.120.256008
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Article ; Online: Dopamine D3 receptor binding of (18)F-fallypride: Evaluation using in vitro and in vivo PET imaging studies.

Mukherjee, Jogeshwar / Constantinescu, Cristian C / Hoang, Angela T / Jerjian, Taleen / Majji, Divya / Pan, Min-Liang

Synapse (New York, N.Y.)

2015 Volume 69, Issue 12, Page(s) 577–591

Abstract: Identification of dopamine D3 receptors (D3R) in vivo is important to understand several brain functions related to addiction. The goal of this work was to identify D3R binding of the dopamine D2 receptor (D2R)/D3R imaging agent, (18)F-fallypride. Brain ... ...

Abstract	Identification of dopamine D3 receptors (D3R) in vivo is important to understand several brain functions related to addiction. The goal of this work was to identify D3R binding of the dopamine D2 receptor (D2R)/D3R imaging agent, (18)F-fallypride. Brain slices from male Sprague-Dawley rats (n = 6) and New Zealand White rabbits (n = 6) were incubated with (18)F-fallypride and D3R selective agonist (R)-7-OH-DPAT (98-fold D3R selective). Rat slices were also treated with BP 897 (68-fold D3R selective partial agonist) and NGB 2904 (56-fold D3R selective antagonist). In vivo rat studies (n = 6) were done on Inveon PET using 18-37 MBq (18)F-fallypride and drug-induced displacement by (R)-7-OH-DPAT, BP 897 and NGB 2904. PET/CT imaging of wild type (WT, n = 2) and D2R knock-out (KO, n = 2) mice were carried out with (18)F-fallypride. (R)-7-OH-DPAT displaced binding of (18)F-fallypride, both in vitro and in vivo. In vitro, at 10 nM (R)-7-OH-DPAT, (18)F-fallypride binding in the rat ventral striatum (VST) and dorsal striatum (DST) and rabbit nucleus accumbens were reduced by ∼10-15%. At 10 μM (R)-7-OH-DPAT all regions in rat and rabbit were reduced by ≥85%. In vivo reductions for DST and VST before and after (R)-7-OH-DPAT were: low-dose (0.015 mg kg(-1)) DST -22%, VST -29%; high-dose (1.88 mg kg(-1)) DST -58%, VST -77%, suggesting D3R/D2R displacement. BP 897 and NGB 2904 competed with (18)F-fallypride in vitro, but unlike BP 897, NGB 2904 did not displace (18)F-fallypride in vivo. The D2R KO mice lacked (18)F-fallypride binding in the DST. In summary, our findings suggest that up to 20% of (18)F-fallypride may be bound to D3R sites in vivo.
MeSH term(s)	Animals ; Benzamides/pharmacokinetics ; Brain/diagnostic imaging ; Brain/metabolism ; Dopamine Agonists/pharmacology ; Dopamine Antagonists/pharmacology ; Fluorenes/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Piperazines/pharmacology ; Positron-Emission Tomography ; Protein Binding ; Pyrrolidines/pharmacokinetics ; Rabbits ; Radiopharmaceuticals/pharmacokinetics ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D3/antagonists & inhibitors ; Receptors, Dopamine D3/metabolism ; Species Specificity ; Tetrahydronaphthalenes/pharmacology ; Tissue Distribution
Chemical Substances	Benzamides ; Dopamine Agonists ; Dopamine Antagonists ; Fluorenes ; N-((1-allyl-2-pyrrolidinyl)methyl)-5-(3-fluoropropyl)-2,3-dimethoxybenzamide ; NGB 2904 ; Piperazines ; Pyrrolidines ; Radiopharmaceuticals ; Receptors, Dopamine D3 ; Tetrahydronaphthalenes ; BP 897 (20PLE5W821) ; 7-hydroxy-2-N,N-dipropylaminotetralin (RR7D75YDF4)
Language	English
Publishing date	2015-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	639061-4
ISSN	1098-2396 ; 0885-8276 ; 0887-4476
ISSN (online)	1098-2396
ISSN	0885-8276 ; 0887-4476
DOI	10.1002/syn.21867
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Article ; Online: PET radiotracer development for imaging high-affinity state of dopamine D2 and D3 receptors: Binding studies of fluorine-18 labeled aminotetralins in rodents.

Mukherjee, Jogeshwar / Majji, Divya / Kaur, Jasmeet / Constantinescu, Cristian C / Narayanan, Tanjore K / Shi, Bingzhi / Nour, Mohamed T / Pan, Min-Liang

Synapse (New York, N.Y.)

2017 Volume 71, Issue 3

Abstract: Imaging the high-affinity, functional state (HA) of dopamine D2 and D3 receptors has been pursued in PET imaging studies of various brain functions. We report further evaluation ... ...

Abstract	Imaging the high-affinity, functional state (HA) of dopamine D2 and D3 receptors has been pursued in PET imaging studies of various brain functions. We report further evaluation of
MeSH term(s)	Animals ; Brain/diagnostic imaging ; Brain/metabolism ; Fluorine Radioisotopes/pharmacology ; Male ; Positron-Emission Tomography/methods ; Radiopharmaceuticals/pharmacology ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D2/analysis ; Receptors, Dopamine D3/analysis ; Tetrahydronaphthalenes/pharmacology
Chemical Substances	Fluorine Radioisotopes ; Radiopharmaceuticals ; Receptors, Dopamine D2 ; Receptors, Dopamine D3 ; Tetrahydronaphthalenes
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	639061-4
ISSN	1098-2396 ; 0885-8276 ; 0887-4476
ISSN (online)	1098-2396
ISSN	0885-8276 ; 0887-4476
DOI	10.1002/syn.21950
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