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  1. Article ; Online: Copper and silver nanowires for CO

    Conte, Andrea / Baron, Marco / Bonacchi, Sara / Antonello, Sabrina / Aliprandi, Alessandro

    Nanoscale

    2023  Volume 15, Issue 8, Page(s) 3693–3703

    Abstract: Copper and silver nanowires have been extensively investigated as the next generation of transparent conductive electrodes (TCEs) due to their ability to form percolating networks. Recently, they have been exploited as electrocatalysts for ... ...

    Abstract Copper and silver nanowires have been extensively investigated as the next generation of transparent conductive electrodes (TCEs) due to their ability to form percolating networks. Recently, they have been exploited as electrocatalysts for CO
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr06687d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: HIPK2 in cancer biology and therapy: Recent findings and future perspectives.

    Conte, Andrea / Valente, Valeria / Paladino, Simona / Pierantoni, Giovanna Maria

    Cellular signalling

    2022  Volume 101, Page(s) 110491

    Abstract: Homeodomain-interacting protein kinase 2 (HIPK2) is a serine-threonine kinase that phosphorylates and regulates a plethora of transcriptional regulators and chromatin modifiers. The heterogeneity of its interactome allows HIPK2 to modulate several ... ...

    Abstract Homeodomain-interacting protein kinase 2 (HIPK2) is a serine-threonine kinase that phosphorylates and regulates a plethora of transcriptional regulators and chromatin modifiers. The heterogeneity of its interactome allows HIPK2 to modulate several cellular processes and signaling pathways, ultimately regulating cell fate and proliferation. Because of its p53-dependent pro-apoptotic activity and its downregulation in many tumor types, HIPK2 is traditionally considered a bone fide tumor suppressor gene. However, recent findings revealed that the role of HIPK2 in the pathogenesis of cancer is much more complex, ranging from tumor suppressive to oncogenic, strongly depending on the cellular context. Here, we review the very recent data emerged in the last years about the involvement of HIPK2 in cancer biology and therapy, highlighting the various alterations of this kinase (downregulation, upregulation, mutations and/or delocalization) in dependence on the cancer types. In addition, we discuss the recent advancement in the understanding the tumor suppressive and oncogenic functions of HIPK2, its role in establishing the response to cancer therapies, and its regulation by cancer-associated microRNAs. All these data strengthen the idea that HIPK2 is a key player in many types of cancer; therefore, it could represent an important prognostic marker, a factor to predict therapy response, and even a therapeutic target itself.
    MeSH term(s) Humans ; Tumor Suppressor Protein p53/metabolism ; Apoptosis/genetics ; Protein Serine-Threonine Kinases/genetics ; Neoplasms/genetics ; Neoplasms/therapy ; Biology ; Carrier Proteins/genetics
    Chemical Substances Tumor Suppressor Protein p53 ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; HIPK2 protein, human (EC 2.7.1.-) ; Carrier Proteins
    Language English
    Publishing date 2022-10-12
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1002702-6
    ISSN 1873-3913 ; 0898-6568
    ISSN (online) 1873-3913
    ISSN 0898-6568
    DOI 10.1016/j.cellsig.2022.110491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2579: Show issues Location:
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  3. Article ; Online: Nature Based Solutions on the river environment: an example of cross-disciplinary sustainable management, with local community active participation and visual art as science transfer tool

    Conte, Andrea / Brunetti, Patrizia / Allevato, Enrica / Stazi, Silvia Rita / Antenozio, Maria Luisa / Passatore, Laura / Cardarelli, Maura

    Journal of Environmental Planning and Management. 2023 Sept. 19, v. 66, no. 11 p.2388-2405

    2023  

    Abstract: An attempt to link phytomanagement, art and social involvement is presented. The “Remediation” Project started up from the search of sustainable solutions for the management of a riparian area in the city of Rome. With the participation of citizens, ... ...

    Abstract An attempt to link phytomanagement, art and social involvement is presented. The “Remediation” Project started up from the search of sustainable solutions for the management of a riparian area in the city of Rome. With the participation of citizens, researchers carried out a preliminary survey on the presence of metals within the target ecosystem and a demonstrative experiment on phytoremediation. Several social and cultural events have been organized in connection with the scientific part of the project: a public debate, an art exposition, a performance and two workshops at the experimental field. The Project demonstrated that through art it is possible to raise curiosity on scientific issues; the participated survey on metal pollution highlighted the strict interconnection among environmental matrices (soil/water/bioma) and thus the risk of contamination transfer; the demonstrative experiment, even if very basic in order to be easily approached by citizens, showed the great potential of Nature Based Solutions.
    Keywords administrative management ; ecosystems ; phytoremediation ; pollution ; riparian areas ; risk ; rivers ; soil ; surveys ; Nature Based Solutions ; environmental art ; citizen science ; art and science
    Language English
    Dates of publication 2023-0919
    Size p. 2388-2405.
    Publishing place Routledge
    Document type Article ; Online
    ZDB-ID 2000921-5
    ISSN 1360-0559 ; 0964-0568
    ISSN (online) 1360-0559
    ISSN 0964-0568
    DOI 10.1080/09640568.2020.1822306
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Update on the Regulation of HIPK1, HIPK2 and HIPK3 Protein Kinases by microRNAs.

    Conte, Andrea / Pierantoni, Giovanna Maria

    MicroRNA (Shariqah, United Arab Emirates)

    2018  Volume 7, Issue 3, Page(s) 178–186

    Abstract: The Homeodomain-Interacting Protein Kinases (HIPKs) HIPK1, HIPK2 and HIPK3 are Ser/Thr kinases which interact with homeobox proteins and other transcription factors, acting as transcriptional coactivators or corepressors. HIPKs contribute to regulate ... ...

    Abstract The Homeodomain-Interacting Protein Kinases (HIPKs) HIPK1, HIPK2 and HIPK3 are Ser/Thr kinases which interact with homeobox proteins and other transcription factors, acting as transcriptional coactivators or corepressors. HIPKs contribute to regulate several biological processes, such as signal transduction, apoptosis, embryonic development, DNA-damage response, and cellular proliferation, in response to various extracellular stimuli. Recently it has emerged that, in addition to their role in cancer, fibrosis and diabetes, HIPKs may also be involved in other human diseases, including Amyotrophic Lateral Sclerosis (ALS), Rett syndrome, cerebellar diseases, and retinal vascular dysfunction.
    Methods: Here, we update our previous paper concerning the regulation of HIPK proteins expression by microRNAs (miRNAs), pointing out the most recent findings about new cellular mechanisms and diseases which are affected by the interplay between HIPKs and miRNAs.
    Conclusion: Recently, it has emerged that HIPKs and their related miRNAs are involved in diabetic nephropathy, gastric cancer chemoresistance, cervical cancer progression, and recombinant protein expression in cultured cells. Interestingly, circular RNAs (circRNAs) deriving from HIPK2 and HIPK3 loci also modulate cellular proliferation and viability by sponging several miRNAs, thus emerging as new putative therapeutic targets for diabetes-associated retinal vascular dysfunction, astrogliosis and cancer.
    MeSH term(s) Biomarkers, Tumor/genetics ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Gene Expression Regulation ; Gene Expression Regulation, Neoplastic ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; MicroRNAs/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction
    Chemical Substances Biomarkers, Tumor ; Carrier Proteins ; Intracellular Signaling Peptides and Proteins ; MicroRNAs ; HIPK2 protein, human (EC 2.7.1.-) ; HIPK1 protein, human (EC 2.7.11.1) ; HIPK3 protein, human (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2018-05-24
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 2211-5374
    ISSN (online) 2211-5374
    DOI 10.2174/2211536607666180525102330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Determinants of policy reforms in the fields of R&D, education and innovation

    Conte, Andrea

    Governance, regulation and innovation : theory and evidence from firms and nations , p. 122-145

    EU-27 evidence during the Lisbon decade

    2013  , Page(s) 122–145

    Author's details Andrea Conte
    Keywords EU-Wirtschaftspolitik ; Technologiepolitik ; Bildungspolitik ; Politische Reform ; Wissensgesellschaft ; EU-Staaten
    Language English
    Size graph. Darst.
    Publisher Elgar
    Publishing place Cheltenham [u.a.]
    Document type Article
    ISBN 978-1-78254-065-6 ; 1-78254-065-2
    Database ECONomics Information System

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  6. Article ; Online: Regulation of HIPK Proteins by MicroRNAs.

    Conte, Andrea / Pierantoni, Giovanna Maria

    MicroRNA (Shariqah, United Arab Emirates)

    2015  Volume 4, Issue 3, Page(s) 148–157

    Abstract: Introduction: The homeodomain-interacting protein kinase (HIPK) family consists of four evolutionarily conserved and highly related nuclear serine/threonine kinases of recent discovery. They interact with homeobox proteins and other transcription ... ...

    Abstract Introduction: The homeodomain-interacting protein kinase (HIPK) family consists of four evolutionarily conserved and highly related nuclear serine/threonine kinases of recent discovery. They interact with homeobox proteins and other transcription factors, as well as transcriptional coactivators or corepressors depending on the cellular context. HIPK proteins are sensors for various extracellular stimuli, which control key cellular functions such as signal transduction to downstream effectors that regulate apoptosis, embryonic development, DNA-damage response, and cellular proliferation. Thus, HIPKs are involved in proliferative diseases such as cancer and fibrosis. mRNA levels and protein stability tightly regulate expression levels of HIPKs.
    Methods: Here, we review recent works investigating the regulation of HIPKs expression by microRNAs (miRNAs) that are involved in the control of cell proliferation, sensitivity to chemotherapeutic drugs, epithelial-mesenchymal transition, and glucose-stimulated insulin secretion.
    Conclusion: It appears that HIPK family members, and their related miRNAs, may be considered as novel therapeutic targets for treating cancer, renal fibrosis and type 2 diabetes.
    MeSH term(s) Animals ; Apoptosis ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Cell Nucleus/pathology ; DNA Damage ; Embryonic Development/genetics ; Epithelial-Mesenchymal Transition/genetics ; Fibrosis/genetics ; Fibrosis/metabolism ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Neoplasms/therapy ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Neoplasm/genetics ; RNA, Neoplasm/metabolism
    Chemical Substances MicroRNAs ; Neoplasm Proteins ; RNA, Neoplasm ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2015-09-30
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ISSN 2211-5374
    ISSN (online) 2211-5374
    DOI 10.2174/2211536604666151002002720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: The evolution of the literature on technological change over time

    Conte, Andrea

    a survey

    (Papers on entrepreneurship, growth and public policy ; 0107)

    2006  

    Author's details by Andrea Conte
    Series title Papers on entrepreneurship, growth and public policy ; 0107
    Keywords Technischer Fortschritt ; Innovation ; Wirtschaftswachstum ; Evolutionsökonomik ; Theorie
    Language English
    Size Online-Ressource, 74 S., Text, graph. Darst.
    Publisher Max-Planck-Inst. für Ökonomik
    Publishing place Jena
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  8. Article ; Online: Chronic exposure to l-BMAA cyanotoxin induces cytoplasmic TDP-43 accumulation and glial activation, reproducing an amyotrophic lateral sclerosis-like phenotype in mice.

    Anzilotti, Serenella / Valente, Valeria / Brancaccio, Paola / Franco, Cristina / Casamassa, Antonella / Lombardi, Giovanna / Palazzi, Alessandra / Conte, Andrea / Paladino, Simona / Canzoniero, Lorella Maria Teresa / Annunziato, Lucio / Pierantoni, Giovanna Maria / Pignataro, Giuseppe

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2023  Volume 167, Page(s) 115503

    Abstract: Background: Amyotrophic lateral sclerosis (ALS) is a progressive and often fatal neurodegenerative disease characterized by the loss of Motor Neurons (MNs) in spinal cord, motor cortex and brainstem. Despite significant efforts in the field, the exact ... ...

    Abstract Background: Amyotrophic lateral sclerosis (ALS) is a progressive and often fatal neurodegenerative disease characterized by the loss of Motor Neurons (MNs) in spinal cord, motor cortex and brainstem. Despite significant efforts in the field, the exact pathogenetic mechanisms underlying both familial and sporadic forms of ALS have not been fully elucidated, and the therapeutic possibilities are still very limited. Here we investigate the molecular mechanisms of neurodegeneration induced by chronic exposure to the environmental cyanotoxin L-BMAA, which causes a form of ALS/Parkinson's disease (PD) in several populations consuming food and/or water containing high amounts of this compound.
    Methods: In this effort, mice were chronically exposed to L-BMAA and analyzed at different time points to evaluate cellular and molecular alterations and behavioral deficits, performing MTT assay, immunoblot, immunofluorescence and immunohistochemistry analysis, and behavioral tests.
    Results: We found that cyanotoxin L-BMAA determines apoptotic cell death and a marked astrogliosis in spinal cord and motor cortex, and induces neurotoxicity by favoring TDP-43 cytoplasmic accumulation.
    Conclusions: Overall, our results characterize a new versatile neurotoxic animal model of ALS that may be useful for the identification of new druggable targets to develop innovative therapeutic strategies for this disease.
    Language English
    Publishing date 2023-09-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2023.115503
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.198: Show issues Location:
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  9. Article: Mapping innovative activity using microdata

    Conte, Andrea

    Applied economics letters Vol. 16, No. 16/18 , p. 1795-1799

    2009  Volume 16, Issue 16, Page(s) 1795–1799

    Author's details Andrea Conte
    Language English
    Publisher Routledge
    Publishing place Abingdon
    Document type Article
    ZDB-ID 1181036-1 ; 1484783-8
    ISSN 1466-4291 ; 1350-4851
    ISSN (online) 1466-4291
    ISSN 1350-4851
    Database ECONomics Information System

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  10. Article: Succeeding in innovation

    Conte, Andrea / Vivarelli, Marco

    Empirical economics : a journal of the Institute for Advanced Studies, Vienna, Austria Vol. 47, No. 4 , p. 1317-1340

    key insights on the role of R&D and technological acquisition drawn from company data

    2014  Volume 47, Issue 4, Page(s) 1317–1340

    Author's details Andrea Conte; Marco Vivarelli
    Keywords R&D ; Product innovation ; Process innovation ; Embodied technical change ; Sample selection ; SUR ; Community innovation survey
    Language English
    Publisher Springer
    Publishing place Berlin ; Heidelberg
    Document type Article
    ZDB-ID 519394-1 ; 1462176-9
    ISSN 1435-8921 ; 0377-7332
    ISSN (online) 1435-8921
    ISSN 0377-7332
    Database ECONomics Information System

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