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Article ; Online: Is there any correlation between otitis media and dental malocclusion in children? A systematic review.

Bardellini, E / Amadori, F / Garo, M L / Majorana, A / Conti, G

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry

2023 Volume 24, Issue 4, Page(s) 441–449

Abstract: Purpose: This study aims to evaluate whether there is a correlation between otitis and dental malocclusions.: Methods: Electronic databases were searched for observational studies published until July 2021 without language or time restrictions.: ... ...

Abstract	Purpose: This study aims to evaluate whether there is a correlation between otitis and dental malocclusions. Methods: Electronic databases were searched for observational studies published until July 2021 without language or time restrictions. Prospero: CRD42021270760. Observational studies on children with and without OM and/or malocclusion were included. After removing duplicates and excluding not-eligible articles, two reviewers screened relevant articles independently. Two reviewers independently extracted data and assessed data quality and validity through the Newcastle-Ottawa Scale (NOS) quality assessment tool for non-randomized studies. Results: Five studies met the selection inclusion criteria and were included in the studies for a total of 499 patients. Three studies investigated the relationship between malocclusion and otitis media, while the remaining two studies analyzed the inverse relationship and one of them considered eustachian tube dysfunction as a proxy of OM. An association between malocclusion and otitis media and vice versa emerged, although with relevant limitations. Conclusion: There is some evidence that there is an association between otitis and malocclusion; however, it is not yet possible to establish a definitive correlation.
MeSH term(s)	Humans ; Child ; Otitis Media/complications ; Malocclusion/complications
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Systematic Review
ZDB-ID	2472851-2
ISSN	1996-9805 ; 1818-6300
ISSN (online)	1996-9805
ISSN	1818-6300
DOI	10.1007/s40368-023-00807-0
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Article: Patent method for the extraction and determination of micro- and nano- plastics in organic and inorganic matrix samples: An application on vegetals.

Ferrante, M / Oliveri Conti, G / Zuccarello, P

MethodsX

2020 Volume 7, Page(s) 100989

Abstract: The uncontrolled introduction into the environment of plastic polymers have caused the dispersion of plastic debries, known as microplastics (MPs), that represent an important topic for environmental and human health threats. So far, the absence of ... ...

Abstract	The uncontrolled introduction into the environment of plastic polymers have caused the dispersion of plastic debries, known as microplastics (MPs), that represent an important topic for environmental and human health threats. So far, the absence of effective and efficient extraction methods of MPs (especially for plastic particles with diameters inferior than 10 µm) from complex matrices (water, food, etc.) did not allow to perform the risk estimation and, the consequent assessment of the health impact associated with the exposure to these emergent contaminants. In this paper, a new patented method for the extraction and determination of micro- and nano-plastics in organic and inorganic matrix samples is reported. The method applied in the study has been nationally and internationally protected. The code of the submitted request of international patent's extension in several country of world is PCT/IB2019/051,838 of 7 March 2019, coupled with the accepted Italian patent n. 102,018,000,003,337 of March 7 of 2018 entitled "Method for extraction and determination of microplastics in samples with organic and inorganic matrices". The method applied to our study is based on sedimentation of the particles with density higher than 1 g/cm
Language	English
Publishing date	2020-07-10
Publishing country	Netherlands
Document type	Journal Article
ISSN	2215-0161
ISSN	2215-0161
DOI	10.1016/j.mex.2020.100989
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Article: Subclinical TRAPS treated with canakinumab.

Amatruda, M / Carucci, N S / Fede, C / Conti, G

Reumatismo

2021 Volume 73, Issue 2, Page(s) 131–134

Abstract: Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory disease characterized by recurrent episodes of fever and systemic inflammation. We describe the case of a 19-year-old patient who was referred to our attention ...

Abstract	Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autoinflammatory disease characterized by recurrent episodes of fever and systemic inflammation. We describe the case of a 19-year-old patient who was referred to our attention with frequent subclinical TRAPS episodes characterized by mild arthralgias and crampy abdominal pain, without fever. Inflammatory markers, including serum amyloid A which increases the risk of long-term amyloidosis, were persistently high also when the patient was in good general conditions. Therapy with human anti-interleukin 1β monoclonal antibody, canakinumab, led to disease control and normalization of the inflammatory markers, which are currently still normal. This clinical case supports the need to treat also subclinical TRAPS. In this respect, canakinumab is effective and reduces the risk of developing amyloidosis.
MeSH term(s)	Adult ; Antibodies, Monoclonal, Humanized ; Familial Mediterranean Fever ; Fever ; Hereditary Autoinflammatory Diseases ; Humans ; Young Adult
Chemical Substances	Antibodies, Monoclonal, Humanized ; canakinumab (37CQ2C7X93)
Language	English
Publishing date	2021-08-03
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	414816-2
ISSN	2240-2683 ; 0048-7449
ISSN (online)	2240-2683
ISSN	0048-7449
DOI	10.4081/reumatismo.2021.1406
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Article ; Online: Early Home Visits and Health Outcomes in Low-Income Mothers and Offspring: 18-Year Follow-Up of a Randomized Clinical Trial.

Conti, Gabriella / Smith, Joyce / Anson, Elizabeth / Groth, Susan / Knudtson, Michael / Salvati, Andrea / Olds, David

JAMA network open

2024 Volume 7, Issue 1, Page(s) e2351752

Abstract: Importance: Individuals with low income may have heightened rates of obesity and hypertension.: Objective: To determine whether prenatal and infancy home visitation by nurses reduces maternal and offspring obesity and hypertension.: Design, setting, ...

Abstract	Importance: Individuals with low income may have heightened rates of obesity and hypertension. Objective: To determine whether prenatal and infancy home visitation by nurses reduces maternal and offspring obesity and hypertension. Design, setting, and participants: This randomized clinical trial of prenatal and infancy nurse home visitation in a public health care system in Memphis, Tennessee, enrolled 742 women with no previous live births and at least 2 sociodemographic risk factors (unmarried, <12 years of education, unemployed) from June 1, 1990, through August 31, 1991. At registration during pregnancy, 727 mothers (98%) were unmarried, and 631 (85%) lived below the federal poverty level. At offspring ages 12 and 18 years, maternal and offspring obesity and hypertension were assessed by staff masked to treatment. The data analysis was performed from July 1, 2021, to October 31, 2023. Interventions: Women assigned to the control group received free transportation for prenatal care and child developmental screening and referral at child ages 6, 12, and 24 months. Women assigned to nurse visitation received transportation and screening plus prenatal and infant and toddler nurse home visits. Main outcomes and measures: Obesity and hypertension among mothers and their offspring at child ages 12 and 18 years, although not hypothesized in the original trial design, were analyzed using post-double selection lasso method. Results: Of the 742 participants randomized (mean [SD] age, 18.1 [3.2] years), interviews were completed with 594 mothers and 578 offspring at child age 12 years and 618 mothers and 629 offspring at child age 18 years. Obesity was assessed for 576 offspring at age 12 years and 605 at age 18 years and for 563 and 598 mothers at child ages 12 and 18 years, respectively. Blood pressure was assessed for 568 offspring aged 12 years and 596 aged 18 years and 507 and 592 mothers at child ages 12 and 18 years, respectively. There were no overall treatment-control differences in offspring obesity or hypertension at ages 12 and 18 years combined, although nurse-visited female offspring, compared with controls, had a lower prevalence of obesity (adjusted relative risk [ARR], 0.449; 95% CI, 0.234-0.858; P = .003) and severe obesity (ARR, 0.185; 95% CI, 0.046-0.748; P < .001). There were reductions at ages 12 and 18 years combined for stage 1 and stage 2 hypertension for nurse-visited vs control group mothers, with differences limited to mothers of females (stage 1: ARR, 0.613 [95% CI, 0.440-0.855; P = .001]; stage 2: ARR, 0.217 [95% CI, 0.081-0.582; P < .001]). For both obesity and hypertension outcomes, there was no intervention effect among male offspring or the mothers of males. Self-reported maternal health aligned with program effects on hypertension. Conclusions and relevance: In this clinical trial follow-up at offspring ages 12 and 18, nurse-visited female offspring had lower rates of obesity and mothers of females had lower rates of hypertension than control-group counterparts. These findings suggest that risks for chronic disease among mothers of females and their female offspring who live in extreme poverty may be prevented with prenatal and infant and toddler home visitations by nurses. Trial registration: ClinicalTrials.gov Identifier: NCT00708695.
MeSH term(s)	Adolescent ; Child ; Female ; Humans ; Infant ; Male ; Pregnancy ; Follow-Up Studies ; House Calls ; Hypertension/epidemiology ; Hypertension/prevention & control ; Obesity/epidemiology ; Obesity/prevention & control ; Outcome Assessment, Health Care ; Poverty
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.51752
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Article ; Online: Exploring the One Health Paradigm in Male Breast Cancer.

Tay, Kirsty Luo-Yng / Cowan, George / Chatterji, Subarnarekha / Conti, Giulia / Speirs, Valerie

Journal of mammary gland biology and neoplasia

2024 Volume 29, Issue 1, Page(s) 8

Abstract: How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowledge gap for rare cancers like male breast cancer. One Health is a convergence of human and animal healthcare that encourages cross- ... ...

Abstract	How cancer patterns in humans compare to those of other species remains largely unknown and there is an even bigger knowledge gap for rare cancers like male breast cancer. One Health is a convergence of human and animal healthcare that encourages cross-pollination of medical research uniting human and veterinary medicine. Recognising that breast cancer occurs spontaneously in other male species (e.g. primates, canines, felines), and knowing that no laboratory models exist for male breast cancer, which limits our ability to perform functional studies, we explored the feasibility of applying One Health to breast cancer in men by conducting a narrative review of the topic. Spontaneous development of breast cancer was reported in captive male primates and in companion canines and felines. Some parallels in tumour biology of human male breast cancer with canines and primates were found. The age distribution, pattern of biomarker expression and metastasis were similar, with mammary tumours typically detected after two-thirds of average lifespan. However, instances of triple negative and inflammatory breast cancer, which are rarely observed in human male breast cancer, were found in canines and histological classification was inconsistent between species. These disparities need redressing to enable full exploration of the One Health paradigm in rare cancers.
MeSH term(s)	Humans ; Male ; Animals ; Cats ; Dogs ; Breast Neoplasms, Male ; Cat Diseases ; One Health ; Dog Diseases ; Primates
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1327345-0
ISSN	1573-7039 ; 1083-3021
ISSN (online)	1573-7039
ISSN	1083-3021
DOI	10.1007/s10911-024-09560-6
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Article ; Online: Severe prenatal shocks and adolescent health: Evidence from the Dutch Hunger Winter.

Conti, Gabriella / Poupakis, Stavros / Ekamper, Peter / Bijwaard, Govert E / Lumey, L H

Economics and human biology

2024 Volume 53, Page(s) 101372

Abstract: This paper investigates health impacts at the end of adolescence of prenatal exposure to multiple shocks, by exploiting the unique natural experiment of the Dutch Hunger Winter. At the end of World War II, a famine occurred abruptly in the Western ... ...

Abstract	This paper investigates health impacts at the end of adolescence of prenatal exposure to multiple shocks, by exploiting the unique natural experiment of the Dutch Hunger Winter. At the end of World War II, a famine occurred abruptly in the Western Netherlands (November 1944-May 1945), pushing the previously and subsequently well-nourished Dutch population to the brink of starvation. We link high-quality military recruits data with objective health measurements for the cohorts born in the years surrounding WWII with newly digitised historical records on calories and nutrient composition of the war rations, daily temperature, and warfare deaths. Using difference-in-differences and triple differences research designs, we first show that the cohorts exposed to the Dutch Hunger Winter since early gestation have a higher Body Mass Index and an increased probability of being obese at age 18. We then find that this effect is partly moderated by warfare exposure and a reduction in energy-adjusted protein intake. Lastly, we account for selective mortality using a copula-based approach and newly-digitised data on survival rates, and find evidence of both selection and scarring effects. These results emphasise the complexity of the mechanisms at play in studying the consequences of early conditions.
MeSH term(s)	Humans ; Netherlands ; Female ; Adolescent ; Prenatal Exposure Delayed Effects ; Pregnancy ; World War II ; Body Mass Index ; Male ; History, 20th Century ; Famine/statistics & numerical data ; Adolescent Health ; Starvation ; Obesity/epidemiology ; Military Personnel/statistics & numerical data
Language	English
Publishing date	2024-03-02
Publishing country	Netherlands
Document type	Journal Article ; Historical Article
ZDB-ID	2099749-8
ISSN	1873-6130 ; 1570-677X
ISSN (online)	1873-6130
ISSN	1570-677X
DOI	10.1016/j.ehb.2024.101372
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Article: Immunoglobulin A vasculitis nephritis: Current understanding of pathogenesis and treatment.

Amatruda, Michela / Carucci, Nicolina Stefania / Chimenz, Roberto / Conti, Giovanni

World journal of nephrology

2023 Volume 12, Issue 4, Page(s) 82–92

Abstract: The clinical spectrum of immunoglobulin A vasculitis nephritis (IgAVN) ranges from the relatively common transitory microscopic hematuria and/or low-grade proteinuria to nephritic or nephrotic syndrome, rapidly progressive glomerulonephritis, or even ... ...

Abstract	The clinical spectrum of immunoglobulin A vasculitis nephritis (IgAVN) ranges from the relatively common transitory microscopic hematuria and/or low-grade proteinuria to nephritic or nephrotic syndrome, rapidly progressive glomerulonephritis, or even renal failure. Clinical and experimental studies have shown a multifactor pathogenesis: Infection triggers, impaired glycosylation of IgA1, complement activation, Toll-like-receptor activation and B cell proliferation. This knowledge can identify IgAVN patients at a greater risk for adverse outcome and increase the evidence for treatment recommendations.
Language	English
Publishing date	2023-09-09
Publishing country	United States
Document type	Journal Article ; Review
ISSN	2220-6124
ISSN	2220-6124
DOI	10.5527/wjn.v12.i4.82
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Article ; Online: The Impact of the COVID-19 Pandemic on Pediatric Dentistry: Insights from an Italian Cross-Sectional Survey.

Conti, Giulio / Amadori, Francesca / Bordanzi, Alessandra / Majorana, Alessandra / Bardellini, Elena

Dentistry journal

2023 Volume 11, Issue 6

Abstract: Background: The COVID-19 pandemic has had a significant impact on pediatric dentistry and also dental education. This study aimed to assess the observed changes in children's oral health by pediatric dentists and also served as an educational tool for ... ...

Abstract	Background: The COVID-19 pandemic has had a significant impact on pediatric dentistry and also dental education. This study aimed to assess the observed changes in children's oral health by pediatric dentists and also served as an educational tool for dentistry students during the pandemic. Methods: Postgraduate students in pediatric dentistry prepared a survey addressed to Italian pediatric dentists. Over 5476 dentists were invited to participate, and collaboration among the students took place through virtual meetings and electronic platforms. The online questionnaire was composed of 29 questions focusing on the management of pediatric patients during and after the lockdown period. A descriptive statistic was used for data analysis, and chi-square tests were performed ( Results: A total of 1752 pediatric dentists participated in the survey. During the lockdown, 68.3% of dentists exclusively handled dental emergencies. In the subsequent semester, a significant decrease in the number of pediatric treatments was reported. Pediatric dentists also noted a decline in children's oral hygiene practices, a deterioration in dietary habits, and an increase in anxiety during dental procedures. Conclusions: This survey shed light on the diverse effects of the pandemic on children's oral health and also provided valuable educational insights.
Language	English
Publishing date	2023-06-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681351-8
ISSN	2304-6767 ; 2304-6767
ISSN (online)	2304-6767
ISSN	2304-6767
DOI	10.3390/dj11060154
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Article ; Online: Shortage of paediatric intensive care unit beds in Italy.

Minardi, Carmelo / Conti, Giorgio / Moscatelli, Andrea / Tesoro, Simonetta / Bussolin, Leonardo

Lancet (London, England)

2023 Volume 402, Issue 10412, Page(s) 1525

MeSH term(s)	Humans ; Child ; Intensive Care Units, Pediatric ; Intensive Care Units ; Italy
Language	English
Publishing date	2023-10-26
Publishing country	England
Document type	Letter
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(23)01791-9
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Article: Intranasal nerve growth factor for prevention and recovery of the outcomes of traumatic brain injury.

Manni, Luigi / Conti, Giorgio / Chiaretti, Antonio / Soligo, Marzia

Neural regeneration research

2022 Volume 18, Issue 4, Page(s) 773–778

Abstract: Traumatic brain injury is one of the main causes of mortality and disability worldwide. Traumatic brain injury is characterized by a primary injury directly induced by the impact, which progresses into a secondary injury that leads to cellular and ... ...

Abstract	Traumatic brain injury is one of the main causes of mortality and disability worldwide. Traumatic brain injury is characterized by a primary injury directly induced by the impact, which progresses into a secondary injury that leads to cellular and metabolic damages, starting in the first few hours and days after primary mechanical injury. To date, traumatic brain injury is not targetable by therapies aimed at preventing and/or limiting the outcomes of secondary damage but only by palliative therapies. Nerve growth factor is a neurotrophin targeting neuronal and non-neuronal cells, potentially useful in preventing/limiting the outcomes of secondary damage in traumatic brain injury. This potential has further increased in the last two decades since the possibility of reaching neurotrophin targets in the brain through its intranasal delivery has been exploited. Indeed, molecules intranasally delivered to the brain parenchyma may easily bypass the blood-brain barrier and reach their therapeutic targets in the brain, with favorable kinetics, dynamics, and safety profile. In the first part of this review, we aimed to report the traumatic brain injury-induced dysfunctional mechanisms that may benefit from nerve growth factor treatment. In the second part, we then exposed the experimental evidence relating to the action of nerve growth factor (both in vitro and in vivo, after administration routes other than intranasal) on some of these mechanisms. In the last part of the work, we, therefore, discussed the few manuscripts that analyze the effects of treatment with nerve growth factor, intranasally delivered to the brain parenchyma, on the outcomes of traumatic brain injury.
Language	English
Publishing date	2022-10-17
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.354513
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