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  1. Article: Redo surgery after low anterior resection for chronic pelvic sinus and anastomotic disruption. Could pull-through procedure with delayed anastomosis be a feasible alternative? Case reports and narrative review.

    Banchini, Filippo / Luzietti, Enrico / Conti, Luigi / Palmieri, Gerardo / Capelli, Patrizio

    International journal of surgery case reports

    2022  Volume 93, Page(s) 106967

    Abstract: Introduction: A considerable step forward in low rectal cancer resection has been done in the last decades. Maintaining total mesorectal excision as the gold standard treatment, new techniques such as Trans-Anal Mini-Invasive Surgery (TAMIS) and Trans- ... ...

    Abstract Introduction: A considerable step forward in low rectal cancer resection has been done in the last decades. Maintaining total mesorectal excision as the gold standard treatment, new techniques such as Trans-Anal Mini-Invasive Surgery (TAMIS) and Trans-Anal Total Mesorectal Excision (TATME), which have been added to improve skills in laparoscopic and robotic surgery, currently represent the advancement of this procedure. Despite improvements in surgical techniques, complications after low anterior resection for rectal cancer still remain a challenge. Drainage and colostomy are the main treatments used to overcome the problem caused by anastomosis failure, and most patients will never been restored. Different techniques of redo surgery could be proposed to deal complex cases, although remaining high risk procedures.
    Case presentation: We present two clinical cases with a late complication of the colorectal anastomosis: one with a late leakage of low colorectal anastomoses, treated with Hartman procedure, that developed a pelvic chronic sinus; the another one with complete anastomotic disruption after massive suture bleeding; both treated with delayed pull-through anastomosis, according to Turnbull-Cutait technique. We also made a review of relative literature, in order to back our therapeutic iters.
    Discussion: Both the procedures were carried out satisfactorily, with restoration of intestinal continuity and good anastomotic result. It allows the resolutions of the chronic sepsis caused by the pelvic sinus and maintenance of intestinal continuity with a good Wexner incontinence score. Literary review demonstrated that this procedure still remains undervalued and not widely exploited.
    Conclusion: Delayed pull-through coloanal anastomosis could be considered as a valid option, in order to preserve intestinal continuity in septic or complicated low colorectal anastomosis.
    Language English
    Publishing date 2022-03-29
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.106967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Personal technique for minimally invasive VATS lobectomy with en-bloc chest wall resection for T3 NSCLC.

    Conti, Luigi / Delfanti, Rocco / Capelli, Patrizio

    Updates in surgery

    2021  Volume 73, Issue 6, Page(s) 2393–2395

    MeSH term(s) Carcinoma, Non-Small-Cell Lung/surgery ; Humans ; Lung Neoplasms/surgery ; Pneumonectomy ; Thoracic Surgery, Video-Assisted ; Thoracic Wall/surgery
    Language English
    Publishing date 2021-04-12
    Publishing country Italy
    Document type Letter
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-021-01052-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Breaking the habit in the Covid Era: how is changed the routine of a surgeon in mostly affected italian province, Piacenza, Emilia Romagna.

    Conti, Luigi / Grassi, Carmine / Banchini, Filippo

    Acta bio-medica : Atenei Parmensis

    2020  Volume 91, Issue 3, Page(s) e2020043

    Abstract: The Sars-Cov2 Pandemic in Italy gave rise in Piacenza, northern Emilia, to one of the most extensive contagions ever recorded in Italy, the area being hit from the beginning of February, with all its dramatic force and enormous impact in terms of human ... ...

    Abstract The Sars-Cov2 Pandemic in Italy gave rise in Piacenza, northern Emilia, to one of the most extensive contagions ever recorded in Italy, the area being hit from the beginning of February, with all its dramatic force and enormous impact in terms of human lives, upsetting social lives. Piacenza is only few kilometers away from what was unexpectedly identified as the first known outbreak in the Western world, registered in Codogno, a small town in the province of Lodi, where the first verified Italian case of the infection Covid- 19 was isolated.Due to the advancement of the contagion and the exponential increase of Covid cases which required hospitalization all the surgical wards of our Hospital, except for the Emergency Surgery of the Hospital's central hub "Guglielmo da Saliceto" of Piacenza, were converted into Covid wards with various degrees of management care on behalf of the personnel, as also the operating theatres became new ICU units. Consequently, the professional life habits of the surgeons in general have radically changed: the surgeons have been working for about 70% of their working hours in internist support activities for the management of Covid-correlated pneumonia patients.Since then however, many questions have arisen during our daily reflections regarding the need for future planning of our surgery procedures: how much longer can we delay the planning of our selected surgery? Which epidemiological parameters, and other, should we identify in order to start up selected general surgery?For how long can selected surgery be deferred without compromising outcomes and mid to long term mortality in oncological patients in our province, considering also the diagnostic-therapeutic delays in these exceptional months of the Covid era?
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Coronavirus Infections/psychology ; Disease Transmission, Infectious/prevention & control ; Habits ; Humans ; Italy/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/psychology ; SARS-CoV-2 ; Surgeons/psychology
    Keywords covid19
    Language English
    Publishing date 2020-09-07
    Publishing country Italy
    Document type Letter
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v91i3.9861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Could the top-down right hemicolectomy be an easier alternative to the classic medial-to-lateral approach in obese patients? A case report with video example.

    Banchini, Filippo / Luzietti, Enrico / Romboli, Andrea / Palmieri, Gerardo / Conti, Luigi / Capelli, Patrizio

    International journal of surgery case reports

    2022  Volume 100, Page(s) 107752

    Language English
    Publishing date 2022-10-17
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2022.107752
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Laparoscopic Resection of Synchronous Liver Metastasis Involving the Left Hepatic Vein and the Common Trunk Bifurcation: A Strategy of Parenchyma-Sparing Resection with Left Sectionectomy and 4a Subsegmentectomy by Arantius Approach.

    Banchini, Filippo / Luzietti, Enrico / Palmieri, Gerardo / Bonfili, Deborah / Romboli, Andrea / Conti, Luigi / Capelli, Patrizio

    Healthcare (Basel, Switzerland)

    2022  Volume 10, Issue 3

    Abstract: When colorectal cancer presents with liver metastasis, hepatic resection remains the most important factor in prolonging survival, and new paradigms have been proposed to augment resectability. An adequate liver remnant and vascularisation are the only ... ...

    Abstract When colorectal cancer presents with liver metastasis, hepatic resection remains the most important factor in prolonging survival, and new paradigms have been proposed to augment resectability. An adequate liver remnant and vascularisation are the only limits in complex liver resection, and parenchyma-sparing surgery is a strategy for minimising the complications, preserving liver function, and allowing patients to undergo further liver resection. The laparoscopic approach represents a new challenge, especially when lesions are located in the superior or posterior part of the liver. We discuss the case of an 81-year-old patient with a single synchronous liver metastasis involving the left hepatic vein and leaning into the middle hepatic vein at the common trunk, where we performed a simultaneous laparoscopic colonic resection with a left sectionectomy extended to segment 4a. The strategic approach to the Arantius ligament by joining the left and middle hepatic vein allowed us to avoid a major liver hepatectomy, preserve the liver parenchyma, reduce complications, enhance patient recovery, and perform the entire procedure by laparoscopy. Our example suggests that the Arantius approach to the left hepatic vein and the common trunk could be a feasible approach to consider in laparoscopic surgery for lesions located in their proximity.
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare10030517
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Potential pitfalls associated with testing of enzyme preparations in the Salmonella/microsome assay.

    Conti, Luigi / Crebelli, Riccardo

    Regulatory toxicology and pharmacology : RTP

    2016  Volume 80, Page(s) 291–294

    Abstract: The effect of a sample of food enzyme preparations on S9 activity was evaluated in bacterial mutation assays with the Salmonella typhimurium strains TA98 and TA100 using benzo(a)pyrene, 2-aminoanthracene and 2-aminofluorene as model compounds. Under the ... ...

    Abstract The effect of a sample of food enzyme preparations on S9 activity was evaluated in bacterial mutation assays with the Salmonella typhimurium strains TA98 and TA100 using benzo(a)pyrene, 2-aminoanthracene and 2-aminofluorene as model compounds. Under the experimental conditions applied, Aspergillus oryzae protease and porcine pancreas trypsin, applied at low non-toxic doses, proved to effectively inhibit the metabolic activation of benzo(a)pyrene by Aroclor induced rat liver 9, while the activation of 2-aminoanthracene and 2-aminofluorene was only marginally affected. The tolerance of metabolic activation of 2-aminoanthracene to the presence of proteolytic enzymes, compared to the strong inhibition elicited on the metabolic activation of benzo(a)pyrene, points to the involvement of different components of liver S9 in their biotransformation. Overall, data indicate that the use of 2-aminoanthracene as positive control in the Ames test can give a misleading indication of S9 proficiency, and thus it should be used with caution or in conjunction with other chemicals, especially in the testing of crude enzyme preparations in which proteases may be present as minor components.
    MeSH term(s) Activation, Metabolic ; Anthracenes/metabolism ; Anthracenes/toxicity ; Aspergillus oryzae/enzymology ; Bacterial Proteins/isolation & purification ; Bacterial Proteins/toxicity ; Benzo(a)pyrene/metabolism ; Benzo(a)pyrene/toxicity ; DNA, Bacterial/drug effects ; DNA, Bacterial/genetics ; Fluorenes/metabolism ; Fluorenes/toxicity ; Humans ; Lipase/isolation & purification ; Lipase/toxicity ; Microsomes/enzymology ; Mutagenesis ; Mutagenicity Tests/methods ; Pancreas/enzymology ; Peptide Hydrolases/isolation & purification ; Peptide Hydrolases/toxicity ; Reproducibility of Results ; Risk Assessment ; Salmonella typhimurium/drug effects ; Salmonella typhimurium/genetics
    Chemical Substances Anthracenes ; Bacterial Proteins ; DNA, Bacterial ; Fluorenes ; Benzo(a)pyrene (3417WMA06D) ; 2-aminofluorene (3A69OS195N) ; 2-anthramine (8240818JGU) ; Lipase (EC 3.1.1.3) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2016-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604672-1
    ISSN 1096-0295 ; 0273-2300
    ISSN (online) 1096-0295
    ISSN 0273-2300
    DOI 10.1016/j.yrtph.2016.06.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Swyer-James-MacLeod syndrome presenting as spontaneous pneumothorax in an adult: Case report and review of literature.

    Conti, Luigi / Palmieri, Gerardo / Delfanti, Rocco / Grassi, Carmine / Daccò, Maria Diletta / Capelli, Patrizio

    Radiology case reports

    2021  Volume 16, Issue 5, Page(s) 1133–1137

    Abstract: Swyer-James-MacLeod Syndrome (SJMS) is an uncommon, emphysematous disease characterized by obliteration of the small bronchioles, hypoplasia/or absence of pulmonary artery and peripheral vascular bed. It is most commonly diagnosed in childhood. Patients ... ...

    Abstract Swyer-James-MacLeod Syndrome (SJMS) is an uncommon, emphysematous disease characterized by obliteration of the small bronchioles, hypoplasia/or absence of pulmonary artery and peripheral vascular bed. It is most commonly diagnosed in childhood. Patients are often asymptomatic or they could suffer from symptoms of recurrent pulmonary infections. Spontaneous pneumothorax is a rare presentation of this syndrome. We report a case of a 42-year old female patient presented at our Emergency Department with complaints of dyspnea and pleuritic chest pain with a diagnosis of spontaneous pneumothorax in emphysematous disease. The diagnosis of SJMS is usually based on imaging and clinical findings rather than on the results of pathologic examination; indeed, asymptomatic adult patients with SJMS are often diagnosed after a chest radiograph obtained for another reason. High-resolution computed tomography (HRCT) seems to be the most appropriate technique for the diagnosis. SJMS can be associated with spontaneous pneumothorax which represent an emergency condition due to the underlying pathological disease. The surgical treatment of the affected lung should be considered when conservative approach is ineffective.
    Language English
    Publishing date 2021-03-08
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2021.02.047
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  8. Article ; Online: Left diaphragmatic rupture in vehicle trauma: Report of surgical treatment and complications of two consecutive cases.

    Conti, Luigi / Grassi, Carmine / Delfanti, Rocco / Cattaneo, Gaetano Maria / Banchini, Filippo / Capelli, Patrizio

    Acta bio-medica : Atenei Parmensis

    2021  Volume 92, Issue S1, Page(s) e2021121

    Abstract: Background and aims: Diaphragmatic ruptures are associated with blunt abdominal or thoracic trauma and often occur in car and motorbike accident with a high energy impact.: Case presentation: We report two cases of patients victims of car and ... ...

    Abstract Background and aims: Diaphragmatic ruptures are associated with blunt abdominal or thoracic trauma and often occur in car and motorbike accident with a high energy impact.
    Case presentation: We report two cases of patients victims of car and motorbike accidents that were referred to the Emergency Department of our Hospital in August and September 2017 for a politrauma. The patients were both diagnosed with a left diaphragmatic rupture with herniation of the stomach in the chest, and decomposed fractures of the ribs. One of the two patients reported a large abdominal wound with loss of substance in the site of the impact. Both patients underwent to open emergency surgery with primary repair of the phrenic rupture. The post-operative course was characterized by the occurrence of complications such as respiratory distress and emothorax for one of the patients.
    Conclusion: Traumatic rupture of the diaphragm can be associated to blunt or penetrating abdominal trauma in car and motorbike accident with a prevalence of the left-sided lesions. In patients with politrauma an associate rupture of the diaphragm should be always suspected especially in motor accident where high energy impact can generate a traumatic laceration of the respiratory muscle. The treatment of associate thoracic wall fractures to prevent weaning and respiratory distress in intubated patient should be discussed.
    MeSH term(s) Abdominal Injuries/diagnostic imaging ; Abdominal Injuries/etiology ; Abdominal Injuries/surgery ; Diaphragm/diagnostic imaging ; Diaphragm/injuries ; Diaphragm/surgery ; Fractures, Bone ; Humans ; Rupture/surgery ; Wounds, Nonpenetrating/diagnostic imaging ; Wounds, Nonpenetrating/etiology ; Wounds, Nonpenetrating/surgery
    Language English
    Publishing date 2021-04-30
    Publishing country Italy
    Document type Case Reports ; Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v92iS1.10931
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Advanced stage empyemas in community-acquired pneumonia: how hospital re-organization during the Covid-19 pandemic affected the increase in surgically treated cases.

    Conti, Luigi / Delfanti, Rocco / Grassi, Carmine / Chiesa, Sara / Cattaneo, Gaetano Maria / Capelli, Patrizio / Banchini, Filippo

    Acta bio-medica : Atenei Parmensis

    2022  Volume 93, Issue 1, Page(s) e2022059

    Abstract: The cause of pleural empyema is bacterial pneumonia and three stages has been described in the evolution of this disease: exudative, fibrino-purulent and organizational phases. The first therapeutic intervention is the antibiotic therapy; where ... ...

    Abstract The cause of pleural empyema is bacterial pneumonia and three stages has been described in the evolution of this disease: exudative, fibrino-purulent and organizational phases. The first therapeutic intervention is the antibiotic therapy; where pharmacological therapy alone is not sufficient to eradicate the infection, it is also necessary a surgical treatment. Since the province of Piacenza having been in the epicenter area during the first Sars-Cov 2 pandemic wave in March 2020 and the number of patients with Covid-related pneumonia required invasive and non-invasive respiratory support, had a considerable organizational impact on pulmonology and respiratory unit, hindering an optimal treatment of the bacterial pneumonia both in community as well as in the hospital. Among the many "collateral" damages of the epidemiological wave of the infection with Sars Cov-2, we have been able to observe in our Hospital, also an increase of pulmonary empyemas diagnosed at an advanced stage for what we believe to be organizational and social causes directly related to the pandemic: in order to cope with the emergency the Unit of Pneumology has been since March nearly uninterruptedly dedicated to the exclusive treatment of covid patients so the pneumologist has been removed due to the need from outpatient and residential management of general pneumology.
    MeSH term(s) COVID-19 ; Empyema, Pleural/diagnosis ; Empyema, Pleural/epidemiology ; Empyema, Pleural/therapy ; Hospitals ; Humans ; Pandemics ; Pneumonia
    Language English
    Publishing date 2022-03-14
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2114240-3
    ISSN 2531-6745 ; 0392-4203
    ISSN (online) 2531-6745
    ISSN 0392-4203
    DOI 10.23750/abm.v93i1.11606
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Evaluation of the mutagenicity of simple substituted quinoxalines in Salmonella typhimurium.

    Conti, Luigi / Crebelli, Riccardo

    Drug and chemical toxicology

    2015  Volume 39, Issue 2, Page(s) 213–216

    Abstract: Limited information is available on the genotoxicity of simple quinoxalines, distinct from the food related carcinogenic derivatives bearing an aromatic amino group. Isolated positive results, with no apparent structure-activity relationships, were ... ...

    Abstract Limited information is available on the genotoxicity of simple quinoxalines, distinct from the food related carcinogenic derivatives bearing an aromatic amino group. Isolated positive results, with no apparent structure-activity relationships, were reported in earlier studies on alkyl substituted quinoxalines, raising a safety concern in some regulatory authorities in view of the potential human exposure related to their use as food flavors. In order to elucidate the genotoxic hazard posed by simple quinoxalines, in this work a random set of mono- and bi-substituted methyl, chloro- and hydroxyl- quinoxalines have been tested in an OECD-compliant bacterial reversion test (TG 471). The results obtained do not highlight any genotoxic potential in the set of quinoxalines examined, and suggest that this may be a common trait for other simple substituted quinoxalines. Earlier published positive findings were not confirmed in this work, which call for a cautious approach in the use of literature data for regulatory purpose.
    MeSH term(s) Mutagenicity Tests ; Mutagens/chemistry ; Mutagens/toxicity ; Quinoxalines/chemistry ; Quinoxalines/toxicity ; Salmonella typhimurium/drug effects ; Salmonella typhimurium/genetics ; Structure-Activity Relationship
    Chemical Substances Mutagens ; Quinoxalines
    Language English
    Publishing date 2015-09-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 548368-2
    ISSN 1525-6014 ; 0148-0545
    ISSN (online) 1525-6014
    ISSN 0148-0545
    DOI 10.3109/01480545.2015.1079917
    Database MEDical Literature Analysis and Retrieval System OnLINE

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