Article ; Online: Inflammation, Autoinflammation and Autoimmunity in Inflammatory Bowel Diseases.
Current issues in molecular biology
2023 Volume 45, Issue 7, Page(s) 5534–5557
Abstract: In this review, the role of innate and adaptive immunity in the pathogenesis of inflammatory bowel diseases (IBD) is reported. In IBD, an altered innate immunity is often found, with increased Th17 and decreased Treg cells infiltrating the intestinal ... ...
| Abstract | In this review, the role of innate and adaptive immunity in the pathogenesis of inflammatory bowel diseases (IBD) is reported. In IBD, an altered innate immunity is often found, with increased Th17 and decreased Treg cells infiltrating the intestinal mucosa. An associated increase in inflammatory cytokines, such as IL-1 and TNF-α, and a decrease in anti-inflammatory cytokines, such as IL-10, concur in favoring the persistent inflammation of the gut mucosa. Autoinflammation is highlighted with insights in the role of inflammasomes, which activation by exogenous or endogenous triggers might be favored by mutations of NOD and NLRP proteins. Autoimmunity mechanisms also take place in IBD pathogenesis and in this context of a persistent immune stimulation by bacterial antigens and antigens derived from intestinal cells degradation, the adaptive immune response takes place and results in antibodies and autoantibodies production, a frequent finding in these diseases. Inflammation, autoinflammation and autoimmunity concur in altering the mucus layer and enhancing intestinal permeability, which sustains the vicious cycle of further mucosal inflammation. |
|---|---|
| Language | English |
| Publishing date | 2023-06-30 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Review |
| ZDB-ID | 2000024-8 |
| ISSN | 1467-3045 ; 1467-3037 |
| ISSN (online) | 1467-3045 |
| ISSN | 1467-3037 |
| DOI | 10.3390/cimb45070350 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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