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Article ; Online: Total metabolic tumor volume on

Tricarico, Pierre / Chardin, David / Martin, Nicolas / Contu, Sara / Hugonnet, Florent / Otto, Josiane / Humbert, Olivier

Journal for immunotherapy of cancer

2024 Volume 12, Issue 4

Abstract: Purpose: Because of atypical response imaging patterns in patients with metastatic non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICPIs), new biomarkers are needed for a better monitoring of treatment efficacy. The aim of ... ...

Abstract	Purpose: Because of atypical response imaging patterns in patients with metastatic non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICPIs), new biomarkers are needed for a better monitoring of treatment efficacy. The aim of this prospective study was to evaluate the prognostic value of volume-derived positron-emission tomography (PET) parameters on baseline and follow-up Methods: Patients with metastatic NSCLC were included in two different single-center prospective trials. Results: 110 patients were prospectively included. On PET Conclusion: The absolute value of residual metabolic tumor volume, assessed 6-8 weeks after the start of ICPI, is an optimal and independent prognostic measure, exceeding and complementing conventional PERCIST criteria. Oncologists should consider it in patients with first tumor progression according to PERCIST criteria, as it helps identify patients who benefit from continued treatment. Trial registration number: 2018-A02116-49; NCT03584334.
MeSH term(s)	Humans ; Fluorodeoxyglucose F18 ; Male ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Positron Emission Tomography Computed Tomography/methods ; Female ; Middle Aged ; Aged ; Tumor Burden ; Immunotherapy/methods ; Prospective Studies ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/metabolism ; Adult ; Neoplasm Metastasis ; Immune Checkpoint Inhibitors/therapeutic use ; Immune Checkpoint Inhibitors/pharmacology ; Aged, 80 and over
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-04-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2719863-7
ISSN	2051-1426 ; 2051-1426
ISSN (online)	2051-1426
ISSN	2051-1426
DOI	10.1136/jitc-2023-007628
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Validation and Improvement of a Convolutional Neural Network to Predict the Involved Pathology in a Head and Neck Surgery Cohort.

Culié, Dorian / Schiappa, Renaud / Contu, Sara / Scheller, Boris / Villarme, Agathe / Dassonville, Olivier / Poissonnet, Gilles / Bozec, Alexandre / Chamorey, Emmanuel

International journal of environmental research and public health

2022 Volume 19, Issue 19

Abstract: The selection of patients for the constitution of a cohort is a major issue for clinical research (prospective studies and retrospective studies in real life). Our objective was to validate in real life conditions the use of a Deep Learning process based ...

Abstract	The selection of patients for the constitution of a cohort is a major issue for clinical research (prospective studies and retrospective studies in real life). Our objective was to validate in real life conditions the use of a Deep Learning process based on a neural network, for the classification of patients according to the pathology involved in a head and neck surgery department. 24,434 Electronic Health Records (EHR) from the first visit between 2000 and 2020 were extracted. More than 6000 EHR were manually classified in ten groups of interest according to the reason for consultation with a clinical relevance. A convolutional neural network (TensorFlow, previously reported by Hsu et al.) was then used to predict the group of patients based on their pathology, using two levels of classification based on clinically relevant criteria. On the first and second level of classification, macro-average performances were: 0.95, 0.83, 0.85, 0.97, 0.84 and 0.93, 0.76, 0.83, 0.96, 0.79 for accuracy, recall, precision, specificity and F1-score versus accuracy, recall and precision of 0.580, 580 and 0.582 for Hsu et al., respectively. We validated this model to predict the pathology involved and to constitute clinically relevant cohorts in a tertiary hospital. This model did not require a preprocessing stage, was used in French and showed equivalent or better performances than other already published techniques.
MeSH term(s)	Cohort Studies ; Electronic Health Records ; Humans ; Neural Networks, Computer ; Prospective Studies ; Retrospective Studies
Language	English
Publishing date	2022-09-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph191912200
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Article ; Online: Robotic assessment of the contribution of motor commands to wrist position sense.

Contu, Sara / Marini, Francesca / Masia, Lorenzo

IEEE ... International Conference on Rehabilitation Robotics : [proceedings

2017 Volume 2017, Page(s) 941–946

Abstract: Assessing joint position sense for rehabilitation after neurological injury provides a prognostic factor in recovery and long-term functional outcomes. A common method for testing joint position sense involves the active replication of a joint ... ...

Abstract	Assessing joint position sense for rehabilitation after neurological injury provides a prognostic factor in recovery and long-term functional outcomes. A common method for testing joint position sense involves the active replication of a joint configuration presented via a passive movement. However, recent evidence showed how this sense is mediated by the centrally generated signals of motor command, such that movements produced volitionally may be coded differently from passive movements and accuracy may be different when matching targets presented actively. To verify this hypothesis we asked ten participants to actively replicate a target wrist angle with the help of a visual feedback in two conditions, which differed in the mode of target presentation: active (aaJPM) or passive (paJPM). The accuracy of target matching, directional bias and variability were analyzed, as well as speed and smoothness of the matching movement and criterion movement in the aaJPM. Overall results indicate higher accuracy and lower variability in the paJPM, while directional bias showed the tendency to overshoot the target regardless of condition. The speed did not differ in the two conditions and movements were smoother in the aaJPM, suggesting a higher confidence by participants in their matching ability. In conclusion, this study suggests that motor commands negatively affect the accuracy of joint position sense when matching involves the integration of visual and proprioceptive information.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ISSN	1945-7901
ISSN (online)	1945-7901
DOI	10.1109/ICORR.2017.8009370
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Article ; Online: Validation of RUBY for Breast Cancer Knowledge Extraction From a Large French Electronic Medical Record System.

Schiappa, Renaud / Contu, Sara / Culie, Dorian / Chateau, Yann / Gal, Jocelyn / Pace-Loscos, Tanguy / Bailleux, Caroline / Haudebourg, Juliette / Ferrero, Jean-Marc / Barranger, Emmanuel / Chamorey, Emmanuel

JCO clinical cancer informatics

2023 Volume 7, Page(s) e2200130

Abstract: Purpose: RUBY is a tool for extracting clinical data on breast cancer from French medical records on the basis of named entity recognition models combined with keyword extraction and postprocessing rules. Although initial results showed a high precision ...

Abstract	Purpose: RUBY is a tool for extracting clinical data on breast cancer from French medical records on the basis of named entity recognition models combined with keyword extraction and postprocessing rules. Although initial results showed a high precision of the system in extracting clinical information from surgery, pathology, and biopsy reports (≥92.7%) and good precision in extracting data from consultation reports (81.8%), its validation is needed before its use in routine practice. Methods: In this work, we analyzed RUBY's performance compared with the manual entry and we evaluated the generalizability of the approach on different sets of reports collected on a span of 40 years. Results: RUBY performed similarly or better than the manual entry for 15 of 27 variables. It showed similar performances when structuring newer reports but failed to extract entities for which changes in terminology appeared. Finally, our tool could automatically structure 15,990 reports in 77 minutes. Conclusion: RUBY can automate the data entry process of a set of variables and reduce its burden, but a continuous evaluation of the format and structure of the reports and a subsequent update of the system is necessary to ensure its robustness.
MeSH term(s)	Humans ; Female ; Breast Neoplasms/diagnosis ; Information Storage and Retrieval ; Electronic Health Records ; Software ; Biopsy
Language	English
Publishing date	2023-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2473-4276
ISSN (online)	2473-4276
DOI	10.1200/CCI.22.00130
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Article ; Online: Robot-assisted assessment of wrist proprioception: does wrist proprioceptive acuity follow Weber's law?

Contu, Sara / Marini, Francesca / Cappello, Leonardo / Masia, Lorenzo

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2016 Volume 2016, Page(s) 4610–4613

Abstract: Proprioception is essential for planning and controlling limb posture and movement. In our recent work, we introduced a standardized robot-aided method for measuring proprioceptive discrimination thresholds at the wrist to obtain reliable and accurate ... ...

Abstract	Proprioception is essential for planning and controlling limb posture and movement. In our recent work, we introduced a standardized robot-aided method for measuring proprioceptive discrimination thresholds at the wrist to obtain reliable and accurate measures of proprioceptive acuity. Weber's law defines discrimination thresholds as a constant ratio between the just noticeable difference and the reference or standard stimulus. Reporting Weber's fractions thus provides the possibility of comparing results with the reports of others collected worldwide. This work aims to determine that Weber's Law holds for proprioceptive discrimination thresholds and to provide Weber's fraction for wrist joint proprioception. To this end, eight healthy subjects experienced two passive wrist movements of different amplitude and verbally indicated which was larger. An adaptive psychophysical procedure established the amplitude of the largest stimulus according to participants' responses. This comparison stimulus was then compared to a standard stimulus amplitude of 10°, 20°, 30° or 40°. The discrimination thresholds for each standard stimulus were established at the 75% correct response level. The obtained thresholds followed Weber's Law indicating that larger amplitudes were associated with higher discrimination thresholds. Based on a linear regression function the overall Weber's fraction, defined as the slope of the line, was computed to be 0.09. This result expands the present limited knowledge on wrist proprioception showing that its proprioceptive acuity follows Weber's law.
MeSH term(s)	Adult ; Differential Threshold/physiology ; Female ; Humans ; Male ; Models, Biological ; Physical Stimulation ; Proprioception/physiology ; Range of Motion, Articular ; Regression Analysis ; Robotics/methods ; Wrist/physiology ; Wrist Joint/physiology
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2016.7591754
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Article ; Online: A preliminary study for quantitative assessment of upper limb proprioception.

Contu, Sara / Hussain, Asif / Masia, Lorenzo / Campolo, Domenico

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2016 Volume 2016, Page(s) 4614–4617

Abstract: Proprioception, or sense of position and movement of the body, strongly correlates with motor recovery of the hemiplegic arm. The evaluation of the awareness of the location of joints in space involves measuring the accuracy of joint-angle replication. ... ...

Abstract	Proprioception, or sense of position and movement of the body, strongly correlates with motor recovery of the hemiplegic arm. The evaluation of the awareness of the location of joints in space involves measuring the accuracy of joint-angle replication. Robotic devices allow an accurate manipulation of joint movements necessary to assess proprioceptive status. This study evaluated the proprioceptive performance of healthy subjects by mean of the H-Man, a planar robot designed for upper-limb rehabilitation to gather preliminary normative data for neurorehabilitation applications. Twelve participants were equally divided into Aged and Young groups and were asked to indicate when their dominant hand position matched a predefined target in the contralateral, sagittal and ipsilateral direction. Results indicated a better performance for movements towards the contralateral target in terms of both absolute and signed error while there was not a significant effect of age group. Error variability was not affected by the target location and participants' age. The present study established preliminary proprioceptive metrics that could assist in providing information about the normal range of proprioceptive acuity of healthy subjects of different age.
MeSH term(s)	Adult ; Female ; Humans ; Male ; Middle Aged ; Movement ; Proprioception/physiology ; Upper Extremity/physiology ; Young Adult
Language	English
Publishing date	2016-08
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2016.7591755
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Article ; Online: Wrist proprioceptive acuity: A comprehensive robot-aided assessment.

Cappello, Leonardo / Contu, Sara / Konczak, Juergen / Masia, Lorenzo

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2016 Volume 2015, Page(s) 3594–3597

Abstract: Proprioception is the sense of the body awareness. Proprioceptive deficits represent frequent consequences of several neurological conditions like stroke, Parkinson's disease and others. The assessment of such somatosensory function is crucial, although ... ...

Abstract	Proprioception is the sense of the body awareness. Proprioceptive deficits represent frequent consequences of several neurological conditions like stroke, Parkinson's disease and others. The assessment of such somatosensory function is crucial, although the available clinical tests are not sensitive enough. The human wrist is a crucial joint for many activities of daily living and to address the lack of its characterization in terms of proprioceptive acuity the authors in previous studies proposed a novel method that combined the use of a 3-DoF robot and a threshold haunting paradigm. Further experiments were performed to characterize the proprioceptive acuity of the dominant wrist for adduction, extension, pronation and supination by using a 2-alternative-forced-choice test. The acuity thresholds obtained from six subjects (mean values ± standard deviation of 1.65±0.39 for extension, 1.13±0.34 for adduction, 1.90±0.58 for pronation and 1.70±0.30 for supination) were finally combined with the ones harvested in the previous studies for flexion and abduction in order to build the first comprehensive database of human wrist proprioceptive acuity.
MeSH term(s)	Activities of Daily Living ; Adult ; Humans ; Pronation ; Proprioception ; Range of Motion, Articular ; Robotics ; Supination ; Wrist/physiology ; Wrist Joint/physiology ; Young Adult
Language	English
Publishing date	2016-01-12
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2015.7319170
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Article ; Online: Preliminary analysis of non-dominant proprioceptive acuity and interlimb asymmetry in the human wrist.

Contu, Sara / Cappello, Leonardo / Konczak, Jurgen / Masia, Lorenzo

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2016 Volume 2015, Page(s) 3598–3601

Abstract: Proprioception provides information about limb configuration which are essential for planning and controlling its posture and movement. Asymmetries in the way dominant and non-dominant limbs exploit proprioceptive information have been previously ... ...

Abstract	Proprioception provides information about limb configuration which are essential for planning and controlling its posture and movement. Asymmetries in the way dominant and non-dominant limbs exploit proprioceptive information have been previously evaluated, with contradictory results due to the difference in the employed methodology. A measure of proprioceptive acuity that does not reflect the influence of one limb on the other consists in the evaluation of the psychophysical threshold. This metric, evaluated separately for each limb and involving only passive movements, reflects a reliable measure of proprioceptive acuity. The aim of this work is to first evaluate the proprioceptive acuity of the non-dominant wrist joint in flexion/extension and adduction/abduction and to compare these results to the acuity of the dominant wrist. Data were collected during a unidirectional 2-alternative-forcedchoice test performed by six right-handed subjects. We found acuity of 1.31°, 1.26°, 1.33° and 1.63° respectively for abduction, adduction, extension and flexion of the non-dominant wrist. Acuity of the dominant wrist was assessed for five of the subjects for abduction and flexion and resulted lower (mean values were respectively 1.64° and 2.14°). The preliminary results suggest a leading role of the non-dominant wrist in the processing of the proprioceptive feedback.
MeSH term(s)	Adult ; Functional Laterality ; Humans ; Movement ; Posture ; Proprioception ; Range of Motion, Articular ; Wrist/physiology ; Wrist Joint/physiology ; Young Adult
Language	English
Publishing date	2016-01-12
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2015.7319171
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Article ; Online: The Role of Visual and Haptic Feedback During Dynamically Coupled Bimanual Manipulation.

Contu, Sara / Hughes, Charmayne Mary Lee / Masia, Lorenzo

IEEE transactions on haptics

2016 Volume 9, Issue 4, Page(s) 536–547

Abstract: The mechanisms that underlie the control of bimanual actions in which the two hands act separately to manipulate different objects (uncoupled independent control) has been well studied. In contrast, much less is known about how the central nervous system ...

Abstract	The mechanisms that underlie the control of bimanual actions in which the two hands act separately to manipulate different objects (uncoupled independent control) has been well studied. In contrast, much less is known about how the central nervous system controls bimanual actions that require the two hands act cooperatively to manipulate a single object (dynamically coupled control). Furthermore, there is scant research into the manual lateralization and role assignment in the processing of visual and haptic feedback during dynamically coupled bimanual tasks. In this experiment, we examined the role of the dominant and non-dominant hands during a dynamically coupled bimanual task in which visual and haptic feedback regarding object penetration were manipulated. Twelve subjects performed a bimanual grasp and reach task towards different target locations in the workspace by using two identical wrist robotic devices. Results showed haptic feedback is necessary for task completion, and that hand specialization plays a fundamental role in spatial and temporal coordination between the two limbs.
MeSH term(s)	Adult ; Feedback, Sensory/physiology ; Female ; Functional Laterality/physiology ; Hand/physiology ; Humans ; Male ; Psychomotor Performance/physiology ; Robotics ; Touch Perception/physiology ; Visual Perception/physiology ; Young Adult
Language	English
Publishing date	2016-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2329-4051
ISSN (online)	2329-4051
DOI	10.1109/TOH.2016.2609909
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Article ; Online: Codification mechanisms of wrist position sense.

Marini, Francesca / Contu, Sara / Morasso, Pietro / Masia, Lorenzo / Zenzeri, Jacopo

IEEE ... International Conference on Rehabilitation Robotics : [proceedings

2017 Volume 2017, Page(s) 44–49

Abstract: Proprioceptive signals from cutaneous, joint, tendon and muscle receptors create the basis for bodily perception and are known to be essential for motor control. However, which are the mechanisms underlying the proprioceptive signals and which are the ... ...

Abstract	Proprioceptive signals from cutaneous, joint, tendon and muscle receptors create the basis for bodily perception and are known to be essential for motor control. However, which are the mechanisms underlying the proprioceptive signals and which are the variables that affect them is still a matter of debate. In particular, what is worth to investigate is, namely, the codification of proprioceptive information related to pointing movements of the wrist towards kinesthetic targets. In this work we asked 10 healthy adults to perform with their wrist a robot-aided proprioceptive matching task, in which the starting position of the matching movements was shifted forward or backward, in order to ascertain to which extent such shifts cause target over/under estimation and how important is movement's length on task performance. Results indicate that accuracy and precision of performance are highly correlated with the starting position and targets tended to be undershot when the active matching movements were longer. Moreover, further analysis revealed a consistent decrement of movement speed for shorter movements and conversely, faster displacement in case of backward of starting position.
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article
ISSN	1945-7901
ISSN (online)	1945-7901
DOI	10.1109/ICORR.2017.8009219
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