Article ; Online: Chronic Exposure to a PFAS Mixture Resembling AFFF-Impacted Surface Water Decreases Body Size in Northern Leopard Frogs (
Environmental science & technology
2023 Volume 57, Issue 40, Page(s) 14797–14806
Abstract: Per- and polyfluoroalkyl substances (PFAS) occur in the environment as mixtures, yet mixture toxicity remains poorly understood. Aqueous film-forming foams (AFFFs) are a common source of PFAS. Our objective was to examine chronic effects of a complex ... ...
| Abstract | Per- and polyfluoroalkyl substances (PFAS) occur in the environment as mixtures, yet mixture toxicity remains poorly understood. Aqueous film-forming foams (AFFFs) are a common source of PFAS. Our objective was to examine chronic effects of a complex PFAS mixture on amphibian growth and development. We tested toxicity of a five-chemical PFAS mixture summing to 10 μg/L and that accounts for >90% of the PFAS in AFFF-affected surface waters: perfluorooctane sulfonate (PFOS, 40%), perfluorohexane sulfonic acid (PFHxS, 30%), perflurooctanoic acid (PFOA, 12.5%), perfluorohexanoic acid (PFHxA, 12.5%), and perfluoropentanoic acid (PFPeA, 5%). We also included treatments to determine whether PFOS drove mixture toxicity and whether PFOS and mixture components act additively. We exposed Northern leopard frog ( |
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| MeSH term(s) | Animals ; Water ; Rana pipiens ; Water Pollutants, Chemical/toxicity ; Water Pollutants, Chemical/analysis ; Alkanesulfonic Acids/toxicity ; Fluorocarbons/toxicity ; Fluorocarbons/analysis ; Larva ; Body Size |
| Chemical Substances | Water (059QF0KO0R) ; Water Pollutants, Chemical ; Alkanesulfonic Acids ; Fluorocarbons |
| Language | English |
| Publishing date | 2023-08-23 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. |
| ISSN | 1520-5851 |
| ISSN (online) | 1520-5851 |
| DOI | 10.1021/acs.est.3c01118 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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