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  1. Article ; Online: Commentary: Promoting generalisation in qualitative nursing research using the multiple case narrative approach: a methodological overview.

    Cooke, Mary

    Journal of research in nursing : JRN

    2023  Volume 28, Issue 5, Page(s) 382–383

    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173772-1
    ISSN 1744-988X ; 1744-9871
    ISSN (online) 1744-988X
    ISSN 1744-9871
    DOI 10.1177/17449871231199743
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  2. Article ; Online: Invited discussant comments during the UCL-Penn Global COVID Study webinar 'How Do We Trust (Again): Paranoia and Mental Health': part 2 of 2.

    Cooke, Mitch

    UCL open environment

    2022  Volume 4, Page(s) e003

    Abstract: Loneliness has been reported by the UCL-Penn Global COVID Study participants throughout the pandemic year, not surprisingly, although this has been an issue that has been manifesting itself even before the pandemic. In identifying loneliness in ... ...

    Abstract Loneliness has been reported by the UCL-Penn Global COVID Study participants throughout the pandemic year, not surprisingly, although this has been an issue that has been manifesting itself even before the pandemic. In identifying loneliness in communities, the built environment industry and professionals have been looking at how good and targeted design in the public realm and master planning can help to firstly design interventions and secondly orchestrate or manage these spaces in a way that helps create opportunities to address loneliness. Furthermore, how these spaces create opportunities for people to both interact with each other but also interact with the space can help connect people together and with nature/biodiversity. In doing so this also helps to create better health outcomes for mental health and wellbeing, as well as physical health and wellbeing. Coronavirus (Covid-19) and the associated lockdown periods have caused people to reconnect with local green spaces and has focused the attention to what these spaces provide in terms of opportunities and benefits for people. As a result, the value placed on these and the expectation of how they will provide value to communities is increasing and will continue to increase in the post-Covid-19 world. Better connected, activated and well-structured public realm and green spaces will be central to the development of projects and schemes for housing, and mixed used schemes in the forthcoming years.
    Language English
    Publishing date 2022-11-01
    Publishing country England
    Document type Journal Article
    ISSN 2632-0886
    ISSN (online) 2632-0886
    DOI 10.14324/111.444/ucloe.100003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Novel insights into the RTK-dependent metastatic phenotype of KRAS-mutant lung adenocarcinoma.

    Cooke, Mariana

    Molecular & cellular oncology

    2021  Volume 8, Issue 6, Page(s) 2013723

    Abstract: In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation of membrane ... ...

    Abstract In a recent study, our group identified RAC guanine nucleotide exchange factors (RAC-GEFs) driving motility signaling in KRAS mutant lung adenocarcinoma cells. The RAC-GEFs FARP1, ARHGEF39 and TIAM2 play fundamental roles in the formation of membrane ruffles in response to growth factor receptor stimulation.
    Language English
    Publishing date 2021-12-14
    Publishing country United States
    Document type Journal Article
    ISSN 2372-3556
    ISSN 2372-3556
    DOI 10.1080/23723556.2021.2013723
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  4. Article ; Online: Exploring Strengths of Prelicensure Nursing Students to Build Leadership Potential.

    Cooke, Marcia

    Nurse educator

    2021  Volume 46, Issue 6, Page(s) E139–E140

    MeSH term(s) Education, Nursing, Baccalaureate ; Humans ; Leadership ; Nursing Education Research ; Students, Nursing
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1034267-9
    ISSN 1538-9855 ; 0363-3624
    ISSN (online) 1538-9855
    ISSN 0363-3624
    DOI 10.1097/NNE.0000000000001067
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2904: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Protein kinase C signaling "in" and "to" the nucleus: Master kinases in transcriptional regulation.

    Kazanietz, Marcelo G / Cooke, Mariana

    The Journal of biological chemistry

    2024  Volume 300, Issue 3, Page(s) 105692

    Abstract: PKC is a multifunctional family of Ser-Thr kinases widely implicated in the regulation of fundamental cellular functions, including proliferation, polarity, motility, and differentiation. Notwithstanding their primary cytoplasmic localization and ... ...

    Abstract PKC is a multifunctional family of Ser-Thr kinases widely implicated in the regulation of fundamental cellular functions, including proliferation, polarity, motility, and differentiation. Notwithstanding their primary cytoplasmic localization and stringent activation by cell surface receptors, PKC isozymes impel prominent nuclear signaling ultimately impacting gene expression. While transcriptional regulation may be wielded by nuclear PKCs, it most often relies on cytoplasmic phosphorylation events that result in nuclear shuttling of PKC downstream effectors, including transcription factors. As expected from the unique coupling of PKC isozymes to signaling effector pathways, glaring disparities in gene activation/repression are observed upon targeting individual PKC family members. Notably, specific PKCs control the expression and activation of transcription factors implicated in cell cycle/mitogenesis, epithelial-to-mesenchymal transition and immune function. Additionally, PKCs isozymes tightly regulate transcription factors involved in stepwise differentiation of pluripotent stem cells toward specific epithelial, mesenchymal, and hematopoietic cell lineages. Aberrant PKC expression and/or activation in pathological conditions, such as in cancer, leads to profound alterations in gene expression, leading to an extensive rewiring of transcriptional networks associated with mitogenesis, invasiveness, stemness, and tumor microenvironment dysregulation. In this review, we outline the current understanding of PKC signaling "in" and "to" the nucleus, with significant focus on established paradigms of PKC-mediated transcriptional control. Dissecting these complexities would allow the identification of relevant molecular targets implicated in a wide spectrum of diseases.
    MeSH term(s) Gene Expression Regulation/genetics ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Protein Kinase C/genetics ; Protein Kinase C/metabolism ; Signal Transduction ; Transcription Factors/metabolism ; Humans ; Animals ; Cell Nucleus/enzymology ; Cell Nucleus/genetics
    Chemical Substances Isoenzymes ; Protein Kinase C (EC 2.7.11.13) ; Transcription Factors
    Language English
    Publishing date 2024-01-30
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2024.105692
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Commentary: Lessons learnt: Examining the use of case-study methodology for nursing research in the context of palliative care.

    Cooke, Mary

    Journal of research in nursing : JRN

    2019  Volume 24, Issue 6, Page(s) 460–461

    Language English
    Publishing date 2019-09-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2173772-1
    ISSN 1744-988X ; 1744-9871
    ISSN (online) 1744-988X
    ISSN 1744-9871
    DOI 10.1177/1744987119873206
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  7. Article: Estimating implicit and explicit racial and ethnic bias among community pharmacists in Canada.

    Alzahrani, Fahad / Waite, Nancy / Beazely, Michael / Cooke, Martin

    Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

    2024  Volume 32, Issue 5, Page(s) 102024

    Abstract: Background: Bias, whether implicit (unconscious) or explicit (conscious), can lead to preferential treatment of specific social groups and antipathy towards others. When healthcare professionals (HCPs), including pharmacists, act on these biases, ... ...

    Abstract Background: Bias, whether implicit (unconscious) or explicit (conscious), can lead to preferential treatment of specific social groups and antipathy towards others. When healthcare professionals (HCPs), including pharmacists, act on these biases, patient care and health outcomes can be adversely affected. This study aims to estimate implicit and explicit racial/ethnic bias towards Black and Arab people among community pharmacists in Ontario, Canada.
    Methods: Community pharmacists participated in a secure, web-based survey using a cross-sectional design that included Harvard's Race and Arab Implicit Association Tests (IATs) to examine bias towards Black and Arab people. Explicit (stated) preferences were measured by self-report. Data were analyzed using descriptive and inferential statistics.
    Results: The study surveyed 407 community pharmacists, 56.1 % of whom were women with an average age of 46.9. Implicit Association Test (IAT) results showed a statistically significant moderate preference for white people over both Black (mean IAT = 0.41) and Arab people (mean IAT = 0.35). However, most pharmacists explicitly stated that they had no racial/ethnic preference, with 75.7 % expressing a neutral preference between Black and white and 66.6 % neutral between Arab and white. However, a slight preference for white individuals was observed. Demographic factors such as age, place of birth, race/ethnicity, and experience significantly impacted IAT scores. For example, older, Canadian-born, white pharmacists with more experience displayed higher implicit bias scores. A mild correlation was found between implicit and explicit bias, indicating as implicit bias increases, explicit bias tends to become more negative.
    Conclusions: This study is the first to explore the issue of pharmacist bias in Canada and concentrate on anti-Arab bias. Our findings reveal that Ontario community pharmacists tend to have an unconscious inclination towards white people, which calls for further understanding of this matter. Additionally, we discovered a moderate degree of anti-Arab bias, indicating that studies on other HCPs should consider bias against this social group. Educational interventions are needed to address the implicit biases among community pharmacists in Ontario, Canada. These findings should aim to raise self-awareness of biases, educate about the potential implications of these biases on patient care, and provide strategies to reduce bias.
    Language English
    Publishing date 2024-03-11
    Publishing country Saudi Arabia
    Document type Journal Article
    ZDB-ID 1378024-4
    ISSN 1319-0164
    ISSN 1319-0164
    DOI 10.1016/j.jsps.2024.102024
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4758: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Protocol for fluorescence-activated cell sorting of human EpCAM

    Sullivan, Neil T / Cooke, Mariana

    STAR protocols

    2022  Volume 3, Issue 2, Page(s) 101367

    Abstract: Here, we describe a protocol for fluorescence-activated cell sorting (FACS) of human ... ...

    Abstract Here, we describe a protocol for fluorescence-activated cell sorting (FACS) of human EpCAM
    MeSH term(s) Epithelial Cell Adhesion Molecule/genetics ; Flow Cytometry/methods ; Gene Expression ; Guanine ; Guanine Nucleotide Exchange Factors ; Humans ; Lung Neoplasms/genetics ; Nucleotides
    Chemical Substances EPCAM protein, human ; Epithelial Cell Adhesion Molecule ; Guanine Nucleotide Exchange Factors ; Nucleotides ; Guanine (5Z93L87A1R)
    Language English
    Publishing date 2022-05-02
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2666-1667
    ISSN (online) 2666-1667
    DOI 10.1016/j.xpro.2022.101367
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  9. Article ; Online: Overarching roles of diacylglycerol signaling in cancer development and antitumor immunity.

    Cooke, Mariana / Kazanietz, Marcelo G

    Science signaling

    2022  Volume 15, Issue 729, Page(s) eabo0264

    Abstract: Diacylglycerol (DAG) is a lipid second messenger that is generated in response to extracellular stimuli and channels intracellular signals that affect mammalian cell proliferation, survival, and motility. DAG exerts a myriad of biological functions ... ...

    Abstract Diacylglycerol (DAG) is a lipid second messenger that is generated in response to extracellular stimuli and channels intracellular signals that affect mammalian cell proliferation, survival, and motility. DAG exerts a myriad of biological functions through protein kinase C (PKC) and other effectors, such as protein kinase D (PKD) isozymes and small GTPase-regulating proteins (such as RasGRPs). Imbalances in the fine-tuned homeostasis between DAG generation by phospholipase C (PLC) enzymes and termination by DAG kinases (DGKs), as well as dysregulation in the activity or abundance of DAG effectors, have been widely associated with tumor initiation, progression, and metastasis. DAG is also a key orchestrator of T cell function and thus plays a major role in tumor immunosurveillance. In addition, DAG pathways shape the tumor ecosystem by arbitrating the complex, dynamic interaction between cancer cells and the immune landscape, hence representing powerful modifiers of immune checkpoint and adoptive T cell-directed immunotherapy. Exploiting the wide spectrum of DAG signals from an integrated perspective could underscore meaningful advances in targeted cancer therapy.
    MeSH term(s) Animals ; Diacylglycerol Kinase/metabolism ; Diglycerides/metabolism ; Ecosystem ; Mammals/metabolism ; Neoplasms/therapy ; Signal Transduction
    Chemical Substances Diglycerides ; Diacylglycerol Kinase (EC 2.7.1.107)
    Language English
    Publishing date 2022-04-12
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.abo0264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The impact of speech type on listening effort and intelligibility for native and non-native listeners.

    Simantiraki, Olympia / Wagner, Anita E / Cooke, Martin

    Frontiers in neuroscience

    2023  Volume 17, Page(s) 1235911

    Abstract: Listeners are routinely exposed to many different types of speech, including artificially-enhanced and synthetic speech, styles which deviate to a greater or lesser extent from naturally-spoken exemplars. While the impact of differing speech types on ... ...

    Abstract Listeners are routinely exposed to many different types of speech, including artificially-enhanced and synthetic speech, styles which deviate to a greater or lesser extent from naturally-spoken exemplars. While the impact of differing speech types on intelligibility is well-studied, it is less clear how such types affect cognitive processing demands, and in particular whether those speech forms with the greatest intelligibility in noise have a commensurately lower listening effort. The current study measured intelligibility, self-reported listening effort, and a pupillometry-based measure of cognitive load for four distinct types of speech: (i) plain i.e. natural unmodified speech; (ii) Lombard speech, a naturally-enhanced form which occurs when speaking in the presence of noise; (iii) artificially-enhanced speech which involves spectral shaping and dynamic range compression; and (iv) speech synthesized from text. In the first experiment a cohort of 26 native listeners responded to the four speech types in three levels of speech-shaped noise. In a second experiment, 31 non-native listeners underwent the same procedure at more favorable signal-to-noise ratios, chosen since second language listening in noise has a more detrimental effect on intelligibility than listening in a first language. For both native and non-native listeners, artificially-enhanced speech was the most intelligible and led to the lowest subjective effort ratings, while the reverse was true for synthetic speech. However, pupil data suggested that Lombard speech elicited the lowest processing demands overall. These outcomes indicate that the relationship between intelligibility and cognitive processing demands is not a simple inverse, but is mediated by speech type. The findings of the current study motivate the search for speech modification algorithms that are optimized for both intelligibility and listening effort.
    Language English
    Publishing date 2023-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2411902-7
    ISSN 1662-453X ; 1662-4548
    ISSN (online) 1662-453X
    ISSN 1662-4548
    DOI 10.3389/fnins.2023.1235911
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