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Article ; Online: Using An Air Duster to Unstick The Hyfrecator Sheath.

Jetter, Nathan / Cooke, Natasha

Journal of the American Academy of Dermatology

2024

Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2024.04.059
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Article ; Online: A review on statistical and machine learning competing risks methods.

Monterrubio-Gómez, Karla / Constantine-Cooke, Nathan / Vallejos, Catalina A

Biometrical journal. Biometrische Zeitschrift

2024 Volume 66, Issue 2, Page(s) e2300060

Abstract: When modeling competing risks (CR) survival data, several techniques have been proposed in both the statistical and machine learning literature. State-of-the-art methods have extended classical approaches with more flexible assumptions that can improve ... ...

Abstract	When modeling competing risks (CR) survival data, several techniques have been proposed in both the statistical and machine learning literature. State-of-the-art methods have extended classical approaches with more flexible assumptions that can improve predictive performance, allow high-dimensional data and missing values, among others. Despite this, modern approaches have not been widely employed in applied settings. This article aims to aid the uptake of such methods by providing a condensed compendium of CR survival methods with a unified notation and interpretation across approaches. We highlight available software and, when possible, demonstrate their usage via reproducible R vignettes. Moreover, we discuss two major concerns that can affect benchmark studies in this context: the choice of performance metrics and reproducibility.
MeSH term(s)	Models, Statistical ; Reproducibility of Results ; Machine Learning
Language	English
Publishing date	2024-02-13
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	131640-0
ISSN	1521-4036 ; 0323-3847 ; 0006-3452
ISSN (online)	1521-4036
ISSN	0323-3847 ; 0006-3452
DOI	10.1002/bimj.202300060
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Article ; Online: How to convey a diagnosis of skin cancer: patient preferences.

Cooke, N / Colver, G B

The British journal of dermatology

2016 Volume 175, Issue 2, Page(s) 398–400

MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Checklist ; Choice Behavior ; Communication ; Female ; Humans ; Male ; Melanoma/diagnosis ; Melanoma/psychology ; Middle Aged ; Pamphlets ; Patient Preference ; Physician-Patient Relations ; Skin Neoplasms/diagnosis ; Skin Neoplasms/psychology ; Surveys and Questionnaires ; Telephone ; Truth Disclosure ; Young Adult
Language	English
Publishing date	2016-08
Publishing country	England
Document type	Letter
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1111/bjd.14456
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Article ; Online: A review of mathematical models of human trust in automation.

Rodriguez Rodriguez, Lucero / Bustamante Orellana, Carlos E / Chiou, Erin K / Huang, Lixiao / Cooke, Nancy / Kang, Yun

Frontiers in neuroergonomics

2023 Volume 4, Page(s) 1171403

Abstract: Understanding how people trust autonomous systems is crucial to achieving better performance and safety in human-autonomy teaming. Trust in automation is a rich and complex process that has given rise to numerous measures and approaches aimed at ... ...

Abstract	Understanding how people trust autonomous systems is crucial to achieving better performance and safety in human-autonomy teaming. Trust in automation is a rich and complex process that has given rise to numerous measures and approaches aimed at comprehending and examining it. Although researchers have been developing models for understanding the dynamics of trust in automation for several decades, these models are primarily conceptual and often involve components that are difficult to measure. Mathematical models have emerged as powerful tools for gaining insightful knowledge about the dynamic processes of trust in automation. This paper provides an overview of various mathematical modeling approaches, their limitations, feasibility, and generalizability for trust dynamics in human-automation interaction contexts. Furthermore, this study proposes a novel and dynamic approach to model trust in automation, emphasizing the importance of incorporating different timescales into measurable components. Due to the complex nature of trust in automation, it is also suggested to combine machine learning and dynamic modeling approaches, as well as incorporating physiological data.
Language	English
Publishing date	2023-06-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ISSN	2673-6195
ISSN (online)	2673-6195
DOI	10.3389/fnrgo.2023.1171403
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Article ; Online: CorrespondenceUpdosing of secukinumab to every 2 weeks results in superior efficacy in patients with severe psoriasis weighing 90 kg or more: a real-world prospective observational study.

McGuire, Niamh / Elamin, Shahd / Gough, Pamela / Cooke, Nicola / McGrath, Conor / McKenna, Kevin / O'Kane, Donal

Clinical and experimental dermatology

2023 Volume 48, Issue 7, Page(s) 793–812

MeSH term(s)	Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Psoriasis/drug therapy ; Prospective Studies ; Treatment Outcome ; Severity of Illness Index ; Double-Blind Method
Chemical Substances	secukinumab (DLG4EML025) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Observational Study ; Letter
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1093/ced/llad035
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Article: A Case of Ischemia-Induced Perianal Ulceration Mimicking Pyoderma Gangrenosum.

Lavery, Michael Joseph / Cooke, Nicola

Skinmed

2017 Volume 15, Issue 3, Page(s) 235–237

Abstract: A 68-year-old woman, with a 75-pack-year smoking history and a history of chronic excess alcohol intake, presented with a 5-week history of worsening perianal pain and ulceration. She recently had an inpatient admission with back pain and urinary tract ... ...

Abstract	A 68-year-old woman, with a 75-pack-year smoking history and a history of chronic excess alcohol intake, presented with a 5-week history of worsening perianal pain and ulceration. She recently had an inpatient admission with back pain and urinary tract infection during which she developed diarrhea and fecal incontinence. Initially, the perianal ulceration was diagnosed as severe irritant contact dermatitis and treated with barrier creams and topical clobetasone 17-butyrate 0.05% weight for weight, oxytetracycline 3.0% weight for weight and nystatin cream (Trimovate
MeSH term(s)	Aged ; Anal Canal ; Aorta, Abdominal ; Buttocks ; Diagnosis, Differential ; Female ; Femoral Artery ; Humans ; Iliac Artery ; Ischemia/etiology ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/surgery ; Pyoderma Gangrenosum/diagnosis ; Skin Ulcer/diagnosis ; Skin Ulcer/etiology
Language	English
Publishing date	2017-06-01
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2171125-2
ISSN	1540-9740
ISSN	1540-9740
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Article ; Online: Upper limb position affects pain-free grip strength in individuals with lateral elbow tendinopathy.

Cooke, Nikki / Obst, Steven / Vicenzino, Bill / Hodges, Paul W / Heales, Luke J

Physiotherapy research international : the journal for researchers and clinicians in physical therapy

2021 Volume 26, Issue 3, Page(s) e1906

Abstract: Background and purpose: Pain-free grip (PFG) force is commonly used to monitor treatment outcomes in lateral elbow tendinopathy (LET); however, it is unclear whether changes in forearm and elbow position affect PFG force values. This study aims to ... ...

Abstract	Background and purpose: Pain-free grip (PFG) force is commonly used to monitor treatment outcomes in lateral elbow tendinopathy (LET); however, it is unclear whether changes in forearm and elbow position affect PFG force values. This study aims to examine the effect of elbow/shoulder and forearm position on non-normalised and normalised PFG force in individuals with unilateral LET. Methods: A cohort study including 21 subjects with clinically diagnosed unilateral LET (13 females, mean [SD] age 50 [8] years) performed PFG force (symptomatic arm) and maximal grip (asymptomatic arm) tasks using four upper limb positions: (1) shoulder neutral, elbow flexed (90°), forearm pronated; (2) shoulder neutral, elbow flexed (90°), forearm neutral; (3) shoulder flexed (90°), elbow extended, forearm pronated; and (4) shoulder flexed (90°), elbow extended, forearm neutral. PFG force was normalised to the maximal grip of the asymptomatic side. Repeated-measures analyses of variance were used to compare non-normalised and PFG force normalised to maximal grip between positions. Results: Both non-normalised and normalised PFG forces were greater in position 2 than position 1, position 3 and position 4 (elbow-by-forearm interaction non-normalised p = 0.002, normalised p = 0.004). There were no differences between positions 1, 3 and 4 for either non-normalised or normalised PFG strength. Discussion: This study shows that PFG force was higher when performed with forearm neutral supination/pronation, elbow flexion and shoulder neutral than other tested positions, and irrespective of whether PFG force was normalised to the maximal grip force of the contralateral limb. This indicates that arm position should be standardised for comparison.
MeSH term(s)	Cohort Studies ; Elbow ; Elbow Tendinopathy ; Female ; Hand Strength ; Humans ; Middle Aged ; Pronation ; Range of Motion, Articular
Language	English
Publishing date	2021-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1432038-1
ISSN	1471-2865 ; 1358-2267
ISSN (online)	1471-2865
ISSN	1358-2267
DOI	10.1002/pri.1906
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Article: Getting it right first time (GIRFT): A closed loop study of hip arthroplasty documentation in a trauma and orthopaedic department.

Sandhu, Jasmesh / Sharma, Hemant / Jabr, Yamen / Sidaginamale, Raghavendra / Logishetty, Rajanikanth / Cooke, Nick / Brewster, Nigel

Annals of medicine and surgery (2012)

2020 Volume 61, Page(s) 110–114

Abstract: Introduction: The objectives of this study conducted in the University Hospital of North Tees, UK were to: (i) Identify if the current hip arthroplasty documentation met good compliance with the Getting It Right First Time (GIRFT) hip arthroplasty ... ...

Abstract	Introduction: The objectives of this study conducted in the University Hospital of North Tees, UK were to: (i) Identify if the current hip arthroplasty documentation met good compliance with the Getting It Right First Time (GIRFT) hip arthroplasty guidance (ii) Improve current documentation with a transition from hand-written notes to an online typed personalised operative hip arthroplasty template (iii) Improve the quality of documentation and adherence to GIRFT guidance in hip arthroplasty. Methods: We led a team of 7 doctors to review University Hospital of North Tees compliance against 24 criteria laid out by GIRFT. After examining 20 operative records retrospectively at random from a spread of orthopaedic consultants in the department, it was shown that there was poor compliance against GIRFT guidelines. We proposed a pragmatic solution of incorporating a pre-populated hip arthroplasty online template adhering to GIRFT guidance into our local 'Trackcare' system. Following that, we closed the audit loop by prospectively reviewing 20 operative notes. Results: Our initial results showed that poor compliance ranging 0%-100% over the 24 criteria. The findings of the 24 criteria with the online hip arthroplasty template in place showed a significant improvement between 80 and 100% compliance over the 24 criteria. Conclusion: The majority of the issues identified are modifiable risks factors which were amenable to some simple pragmatic solutions. A review of a single surgeon template has shown that it is simple to use, has excellent compliance (has pre-populated 24 criteria), takes 6-7 min to complete the operative notes, easily auditable and thus appears promising in minimising medico-legal claims for surgeons and the Trust.
Language	English
Publishing date	2020-12-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1016/j.amsu.2020.12.032
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Article ; Online: Longitudinal Fecal Calprotectin Profiles Characterize Disease Course Heterogeneity in Crohn's Disease.

Constantine-Cooke, Nathan / Monterrubio-Gómez, Karla / Plevris, Nikolas / Derikx, Lauranne A A P / Gros, Beatriz / Jones, Gareth-Rhys / Marioni, Riccardo E / Lees, Charlie W / Vallejos, Catalina A

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2023 Volume 21, Issue 11, Page(s) 2918–2927.e6

Abstract: Background and aims: The progressive nature of Crohn's disease is highly variable and hard to predict. In addition, symptoms correlate poorly with mucosal inflammation. There is therefore an urgent need to better characterize the heterogeneity of ... ...

Abstract	Background and aims: The progressive nature of Crohn's disease is highly variable and hard to predict. In addition, symptoms correlate poorly with mucosal inflammation. There is therefore an urgent need to better characterize the heterogeneity of disease trajectories in Crohn's disease by utilizing objective markers of inflammation. We aimed to better understand this heterogeneity by clustering Crohn's disease patients with similar longitudinal fecal calprotectin profiles. Methods: We performed a retrospective cohort study at the Edinburgh IBD Unit, a tertiary referral center, and used latent class mixed models to cluster Crohn's disease subjects using fecal calprotectin observed within 5 years of diagnosis. Information criteria, alluvial plots, and cluster trajectories were used to decide the optimal number of clusters. Chi-square test, Fisher's exact test, and analysis of variance were used to test for associations with variables commonly assessed at diagnosis. Results: Our study cohort comprised 356 patients with newly diagnosed Crohn's disease and 2856 fecal calprotectin measurements taken within 5 years of diagnosis (median 7 per subject). Four distinct clusters were identified by characteristic calprotectin profiles: a cluster with consistently high fecal calprotectin and 3 clusters characterized by different downward longitudinal trends. Cluster membership was significantly associated with smoking (P = .015), upper gastrointestinal involvement (P < .001), and early biologic therapy (P < .001). Conclusions: Our analysis demonstrates a novel approach to characterizing the heterogeneity of Crohn's disease by using fecal calprotectin. The group profiles do not simply reflect different treatment regimens and do not mirror classical disease progression endpoints.
MeSH term(s)	Humans ; Crohn Disease/diagnosis ; Crohn Disease/therapy ; Biomarkers ; Retrospective Studies ; Leukocyte L1 Antigen Complex ; Disease Progression ; Inflammation ; Feces ; Severity of Illness Index
Chemical Substances	Biomarkers ; Leukocyte L1 Antigen Complex
Language	English
Publishing date	2023-03-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2023.03.026
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Article ; Online: Multiple infliximab biosimilar switches appear to be safe and effective in a real-world inflammatory bowel disease cohort.

Gros, Beatriz / Plevris, Nikolas / Constantine-Cooke, Nathan / Lyons, Mathew / O'Hare, Claire / Noble, Colin / Arnott, Ian D / Jones, Gareth-Rhys / Lees, Charlie W / Derikx, Lauranne A A P

United European gastroenterology journal

2023 Volume 11, Issue 2, Page(s) 179–188

Abstract: Background: Switching from originator infliximab (IFX) to biosimilar IFX is effective and safe. However, data on multiple switching are scarce. The Edinburgh inflammatory bowel disease (IBD) unit has undertaken three switch programmes: (1) Remicade to ... ...

Abstract	Background: Switching from originator infliximab (IFX) to biosimilar IFX is effective and safe. However, data on multiple switching are scarce. The Edinburgh inflammatory bowel disease (IBD) unit has undertaken three switch programmes: (1) Remicade to CT-P13 (2016), (2) CT-P13 to SB2 (2020), and (3) SB2 to CT-P13 (2021). Objective: The primary endpoint of this study was to assess CT-P13 persistence following switch from SB2. Secondary endpoints included persistence stratified by the number of biosimilar switches (single, double and triple), effectiveness and safety. Methods: We performed a prospective, observational, cohort study. All adult IBD patients on IFX biosimilar SB2 underwent an elective switch to CT-P13. Patients were reviewed in a virtual biologic clinic with protocol driven collection of clinical disease activity, C-reactive protein (CRP), faecal calprotectin (FC), IFX trough/antibody levels, and drug survival. Results: 297 patients (CD n = 196 [66%], ulcerative colitis/inflammatory bowel disease unclassified n = 101, [34%]) were switched (followed-up: 7.5 months [6.8-8.1]). This was the third, second and first IFX switch for 67/297 (22.5%), 138/297 (46.5%) and 92/297 (31%) of the cohort respectively. 90.6% of patients remained on IFX during follow-up. The number of switches was not independently associated with IFX persistence after adjusting for confounders. Clinical (p = 0.77), biochemical (CRP ≤5 mg/ml; p = 0.75) and faecal biomarker (FC<250 µg/g; p = 0.63) remission were comparable at baseline, week 12 and week 24. Conclusion: Multiple successive switches from IFX originator to biosimilars are effective and safe in patients with IBD, irrespective of the number of IFX switches.
MeSH term(s)	Adult ; Humans ; Infliximab/therapeutic use ; Biosimilar Pharmaceuticals/adverse effects ; Prospective Studies ; Cohort Studies ; Gastrointestinal Agents/adverse effects ; Drug Substitution ; Inflammatory Bowel Diseases/drug therapy ; C-Reactive Protein/analysis ; Leukocyte L1 Antigen Complex
Chemical Substances	Infliximab (B72HH48FLU) ; Biosimilar Pharmaceuticals ; Gastrointestinal Agents ; C-Reactive Protein (9007-41-4) ; Leukocyte L1 Antigen Complex
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2728585-6
ISSN	2050-6414 ; 2050-6406
ISSN (online)	2050-6414
ISSN	2050-6406
DOI	10.1002/ueg2.12357
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