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  1. Article ; Online: Poor adherence to national guidance in the management of patients with metastatic bone disease.

    Stevenson, Jonathan / Cool, Paul / Ashford, Robert

    The bone & joint journal

    2024  Volume 106-B, Issue 1, Page(s) 6–8

    MeSH term(s) Humans ; Bone Diseases ; Guideline Adherence
    Language English
    Publishing date 2024-01-01
    Publishing country England
    Document type Editorial
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.106B1.BJJ-2023-0979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6989: Show issues Location:
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  2. Article ; Online: Poor adherence to national guidance in the management of patients with metastatic bone disease.

    Stevenson, Jonathan / Cool, Paul / Ashford, Robert

    The bone & joint journal

    2023  Volume 105-B, Page(s) xxx

    MeSH term(s) Humans ; Bone Diseases/therapy ; Guideline Adherence ; Neoplasm Metastasis/therapy
    Language English
    Publishing date 2023-10-17
    Publishing country England
    Document type Editorial
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.105B.BJJ-2023-0979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article: The impact and efficacy of surveillance in patients with sarcoma of the extremities.

    Cool, P / Cribb, G

    Bone & joint research

    2017  Volume 6, Issue 4, Page(s) 224–230

    Abstract: Objectives: In this cross sectional study, the impact and the efficacy of a surveillance programme for sarcomas of the extremities was analysed.: Methods: All patients who had treatment with curative intent for a high-grade sarcoma and were diagnosed ...

    Abstract Objectives: In this cross sectional study, the impact and the efficacy of a surveillance programme for sarcomas of the extremities was analysed.
    Methods: All patients who had treatment with curative intent for a high-grade sarcoma and were diagnosed before 2014 were included and followed for a minimum of two years.
    Results: Of the 909 patients who had a review appointment in 2014, 131 were under review for a high-grade sarcoma of the extremities following treatment with curative intent. Of these patients, three patients died of disease, two patients died of other causes, 12 are alive, with disease, and 114 have no evidence of disease. The surveillance programme accounts for 14% of all review appointments.Four of five patients (80%) who developed local recurrence identified the recurrence themselves. Chest radiographs are adequate in identifying metastatic disease and 11 (73%) of metastases were diagnosed during a routine follow up visit. However, the chance of cure is small and only two patients were referred for a metastatectomy. Of these only one survived for more than two years.The mean time for developing metastatic disease and local recurrence was 2.0 and 3.9 years respectively. Once identified, the mean time to death was 2.1 years for patients with metastatic disease.
    Conclusions: Surveillance of sarcoma patients makes up a substantial amount of the workload of a sarcoma unit. The chance of cure following identification of local recurrence or metastatic disease, however, is small. Alternative methods of surveillance that allow better evaluation of the patient's needs are recommended.
    Language English
    Publishing date 2017-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2669244-2
    ISSN 2046-3758
    ISSN 2046-3758
    DOI 10.1302/2046-3758.64.BJR-2016-0253.R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Clinical outcome of open ankle fractures in patients above 70 years of age.

    Zahra, Wajiha / Seifo, Mina / Cool, Paul / Ford, David / Okoro, Tosan

    World journal of orthopedics

    2023  Volume 14, Issue 7, Page(s) 554–561

    Abstract: Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older than ... ...

    Abstract Background: Open fractures of the ankle are complex injuries requiring multidisciplinary input and are associated with significant morbidity and mortality. However, data on the clinical outcomes of open ankle fracture management in patients older than 70 is minimal.
    Aim: To evaluate the clinical outcomes following open ankle fracture management in patients older than 70. Our secondary aim is to look at predictors of poor outcomes.
    Methods: Following local research and audit department registration, 22 years of prospectively collated data from an electronic database in a district general hospital were assessed. All patients older than 70 years of age with an open ankle fracture requiring surgical intervention were identified. Demographic information, the nature, and the number of surgical interventions were collated. Complications, including surgical site infection (SSI), venous thromboembolic events (VTEs) during hospital stay, and mortality rate, were reviewed.
    Results: A total of 37 patients were identified (median age: 84 years, range: 70-98);
    Conclusion: An open ankle fracture in a patient older than 70 years has at least a 20% chance of requiring repeated surgical intervention due to deep SSIs. The presence of a cardiac history appears to be the main predictor for wound complications.
    Language English
    Publishing date 2023-07-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649712-8
    ISSN 2218-5836
    ISSN 2218-5836
    DOI 10.5312/wjo.v14.i7.554
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A Rare Presentation of a Solitary Melanoma Bone Metastasis.

    Reipond, Lucy / Ford, David / Cool, Paul

    Cureus

    2022  Volume 14, Issue 1, Page(s) e21479

    Abstract: A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excised ... ...

    Abstract A 74-year-old woman presented with sudden onset pain and swelling in her right wrist. Plain radiographs showed a pathological fracture through a lytic lesion. The patient had a past medical history of melanoma on her right thigh, which had been excised two years previously. She was referred to the bone cancer unit to undergo a series of investigations that included a magnetic resonance imaging scan, bone scintigraphy and a computed tomography-guided biopsy. Collectively, all investigations revealed a solitary bone metastasis from her previous melanoma in the right distal radius. The patient was treated symptomatically and underwent internal fixation with cement augmentation for symptom control. With the incidence of melanoma increasing, this case demonstrates the importance of being vigilant of unusual presentations.
    Language English
    Publishing date 2022-01-21
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.21479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Porphyrin functionalized bismuth ferrite for enhanced solar light photocatalysis.

    Tudisco, C / Pulvirenti, L / Cool, P / Condorelli, G G

    Dalton transactions (Cambridge, England : 2003)

    2020  Volume 49, Issue 25, Page(s) 8652–8660

    Abstract: In this work, multiferroic bismuth ferrite (BFO) was functionalized with meso-tetraphenylporphine-4,4',4'',4'''-tetracarboxylic acid (TCPP). This new hybrid organic-inorganic material shows an enhanced photocatalytic activity for the degradation of ... ...

    Abstract In this work, multiferroic bismuth ferrite (BFO) was functionalized with meso-tetraphenylporphine-4,4',4'',4'''-tetracarboxylic acid (TCPP). This new hybrid organic-inorganic material shows an enhanced photocatalytic activity for the degradation of organic dyes as it combines the properties of BFO which is an efficient visible light photocatalyst with peculiar porphyrin absorption in visible light. The anchoring of TCPP to the OH-terminations of the BFO surface through its carboxylic tethering groups was demonstrated using X-ray photoelectron spectroscopy and FT-IR spectroscopy. The photocatalytic activity of the material was also demonstrated through the photocatalytic degradation of Methylene Blue (MB) and Rhodamine-B (Rhd-B) in water under simulated solar light illumination. The TCPP molecules anchored to BFO slightly decrease (∼0.06 eV) the bandgap energy of the system and act as new catalytic centres, thus improving its photocatalytic activity. A photodegradation mechanism was also proposed. This new material is reusable and stable, as it maintains an unmodified photo-activity after several MB discoloration runs.
    Language English
    Publishing date 2020-06-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c9dt04514g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Prognostic indicators of outcome for patients with skeletal metastases from carcinoma of the prostate.

    Shepherd, K L / Cool, P / Cribb, G

    The bone & joint journal

    2018  Volume 100-B, Issue 12, Page(s) 1647–1654

    Abstract: Aims: The purpose of this study was to identify prognostic indicators of outcome at presentation to the orthopaedic surgeon, in patients with metastatic prostate cancer. Our aim was to use this information in a pragmatic, clinic-based approach so that ... ...

    Abstract Aims: The purpose of this study was to identify prognostic indicators of outcome at presentation to the orthopaedic surgeon, in patients with metastatic prostate cancer. Our aim was to use this information in a pragmatic, clinic-based approach so that surgical decision making could be optimized to benefit the patient in their remaining lifetime.
    Patients and methods: A cohort analysis was undertaken of all patients with metastatic disease of the prostate who presented to a regional orthopaedic centre in the United Kingdom between 2003 and 2016. Biochemical data were collected in addition to disease and demographic data. These included: prostate-specific antigen (PSA) at orthopaedic presentation; haemoglobin (Hb); platelets (plt); alkaline phosphatase (ALP); albumin (Alb); and corrected calcium (CaC). Statistical analysis included Kaplan-Meier survival analysis, and a Cox proportional hazards model was fitted to the data.
    Results: From the departmental database, 137 episodes were identified in 136 patients with a median age at presentation of 72 years (interquartile range (IQR) 66 to 78). Most patients had stage IV disease (n = 98, 72%), and most did not undergo surgical intervention. At one-year follow-up, 50% of patients had died. Biomarkers found to be independently associated with poor survival were: low Hb, low Alb, relatively low PSA (< 30 mmol/l), and a raised ALP. Patients who needed surgical intervention had a poorer survival rate than patients who were managed nonoperatively.
    Conclusion: The study findings are important for orthopaedic clinical practice in the management of patients with metastatic prostate cancer. The interpretation of routine blood tests can help to predict survival in patients who present with orthopaedic manifestations of prostate cancer. A lower PSA is not necessarily a good prognostic sign. We believe that simple blood testing should be carried out routinely when assessing a patient, guiding potential surgical management and palliative care in the future.
    MeSH term(s) Aged ; Bone Neoplasms/mortality ; Bone Neoplasms/secondary ; Bone Neoplasms/surgery ; Combined Modality Therapy ; Follow-Up Studies ; Humans ; Male ; Neoplasm Staging ; Palliative Care/methods ; Prostatic Neoplasms/mortality ; Prostatic Neoplasms/pathology ; Retrospective Studies ; Survival Rate/trends ; Time Factors ; United Kingdom/epidemiology
    Language English
    Publishing date 2018-11-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.100B12.BJJ-2018-0697.R1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The use of plots in orthopaedic literature.

    Cool, P / Ockendon, M

    The bone & joint journal

    2015  Volume 97-B, Issue 12, Page(s) 1593–1603

    Abstract: Plots are an elegant and effective way to represent data. At their best they encourage the reader and promote comprehension. A graphical representation can give a far more intuitive feel to the pattern of results in the study than a list of numerical ... ...

    Abstract Plots are an elegant and effective way to represent data. At their best they encourage the reader and promote comprehension. A graphical representation can give a far more intuitive feel to the pattern of results in the study than a list of numerical data, or the result of a statistical calculation. The temptation to exaggerate differences or relationships between variables by using broken axes, overlaid axes, or inconsistent scaling between plots should be avoided. A plot should be self-explanatory and not complicated. It should make good use of the available space. The axes should be scaled appropriately and labelled with an appropriate dimension. Plots are recognised statistical methods of presenting data and usually require specialised statistical software to create them. The statistical analysis and methods to generate the plots are as important as the methodology of the study itself. The software, including dates and version numbers, as well as statistical tests should be appropriately referenced. Following some of the guidance provided in this article will enhance a manuscript.
    MeSH term(s) Data Interpretation, Statistical ; Humans ; Orthopedics ; Periodicals as Topic ; Software
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2697156-2
    ISSN 2049-4408 ; 2049-4394
    ISSN (online) 2049-4408
    ISSN 2049-4394
    DOI 10.1302/0301-620X.97B12.36167
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Structured LDH/Bentonite Composites for Chromium Removal and Recovery from Aqueous Solutions.

    De Geest, Mitra / Michielsen, Bart / Ciocarlan, Radu-G / Cool, Pegie / Seftel, Elena M

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 12

    Abstract: This study focuses on chromium removal through adsorption and ion exchange using structured calcined layered double hydroxide (LDH) (MgAl)-bentonite composites. Firstly, the powders were structured into granulates to study the effect on Cr sorption ... ...

    Abstract This study focuses on chromium removal through adsorption and ion exchange using structured calcined layered double hydroxide (LDH) (MgAl)-bentonite composites. Firstly, the powders were structured into granulates to study the effect on Cr sorption kinetics to circumvent the limitations of working with powders in real-life applications. Secondly, the regeneration of the structured composites was optimized to enable multi-cycling operation, which is the key for their applicability beyond laboratory scale. Firstly, the LDH/bentonite ratio was optimized to obtain the best performance for the removal of Cr
    Language English
    Publishing date 2023-06-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28124879
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Genomic Sequencing to Diagnose Prosthetic Joint Infection in the Knee: A Case Report.

    Wilkinson, Hollie / McCarthy, Helen S / Perry, Jade / Smith, Tony / Wright, Karina / Cool, Paul

    Cureus

    2023  Volume 15, Issue 5, Page(s) e38788

    Abstract: There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial to ... ...

    Abstract There is currently no "gold-standard" method to diagnose prosthetic joint infections (PJI), and the current practice of using microbiological cultures has many limitations. The identification of the bacterial species causing the infection is crucial to guide treatment; therefore, a robust method needs to be developed. Here, we attempt to use genomic sequencing with the MinION device from Oxford Nanopore Technologies to identify the species of bacteria causing PJI in a 61-year-old male. Genomic sequencing with the MinION presents an opportunity to produce species identification in real-time and at a smaller cost than current methods. By comparing results with standard hospital microbiological cultures, this study suggests that nanopore sequencing using the MinION could be a faster and more sensitive method to diagnose PJI than microbiological cultures.
    Language English
    Publishing date 2023-05-09
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.38788
    Database MEDical Literature Analysis and Retrieval System OnLINE

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