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  1. Book ; Online ; E-Book: Assisted reproduction techniques

    Sharif, Khaldoun / Coomarasamy, Arri

    challenges and management options

    2021  

    Author's details edited by Khaldoun Sharif, Arri Coomarasamy
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xxxiii, 778 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020944983
    ISBN 978-1-119-62211-6 ; 9781119622109 ; 1-119-62211-5 ; 1119622107
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: Assisted reproduction techniques

    Sharif, Khaldoun / Coomarasamy, Arri

    challenges and management options

    2012  

    Author's details ed. by Khaldoun Sharif ; Arri Coomarasamy
    Keywords Reproductive Techniques, Assisted ; Infertility / complications ; Reproductive Health Services / manpower ; Pregnancy / physiology ; Risk Assessment
    Language English
    Size 442 Seiten
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT017169685
    ISBN 978-1-4443-3555-2 ; 1-4443-3555-3
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2012 A 1197 order for loan Magazin

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  3. Book: Gynaecology

    Pundir, Jyotsna / Coomarasamy, Arri

    evidence-based algorithms

    2016  

    Author's details Jyotsna Pundir, Arri Coomarasamy
    Keywords Genital Diseases, Female / diagnosis ; Genital Diseases, Female / therapy ; Algorithms ; Decision Support Techniques
    Language English
    Size xiv, 310 Seiten, Illustrationen, Diagramme
    Publisher Cambrige University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index
    HBZ-ID HT018958443
    ISBN 978-1-107-48069-8 ; 1316311120 ; 9781316311127 ; 1-107-48069-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1094 available for loan (reading room) Lesesaal EG

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  4. Book: Obstetrics

    Pundir, Jyotsna / Coomarasamy, Arri

    evidence-based algorithms

    2016  

    Author's details Jyotsna Pundir, Arri Coomarasamy
    Keywords Pregnancy Complications / diagnosis ; Pregnancy Complications / therapy ; Algorithms ; Decision Support Techniques
    Language English
    Size XIV, 337 Seiten
    Publisher Cambridge University Press
    Publishing place Cambridge
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT018946255
    ISBN 978-1-107-61893-0 ; 1-107-61893-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 870 available for loan (reading room) Lesesaal EG

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  5. Book: Gynecologic and obstetric surgery

    Coomarasamy, Arri

    challenges and management options

    2016  

    Abstract: Obstetric and gynecologic surgery is a craft that requires sound knowledge and skills. The knowledge and skills will need to be applied to the specifics of each surgical patient to enable the best surgical management and minimize complications. This ... ...

    Author's details edited by Arri Coomarasamy, Mahmood I. Shafi, G. Willy Davila, Kiong K. Chan ; section editors, Pallavi Latthe, Janesh Gupta, Phil Moore, T. Justin Clark, Kavita Singh ; editorial co-coordinator, Helen Marie Williams
    Abstract "Obstetric and gynecologic surgery is a craft that requires sound knowledge and skills. The knowledge and skills will need to be applied to the specifics of each surgical patient to enable the best surgical management and minimize complications. This resource book offers insightful management options to many of the challenges a gynecologic or obstetric surgeon may face before, during or after an operation. Designed to guide the surgeon to safe practice throughout all stages of surgical management, it offers case studies, management options with tips and tricks, and ideas for prevention of complications. Key points and summaries are provided at the end of each chapter for 'elevator reading', i.e., quick brushing up of facts on the way to facing a challenge. Divided into two sections the book first covers general pre, intra and post-operative challenges and, second, specific operative procedures within the specialist areas in obstetrics and gynecology"--Provided by publisher.
    MeSH term(s) Gynecologic Surgical Procedures ; Obstetric Surgical Procedures ; Urologic Surgical Procedures
    Language English
    Size xix, 555 pages :, illustrations
    Document type Book
    ISBN 9780470657614 ; 0470657618
    Database Catalogue of the US National Library of Medicine (NLM)

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  6. Article ; Online: A re-analysis of 150 women's health trials to investigate how the Bayesian approach may offer a solution to the misinterpretation of statistical findings.

    Hemming, Karla / Melo, Pedro / Luo, Rong / Taljaard, Monica / Coomarasamy, Arri

    BJOG : an international journal of obstetrics and gynaecology

    2023  Volume 130, Issue 13, Page(s) 1629–1638

    Abstract: Objective: To investigate whether a Bayesian interpretation might help prevent misinterpretation of statistical findings and support authors to differentiate evidence of no effect from statistical uncertainty.: Design: A Bayesian re-analysis to ... ...

    Abstract Objective: To investigate whether a Bayesian interpretation might help prevent misinterpretation of statistical findings and support authors to differentiate evidence of no effect from statistical uncertainty.
    Design: A Bayesian re-analysis to determine posterior probabilities of clinically important effects (e.g., a large effect is set at a 4 percentage point difference and a trivial effect to be within a 0.5 percentage point difference). Posterior probabilities greater than 95% are considered as strong statistical evidence, and less than 95% as inconclusive.
    Sample: 150 major women's health trials with binary outcomes.
    Main outcome measures: Posterior probabilities of large, moderate, small and trivial effects.
    Results: Under frequentist methods, 48 (32%) were statistically significant (p-value ≤ 0.05) and 102 (68%) statistically non-significant. The frequentist and Bayesian point estimates and confidence intervals showed strong concordance. Of the statistically non-significant trials (n = 102), the Bayesian approach classified the majority (94, 92%) as inconclusive, neither able to confirm or refute effectiveness. A small number of statistically non-significant findings (8, 8%) were classified as having strong statistical evidence of an effect.
    Conclusions: Whilst almost all trials report confidence intervals, in practice most statistical findings are interpreted on the basis of statistical significance, mostly concluding evidence of no effect. Findings here suggest the majority are likely uncertain. A Bayesian approach could help differentiate evidence of no effect from statistical uncertainty.
    MeSH term(s) Female ; Humans ; Bayes Theorem ; Probability ; Women's Health ; Uncertainty
    Language English
    Publishing date 2023-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2000931-8
    ISSN 1471-0528 ; 0306-5456 ; 1470-0328
    ISSN (online) 1471-0528
    ISSN 0306-5456 ; 1470-0328
    DOI 10.1111/1471-0528.17570
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um I Zs.121: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Evidence for the effectiveness of immunologic therapies in women with subfertility and/or undergoing assisted reproduction.

    Melo, Pedro / Thornton, Teresa / Coomarasamy, Arri / Granne, Ingrid

    Fertility and sterility

    2022  Volume 117, Issue 6, Page(s) 1144–1159

    Abstract: Implantation is a critical step in the establishment of a successful pregnancy, depending on a complex immune-endocrine dialogue between the developing embryo and maternal endometrium. Research suggests that altered immunity in the maternal decidua ... ...

    Abstract Implantation is a critical step in the establishment of a successful pregnancy, depending on a complex immune-endocrine dialogue between the developing embryo and maternal endometrium. Research suggests that altered immunity in the maternal decidua results in implantation impairment and failure. Immunomodulatory drugs have, thus, been widely used in assisted conception to aid embryo implantation, despite an absence of consensus on their effectiveness and safety. We conducted a systematic review and meta-analysis of interventional studies investigating the use of immunomodulators in women undergoing assisted reproduction. Evidence was uncertain of an effect for most of the included interventions, owing to heterogeneous findings and a paucity of high-quality studies. For certain patient subgroups, however, the use of specific immunomodulatory therapies may offer some benefit. There is a need for further large randomized controlled trials to corroborate these findings.
    MeSH term(s) Embryo Implantation ; Endometrium ; Female ; Fertilization in Vitro ; Humans ; Immunotherapy ; Infertility/diagnosis ; Infertility/therapy ; Pregnancy
    Language English
    Publishing date 2022-05-23
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 80133-1
    ISSN 1556-5653 ; 0015-0282
    ISSN (online) 1556-5653
    ISSN 0015-0282
    DOI 10.1016/j.fertnstert.2022.04.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 73: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Sporadic pregnancy loss and recurrent miscarriage.

    Devall, Adam J / Coomarasamy, Arri

    Best practice & research. Clinical obstetrics & gynaecology

    2020  Volume 69, Page(s) 30–39

    Abstract: Progesterone is essential for the maintenance of pregnancy, and progesterone deficiency is associated with miscarriage. The subject of whether progesterone supplementation in early pregnancy can prevent miscarriage has been a long-standing research ... ...

    Abstract Progesterone is essential for the maintenance of pregnancy, and progesterone deficiency is associated with miscarriage. The subject of whether progesterone supplementation in early pregnancy can prevent miscarriage has been a long-standing research question and has been investigated and debated in the medical literature for over 70 years. During this time, several different progestogens have been synthesised and tested for the prevention of miscarriage. In this chapter, we describe the prior evidence alongside the latest research using micronized natural progesterone as well as synthetic progestogens, which were used to treat both recurrent and threatened miscarriage. The totality of evidence indicates that women with a past history of miscarriage who present with bleeding in early pregnancy may benefit from the use of vaginal micronized progesterone. The clinical implications of the findings are discussed.
    MeSH term(s) Abortion, Habitual/etiology ; Abortion, Habitual/prevention & control ; Abortion, Spontaneous/prevention & control ; Abortion, Threatened/drug therapy ; Abortion, Threatened/prevention & control ; Female ; Humans ; Pregnancy ; Progesterone ; Progestins/therapeutic use ; Vagina
    Chemical Substances Progestins ; Progesterone (4G7DS2Q64Y)
    Language English
    Publishing date 2020-09-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2020.09.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 1040: Show issues Location:
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  9. Article ; Online: Carbetocin: Worth the extra expense?

    Gallos, Ioannis D / Coomarasamy, Arri

    Best practice & research. Clinical obstetrics & gynaecology

    2019  Volume 61, Page(s) 55–65

    Abstract: Every six minutes, a mother dies from post-partum haemorrhage (PPH) in low- and middle-income countries, often in the prime of her life and often leaving behind a young family. To prevent PPH, the routine administration of a uterus-contracting (' ... ...

    Abstract Every six minutes, a mother dies from post-partum haemorrhage (PPH) in low- and middle-income countries, often in the prime of her life and often leaving behind a young family. To prevent PPH, the routine administration of a uterus-contracting ('uterotonic') agent is a standard practice across the world. Oxytocin is the standard uterotonic agent recommended for this purpose, and is recommended for all women giving birth. Oxytocin is problematic as it requires cold storage and transport, and in low-resource settings, the cold chain is not commonly available. Hence, using heat-stable carbetocin in these settings can be advantageous. Heat-stable carbetocin is a promising alternative to oxytocin. Because of its heat stability, it can overcome the persistent problems with oxytocin quality as it does not require cold chain for storage and transport. Considering the totality of the evidence, it appears to have some additional desirable effects compared with oxytocin and a very favourable side effect profile similar to oxytocin. However, because carbetocin costs 20 times more than oxytocin and is not widely available yet, oxytocin remains the mainstay for prevention of PPH. However, this may change as WHO has signed a memorandum of understanding with the manufacturer to provide carbetocin for the public sector of LMIC at a similar price level to that of oxytocin. Currently, carbetocin is being registered in 90 low- and middle-income countries to be made available and improve access to this life-saving uterotonic agent.
    MeSH term(s) Female ; Humans ; Oxytocics/economics ; Oxytocics/therapeutic use ; Oxytocin/analogs & derivatives ; Oxytocin/economics ; Oxytocin/therapeutic use ; Parturition ; Postpartum Hemorrhage/drug therapy ; Pregnancy
    Chemical Substances Oxytocics ; Oxytocin (50-56-6) ; carbetocin (88TWF8015Y)
    Language English
    Publishing date 2019-04-30
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2019.04.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1040: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Preventing postpartum hemorrhage: A network meta-analysis on routes of administration of uterotonics.

    Papadopoulou, Argyro / Tournas, Georgios / Georgiopoulos, Georgios / Antsaklis, Panos / Daskalakis, Georgios / Coomarasamy, Arri / Devall, Adam J

    European journal of obstetrics, gynecology, and reproductive biology

    2024  Volume 295, Page(s) 172–180

    Abstract: 1.: Objective: To perform a network meta-analysis to specify the route of administration that maximises the effectiveness of each of the available prophylactic uterotonics without increasing the risk for side effects. 2.: Data sources: Literature ... ...

    Abstract 1.
    Objective: To perform a network meta-analysis to specify the route of administration that maximises the effectiveness of each of the available prophylactic uterotonics without increasing the risk for side effects. 2.
    Data sources: Literature searches on 12th September 2022 included: CENTRAL, MEDLINE, Embase, CINAHL, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform. The reference lists of the retrieved study records were also searched. 3.
    Study eligibility criteria: Population: Randomized controlled trials involving women in the third stage of labour after a vaginal or caesarean delivery in hospital or community settings.
    Interventions: Systemically administered prophylactic uterotonics of any route and dose for primary postpartum hemorrhage prevention. Comparison: Any other prophylactic uterotonic, or a different route or dose of a given uterotonic, or placebo, or no treatment. Outcomes (primary): postpartum hemorrhage ≥ 500 mL and ≥ 1000 mL. 4.
    Study appraisal and synthesis methods: Risk of bias and trustworthiness assessments were performed, according to Cochrane's guidance. Direct, indirect and network meta-analyses were conducted, and results were summarized either as risk ratio or mean difference with 95% confidence intervals for dichotomous and continuous outcomes, respectively. The certainty of generated evidence was assessed according to the GRADE approach. Cumulative probabilities were calculated and the surface under the cumulative ranking curve was used to create a ranking of the available drugs. 5.
    Results: One hundred eighty-one studies involving 122,867 randomised women were included. Most studies were conducted in hospital settings in lower-middle income countries and involved women delivering vaginally. When compared with intramuscular oxytocin, carbetocin (RR 0.58, 95 % CI 0.40-0.84) and oxytocin (RR 0.75, 95 % CI 0.59-0.97) by an intravenous bolus, and intramuscular ergometrine plus oxytocin combination (RR 0.71, 95 % CI 0.56-0.91) are probably more effective in preventing primary postpartum hemorrhage. Intramuscularly administered oxytocin and carbetocin by an intravenous bolus have a favourable side effects profile. 6.
    Conclusions: Generated evidence was generally moderate and global inconsistency was low. Carbetocin and oxytocin by an intravenous bolus, and intramuscular ergometrine plus oxytocin combination are probably the top uterotonics for primary postpartum hemorrhage prevention. Large scale studies exploring different routes of administration for available prophylactic uterotonics, and women's views should be conducted.
    MeSH term(s) Pregnancy ; Female ; Humans ; Postpartum Hemorrhage/prevention & control ; Postpartum Hemorrhage/drug therapy ; Oxytocin ; Oxytocics ; Ergonovine/therapeutic use ; Network Meta-Analysis ; Labor Stage, Third ; Randomized Controlled Trials as Topic
    Chemical Substances Oxytocin (50-56-6) ; Oxytocics ; Ergonovine (WH41D8433D)
    Language English
    Publishing date 2024-02-14
    Publishing country Ireland
    Document type Meta-Analysis ; Journal Article ; Review
    ZDB-ID 190605-7
    ISSN 1872-7654 ; 0301-2115 ; 0028-2243
    ISSN (online) 1872-7654
    ISSN 0301-2115 ; 0028-2243
    DOI 10.1016/j.ejogrb.2024.02.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 837: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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