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Article ; Online: Staff perceptions of prescription and over-the-counter drug dependence services in England: a qualitative study.

Coombes, Heidi / Cooper, Richard J

2019 Volume 14, Issue 1, Page(s) 41

Abstract: Background: Dependence to prescription and over-the-counter (OTC) drugs represents an increasing public health and clinical problem both in England and internationally. However, relatively little is known about those affected, particularly in relation ... ...

Abstract	Background: Dependence to prescription and over-the-counter (OTC) drugs represents an increasing public health and clinical problem both in England and internationally. However, relatively little is known about those affected, particularly in relation to their management at drug dependence treatment centres. This study aimed to explore the views and experiences of health care professionals (HCPs) working in formal drug treatment services in relation to supporting clients with prescription and OTC drug dependence. Methods: An exploratory, qualitative design was used involving semi-structured telephone interviews. 15 staff were recruited using purposive sampling to represent a variety of different professional roles, funding (NHS, charity and local government) and geographical locations across England. Transcribed interviews were analysed using Braun and Clarke's six stage thematic analysis. Results: Current services were considered to be inappropriate for the treatment of OTC and prescription drug dependence, which was perceived to be a significantly under-recognised issue affecting a range of individuals but particularly those taking opioid analgesics. Negativity around current treatment services involved concerns that these were more suited for illicit drug users and this was exacerbated by a lack of specific resources, funding and commissioning. There was a perceived variation in service provision in different areas and a further concern about the lack of formal treatment guidelines and care pathways. Participants felt there to be stigma for affected clients in both the diagnosis of OTC or prescription drug dependence and also attendance at drug treatment centres which adversely impacted service engagement. Suggested service improvements included commissioning new specific services in general practices and pain management clinics, developing national guidelines and care pathways to ensure equal access to treatment and increasing awareness amongst the public and HCPs. Conclusions: This study reveals considerable negativity and concern about current treatment services for prescription and OTC drug dependence in England from the perspective of those working in such services. Policy and practice improvement are suggested to improve outcomes for this neglected group in relation to increasing funding, guidelines and awareness.
MeSH term(s)	Adult ; Analgesics, Opioid/administration & dosage ; Attitude of Health Personnel ; Critical Pathways/standards ; England/epidemiology ; Female ; Financing, Government ; Health Services Accessibility/standards ; Humans ; Interviews as Topic ; Male ; Middle Aged ; Nonprescription Drugs/administration & dosage ; Practice Guidelines as Topic/standards ; Prescription Drugs/administration & dosage ; Qualitative Research ; Social Stigma ; State Medicine ; Substance Abuse Treatment Centers/economics ; Substance Abuse Treatment Centers/organization & administration ; Substance Abuse Treatment Centers/standards ; Substance-Related Disorders/rehabilitation
Chemical Substances	Analgesics, Opioid ; Nonprescription Drugs ; Prescription Drugs
Language	English
Publishing date	2019-11-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2492632-2
ISSN	1940-0640 ; 1940-0640
ISSN (online)	1940-0640
ISSN	1940-0640
DOI	10.1186/s13722-019-0170-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Book ; Conference proceedings: Business improvement through software measurement

Coombes, H

1998

Institution	FESMA Technologisch Instituut / Section on Software Metrics
Event/congress	European Software Measurement Conference (1998.05.06-08, Antwerpen) ; FESMA 98 (1998.05.06-08, Antwerpen)
Author's details	FESMA 98, The European Software Measurement Conference, Antwerpen, May 6 - 8, 1998. Eds.: H. Coombes ... Organized by: Technologisch Instituut vzw (Technological Institute), Section on Software Metrics
Language	English
Size	641 S
Publishing place	Antwerpen
Document type	Book ; Conference proceedings
ISBN	9076019037 ; 9789076019031
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article: The Technological Basis of a Balloon-Expandable TAVR System: Non-occlusive Deployment, Anchorage in the Absence of Calcification and Polymer Leaflets.

Appa, Harish / Park, Kenneth / Bezuidenhout, Deon / van Breda, Braden / de Jongh, Bruce / de Villiers, Jandré / Chacko, Reno / Scherman, Jacques / Ofoegbu, Chima / Swanevelder, Justiaan / Cousins, Michael / Human, Paul / Smith, Robin / Vogt, Ferdinand / Podesser, Bruno K / Schmitz, Christoph / Conradi, Lenard / Treede, Hendrik / Schröfel, Holger /

Fischlein, Theodor / Grabenwöger, Martin / Luo, Xinjin / Coombes, Heather / Matskeplishvili, Simon / Williams, David F / Zilla, Peter

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 791949

Abstract: Leaflet durability and costs restrict contemporary trans-catheter aortic valve replacement (TAVR) largely to elderly patients in affluent countries. TAVR that are easily deployable, avoid secondary procedures and are also suitable for younger patients ... ...

Abstract	Leaflet durability and costs restrict contemporary trans-catheter aortic valve replacement (TAVR) largely to elderly patients in affluent countries. TAVR that are easily deployable, avoid secondary procedures and are also suitable for younger patients and non-calcific aortic regurgitation (AR) would significantly expand their global reach. Recognizing the reduced need for post-implantation pacemakers in balloon-expandable (BE) TAVR and the recent advances with potentially superior leaflet materials, a trans-catheter BE-system was developed that allows tactile, non-occlusive deployment without rapid pacing, direct attachment of both bioprosthetic and polymer leaflets onto a shape-stabilized scallop and anchorage achieved by plastic deformation even in the absence of calcification. Three sizes were developed from nickel-cobalt-chromium MP35N alloy tubes: Small/23 mm, Medium/26 mm and Large/29 mm. Crimp-diameters of valves with both bioprosthetic (sandwich-crosslinked decellularized pericardium) and polymer leaflets (triblock polyurethane combining siloxane and carbonate segments) match those of modern clinically used BE TAVR. Balloon expansion favors the wing-structures of the stent thereby creating supra-annular anchors whose diameter exceeds the outer diameter at the waist level by a quarter. In the pulse duplicator, polymer and bioprosthetic TAVR showed equivalent fluid dynamics with excellent EOA, pressure gradients and regurgitation volumes. Post-deployment fatigue resistance surpassed ISO requirements. The radial force of the helical deployment balloon at different filling pressures resulted in a fully developed anchorage profile of the valves from two thirds of their maximum deployment diameter onwards. By combining a unique balloon-expandable TAVR system that also caters for non-calcific AR with polymer leaflets, a powerful, potentially disruptive technology for heart valve disease has been incorporated into a TAVR that addresses global needs. While fulfilling key prerequisites for expanding the scope of TAVR to the vast number of patients of low- to middle income countries living with rheumatic heart disease the system may eventually also bring hope to patients of high-income countries presently excluded from TAVR for being too young.
Language	English
Publishing date	2022-03-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.791949
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Book ; Online: G4CMP

Kelsey, M. H. / Agnese, R. / Alam, Y. F. / Langroudy, I. Ataee / Azadbakht, E. / Brandt, D. / Bunker, R. / Cabrera, B. / Chang, Y. -Y. / Coombes, H. / Cormier, R. M. / Diamond, M. D. / Edwards, E. R. / Figueroa-Feliciano, E. / Gao, J. / Harrington, P. M. / Hong, Z. / Hui, M. / Kurinsky, N. A. /

Lawrence, R. E. / Loer, B. / Masten, M. G. / Michaud, E. / Michielin, E. / Miller, J. / Novati, V. / Oblath, N. S. / Orrell, J. L. / Perry, W. L. / Redl, P. / Reynolds, T. / Saab, T. / Sadoulet, B. / Serniak, K. / Singh, J. / Speaks, Z. / Stanford, C. / Stevens, J. R. / Strube, J. / Toback, D. / Ullom, J. N. / VanDevender, B. A. / Vissers, M. R. / Wilson, M. J. / Wilson, J. S. / Zatschler, B. / Zatschler, S.

Condensed Matter Physics Simulation Using the Geant4 Toolkit

2023

Abstract: G4CMP simulates phonon and charge transport in cryogenic semiconductor crystals using the Geant4 toolkit. The transport code is capable of simulating the propagation of acoustic phonons as well as electron and hole charge carriers. Processes for ... ...

Abstract	G4CMP simulates phonon and charge transport in cryogenic semiconductor crystals using the Geant4 toolkit. The transport code is capable of simulating the propagation of acoustic phonons as well as electron and hole charge carriers. Processes for anisotropic phonon propagation, oblique charge-carrier propagation, and phonon emission by accelerated charge carriers are included. The simulation reproduces theoretical predictions and experimental observations such as phonon caustics, heat-pulse propagation times, and mean charge-carrier drift velocities. In addition to presenting the physics and features supported by G4CMP, this report outlines example applications from the dark matter and quantum information science communities. These communities are applying G4CMP to model and design devices for which the energy transported by phonons and charge carriers is germane to the performance of superconducting instruments and circuits placed on silicon and germanium substrates. The G4CMP package is available to download from GitHub: github.com/kelseymh/G4CMP. Comment: 21 pages, 11 figures, 10 tables
Keywords	High Energy Physics - Experiment ; Quantum Physics
Subject code	621
Publishing date	2023-02-12
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Literature and criticism

Coombes, H

(A Pelican book)

1971

Author's details	H. Coombes
Series title	A Pelican book
Language	English
Size	160 S.
Edition	Repr.
Publisher	Penguin
Publishing place	Harmondsworth
Document type	Book
Database	Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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Article ; Online: First Measurement of the Nuclear-Recoil Ionization Yield in Silicon at 100 eV.

Albakry, M F / Alkhatib, I / Alonso, D / Amaral, D W P / Aralis, T / Aramaki, T / Arnquist, I J / Ataee Langroudy, I / Azadbakht, E / Banik, S / Bathurst, C / Bhattacharyya, R / Brink, P L / Bunker, R / Cabrera, B / Calkins, R / Cameron, R A / Cartaro, C / Cerdeño, D G /

Chang, Y-Y / Chaudhuri, M / Chen, R / Chott, N / Cooley, J / Coombes, H / Corbett, J / Cushman, P / Das, S / De Brienne, F / Rios, M / Dharani, S / di Vacri, M L / Diamond, M D / Elwan, M / Fascione, E / Figueroa-Feliciano, E / Fink, C W / Fouts, K / Fritts, M / Gerbier, G / Germond, R / Ghaith, M / Golwala, S R / Hall, J / Harms, S A S / Hassan, N / Hines, B A / Hong, Z / Hoppe, E W / Hsu, L / Huber, M E / Iyer, V / Kashyap, V K S / Kelsey, M H / Kubik, A / Kurinsky, N A / Lee, M / Litke, M / Liu, J / Liu, Y / Loer, B / Lopez Asamar, E / Lukens, P / MacFarlane, D B / Mahapatra, R / Mast, N / Mayer, A J / Meyer Zu Theenhausen, H / Michaud, É / Michielin, E / Mirabolfathi, N / Mohanty, B / Nebolsky, B / Nelson, J / Neog, H / Novati, V / Orrell, J L / Osborne, M D / Oser, S M / Page, W A / Pandey, L / Pandey, S / Partridge, R / Pedreros, D S / Perna, L / Podviianiuk, R / Ponce, F / Poudel, S / Pradeep, A / Pyle, M / Rau, W / Reid, E / Ren, R / Reynolds, T / Tanner, E / Roberts, A / Robinson, A E / Saab, T / Sadek, D / Sadoulet, B / Sahoo, S P / Saikia, I / Sander, J / Sattari, A / Schmidt, B / Schnee, R W / Scorza, S / Serfass, B / Poudel, S S / Sincavage, D J / Sinervo, P / Speaks, Z / Street, J / Sun, H / Terry, G D / Thasrawala, F K / Toback, D / Underwood, R / Verma, S / Villano, A N / von Krosigk, B / Watkins, S L / Wen, O / Williams, Z / Wilson, M J / Winchell, J / Wykoff, K / Yellin, S / Young, B A / Yu, T C / Zatschler, B / Zatschler, S / Zaytsev, A / Zeolla, A / Zhang, E / Zheng, L / Zheng, Y / Zuniga, A / An, P / Barbeau, P S / Hedges, S C / Li, L / Runge, J

Physical review letters

2023 Volume 131, Issue 9, Page(s) 91801

Abstract: We measured the nuclear-recoil ionization yield in silicon with a cryogenic phonon-sensitive gram-scale detector. Neutrons from a monoenergetic beam scatter off of the silicon nuclei at angles corresponding to energy depositions from 4 keV down to 100 eV, ...

Abstract	We measured the nuclear-recoil ionization yield in silicon with a cryogenic phonon-sensitive gram-scale detector. Neutrons from a monoenergetic beam scatter off of the silicon nuclei at angles corresponding to energy depositions from 4 keV down to 100 eV, the lowest energy probed so far. The results show no sign of an ionization production threshold above 100 eV. These results call for further investigation of the ionization yield theory and a comprehensive determination of the detector response function at energies below the keV scale.
Language	English
Publishing date	2023-09-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.091801
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Article ; Online: Constraints on Lightly Ionizing Particles from CDMSlite.

Alkhatib, I / Amaral, D W P / Aralis, T / Aramaki, T / Arnquist, I J / Ataee Langroudy, I / Azadbakht, E / Banik, S / Barker, D / Bathurst, C / Bauer, D A / Bezerra, L V S / Bhattacharyya, R / Bowles, M A / Brink, P L / Bunker, R / Cabrera, B / Calkins, R / Cameron, R A /

Cartaro, C / Cerdeño, D G / Chang, Y-Y / Chaudhuri, M / Chen, R / Chott, N / Cooley, J / Coombes, H / Corbett, J / Cushman, P / De Brienne, F / di Vacri, M L / Diamond, M D / Fascione, E / Figueroa-Feliciano, E / Fink, C W / Fouts, K / Fritts, M / Gerbier, G / Germond, R / Ghaith, M / Golwala, S R / Harris, H R / Hines, B A / Hollister, M I / Hong, Z / Hoppe, E W / Hsu, L / Huber, M E / Iyer, V / Jardin, D / Jastram, A / Kashyap, V K S / Kelsey, M H / Kubik, A / Kurinsky, N A / Lawrence, R E / Li, A / Loer, B / Lopez Asamar, E / Lukens, P / MacFarlane, D B / Mahapatra, R / Mandic, V / Mast, N / Mayer, A J / Meyer Zu Theenhausen, H / Michaud, É M / Michielin, E / Mirabolfathi, N / Mohanty, B / Morales Mendoza, J D / Nagorny, S / Nelson, J / Neog, H / Novati, V / Orrell, J L / Oser, S M / Page, W A / Partridge, R / Podviianiuk, R / Ponce, F / Poudel, S / Pradeep, A / Pyle, M / Rau, W / Reid, E / Ren, R / Reynolds, T / Roberts, A / Robinson, A E / Saab, T / Sadoulet, B / Sander, J / Sattari, A / Schnee, R W / Scorza, S / Serfass, B / Sincavage, D J / Stanford, C / Street, J / Toback, D / Underwood, R / Verma, S / Villano, A N / von Krosigk, B / Watkins, S L / Wilson, J S / Wilson, M J / Winchell, J / Wright, D H / Yellin, S / Young, B A / Yu, T C / Zhang, E / Zhang, H G / Zhao, X / Zheng, L

Physical review letters

2021 Volume 127, Issue 8, Page(s) 81802

Abstract: The Cryogenic Dark Matter Search low ionization threshold experiment (CDMSlite) achieved efficient detection of very small recoil energies in its germanium target, resulting in sensitivity to lightly ionizing particles (LIPs) in a previously unexplored ... ...

Abstract	The Cryogenic Dark Matter Search low ionization threshold experiment (CDMSlite) achieved efficient detection of very small recoil energies in its germanium target, resulting in sensitivity to lightly ionizing particles (LIPs) in a previously unexplored region of charge, mass, and velocity parameter space. We report first direct-detection limits calculated using the optimum interval method on the vertical intensity of cosmogenically produced LIPs with an electric charge smaller than e/(3×10^{5}), as well as the strongest limits for charge ≤e/160, with a minimum vertical intensity of 1.36×10^{-7} cm^{-2} s^{-1} sr^{-1} at charge e/160. These results apply over a wide range of LIP masses (5 MeV/c^{2} to 100 TeV/c^{2}) and cover a wide range of βγ values (0.1-10^{6}), thus excluding nonrelativistic LIPs with βγ as small as 0.1 for the first time.
Language	English
Publishing date	2021-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.081802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Light Dark Matter Search with a High-Resolution Athermal Phonon Detector Operated above Ground.

Alkhatib, I / Amaral, D W P / Aralis, T / Aramaki, T / Arnquist, I J / Ataee Langroudy, I / Azadbakht, E / Banik, S / Barker, D / Bathurst, C / Bauer, D A / Bezerra, L V S / Bhattacharyya, R / Binder, T / Bowles, M A / Brink, P L / Bunker, R / Cabrera, B / Calkins, R /

Cameron, R A / Cartaro, C / Cerdeño, D G / Chang, Y-Y / Chaudhuri, M / Chen, R / Chott, N / Cooley, J / Coombes, H / Corbett, J / Cushman, P / De Brienne, F / di Vacri, M L / Diamond, M D / Fascione, E / Figueroa-Feliciano, E / Fink, C W / Fouts, K / Fritts, M / Gerbier, G / Germond, R / Ghaith, M / Golwala, S R / Harris, H R / Herbert, N / Hines, B A / Hollister, M I / Hong, Z / Hoppe, E W / Hsu, L / Huber, M E / Iyer, V / Jardin, D / Jastram, A / Kashyap, V K S / Kelsey, M H / Kubik, A / Kurinsky, N A / Lawrence, R E / Li, A / Loer, B / Lopez Asamar, E / Lukens, P / MacDonell, D / MacFarlane, D B / Mahapatra, R / Mandic, V / Mast, N / Mayer, A J / Meyer Zu Theenhausen, H / Michaud, É M / Michielin, E / Mirabolfathi, N / Mohanty, B / Morales Mendoza, J D / Nagorny, S / Nelson, J / Neog, H / Novati, V / Orrell, J L / Oser, S M / Page, W A / Pakarha, P / Partridge, R / Podviianiuk, R / Ponce, F / Poudel, S / Pyle, M / Rau, W / Reid, E / Ren, R / Reynolds, T / Roberts, A / Robinson, A E / Saab, T / Sadoulet, B / Sander, J / Sattari, A / Schnee, R W / Scorza, S / Serfass, B / Sincavage, D J / Stanford, C / Street, J / Toback, D / Underwood, R / Verma, S / Villano, A N / von Krosigk, B / Watkins, S L / Wills, L / Wilson, J S / Wilson, M J / Winchell, J / Wright, D H / Yellin, S / Young, B A / Yu, T C / Zhang, E / Zhang, H G / Zhao, X / Zheng, L / Camilleri, J / Kolomensky, Yu G / Zuber, S

Physical review letters

2021 Volume 127, Issue 6, Page(s) 61801

Abstract: We present limits on spin-independent dark matter-nucleon interactions using a 10.6 g Si athermal phonon detector with a baseline energy resolution of σ_{E}=3.86±0.04(stat)_{-0.00}^{+0.19}(syst) eV. This exclusion analysis sets the most stringent dark ... ...

Abstract	We present limits on spin-independent dark matter-nucleon interactions using a 10.6 g Si athermal phonon detector with a baseline energy resolution of σ_{E}=3.86±0.04(stat)_{-0.00}^{+0.19}(syst) eV. This exclusion analysis sets the most stringent dark matter-nucleon scattering cross-section limits achieved by a cryogenic detector for dark matter particle masses from 93 to 140 MeV/c^{2}, with a raw exposure of 9.9 g d acquired at an above-ground facility. This work illustrates the scientific potential of detectors with athermal phonon sensors with eV-scale energy resolution for future dark matter searches.
Language	English
Publishing date	2021-08-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.127.061801
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Article: Assessment of the Oxoid I.M. reagent card for infectious mononucleosis.

Aldridge, R / Coombes, H / Prowle, B

Medical laboratory technology

1973 Volume 30, Issue 1, Page(s) 57–60

MeSH term(s)	Hemagglutination Tests ; Indicators and Reagents ; Infectious Mononucleosis/diagnosis ; Mass Screening ; Methods ; Reagent Strips
Chemical Substances	Indicators and Reagents ; Reagent Strips
Language	English
Publishing date	1973-01
Publishing country	England
Document type	Journal Article
ZDB-ID	120017-3
ISSN	0022-2607
ISSN	0022-2607
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Book: Edward Thomas

Coombes, Henri

1956

Author's details	H. Coombes
Language	English
Size	256 S, leaf. port, 21 cm
Publisher	Chatto & Windus
Publishing place	London
Document type	Book
Database	Former special subject collection: coastal and deep sea fishing

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