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  1. Article: Design for a mail survey to determine prevalence of sars-cov-2 antibodies in the united states

    Frasier, Alicia M. / Guyer, Heidi / Di Grande, Laura / Domanico, Rose / Cooney, Darryl / Eckman, Stephanie

    Surv. Res. Methods

    Abstract: Although counts of the novel Coronavirus (SARS-CoV-2) infections and deaths are reported by several sources online, precise estimation of the exposed proportion of the population is not possible in most areas of the world. Estimates of other disease ... ...

    Abstract Although counts of the novel Coronavirus (SARS-CoV-2) infections and deaths are reported by several sources online, precise estimation of the exposed proportion of the population is not possible in most areas of the world. Estimates of other disease prevalence in the United States are often obtained through in-person seroprevalence surveys. The availability of testing only for individuals with symptoms, combined with stay-at-home and social distancing mandates to stem the spread of the disease, limit in-person data collection options. A probability-based mail survey with at-home, self-administered testing is a feasible method to safely estimate SARS-CoV-2 antibody prevalence within the United States while also easing burden on the U.S. public and health care system. This mail survey could be a one-time, cross-sectional design, or a repeated cross-sectional or longitudinal survey. We discuss several options for designing and conducting this survey.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #613630
    Database COVID19

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  2. Article: Design for a Mail Survey to Determine Prevalence of SARS-CoV-2 Antibodies in the United States Reply

    Frasier, Alicia M. / Guyer, Heidi / DiGrande, Laura / Domanico, Rose / Cooney, Darryl / Eckman, Stephanie

    Survey Research Methods

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #613629
    Database COVID19

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  3. Article ; Online: Quantitative Bias Analysis in Regulatory Settings.

    Lash, Timothy L / Fox, Matthew P / Cooney, Darryl / Lu, Yun / Forshee, Richard A

    American journal of public health

    2016  Volume 106, Issue 7, Page(s) 1227–1230

    Abstract: Nonrandomized studies are essential in the postmarket activities of the US Food and Drug Administration, which, however, must often act on the basis of imperfect data. Systematic errors can lead to inaccurate inferences, so it is critical to develop ... ...

    Abstract Nonrandomized studies are essential in the postmarket activities of the US Food and Drug Administration, which, however, must often act on the basis of imperfect data. Systematic errors can lead to inaccurate inferences, so it is critical to develop analytic methods that quantify uncertainty and bias and ensure that these methods are implemented when needed. "Quantitative bias analysis" is an overarching term for methods that estimate quantitatively the direction, magnitude, and uncertainty associated with systematic errors influencing measures of associations. The Food and Drug Administration sponsored a collaborative project to develop tools to better quantify the uncertainties associated with postmarket surveillance studies used in regulatory decision making. We have described the rationale, progress, and future directions of this project.
    MeSH term(s) Bias ; Humans ; Product Surveillance, Postmarketing/methods ; Research Design ; Uncertainty ; United States ; United States Food and Drug Administration/organization & administration
    Language English
    Publishing date 2016-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 121100-6
    ISSN 1541-0048 ; 0090-0036 ; 0002-9572
    ISSN (online) 1541-0048
    ISSN 0090-0036 ; 0002-9572
    DOI 10.2105/AJPH.2016.303199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: False positive rate of carbon monoxide saturation by pulse oximetry of emergency department patients.

    Weaver, Lindell K / Churchill, Susan K / Deru, Kayla / Cooney, Darryl

    Respiratory care

    2013  Volume 58, Issue 2, Page(s) 232–240

    Abstract: Background: Symptoms of carbon monoxide (CO) poisoning are non-specific. Diagnosis requires suspicion of exposure, confirmed by measuring ambient CO levels or carboxyhemoglobin (COHb). An FDA-approved pulse oximeter (Rad-57) can measure CO saturation (S( ...

    Abstract Background: Symptoms of carbon monoxide (CO) poisoning are non-specific. Diagnosis requires suspicion of exposure, confirmed by measuring ambient CO levels or carboxyhemoglobin (COHb). An FDA-approved pulse oximeter (Rad-57) can measure CO saturation (S(pCO)). The device accuracy has implications for clinical decision-making.
    Methods: From April 1 to August 15, 2008, study personnel measured S(pCO) and documented demographic factors at time of clinical blood draw, in a convenience sample of 1,363 subjects presenting to the emergency department at Intermountain Medical Center, Murray, Utah. The technician then assayed COHb. COHb and S(pCO) values were compared by subject; false positive or negative values were defined as S(pCO) at least 3 percentage points greater or less than COHb level, reported by the manufacturer to be ± 1 SD in performance.
    Results: In 1,363 subjects, 613 (45%) were male, 1,141 (84%) were light-skinned, 14 in shock, 4 with CO poisoning, and 122 (9%) met the criteria for a false positive value (range 3-19 percentage points), while 247 (18%) met the criteria for a false negative value (-13 to -3 percentage points). Risks for a false positive S(pCO) reading included being female and having a lower perfusion index. Methemoglobin, body temperature, and blood pressure also appear to influence the S(pCO) accuracy. There was variability among monitors, possibly related to technician technique, as rotation of monitors among technicians was not enforced.
    Conclusions: While the Rad-57 pulse oximeter functioned within the manufacturer's specifications, clinicians using the Rad-57 should expect some S(pCO) readings to be significantly higher or lower than COHb measurements, and should not use S(pCO) to direct triage or patient management. An elevated S(pCO) could broaden the diagnosis of CO poisoning in patients with non-specific symptoms. However, a negative S(pCO) level in patients suspected of having CO poisoning should never rule out CO poisoning, and should always be confirmed by COHb.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carbon Monoxide/blood ; Carbon Monoxide Poisoning/blood ; Carbon Monoxide Poisoning/diagnosis ; Carboxyhemoglobin/metabolism ; Child ; Child, Preschool ; Emergency Medical Services ; False Negative Reactions ; False Positive Reactions ; Female ; Humans ; Male ; Middle Aged ; Oximetry/instrumentation ; Sex Factors ; Young Adult
    Chemical Substances Carbon Monoxide (7U1EE4V452) ; Carboxyhemoglobin (9061-29-4)
    Language English
    Publishing date 2013-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 603252-7
    ISSN 1943-3654 ; 0098-9142 ; 0020-1324
    ISSN (online) 1943-3654
    ISSN 0098-9142 ; 0020-1324
    DOI 10.4187/respcare.01744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Gynecologic oncologists involvement on ovarian cancer standard of care receipt and survival.

    Rim, Sun Hee / Hirsch, Shawn / Thomas, Cheryll C / Brewster, Wendy R / Cooney, Darryl / Thompson, Trevor D / Stewart, Sherri L

    World journal of obstetrics and gynecology

    2016  Volume 5, Issue 2, Page(s) 187–196

    Abstract: Aim: To examine the influence of gynecologic oncologists (GO) in the United States on surgical/chemotherapeutic standard of care (SOC), and how this translates into improved survival among women with ovarian cancer (OC).: Methods: Surveillance, ... ...

    Abstract Aim: To examine the influence of gynecologic oncologists (GO) in the United States on surgical/chemotherapeutic standard of care (SOC), and how this translates into improved survival among women with ovarian cancer (OC).
    Methods: Surveillance, Epidemiology, and End Result (SEER)-Medicare data were used to identify 11688 OC patients (1992-2006). Only Medicare recipients with an initial surgical procedure code (
    Results: About 34% received surgery from a GO and 25% received the overall SOC. One-third of women had a GO involved sometime during their care. Women receiving surgery from a GO
    Conclusion: A survival advantage associated with receiving surgical SOC and overall treatment by a GO is supported. Persistent survival differences, particularly among those not receiving the SOC, require further investigation.
    Language English
    Publishing date 2016-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2711997-X
    ISSN 2218-6220
    ISSN 2218-6220
    DOI 10.5317/wjog.v5.i2.187
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Anaphylaxis in Schools: Results of the EPIPEN4SCHOOLS Survey Combined Analysis.

    White, Martha V / Hogue, Susan L / Odom, Dawn / Cooney, Darryl / Bartsch, Jennifer / Goss, Diana / Hollis, Kelly / Herrem, Christopher / Silvia, Suyapa

    Pediatric allergy, immunology, and pulmonology

    2016  Volume 29, Issue 3, Page(s) 149–154

    Abstract: A pilot survey described the characteristics of anaphylactic events occurring in an initial set of participating U.S. schools during the 2013-2014 school year. This survey was subsequently readministered to large school districts, which were ... ...

    Abstract A pilot survey described the characteristics of anaphylactic events occurring in an initial set of participating U.S. schools during the 2013-2014 school year. This survey was subsequently readministered to large school districts, which were underrepresented in initial results. A cross-sectional survey was administered to the U.S. schools that were participating in the EPIPEN4SCHOOLS
    Language English
    Publishing date 2016-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2566338-0
    ISSN 2151-321X
    ISSN 2151-321X
    DOI 10.1089/ped.2016.0675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Health Care Transition Experiences of Males with Childhood-onset Duchenne and Becker Muscular Dystrophy: Findings from the Muscular Dystrophy Surveillance Tracking and Research Network (MD STARnet) Health Care Transitions and Other Life Experiences Survey.

    Paramsothy, Pangaja / Herron, Adrienne R / Lamb, Molly M / Kinnett, Kathi / Wolff, Jodi / Yang, Michele L / Oleszek, Joyce / Pandya, Shree / Kennedy, Annie / Cooney, Darryl / Fox, Deborah / Sheehan, Daniel

    PLoS currents

    2018  Volume 10

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2018-08-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2583641-9
    ISSN 2157-3999
    ISSN 2157-3999
    DOI 10.1371/currents.md.7de8a1c6798d7a48d38ea09bd624e1cd
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Effect of Gynecologic Oncologist Availability on Ovarian Cancer Mortality.

    Stewart, Sherri L / Cooney, Darryl / Hirsch, Shawn / Westervelt, Lauren / Richards, Thomas B / Rim, Sun Hee / Thomas, Cheryll C

    World journal of obstetrics and gynecology

    2014  Volume 3, Issue 2, Page(s) 71–77

    Abstract: Aim: To determine the association between the distribution of gynecologic oncologist (GO) and population-based ovarian cancer death rates.: Materials and methods: Data on ovarian cancer incidence and mortality in the United States (U.S.) was ... ...

    Abstract Aim: To determine the association between the distribution of gynecologic oncologist (GO) and population-based ovarian cancer death rates.
    Materials and methods: Data on ovarian cancer incidence and mortality in the United States (U.S.) was supplemented with U.S. census data, and analyzed in relation to practicing GOs. GO locations were geocoded to link association between county variables and GO availability. Logistic regression was used to measure areas of high and low ovarian cancer mortality, adjusting for contextual variables.
    Results: Practicing GOs were unevenly distributed in the United States, with the greatest numbers in metropolitan areas. Ovarian cancer incidence and death rates increased as distance to a practicing GO increased. A relatively small number (153) of counties within 24 miles of a GO had high ovarian cancer death rates compared to 577 counties located 50 or more miles away with high ovarian cancer death rates. Counties located 50 or more miles away from a GO practice had an almost 60% greater odds of high ovarian cancer mortality compared to those with closer practicing GOs (OR 1.59, 95% CI 1.18-2.15).
    Conclusion: The distribution of GOs across the United States appears to be significantly associated with ovarian cancer mortality. Efforts that facilitate outreach of GOs to certain populations may increase geographic access. Future studies examining other factors associated with lack of GO access (e.g. insurance and other socioeconomic factors) at the individual level will assist with further defining barriers to quality ovarian cancer care in the United States.
    Language English
    Publishing date 2014-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2711997-X
    ISSN 2218-6220
    ISSN 2218-6220
    DOI 10.5317/wjog.v3.i2.71
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A matched-cohort evaluation of a bedside asthma intervention for patients hospitalized at a large urban children's hospital.

    Davis, Adam M / Benson, Mindy / Cooney, Darryl / Spruell, Brian / Orelian, Jean

    Journal of urban health : bulletin of the New York Academy of Medicine

    2010  Volume 88 Suppl 1, Page(s) 49–60

    Abstract: Emergency care and hospitalizations account for 36% of asthma-related medical expenses for children. National asthma guidelines emphasize the need for asthma self-management education at multiple points of care, including the hospital, to help prevent ... ...

    Abstract Emergency care and hospitalizations account for 36% of asthma-related medical expenses for children. National asthma guidelines emphasize the need for asthma self-management education at multiple points of care, including the hospital, to help prevent acute exacerbations. The integration of a bedside asthma education program into discharge planning at a busy urban children's hospital aimed to reduce repeat emergency department (ED) visits and hospitalizations by educating the community's highest-risk children and their families about asthma. A trained respiratory professional provided 45 minutes of individualized bedside education to families at the hospital and one follow-up support phone call within 3 weeks after discharge. Children receiving the intervention were matched to a control group of children not receiving the intervention by age and 2 markers of past utilization using data obtained from hospital records. Repeat ED utilization was analyzed using a Cox proportional hazards model controlling for sex, residence, race or ethnicity, and year. Compared to 698 matched controls, no significant improvement was observed in the 698 intervention participants or any subgroups followed for 12 months after the intervention.
    MeSH term(s) Adolescent ; Asthma/therapy ; California ; Caregivers/education ; Child ; Child, Preschool ; Emergency Service, Hospital ; Female ; Hospitals, Pediatric ; Hospitals, Urban ; Humans ; Infant ; Male ; Patient Discharge/standards ; Patient Education as Topic/methods ; Patient Education as Topic/standards ; Patient Readmission/statistics & numerical data ; Proportional Hazards Models ; Self Care/methods ; Self Care/standards
    Language English
    Publishing date 2010-08-18
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1435288-6
    ISSN 1468-2869 ; 1099-3460
    ISSN (online) 1468-2869
    ISSN 1099-3460
    DOI 10.1007/s11524-010-9517-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Contextual Analysis of Breast Cancer Stage at Diagnosis Among Women in the United States, 2004.

    Coughlin, Steven S / Richardson, Lisa C / Orelien, Jean / Thompson, Trevor / Richards, Thomas B / Sabatino, Susan A / Wu, Wei / Cooney, Darryl

    The open health services and policy journal

    2011  Volume 2, Page(s) 45–46

    Abstract: BACKGROUND: To explore contextual effects and to test for interactions, this study examined how breast cancer stage at diagnosis among U.S. women related to individual- and county-level (contextual) variables associated with access to health care and ... ...

    Abstract BACKGROUND: To explore contextual effects and to test for interactions, this study examined how breast cancer stage at diagnosis among U.S. women related to individual- and county-level (contextual) variables associated with access to health care and socioeconomic status. METHODS: Individual-level incidence data were obtained from the National Program of Cancer Registries (NPCR) and the Surveillance, Epidemiology and End-Results (SEER) program. The county of residence of women with diagnosed breast cancer (n = 217,299) was used to link NPCR and SEER data with county-level measures of health care access from the 2004 Area Resource File (ARF). In addition to individual-level covariates such as age, race, and Hispanic ethnicity, we examined county-level covariates (residence in a Health Professional Shortage Area, urban/rural residence; race/ethnicity; and number of health centers/clinics, mammography screening centers, primary care physicians, and obstetrician-gynecologists per 100,000 female population or per 1000 square miles) as predictors of stage of breast cancer at diagnosis. RESULTS: Both individual-level and contextual variables are associated with later stage of breast cancer at diagnosis. Black women and women of "other race" had higher odds of receiving a diagnosis of regional or distant stage breast cancer (P <0.0001 and P = 0.02). With adjustment for age, Hispanics were more likely to receive a diagnosis of later stage breast cancer than non-Hispanics (P <0.0.001). Women living in areas with a higher proportion of black women had greater odds of receiving a diagnosis of regional or late stage breast cancer compared with women living in areas with the lowest proportion of black women. The same was noted for women living in areas with intermediate proportions of Hispanic women (age-adjusted odds ratio [OR], 0.94; 95% confidence interval [CI], 0.92-0.97]. Other important contextual variables associated with stage at diagnosis included the percentage of persons living below the poverty level and the number of office-based physicians per 100,000 women. Women living in counties with a higher proportion of persons living below the poverty level or fewer office-based physicians were more likely to receive a diagnosis of later stage breast cancer than those living in other counties (P < 0.001). In multivariable analysis, residence in areas with a higher proportion of non-Hispanic black women modified the associations of age and Hispanic ethnicity with later stage breast cancer (P = 0.0159 and P = 0.0002, respectively). CONCLUSIONS: This study found that county-level contextual variables related to the availability and accessibility of health care providers and health services can affect the timeliness of breast cancer diagnosis. This information could help public health officials develop interventions to reduce the burden of breast cancer among U.S. women.
    Language English
    Publishing date 2011-02-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2453348-8
    ISSN 1874-9240
    ISSN 1874-9240
    Database MEDical Literature Analysis and Retrieval System OnLINE

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