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  1. Book: Why Mothers Died and How their Lives are Saved

    Cooper, Griselda / Lewis, Gwyneth / Drife, James Owen / Neilson, James P / Knight, Marian / Cantwell, Roch

    The Story of Confidential Enquiries into Maternal Deaths

    2023  

    Author's details James Owen Drife is Emeritus Professor of Obstetrics and Gynaecology at the University of Leeds and was the Medical Director of the CEMD. He has been vice-president of the Royal College of Obstetricians and Gynaecologists and was an elected member of the General Medical Council
    Size 168 p.
    Publisher Cambridge University Press
    Document type Book
    Note PDA Manuell_20
    Format 161 x 241 x 17
    ISBN 9781009218832 ; 1009218832
    Database PDA

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  2. Book: Non-operative treatment of the lumbar spine

    Cooper, Grant

    2015  

    Author's details Grant Cooper
    Keywords Spinal stenosis ; Epidural steroid injection ; Lumbosacral radiculopathy ; Spondylolisthesis ; Musculoskeletal medicine ; Sciatica ; Compression fracture ; Radiofrequency rhizotomy ; Facet joint arthropathy ; Lumbar spine ; Non-operative treatment ; Lower back pain ; Sacroiliac joint pain ; Lumbar radiculopathy ; Piriformis syndrome
    Language English
    Size XIII, 163 S. : Ill.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Switzerland
    Document type Book
    HBZ-ID HT018771880
    ISBN 978-3-319-21442-9 ; 3-319-21442-X ; 978-3-319-21443-6 ; 3-319-21443-8
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: The rise and rise of fentanyl in postmortem casework.

    Cooper, Gail

    Journal of forensic sciences

    2023  Volume 68, Issue 5, Page(s) 1675–1685

    Abstract: Forensic toxicology laboratories are navigating a period of time with increasing drug overdose deaths, an opioid epidemic, the impact of the COVID-19 pandemic, and the illicit drug market flooded with novel psychoactive substances. In New York City, the ... ...

    Abstract Forensic toxicology laboratories are navigating a period of time with increasing drug overdose deaths, an opioid epidemic, the impact of the COVID-19 pandemic, and the illicit drug market flooded with novel psychoactive substances. In New York City, the Department of Forensic Toxicology has experienced a 56% increase in postmortem casework in the past decade with fentanyl detected in 80% of all overdose deaths. Over a period of 2.5 years, 15,638 postmortem cases were tested for the presence of fentanyl and fentanyl analogs using liquid-chromatography tandem mass spectrometry (LCMSMS). Fentanyl was detected in approximately one third of cases and of these 4447 cases with femoral blood. A twofold increase in cases with high concentrations of fentanyl (>100 ng/mL) was observed between 2021 and 2022. The minor metabolite and precursor chemical, 4-ANPP (4-anilino-N-phenethylpiperidine) may help differentiate between illicit and licit fentanyl. 4-ANPP blood concentrations were <10 ng/mL in 98% of the cases and the 4-ANPP:fentanyl ratio was <0.67 for 99.1% of blood specimens. Only six cases had 4-ANPP concentrations higher than the corresponding fentanyl blood concentration. This study also highlights, the changing fentanyl analogs found in postmortem cases since 2016 in NYC with the emergence of fluorofentanyl initially identified in 2020 and continuing to dominate in comparison with the prevalence of other analogs, many of which are no longer detected in casework. The detection of one of the latest drugs to be mixed with fentanyl, namely xylazine, has also increased in prevalence by 36.7% in 2022 compared with 2021.
    MeSH term(s) Humans ; Fentanyl ; Pandemics ; COVID-19 ; Analgesics, Opioid/analysis ; Chromatography, Liquid ; Drug Overdose ; Forensic Toxicology/methods
    Chemical Substances Fentanyl (UF599785JZ) ; Analgesics, Opioid
    Language English
    Publishing date 2023-08-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219216-0
    ISSN 1556-4029 ; 0022-1198
    ISSN (online) 1556-4029
    ISSN 0022-1198
    DOI 10.1111/1556-4029.15353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: The cell

    Cooper, Geoffrey M.

    a molecular approach

    2019  

    Author's details Geoffrey M. Cooper, Professor Emeritus, Boston University
    Keywords Cytology ; Molecular biology ; Cells ; Cell Biology ; Cell Physiological Phenomena ; Molecular Biology
    Language English
    Size xxvii, 783 Seiten, Illustrationen
    Edition International eighth edition
    Publisher Sinauer Associates, an imprint of Oxford University Press
    Publishing place New York
    Publishing country United States
    Document type Book
    HBZ-ID HT020004626
    ISBN 978-1-6053-5863-5 ; 1-6053-5863-0
    Database Catalogue ZB MED Medicine, Health

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  5. Article: On Constitutional Syphilis.

    Cooper, G L

    Medical examiner (Philadelphia, Pa.)

    2023  Volume 5, Issue 49, Page(s) 71–72

    Language English
    Publishing date 2023-12-20
    Publishing country United States
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online: Therapeutic Uses of Botulinum Toxin

    Cooper, Grant

    2007  

    Author's details edited by Grant Cooper
    Keywords Dermatology ; Orthopedics ; Rehabilitation ; Toxicology
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387192
    ISBN 978-1-588-29914-7 ; 978-1-597-45247-2 ; 1-588-29914-7 ; 1-597-45247-5
    DOI 10.1007/978-1-59745-247-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  7. Book ; Online: Essential Physical Medicine and Rehabilitation

    Cooper, Grant

    2006  

    Author's details edited by Grant Cooper
    Keywords Rehabilitation
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387119
    ISBN 978-1-588-29618-4 ; 978-1-597-45100-0 ; 1-588-29618-0 ; 1-597-45100-2
    DOI 10.1007/978-1-59745-100-0
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Online: Pocket Guide to Musculoskeletal Diagnosis

    Cooper, Grant

    2006  

    Author's details by Grant Cooper
    Keywords Orthopedics
    Language English
    Publisher Humana Press Inc
    Publishing place Totowa, NJ
    Document type Book ; Online
    HBZ-ID TT050387139
    ISBN 978-1-588-29674-0 ; 978-1-597-45009-6 ; 1-588-29674-1 ; 1-597-45009-X
    DOI 10.1007/978-1-59745-009-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  9. Article ; Online: What a pain in the … back: a review of current treatment options with a focus on naproxen sodium.

    Weisman, Steven M / Ciavarra, Giovanni / Cooper, Grant

    Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

    2024  Volume 27, Page(s) 12384

    Abstract: Non-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the ... ...

    Abstract Non-specific low back pain (LBP) represents a challenging and prevalent condition that is one of the most common symptoms leading to primary care physician visits. While established guidelines recommend prioritizing non-pharmacological approaches as the primary course of action, pharmacological treatments are advised when non-pharmacological approaches are ineffective or based on patient preference. These guidelines recommend non-steroidal anti-inflammatory drugs (NSAIDs) or skeletal muscle relaxers (SMRs) as the first-line pharmacological options for acute or subacute LBP, while NSAIDs are the exclusive first-line pharmacological option for chronic LBP. Although SMRs are generally effective for acute LBP, the available evidence does not support the view that they improve functional recovery, and their comparative efficacy to NSAIDs and other analgesics remains unknown, while studies have shown them to introduce adverse events without significantly reducing LBP. Moreover, opioids continue to be widely prescribed for LBP, despite limited evidence for effectiveness and known risks of addiction and overdose. Broader use of non-opioid pharmacotherapy, including the appropriate use of OTC options, is critical to addressing the opioid crisis. The balance of evidence indicates that NSAIDs have a favorable benefit-risk profile when compared to other available pharmacological treatment options for non-specific LBP, a condition that is primarily acute in nature and well-suited for self-treatment with OTC analgesics. While clinical guidelines do not differentiate between NSAIDs, evidence indicates that OTC naproxen sodium effectively relieves pain across multiple types of pain models, and furthermore, the 14-h half-life of naproxen sodium allows sustained, all day pain relief with reduced patient pill burden as compared to shorter acting options. Choosing the most appropriate approach for managing LBP, including non-pharmacological options, should be based on the patient's condition, severity of pain, potential risks, and individual patient preference and needs.
    MeSH term(s) Humans ; Naproxen/therapeutic use ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Analgesics ; Analgesics, Opioid ; Low Back Pain/drug therapy ; Low Back Pain/chemically induced
    Chemical Substances Naproxen (57Y76R9ATQ) ; Anti-Inflammatory Agents, Non-Steroidal ; Analgesics ; Analgesics, Opioid
    Language English
    Publishing date 2024-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1422972-9
    ISSN 1482-1826 ; 1482-1826
    ISSN (online) 1482-1826
    ISSN 1482-1826
    DOI 10.3389/jpps.2024.12384
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The functional and psychological impact of delayed hip and knee arthroplasty: a systematic review and meta-analysis of 89,996 patients.

    Cooper, G M / Bayram, J M / Clement, N D

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8032

    Abstract: This systematic review and meta-analysis aimed to determine the impact of presurgical waiting times on pre-/post-operative joint specific pain and function, health-related quality of life (HRQOL) and perspectives of patients awaiting primary elective ... ...

    Abstract This systematic review and meta-analysis aimed to determine the impact of presurgical waiting times on pre-/post-operative joint specific pain and function, health-related quality of life (HRQOL) and perspectives of patients awaiting primary elective total hip (THR) and knee (TKR) replacements. MEDLINE, EMBASE, PUBMED, and CENTRAL databases were searched from inception until 30th January 2023 (CRD42022288128). Secondary literature and unpublished datasets containing paediatric, non-elective, partial, or revision replacement populations were excluded. PRISMA 2020 reporting and GRADE certainty of evidence guidelines were followed. Residual maximum likelihood meta-analysis and linear meta-regression was performed to elucidate the influence of presurgical waiting time. Twenty-six studies were eligible for systematic review and sixteen for meta-analysis, capturing 89,996 patients (60.6% female, mean age 67.4 years) between 2001 and 2022. A significant deterioration in joint function (mean difference (MD):0.0575%; 95% CI 0.0064, 0.1086; p = 0.028(4d.p.); I2 = 73.1%) and HRQOL (MD: 0.05%; 95% CI - 0.0001.0009; p = 0.011(4 d.p.); I2 = 80.6%) was identified per additional day of waiting. Despite qualitative evidence, meta-analysis could not observe a relationship with postoperative outcome data. Patient responses to delayed THR and TKR surgery were unanimously negative. Immediate action should seek to reduce the increased patient anxiety and significant reductions in pre-operative joint functionality and HRQOL associated with prolonged pre-surgical waiting time, whilst mitigating any potential deleterious post-operative effects.
    MeSH term(s) Humans ; Female ; Child ; Aged ; Male ; Arthroplasty, Replacement, Knee ; Quality of Life ; Arthroplasty, Replacement, Hip/adverse effects ; Knee Joint ; Pain, Postoperative
    Language English
    Publishing date 2024-04-05
    Publishing country England
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-58050-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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