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  1. Book: Oxford textbook of rheumatoid arthritis

    Scott, David L. / Galloway, James B. / Cope, Andrew P.

    2020  

    Title variant Textbook of rheumatoid arthritis ; Rheumatoid arthritis
    Author's details edited by David L. Scott, James Galloway, Andrew Cope, Arthur G.Pratt, Vibeke Strand
    Keywords Rheumatoid arthritis
    Language English
    Size xiii, 556 Seiten, Illustrationen, 28 cm
    Publisher Oxford University Press
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT020580433
    ISBN 978-0-19-883143-3 ; 0-19-883143-9
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 A 1310 available for loan (reading room) Lesesaal EG

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  2. Book ; Collection: Arthritis research

    Cope, Andrew P.

    methods and protocols

    (Methods in molecular medicine ; ...)

    2007  

    Author's details ed. by Andrew P. Cope
    Series title Methods in molecular medicine
    ...
    Keywords Arthritis ; Laboratory Techniques and Procedures
    Language English
    Dates of publication 2007-9999
    Size 24 cm
    Publisher Humana
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book ; Collection (display volumes)
    Note Includes bibliographical references and indexes
    HBZ-ID HT015271366
    Database Catalogue ZB MED Medicine, Health

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  3. Book: Arthritis research / 1

    Cope, Andrew P.

    methods and protocols

    (Methods in molecular medicine ; 135)

    2007  

    Author's details ed. by Andrew P. Cope
    Series title Methods in molecular medicine ; 135
    Arthritis research
    Collection Arthritis research
    Language English
    Size XX, 445 S., [4] Bl. : Ill., graph. Darst.
    Publisher Humana
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015271372
    ISBN 1-58829-344-0 ; 978-1-58829-344-2
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 5186 order for loan Magazin

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  4. Book: Arthritis research / 2

    Cope, Andrew P.

    methods and protocols

    (Methods in molecular medicine ; 136)

    2007  

    Author's details ed. by Andrew P. Cope
    Series title Methods in molecular medicine ; 136
    Arthritis research
    Collection Arthritis research
    Language English
    Size XXII, 431 S., [2] Bl. : Ill., graph. Darst.
    Publisher Humana
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015271377
    ISBN 1-58829-918-X ; 978-1-58829-918-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 5187 order for loan Magazin

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  5. Article ; Online: Considerations for Optimal Trial Design for Rheumatoid Arthritis Prevention Studies.

    Cope, Andrew P

    Clinical therapeutics

    2019  Volume 41, Issue 7, Page(s) 1299–1311

    Abstract: The field of rheumatology has made major contributions to medicine through the identification of cellular and molecular targets and with the development of therapies for the treatment of an impressive range of immune-mediated rheumatic diseases. In ... ...

    Abstract The field of rheumatology has made major contributions to medicine through the identification of cellular and molecular targets and with the development of therapies for the treatment of an impressive range of immune-mediated rheumatic diseases. In recent years new milestones have been achieved. These include the recognition of an "at risk" state, defined by distinct clusters of characteristics, including disease-specific autoantibodies in serum and symptom complexes that include inflammatory joint pain. Studies seeking to prevent high-risk individuals from progressing to a state of clinically apparent arthritis have been initiated. Here, exploiting the current evidence base, an experimental framework to inform trial design is described, taking into consideration study patient phenotypes and highlighting the impact of risk stratification and the options available for therapeutic intervention according to the different phases of the preclinical syndrome. Pragmatic primary end points and suggestions for a set of risk-focused trial outcome measures are proposed, including both clinical assessments and patient-reported outcome measures. Rheumatoid arthritis prevention studies provide an important experimental framework for generating deeper insights into risk stratification and for refining trial design in the future. To this end, a research agenda is suggested, together with some considerations for imaging and for biological sampling. This commentary concludes with some of the operational issues that arise from such studies and addresses some of the challenges associated with recruitment and retention of the at-risk trial participant.
    MeSH term(s) Antirheumatic Agents/pharmacology ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/prevention & control ; Clinical Protocols ; Clinical Trials as Topic ; Humans ; Patient Selection ; Rheumatology
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2019-06-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603113-4
    ISSN 1879-114X ; 0149-2918
    ISSN (online) 1879-114X
    ISSN 0149-2918
    DOI 10.1016/j.clinthera.2019.04.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Emerging therapies for pre-RA.

    Cope, Andrew P

    Best practice & research. Clinical rheumatology

    2017  Volume 31, Issue 1, Page(s) 99–111

    Abstract: The field of rheumatology has made major contributions to medicine through the identification of cellular and molecular targets and the development of therapies for the treatment of an impressive range of immune-mediated inflammatory diseases such as ... ...

    Abstract The field of rheumatology has made major contributions to medicine through the identification of cellular and molecular targets and the development of therapies for the treatment of an impressive range of immune-mediated inflammatory diseases such as rheumatoid arthritis. In recent years, new milestones have been achieved. These include the recognition of an at-risk state, characterized by disease specific autoantibodies in serum and inflammatory joint pain, and the initiation of studies seeking to prevent high-risk individuals from progressing to a state of clinically apparent arthritis. Here, the current state of the art of rheumatoid arthritis prevention is described, highlighting the importance of risk stratification and reporting on a growing portfolio of therapeutic interventions targeting different stages of the preclinical syndrome.
    MeSH term(s) Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/prevention & control ; Humans
    Chemical Substances Antirheumatic Agents
    Language English
    Publishing date 2017-09-11
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2052323-3
    ISSN 1532-1770 ; 1521-6942
    ISSN (online) 1532-1770
    ISSN 1521-6942
    DOI 10.1016/j.berh.2017.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Rheumatoid arthritis prevention in arthralgia: fantasy or reality?

    van Steenbergen, Hanna W / Cope, Andrew P / van der Helm-van Mil, Annette H M

    Nature reviews. Rheumatology

    2023  Volume 19, Issue 12, Page(s) 767–777

    Abstract: The concept of a 'window of opportunity' in treating a disease assumes the existence of a time frame during which the trajectory of the disease can be effectively and permanently modified. In rheumatoid arthritis (RA), optimal timing of this period is ... ...

    Abstract The concept of a 'window of opportunity' in treating a disease assumes the existence of a time frame during which the trajectory of the disease can be effectively and permanently modified. In rheumatoid arthritis (RA), optimal timing of this period is presumed to be during the phase before arthritis is clinically apparent and disease is diagnosed. Several proof-of-concept trials of treatment during the 'arthralgia' phase of RA have been completed in the past 4 years, with the underlying notion that temporary treatment at this stage could prevent the development of RA or induce a sustained reduction in the burden of disease. This Review summarizes the results of these trials and reflects on the outcomes in relation to the patients' perspectives. Overall, the majority of symptomatic at-risk individuals could benefit from a fixed period treatment, even if RA does not develop. Various factors must be taken into consideration when translating these findings into clinical practice. More evidence is needed to target the individuals at highest risk, and additional tools are needed to monitor treatment and guide decisions about whether treatment can be discontinued. Without these tools, there is a paradoxical risk of seemingly increasing the incidence of the disease and prolonging disease duration, which is the opposite of what the concept of intervening in the window of opportunity entails.
    MeSH term(s) Humans ; Arthralgia ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/prevention & control ; Fantasy ; Time Factors ; Cost of Illness
    Language English
    Publishing date 2023-10-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/s41584-023-01035-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Moving the pathway goalposts: COPD as an immune-mediated inflammatory disease.

    Cass, Steven P / Cope, Andrew P / Nicolau, Dan V / Russell, Richard E K / Bafadhel, Mona

    The Lancet. Respiratory medicine

    2022  Volume 10, Issue 12, Page(s) 1110–1113

    MeSH term(s) Humans ; Pulmonary Disease, Chronic Obstructive
    Language English
    Publishing date 2022-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(22)00388-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  9. Article ; Online: Signal transduction pathways in chronic inflammatory rheumatic diseases.

    Cope, Andrew P

    The open rheumatology journal

    2012  Volume 6, Page(s) 207–208

    Language English
    Publishing date 2012-09-07
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2395999-X
    ISSN 1874-3129 ; 1874-3129
    ISSN (online) 1874-3129
    ISSN 1874-3129
    DOI 10.2174/1874312901206010207
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  10. Article ; Online: The influence of safety warnings on the prescribing of JAK inhibitors.

    Russell, Mark D / Yang, Zijing / Walter, Ben / Alveyn, Edward / Bechman, Katie / Miracle, Aitana / Nagra, Deepak / Adas, Maryam A / Norton, Sam / Cope, Andrew P / Langan, Sinéad M / Galloway, James B

    The Lancet. Rheumatology

    2024  Volume 6, Issue 3, Page(s) e138–e139

    MeSH term(s) Janus Kinase Inhibitors/adverse effects ; Practice Patterns, Physicians' ; Drug Prescriptions
    Chemical Substances Janus Kinase Inhibitors
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Letter
    ISSN 2665-9913
    ISSN (online) 2665-9913
    DOI 10.1016/S2665-9913(24)00002-X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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