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  1. Article ; Online: Tumor necrosis factor-α levels and non-surgical bleeding in continuous-flow left ventricular assist devices.

    Tabit, Corey E / Coplan, Mitchell J / Chen, Phetcharat / Jeevanandam, Valluvan / Uriel, Nir / Liao, James K

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2017  Volume 37, Issue 1, Page(s) 107–115

    Abstract: Background: Non-surgical bleeding (NSB) due to angiodysplasia is common in left ventricular assist device (LVAD) patients. Thrombin-induced angiopoietin-2 (Ang-2) expression in LVAD patients leads to altered angiogenesis and is associated with lower ... ...

    Abstract Background: Non-surgical bleeding (NSB) due to angiodysplasia is common in left ventricular assist device (LVAD) patients. Thrombin-induced angiopoietin-2 (Ang-2) expression in LVAD patients leads to altered angiogenesis and is associated with lower angiopoietin-1 (Ang-1) and increased NSB. However, the mechanism for decreased Ang-1, made by pericytes, is unknown and the origin of thrombin in LVAD patients is unclear. We hypothesized that high tumor necrosis factor-α (TNF-α) levels in LVAD patients induce pericyte apoptosis, tissue factor (TF) expression and vascular instability.
    Methods: We incubated cultured pericytes with serum from patients with heart failure (HF), LVAD or orthotopic heart transplantation (OHT), with or without TNF-α blockade. We performed several measurements: Ang-1 expression was assessed by reverse transcript-polymerase chain reaction (RT-PCR) and pericyte death fluorescently; TF expression was assessed by RT-PCR in cultured endothelial cells incubated with patient plasma with or without TNF-α blockade; and TF expression was assessed in endothelial biopsy samples from these patients by immunofluorescence. We incubated cultured endothelial cells on Matrigel with patient serum with or without TNF-α blockade and determined tube formation by microscopy.
    Results: Serum from LVAD patients had higher levels of TNF-α, suppressed Ang-1 expression in pericytes, and induced pericyte death, and there was accelerated endothelial tube formation compared with serum from patients without LVADs. TF was higher in both plasma and endothelial cells from LVAD patients, and plasma from LVAD patients induced more endothelial TF expression. All of these effects were reversed or reduced with TNF-α blockade. High levels of TNF-α were associated with increased risk of NSB.
    Conclusions: Elevated TNF-α in LVAD patients is a central regulator of altered angiogenesis, pericyte apoptosis and expression of TF and Ang-1.
    MeSH term(s) Aged ; Female ; Heart-Assist Devices/adverse effects ; Hemorrhage/blood ; Hemorrhage/etiology ; Humans ; Male ; Middle Aged ; Postoperative Complications/blood ; Postoperative Complications/etiology ; Tumor Necrosis Factor-alpha/blood
    Chemical Substances Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2017-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2017.06.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2056: Show issues Location:
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  2. Article ; Online: Community Health Workers Reduce Rehospitalizations and Emergency Department Visits for Low-Socioeconomic Urban Patients With Heart Failure.

    Vohra, Adam S / Chua, Rhys F M / Besser, Stephanie A / Alcain, Charina F / Basnet, Sweta / Battle, Brenda / Coplan, Mitchell J / Liao, James K / Tabit, Corey E

    Critical pathways in cardiology

    2020  Volume 19, Issue 3, Page(s) 139–145

    Abstract: Background: Low-socioeconomic, urban, minority patients with heart failure (HF) often have unique barriers to care. Community health workers (CHWs) are specially trained laypeople who serve as liaisons between underserved communities and the health ... ...

    Abstract Background: Low-socioeconomic, urban, minority patients with heart failure (HF) often have unique barriers to care. Community health workers (CHWs) are specially trained laypeople who serve as liaisons between underserved communities and the health system. It is not known whether CHWs improve outcomes in low-socioeconomic, urban, minority patients with HF.
    Hypothesis: CHWs reduce rehospitalizations, emergency department (ED) visits, and healthcare costs for low-socioeconomic urban patients with HF.
    Methods: Patients admitted with acute decompensated HF were assigned to receive weekly visits by CHW after discharge. Patients were propensity score matched with controls who received usual care. HF-related rehospitalizations, ED visits, and inpatient costs were compared for 12 months following index admission versus the same period before.
    Results: Twenty-eight patients who received weekly visits from a CHW for 12 months after discharge were matched with 28 control patients who did not receive CHWs. Patients who received a CHW had a 75% decrease in HF-related ED visits (0.71 vs. 0.18 visits per patient, P < 0.001), an 89% decrease in HF-related readmissions (0.64 vs. 0.07 admissions per patient, P < 0.005), and a significant decrease in inpatient cost for HF-related visits. In controls receiving usual care, there was no significant change in hospitalizations, ED visits, or costs.
    Conclusions: In conclusion, CHWs are associated with reduced rehospitalizations, ED visits, and inpatient costs in low-socioeconomic, urban, minority patients with HF. CHWs may be a cost-effective method to reduce health care utilization and improve outcomes for this population.
    MeSH term(s) Adult ; Aged ; Community Health Workers/statistics & numerical data ; Emergency Service, Hospital/statistics & numerical data ; Female ; Heart Failure/economics ; Heart Failure/epidemiology ; Heart Failure/therapy ; Humans ; Illinois/epidemiology ; Incidence ; Male ; Middle Aged ; Office Visits/trends ; Patient Readmission/trends ; Retrospective Studies ; Socioeconomic Factors ; Urban Population
    Language English
    Publishing date 2020-03-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2079676-6
    ISSN 1535-2811 ; 1535-282X
    ISSN (online) 1535-2811
    ISSN 1535-282X
    DOI 10.1097/HPC.0000000000000220
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5660: Show issues Location:
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  3. Article ; Online: A clinical pathway for heart failure reduces admissions from the ED without increasing congestion in the ED.

    Spiegel, Thomas F / Wassermann, Travis B / Neumann, Natalie / Coplan, Mitchell J / Spencer, Kirk T / Adelman, Daniel / Sanghani, Rupa Mehta / Tabit, Corey E

    The American journal of emergency medicine

    2017  Volume 36, Issue 7, Page(s) 1202–1208

    Abstract: Background: A multidisciplinary team at a major academic medical center established an Acutely Decompensated Heart Failure Clinical Pathway (ADHFCP) program to reduce inpatient readmission rates among patients with heart failure which, among several ... ...

    Abstract Background: A multidisciplinary team at a major academic medical center established an Acutely Decompensated Heart Failure Clinical Pathway (ADHFCP) program to reduce inpatient readmission rates among patients with heart failure which, among several interventions, included an immediate consultation from a cardiologist familiar with an ADHFCP patient when the patient presented at the Emergency Department (ED). This study analyzed how that program impacted utilization of services in the ED and its subsequent effect on rates of admission from the ED and on disposition times.
    Methods: ADHFCP inpatient visits were retrospectively risk stratified and matched with non-program inpatient visits to create a control group. A Cox survival model analyzed the ADHFCP's impact on patients' likelihood to visit the ED. Multivariable ANOVA evaluated the impact of the program on the patients' likelihood of being admitted when presenting at the ED. The ADHFCP's impact on bed-to-disposition time in the ED was evaluated by Wilcoxon's rank-sum test, as were doses of diuretics administered in the ED.
    Results: The survival analysis showed no impact of the ADHFCP on patients' likelihood of visiting the ED, but ADHFCP patients presenting to the ED were 13.1 (95% CI: 3.6-22.6) percentage points less likely to be admitted. There was no difference in bed-to-disposition times, but ADHFCP patients received diuretics more frequently and at higher doses.
    Conclusions: Improved communication between cardiologists and ED physicians through the establishment of an explicit pathway to coordinate the care of heart failure patients may decrease that population's likelihood of admission without increasing ED disposition times.
    MeSH term(s) Aged ; Case-Control Studies ; Communication ; Critical Pathways ; Disease-Free Survival ; Emergency Service, Hospital/statistics & numerical data ; Facilities and Services Utilization ; Female ; Health Status ; Heart Failure/mortality ; Heart Failure/therapy ; Hospitalization/statistics & numerical data ; Humans ; Interprofessional Relations ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Retrospective Studies
    Language English
    Publishing date 2017-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 605890-5
    ISSN 1532-8171 ; 0735-6757
    ISSN (online) 1532-8171
    ISSN 0735-6757
    DOI 10.1016/j.ajem.2017.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2005: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Cardiology Consultation in the Emergency Department Reduces Re-hospitalizations for Low-Socioeconomic Patients with Acute Decompensated Heart Failure.

    Tabit, Corey E / Coplan, Mitchell J / Spencer, Kirk T / Alcain, Charina F / Spiegel, Thomas / Vohra, Adam S / Adelman, Daniel / Liao, James K / Sanghani, Rupa Mehta

    The American journal of medicine

    2017  Volume 130, Issue 9, Page(s) 1112.e17–1112.e31

    Abstract: Background: Re-hospitalization after discharge for acute decompensated heart failure is a common problem. Low-socioeconomic urban patients suffer high rates of re-hospitalization and often over-utilize the emergency department (ED) for their care. We ... ...

    Abstract Background: Re-hospitalization after discharge for acute decompensated heart failure is a common problem. Low-socioeconomic urban patients suffer high rates of re-hospitalization and often over-utilize the emergency department (ED) for their care. We hypothesized that early consultation with a cardiologist in the ED can reduce re-hospitalization and health care costs for low-socioeconomic urban patients with acute decompensated heart failure.
    Methods: There were 392 patients treated at our center for acute decompensated heart failure who received standardized education and follow-up. Patients who returned to the ED received early consultation with a cardiologist; 392 patients who received usual care served as controls. Thirty- and 90-day re-hospitalization, ED re-visits, heart failure symptoms, mortality, and health care costs were recorded.
    Results: Despite guideline-based education and follow-up, the rate of ED re-visits was not different between the groups. However, the rate of re-hospitalization was significantly lower in patients receiving the intervention compared with controls (odds ratio 0.592), driven by a reduction in the risk of readmission from the ED (0.56 vs 0.79, respectively). Patients receiving the intervention accumulated 14% fewer re-hospitalized days than controls and 57% lower 30-day total health care cost. Despite the reduction in health care resource consumption, mortality was unchanged. After accounting for the total cost of intervention delivery, the health care cost savings was substantially greater than the cost of intervention delivery.
    Conclusion: Early consultation with a cardiologist in the ED as an adjunct to guideline-based follow-up is associated with reduced re-hospitalization and health care cost for low-socioeconomic urban patients with acute decompensated heart failure.
    MeSH term(s) Acute Disease ; Aged ; Cardiology/economics ; Cardiology/methods ; Cardiology/standards ; Case-Control Studies ; Chicago ; Cost Control/methods ; Cost Control/standards ; Emergency Service, Hospital/economics ; Emergency Service, Hospital/organization & administration ; Emergency Service, Hospital/utilization ; Female ; Heart Failure/economics ; Heart Failure/therapy ; Humans ; Male ; Middle Aged ; Organizational Case Studies ; Patient Discharge/economics ; Patient Discharge/standards ; Patient Discharge/statistics & numerical data ; Patient Education as Topic/economics ; Patient Education as Topic/methods ; Patient Education as Topic/organization & administration ; Patient Readmission/economics ; Patient Readmission/statistics & numerical data ; Practice Guidelines as Topic ; Propensity Score ; Referral and Consultation/economics ; Referral and Consultation/standards ; Retrospective Studies ; Socioeconomic Factors ; Tertiary Care Centers/economics ; Tertiary Care Centers/organization & administration ; Urban Health/economics ; Urban Health/statistics & numerical data
    Language English
    Publishing date 2017-04-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80015-6
    ISSN 1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
    ISSN (online) 1555-7162 ; 1873-2178
    ISSN 0002-9343 ; 1548-2766
    DOI 10.1016/j.amjmed.2017.03.044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.289: Show issues Location:
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  5. Article ; Online: Elevated Angiopoietin-2 Level in Patients With Continuous-Flow Left Ventricular Assist Devices Leads to Altered Angiogenesis and Is Associated With Higher Nonsurgical Bleeding.

    Tabit, Corey E / Chen, Phetcharat / Kim, Gene H / Fedson, Savitri E / Sayer, Gabriel / Coplan, Mitchell J / Jeevanandam, Valluvan / Uriel, Nir / Liao, James K

    Circulation

    2016  Volume 134, Issue 2, Page(s) 141–152

    Abstract: Background: Nonsurgical bleeding is the most common adverse event in patients with continuous-flow left ventricular assist devices (LVADs) and is caused by arteriovenous malformations. We hypothesized that deregulation of an angiogenic factor, ... ...

    Abstract Background: Nonsurgical bleeding is the most common adverse event in patients with continuous-flow left ventricular assist devices (LVADs) and is caused by arteriovenous malformations. We hypothesized that deregulation of an angiogenic factor, angiopoietin-2 (Ang-2), in patients with LVADs leads to increased angiogenesis and higher nonsurgical bleeding.
    Methods: Ang-2 and thrombin levels were measured by ELISA and Western blotting, respectively, in blood samples from 101 patients with heart failure, LVAD, or orthotopic heart transplantation. Ang-2 expression in endothelial biopsy was quantified by immunofluorescence. Angiogenesis was determined by in vitro tube formation from serum from each patient with or without Ang-2-blocking antibody. Ang-2 gene expression was measured by reverse transcription-polymerase chain reaction in endothelial cells incubated with plasma from each patient with or without the thrombin receptor blocker vorapaxar.
    Results: Compared with patients with heart failure or those with orthotopic heart transplantation, serum levels and endothelial expression of Ang-2 were higher in LVAD patients (P=0.001 and P<0.001, respectively). This corresponded to an increased angiogenic potential of serum from patients with LVADs (P<0.001), which was normalized with Ang-2 blockade. Furthermore, plasma from LVAD patients contained higher amounts of thrombin (P=0.003), which was associated with activation of the contact coagulation system. Plasma from LVAD patients induced more Ang-2 gene expression in endothelial cells (P<0.001), which was reduced with thrombin receptor blockade (P=0.013). LVAD patients with Ang-2 levels above the mean (12.32 ng/mL) had more nonsurgical bleeding events compared with patients with Ang-2 levels below the mean (P=0.003).
    Conclusions: Our findings indicate that thrombin-induced Ang-2 expression in LVAD patients leads to increased angiogenesis in vitro and may be associated with higher nonsurgical bleeding events. Ang-2 therefore may contribute to arteriovenous malformation formation and subsequent bleeding in LVAD patients.
    MeSH term(s) Aged ; Angiopoietin-2/biosynthesis ; Angiopoietin-2/blood ; Angiopoietin-2/genetics ; Arteriovenous Malformations/complications ; Biomarkers ; Cross-Sectional Studies ; Endothelial Cells/metabolism ; Female ; Heart-Assist Devices ; Hemorrhage/etiology ; Human Umbilical Vein Endothelial Cells ; Humans ; Male ; Middle Aged ; Neovascularization, Pathologic/blood ; Neovascularization, Pathologic/etiology ; Neovascularization, Pathologic/physiopathology ; Thrombin/pharmacology
    Chemical Substances Angiopoietin-2 ; Biomarkers ; Thrombin (EC 3.4.21.5)
    Language English
    Publishing date 2016-07-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.115.019692
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ui IV Zs.60: Show issues Location:
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