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  1. Article ; Online: Students Satisfaction with the Use of PlayDoh® as a Tool to Actively Learn 3D Veterinary Anatomy More Accurately.

    De Melo, Mariana Pereira / Stead, Rachel / Lygo-Baker, Simon / Coppi, A Augusto

    Medical science educator

    2023  Volume 33, Issue 6, Page(s) 1371–1378

    Abstract: Understanding veterinary anatomy is an essential skill for the study of veterinary medicine as well as for diagnostic imaging and therapy. Dissection facilities are increasingly limited in some schools and its alternatives have often focussed on using ... ...

    Abstract Understanding veterinary anatomy is an essential skill for the study of veterinary medicine as well as for diagnostic imaging and therapy. Dissection facilities are increasingly limited in some schools and its alternatives have often focussed on using two-dimensional images. However, the study of veterinary anatomy is mainly concerned with identifying structures and spatial relationships between them within a 3D space, and the use of 2D teaching approaches does not provide accurate information. We tested whether PlayDoh
    Supplementary information: The online version contains supplementary material available at 10.1007/s40670-023-01892-y.
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-023-01892-y
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  2. Article ; Online: Comparison of volume of the forebrain, subarachnoid space and lateral ventricles between dogs with idiopathic epilepsy and controls using a stereological approach: Cavalieri's principle.

    Watson, Fraje / Coppi, A Augusto / Volk, Holger A / Packer, Rowena M A / Tauro, Anna / Rusbridge, Clare

    Canine medicine and genetics

    2021  Volume 8, Issue 1, Page(s) 3

    Abstract: Background: Canine idiopathic epilepsy (IE) is the most common chronic neurological brain disease in dogs, yet it can only be diagnosed by exclusion of all other potential causes. In people, epilepsy has been associated with a reduction in brain volume. ...

    Abstract Background: Canine idiopathic epilepsy (IE) is the most common chronic neurological brain disease in dogs, yet it can only be diagnosed by exclusion of all other potential causes. In people, epilepsy has been associated with a reduction in brain volume. The objective was to estimate the volume of the forebrain (FB), subarachnoid space (SAS) and lateral ventricles (LV) in dogs with IE compared to controls using Cavalieri's principle. MRI scans of case and control dogs were identified from two neurology referral hospital databases. Eight breeds with increased odds of having IE were included: Golden Retriever, Labrador Retriever, Cocker Spaniel, Border terrier, German Shepherd dog, Parson Jack Russell terrier, Boxer, and Border Collie. Five dogs of each breed with IE and up to five controls were systematically and uniformly randomly sampled (SURS). The volume of the FB, SAS and LV were estimated from MRI scans by one blinded observer using Cavalieri's principle.
    Results: One hundred-two dogs were identified; 56 were diagnosed with IE and 46 were controls. There was no statistically significant difference in FB, SAS and LV volume between dogs with IE and controls. Dogs with a history of status epilepticus had significantly larger FB than those without (p = 0.05). There was a border-line trend for LV volume to increase with increasing length of seizure history in the IE group (p = 0.055).
    Conclusion: The volumes of the FB, SAS and LV are not different between dogs with IE and controls, so IE remains a diagnosis of exclusion with no specific neuroanatomical biomarkers identified. This is the first time FB and SAS volume has been compared in dogs with IE. Unfortunately, we have shown that the results reporting significantly larger FBs in dogs with status epilepticus and LV volume increase with length of seizure history were likely confounded by breed and should be interpreted cautiously. Whilst these associations are interesting and clinically relevant, further investigation with breed-specific or larger, breed-diverse populations are required to permit strong conclusions. The Cavalieri principle provided an effective estimation of FB, SAS and LV volumes on MRI, but may be too time-intensive for use in clinical practice.
    Language English
    Publishing date 2021-03-10
    Publishing country England
    Document type Journal Article
    ISSN 2662-9380
    ISSN (online) 2662-9380
    DOI 10.1186/s40575-021-00101-6
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  3. Article: Stereological and allometric studies on neurons and axo-dendritic synapses in superior cervical ganglia.

    Ladd, Fernando V Lobo / Ladd, Aliny A B Lobo / da Silva, Andrea A P / Coppi, A Augusto

    International review of cell and molecular biology

    2014  Volume 311, Page(s) 123–155

    Abstract: The superior cervical ganglion (SCG) plays an important role in neuropathies including Horner's syndrome, stroke, and epilepsy. While mammalian SCGs seem to share certain organizational features, they display natural differences related to the animal ... ...

    Abstract The superior cervical ganglion (SCG) plays an important role in neuropathies including Horner's syndrome, stroke, and epilepsy. While mammalian SCGs seem to share certain organizational features, they display natural differences related to the animal size and side and the complexity and synaptic coverage of their dendritic arborizations. However, apart from the rat SCG, there is little information concerning the number of SCG neurons and synapses, and the nature of relationships between body weight and the numbers and sizes of neurons and synapses remain uncertain. In the recognition of this gap in the literature, in this chapter, we reviewed the current knowledge on the SCG structure and its remodeling during postnatal development across a plethora of large mammalian species, focusing on exotic rodents and domestic animals. Instrumentally, we present stereology as a state-of-the-art 3D technology to assess the SCG 3D structure unbiasedly and suggest future research directions on this topic.
    MeSH term(s) Aging ; Animals ; Axons/metabolism ; Dendrites/metabolism ; Superior Cervical Ganglion/anatomy & histology ; Synapses/metabolism
    Language English
    Publishing date 2014
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2427220-6
    ISSN 1937-6448 ; 0074-7696
    ISSN 1937-6448 ; 0074-7696
    DOI 10.1016/B978-0-12-800179-0.00002-7
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.317: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Stereology shows that damaged liver recovers after protein refeeding.

    Gomes, Silvio Pires / da Silva, Andréa Almeida Pinto / Crisma, Amanda Rabello / Borelli, Primavera / Hernandez-Blazquez, Francisco Javier / de Melo, Mariana P / Bacci, Barbara / Loesch, Andrzej / Coppi, A Augusto

    Nutrition (Burbank, Los Angeles County, Calif.)

    2017  Volume 38, Page(s) 61–69

    Abstract: Objective: The aim of the present study was to investigate the putative effects of a low-protein diet on the three-dimensional structure of hepatocytes and determine whether this scenario could be reversed by restoring the adequate levels of protein to ... ...

    Abstract Objective: The aim of the present study was to investigate the putative effects of a low-protein diet on the three-dimensional structure of hepatocytes and determine whether this scenario could be reversed by restoring the adequate levels of protein to the diet.
    Methods: Using design-based stereology, the total number and volume of hepatocytes were estimated in the liver of mice in healthy and altered (by protein malnutrition) conditions and after protein renutrition.
    Results: This study demonstrated a 65% decrease in the liver volume (3302 mm
    Conclusions: Awareness of these data will add to a better morphologic understanding of malnutrition-induced hepatopathies and will help clinicians improve the diagnosis and treatment of this condition in humans and in veterinary practice.
    Language English
    Publishing date 2017-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639259-3
    ISSN 1873-1244 ; 0899-9007
    ISSN (online) 1873-1244
    ISSN 0899-9007
    DOI 10.1016/j.nut.2017.02.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2290: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

    Patrick, Alison / Seluanov, Michael / Hwang, Chaewon / Tam, Jonathan / Khan, Tanya / Morgenstern, Ari / Wiener, Lauren / Vazquez, Juan M / Zafar, Hiba / Wen, Robert / Muratkalyeva, Malika / Doerig, Katherine / Zagorulya, Maria / Cole, Lauren / Catalano, Sophia / Lobo Ladd, Aliny Ab / Coppi, A Augusto / Coşkun, Yüksel / Tian, Xiao /
    Ablaeva, Julia / Nevo, Eviatar / Gladyshev, Vadim N / Zhang, Zhengdong D / Vijg, Jan / Seluanov, Andrei / Gorbunova, Vera

    Aging

    2016  Volume 8, Issue 5, Page(s) 841–847

    Abstract: Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused ... ...

    Abstract Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the striking difference in oxygen sensitivity between mouse and human cells explains their different rates of aging. To test if this hypothesis is broadly applicable, we cultured cells from 16 rodent species with diverse lifespans in 3% and 21% oxygen and compared their growth rates. Unexpectedly, fibroblasts derived from laboratory mouse strains were the only cells demonstrating extreme sensitivity to oxygen. Cells from hamster, muskrat, woodchuck, capybara, blind mole rat, paca, squirrel, beaver, naked mole rat and wild-caught mice were mildly sensitive to oxygen, while cells from rat, gerbil, deer mouse, chipmunk, guinea pig and chinchilla showed no difference in the growth rate between 3% and 21% oxygen. We conclude that, although the growth of primary fibroblasts is generally improved by maintaining cells in 3% oxygen, the extreme oxygen sensitivity is a peculiarity of laboratory mouse strains, possibly related to their very long telomeres, and fibroblast oxygen sensitivity does not directly correlate with species' lifespan.
    MeSH term(s) Animals ; Cells, Cultured ; Cellular Senescence/drug effects ; Cellular Senescence/physiology ; Fibroblasts/cytology ; Fibroblasts/drug effects ; Longevity/physiology ; Oxidative Stress ; Oxygen/administration & dosage ; Species Specificity ; Telomere/physiology
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.100958
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