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  1. Article ; Online: Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective?

    Coppola, Maurizio / Bevione, Francesco / Mondola, Raffaella

    Journal of xenobiotics

    2022  Volume 12, Issue 1, Page(s) 41–52

    Abstract: Psychedelics extracted from plants have been used in religious, spiritual, and mystic practices for millennia. In 1957, Dr. Hofmann identified and synthesized the prodrug psilocybin, a substance present in more than 200 species of psychedelic mushrooms. ... ...

    Abstract Psychedelics extracted from plants have been used in religious, spiritual, and mystic practices for millennia. In 1957, Dr. Hofmann identified and synthesized the prodrug psilocybin, a substance present in more than 200 species of psychedelic mushrooms. Although there were limitations related to the scientific design of many studies, clinical observations performed during the 1950s and 1960s showed a potential therapeutic effect of psilocybin for patients affected by depressive symptoms, anxiety, and conversion disorder. Psilocybin was classed as a schedule I substance in 1970, but the fascination with psychedelics has remained almost unchanged over time, promoting a new scientific interest starting in the 1990s. Recent studies have provided further evidence supporting the suggestive hypothesis of the therapeutic use of psilocybin for treating various psychiatric disorders, including pathological anxiety, mood depressive disorder, and addiction.
    Language English
    Publishing date 2022-02-07
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2649720-7
    ISSN 2039-4713 ; 2039-4713
    ISSN (online) 2039-4713
    ISSN 2039-4713
    DOI 10.3390/jox12010004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Potential pharmacological perspectives for the treatment/prevention of the SARS-COV-2 infection in opioid dependent patients.

    Coppola, Maurizio / Mondola, Raffaella

    Journal of opioid management

    2020  Volume 16, Issue 3, Page(s) 165–166

    MeSH term(s) Analgesics, Opioid ; Betacoronavirus ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Humans ; Opioid-Related Disorders ; Pandemics/prevention & control ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/prevention & control
    Chemical Substances Analgesics, Opioid
    Keywords covid19
    Language English
    Publishing date 2020-05-12
    Publishing country United States
    Document type Letter
    ZDB-ID 2397614-7
    ISSN 1551-7489
    ISSN 1551-7489
    DOI 10.5055/jom.2020.0564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Opioid receptor antagonists and major depressive disorder: Current knowledge and future perspectives.

    Coppola, Maurizio / Mondola, Raffaella

    Medical hypotheses

    2020  Volume 144, Page(s) 110215

    MeSH term(s) Analgesics, Opioid/therapeutic use ; Depressive Disorder, Major/drug therapy ; Humans ; Narcotic Antagonists/therapeutic use ; Receptors, Opioid, kappa ; Receptors, Opioid, mu/therapeutic use
    Chemical Substances Analgesics, Opioid ; Narcotic Antagonists ; Receptors, Opioid, kappa ; Receptors, Opioid, mu
    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.110215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Phytotherapeutics and SARS-CoV-2 infection: Potential role of bioflavonoids.

    Coppola, Maurizio / Mondola, Raffaella

    Medical hypotheses

    2020  Volume 140, Page(s) 109766

    Keywords covid19
    Language English
    Publishing date 2020-04-22
    Publishing country United States
    Document type Letter
    ZDB-ID 193145-3
    ISSN 1532-2777 ; 0306-9877
    ISSN (online) 1532-2777
    ISSN 0306-9877
    DOI 10.1016/j.mehy.2020.109766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Potential Unconventional Medicines for the Treatment of SARS-CoV-2.

    Coppola, Maurizio / Mondola, Raffaella

    Drug research

    2020  Volume 70, Issue 6, Page(s) 286

    MeSH term(s) Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Repositioning/methods ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-19
    Publishing country Germany
    Document type Letter
    ZDB-ID 2703847-6
    ISSN 2194-9387 ; 2194-9379
    ISSN (online) 2194-9387
    ISSN 2194-9379
    DOI 10.1055/a-1170-4624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Impulsivity in Alcohol-Dependent Patients with and without ADHD: The Role of Atomoxetine.

    Coppola, Maurizio / Mondola, Raffaella

    Journal of psychoactive drugs

    2018  Volume 50, Issue 4, Page(s) 361–366

    Abstract: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of hyperactivity, inattention, and impulsivity. As shown in the literature, this disorder is frequently associated with alcohol and drug abuse. ... ...

    Abstract Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by symptoms of hyperactivity, inattention, and impulsivity. As shown in the literature, this disorder is frequently associated with alcohol and drug abuse. Patients affected by ADHD show high levels of impulsivity and sensation seeking. These characteristics can significantly increase the risk of alcohol abuse, which is itself a clinical condition associated with high levels of impulsivity. Clinical studies suggest that atomoxetine is effective and safe in patients affected by both ADHD and alcohol dependence; however, information focused specifically on impulsivity is very limited. In an open-label study, we evaluated the difference in impulsivity level between alcohol-dependent patients with and without a diagnosis of ADHD. Furthermore, we hypothesized that, in patients with ADHD, atomoxetine could reduce the impulsivity trait.
    MeSH term(s) Adrenergic Uptake Inhibitors/administration & dosage ; Adrenergic Uptake Inhibitors/adverse effects ; Adult ; Aged ; Alcoholism/epidemiology ; Alcoholism/psychology ; Atomoxetine Hydrochloride/administration & dosage ; Atomoxetine Hydrochloride/adverse effects ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Attention Deficit Disorder with Hyperactivity/psychology ; Female ; Humans ; Impulsive Behavior/drug effects ; Male ; Middle Aged ; Young Adult
    Chemical Substances Adrenergic Uptake Inhibitors ; Atomoxetine Hydrochloride (57WVB6I2W0)
    Language English
    Publishing date 2018-06-07
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2018.1471247
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Are physicians fully aware of the potential transgenerational and multigenerational effects of a large opioid misuse in the population?

    Coppola, Maurizio / Mondola, Raffaella

    Journal of opioid management

    2018  Volume 14, Issue 4, Page(s) 237

    MeSH term(s) Awareness ; Humans ; Opioid-Related Disorders/epidemiology ; Opioid-Related Disorders/therapy ; Physicians
    Language English
    Publishing date 2018-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2397614-7
    ISSN 1551-7489
    ISSN 1551-7489
    DOI 10.5055/jom.2018.0454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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