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Article ; Online: Wide-field optical coherence tomography for microstructural analysis of key tissue types: a proof-of-concept evaluation.

Rabindran, Beryl / Corben, Adriana D

2023 Volume 29, Page(s) 1611167

Abstract: Introduction: ...

Abstract	Introduction:
MeSH term(s)	Humans ; Tomography, Optical Coherence/methods ; Margins of Excision
Language	English
Publishing date	2023-07-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1375979-6
ISSN	1532-2807 ; 1219-4956
ISSN (online)	1532-2807
ISSN	1219-4956
DOI	10.3389/pore.2023.1611167
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Article ; Online: Pathology of invasive breast disease.

Corben, Adriana D

The Surgical clinics of North America

2013 Volume 93, Issue 2, Page(s) 363–392

Abstract: Invasive breast cancers constitute a heterogeneous group of lesions. Although the most common types are ductal and lobular, this distinction is not meant to indicate the site of origin within the mammary ductal system. The main purpose of the ... ...

Abstract	Invasive breast cancers constitute a heterogeneous group of lesions. Although the most common types are ductal and lobular, this distinction is not meant to indicate the site of origin within the mammary ductal system. The main purpose of the identification of specific types of invasive breast carcinoma is to refine the prediction of likely behavior and response to treatment also offered by the other major prognostic factors, including lymph node stage, histologic grade, tumor size, and lymphovascular invasion.
MeSH term(s)	Adenocarcinoma, Mucinous/pathology ; Adenocarcinoma, Papillary/pathology ; Biomarkers, Tumor/metabolism ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carcinoma, Adenoid Cystic/pathology ; Carcinoma, Neuroendocrine/pathology ; Female ; Humans ; Neoplasm Invasiveness ; Neoplasms, Ductal, Lobular, and Medullary/pathology ; Prognosis ; Tumor Burden
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2013-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	215713-5
ISSN	1558-3171 ; 0039-6109
ISSN (online)	1558-3171
ISSN	0039-6109
DOI	10.1016/j.suc.2013.01.003
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Article ; Online: Measuring Invasive Breast Carcinoma on Core Biopsy-Is It Necessary?

Liang, Yuanxin / Oza, Twisha / Corben, Adriana / Zeizafoun, Nebras / Alexander, Melissa / Jaffer, Shabnam

Archives of pathology & laboratory medicine

2021 Volume 145, Issue 11, Page(s) 1432–1437

Abstract: Context.—: Pathologic tumor size is significant in the treatment of breast carcinoma and is routinely measured on excision.: Objective.—: To analyze the need for measuring size of invasive mammary carcinoma on biopsy.: Design.—: Nine hundred ... ...

Abstract	Context.—: Pathologic tumor size is significant in the treatment of breast carcinoma and is routinely measured on excision. Objective.—: To analyze the need for measuring size of invasive mammary carcinoma on biopsy. Design.—: Nine hundred twenty-two cases of invasive carcinoma whose size was measured (greatest linear measurement) on biopsy and excision was correlated, including imaging when available (110 cases). Results.—: Patient mean age was 62 years. Most (90%; 830 of 922) carcinomas were ductal and sampled by ultrasound and graded as follows: well, 13% (113 of 922); moderately, 58% (532 of 922), and poorly differentiated, 28% (258 of 922); 19 microinvasive not graded. Tumor mean size was 7.5 mm on biopsy and 14.4 mm on excision. Biopsy modality was as follows: ultrasound, 7.8 mm (92%, 844 of 922); mammotome, 3.3 mm (7%, 65 of 922); and magnetic resonance imaging, 5.9 mm (1%, 13 of 922). Size comparison on biopsy versus excision was biopsy > excision: 8% (72 of 922), biopsy = excision: 10% (95 of 922), and biopsy < excision: 82% (755 of 922). Half (36 of 72) of the biopsy > excision tumors were less than 5 mm, 96% (726 of 755) of biopsy < excision tumors were greater than 5 mm, while those equal on both were predominantly (88%, 84 of 95) less than 10 mm, 20% (19 of 95) of which were microinvasive. Stage changed in 600 cases, staging based on excision in 581 (63%), and staging based on biopsy in 19 (2%). Radiologic-pathologic correlation (n = 110) showed perfect concordance in 11 (10%), 83 (75%) were ±1 to 2 mm, and 16 (15%) were ± more than 3 mm. Difference between the biopsy and excision ranged from a lower limit of 1.3 mm for T1a tumors to 18 mm for T2. Conclusions.—: While most carcinomas are larger on excision, 18% (167 of 922) are larger or equal on biopsy. Factors predictive of biopsy > excision tumors include stage 1 tumors (P < .001), especially less than 5 mm, and sampled by mammotome. We recommend measuring invasive carcinoma on biopsy and excision.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Biopsy, Large-Core Needle ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/diagnostic imaging ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Ductal, Breast/surgery ; Carcinoma, Intraductal, Noninfiltrating/diagnostic imaging ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Carcinoma, Intraductal, Noninfiltrating/surgery ; Carcinoma, Lobular/diagnostic imaging ; Carcinoma, Lobular/pathology ; Carcinoma, Lobular/surgery ; Cell Differentiation ; Databases, Factual ; Female ; Humans ; Middle Aged ; Neoplasm Invasiveness ; Predictive Value of Tests ; Retrospective Studies ; Tumor Burden
Language	English
Publishing date	2021-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	194119-7
ISSN	1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
ISSN (online)	1543-2165
ISSN	0363-0153 ; 0096-8528 ; 0003-9985
DOI	10.5858/arpa.2020-0287-OA
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Article ; Online: Acinic cell carcinoma of breast: morphologic and immunohistochemical review of a rare breast cancer subtype.

Conlon, Niamh / Sadri, Navid / Corben, Adriana D / Tan, Lee K

Human pathology

2016 Volume 51, Page(s) 16–24

Abstract: Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and ... ...

Abstract	Acinic cell carcinoma of breast is a rare subtype of triple-negative breast carcinoma and demonstrates extensive morphologic overlap with acinic cell carcinoma of the salivary gland. In this study, we perform a detailed morphologic and immunohistochemical description of 2 cases of this rare entity and undertake a comprehensive review of all reported cases of breast acinic cell carcinoma in the English language literature to date. One-third of reported cases of breast acinic cell carcinoma have been associated with the presence of a ductal carcinoma not otherwise specified component, which is frequently poorly differentiated. Breast acinic cell carcinoma can demonstrate focal morphologic features similar to microglandular adenosis; these areas are frequently negative for collagen IV and laminin on immunohistochemistry. The true relationship between these 2 entities remains unclear, but we advocate that microglandular adenosis-like areas at the periphery of a breast acinic cell carcinoma should be considered part of the carcinomatous process and re-excised if this process extends to the initial surgical margins.
MeSH term(s)	Breast Neoplasms/pathology ; Carcinoma, Acinar Cell/pathology ; Female ; Fibrocystic Breast Disease/pathology ; Humans ; Immunohistochemistry ; Middle Aged ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	207657-3
ISSN	1532-8392 ; 0046-8177
ISSN (online)	1532-8392
ISSN	0046-8177
DOI	10.1016/j.humpath.2015.12.014
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Article: Use of Myoepithelial Cell Markers in the Differential Diagnosis of Benign, In situ, and Invasive Lesions of the Breast.

Corben, Adriana D / Lerwill, Melinda F

Surgical pathology clinics

2009 Volume 2, Issue 2, Page(s) 351–373

Abstract: Immunohistochemical markers for myoepithelial cells are commonly used to distinguish invasive from noninvasive lesions in the breast. The approach takes advantage of the fact that conventional invasive carcinomas lack surrounding myoepithelial cells, ... ...

Abstract	Immunohistochemical markers for myoepithelial cells are commonly used to distinguish invasive from noninvasive lesions in the breast. The approach takes advantage of the fact that conventional invasive carcinomas lack surrounding myoepithelial cells, whereas nearly all benign lesions and in situ carcinomas retain their myoepithelial cell layer. Although conceptually straightforward, the interpretation of myoepithelial cell markers can be complicated by misleading patterns of reactivity (such as stromal or tumor cell staining) or lack of reactivity (due to reduced numbers of myoepithelial cells or variable antigenicity). In this article, we discuss the advantages and disadvantages of commonly used myoepithelial cell markers, their general utility in distinguishing invasive from noninvasive processes, and pitfalls in their interpretation. We also examine whether the detection of myoepithelial cells is helpful in the evaluation of papillary lesions, another common application. Myoepithelial cell markers can be diagnostically useful in the distinction of many benign, in situ, and invasive lesions, but they must be interpreted in conjunction with careful morphologic analysis.
Language	English
Publishing date	2009-06
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1875-9181
ISSN	1875-9181
DOI	10.1016/j.path.2009.02.003
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Article: Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation.

McNutt, Seth W / Roychowdhury, Tanaya / Pasala, Chiranjeevi / Nguyen, Hieu T / Thornton, Daniel T / Sharma, Sahil / Botticelli, Luke / Digwal, Chander S / Joshi, Suhasini / Yang, Nan / Panchal, Palak / Chakrabarty, Souparna / Bay, Sadik / Markov, Vladimir / Kwong, Charlene / Lisanti, Jeanine / Chung, Sun Young / Ginsberg, Stephen D / Yan, Pengrong /

DeStanchina, Elisa / Corben, Adriana / Modi, Shanu / Alpaugh, Mary / Colombo, Giorgio / Erdjument-Bromage, Hediye / Neubert, Thomas A / Chalkley, Robert J / Baker, Peter R / Burlingame, Alma L / Rodina, Anna / Chiosis, Gabriela / Chu, Feixia

Research square

2024

Abstract: The intricate protein-chaperone network is vital for cellular function. Recent discoveries have unveiled the existence of specialized chaperone complexes called epichaperomes, protein assemblies orchestrating the reconfiguration of protein-protein ... ...

Abstract	The intricate protein-chaperone network is vital for cellular function. Recent discoveries have unveiled the existence of specialized chaperone complexes called epichaperomes, protein assemblies orchestrating the reconfiguration of protein-protein interaction networks, enhancing cellular adaptability and proliferation. This study delves into the structural and regulatory aspects of epichaperomes, with a particular emphasis on the significance of post-translational modifications in shaping their formation and function. A central finding of this investigation is the identification of specific PTMs on HSP90, particularly at residues Ser226 and Ser255 situated within an intrinsically disordered region, as critical determinants in epichaperome assembly. Our data demonstrate that the phosphorylation of these serine residues enhances HSP90's interaction with other chaperones and co-chaperones, creating a microenvironment conducive to epichaperome formation. Furthermore, this study establishes a direct link between epichaperome function and cellular physiology, especially in contexts where robust proliferation and adaptive behavior are essential, such as cancer and stem cell maintenance. These findings not only provide mechanistic insights but also hold promise for the development of novel therapeutic strategies targeting chaperone complexes in diseases characterized by epichaperome dysregulation, bridging the gap between fundamental research and precision medicine.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-4114038/v1
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Article ; Online: Evaluation of surgically excised breast tissue microstructure using wide-field optical coherence tomography.

Schmidt, Hank / Connolly, Courtney / Jaffer, Shabnam / Oza, Twisha / Weltz, Christina R / Port, Elisa R / Corben, Adriana

The breast journal

2019 Volume 26, Issue 5, Page(s) 917–923

Abstract: Background: Currently, positive margins at lumpectomy contribute to health care cost, patient anxiety, and treatment delay. Multiple technology solutions are being explored with the aim of lowering re-excision rates for breast-conserving surgery (BCS). ... ...

Abstract	Background: Currently, positive margins at lumpectomy contribute to health care cost, patient anxiety, and treatment delay. Multiple technology solutions are being explored with the aim of lowering re-excision rates for breast-conserving surgery (BCS). We examined wide-field optical coherence tomography (WF-OCT), an innovative adjunct intraoperative imaging tool for tissue visualization of margins. Methods: This IRB-approved pilot study included women with invasive or in situ carcinoma scheduled for primary BCS. Lumpectomy specimens and any final/revised margins were imaged by optical coherence tomography immediately prior to standard histological processing. The optical coherence tomography used provided two-dimensional, cross-sectional, real-time depth visualization of the margin widths around excised specimens. A volume of images was captured for 10 × 10 cm tissue surface at high resolution (sub-30 μm) to a depth of 2 mm. Integrated interpretation was performed incorporating final pathology linked with the optical image data for correlation. Results: Wide-field optical coherence tomography was performed on 185 tissue samples (50 lumpectomy specimens and 135 additional margin shaves) in 50 subjects. Initial diagnosis was invasive ductal carcinoma (IDC) in 10, ductal carcinoma in situ (DCIS) in 14, IDC/DCIS in 22, invasive lobular carcinoma (ILC) in 2, ILC/DCIS in 1, and sarcoma in 1. Optical coherence tomography was concordant with final pathology in 178/185 tissue samples for overall accuracy of 86% and 96.2% (main specimen alone and main specimen + shave margins). Of seven samples that were discordant, 57% (4/7) were considered close (DCIS < 2 mm from margin) per final pathology. Conclusion: Wide-field optical coherence tomography demonstrated concordance with histology at tissue margins, supporting its potential for use as a real-time adjunct intraoperative imaging tool for margin assessment. Further studies are needed for comprehensive evaluation in the intraoperative setting.
MeSH term(s)	Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Carcinoma, Ductal, Breast/surgery ; Cross-Sectional Studies ; Female ; Humans ; Mastectomy, Segmental ; Pilot Projects ; Tomography, Optical Coherence
Language	English
Publishing date	2019-10-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.13663
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Article ; Online: Response in breast vs axilla after neoadjuvant treatment and implications for nonoperative management of invasive breast cancer.

Schmidt, Hank / Zhaveri, Shruti / Valente, Christopher / Pisapati, Kereeti / Pickholz, Eliana / Weltz, Sarah / Nayak, Anupma / Oza, Twisha / Corben, Adriana / Weltz, Christina / Port, Elisa / Jaffer, Shabnam

The breast journal

2021 Volume 27, Issue 2, Page(s) 120–125

Abstract: Improved imaging and neoadjuvant chemotherapy (NAT) have led to higher pathologic complete response rates (pCR) in patients with invasive breast cancer. This has questioned the necessity of surgery and axillary lymph node (ALN) dissection in these ... ...

Abstract	Improved imaging and neoadjuvant chemotherapy (NAT) have led to higher pathologic complete response rates (pCR) in patients with invasive breast cancer. This has questioned the necessity of surgery and axillary lymph node (ALN) dissection in these patients. Prospective clinical trials are implementing extensive core biopsies of the tumor bed of patients with clinical complete response as a means to identify and spare them breast surgery. In addition, it is anticipated that patients with pCR are most likely going to have no or minimal disease in ALN as well. To verify the feasibility of these trials, we performed a pathologic analysis of all our patients who have undergone NAT from 2009 to present. Using pathology data base, we identified 362 patients treated with neoadjuvant chemotherapy followed by surgery. Clinical and pathologic information including gross and microscopic descriptions as well as biomarker status was collected. pCR was 50% for patients with negative ALN pretreatment but only 28% for patients with positive ALN at diagnosis. Despite achieving pCR in the breast, up to 10% of patients with positive ALN and 1% with negative ALN had persistent disease. Eight percent of patients that were presumed to have no ALN disease either clinically and or by imaging were found to have metastatic carcinoma in ALN. The metastases were predominantly (80%) <5 mm, and not palpable on physical examination and or due to biopsy sampling error. pCR in breast and ALN directly correlated with tumor size, ALN disease, and Her2 positive and triple negative receptor phenotype. In breast cancer patients who are node positive at time of diagnosis with pCR in the breast after neoadjuvant chemotherapy, residual lymph node disease was very uncommon. Further study is warranted to select patients who may avoid breast and axillary surgery post neoadjuvant chemotherapy.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols ; Axilla ; Breast Neoplasms/drug therapy ; Breast Neoplasms/surgery ; Female ; Humans ; Lymph Nodes ; Lymphatic Metastasis ; Neoadjuvant Therapy ; Prospective Studies ; Sentinel Lymph Node Biopsy
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.14125
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Article ; Online: Breast Carcinoma in Young Women: No Evidence of Increasing Rates of Metastatic Breast Carcinoma in a Single Tertiary Center Review.

Conlon, Niamh / Howard, Jane / Catalano, Jeffrey / Gallagher, Meighan / Tan, Lee K / Corben, Adriana D

The breast journal

2016 Volume 22, Issue 3, Page(s) 287–292

Abstract: Breast carcinoma in young women aged less than 40 years attracts a high level of mainstream media coverage, and there is a gap between societal perceptions of the disease as a growing problem and epidemiological trends. Several population studies have ... ...

Abstract	Breast carcinoma in young women aged less than 40 years attracts a high level of mainstream media coverage, and there is a gap between societal perceptions of the disease as a growing problem and epidemiological trends. Several population studies have reported that the overall incidence of breast carcinoma in young women is stable, while one recent article suggested that the relative proportion of breast carcinoma in young women that is metastatic at diagnosis is growing. We sought to establish whether these trends were apparent at our institution. In this study, the clinical database at a breast carcinoma tertiary center was reviewed in terms of clinicopathologic data on patient age, diagnosis, clinical and pathologic stage, hormone receptor status, and HER-2 overexpression status for the period 2000-2011. Over the study period, young patients represented a decreasing proportion of all breast carcinoma cases (10.8% [2000-2003] to 8.7% [2008-2011]; p < 0.0001) treated at our institution. Young patients were more likely than patients aged 40 years or older to present with metastatic (M1) disease (5.4% versus 4.4%; p = 0.009), to be triple negative (21.6% versus 13%; p < 0.001), or to be HER-2 positive (24.3% versus 14.8%; p < 0.01). Young patients with HER-2-positive cancers were significantly more likely to present with metastatic disease (8.3% versus 4.8%; p = 0.004). This study showed no demonstrable increase in the relative proportion of breast cancer occurring in patients aged <40 years over the 12-year period 2000-2011 and no increase in the proportion of young patients presenting with metastatic disease.
MeSH term(s)	Adult ; Breast Neoplasms/epidemiology ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology ; Carcinoma, Intraductal, Noninfiltrating/epidemiology ; Carcinoma, Intraductal, Noninfiltrating/pathology ; Female ; Genetic Testing/statistics & numerical data ; Humans ; Receptor, ErbB-2/metabolism ; Retrospective Studies ; Tertiary Care Centers/statistics & numerical data
Chemical Substances	ERBB2 protein, human (EC 2.7.10.1) ; Receptor, ErbB-2 (EC 2.7.10.1)
Language	English
Publishing date	2016-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1289960-4
ISSN	1524-4741 ; 1075-122X
ISSN (online)	1524-4741
ISSN	1075-122X
DOI	10.1111/tbj.12575
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Article ; Online: Chaperome heterogeneity and its implications for cancer study and treatment.

Wang, Tai / Rodina, Anna / Dunphy, Mark P / Corben, Adriana / Modi, Shanu / Guzman, Monica L / Gewirth, Daniel T / Chiosis, Gabriela

The Journal of biological chemistry

2018 Volume 294, Issue 6, Page(s) 2162–2179

Abstract: The chaperome is the collection of proteins in the cell that carry out molecular chaperoning functions. Changes in the interaction strength between chaperome proteins lead to an assembly that is functionally and structurally distinct from each ... ...

Abstract	The chaperome is the collection of proteins in the cell that carry out molecular chaperoning functions. Changes in the interaction strength between chaperome proteins lead to an assembly that is functionally and structurally distinct from each constituent member. In this review, we discuss the epichaperome, the cellular network that forms when the chaperome components of distinct chaperome machineries come together as stable, functionally integrated, multimeric complexes. In tumors, maintenance of the epichaperome network is vital for tumor survival, rendering them vulnerable to therapeutic interventions that target critical epichaperome network components. We discuss how the epichaperome empowers an approach for precision medicine cancer trials where a new target, biomarker, and relevant drug candidates can be correlated and integrated. We introduce chemical biology methods to investigate the heterogeneity of the chaperome in a given cellular context. Lastly, we discuss how ligand-protein binding kinetics are more appropriate than equilibrium binding parameters to characterize and unravel chaperome targeting in cancer and to gauge the selectivity of ligands for specific tumor-associated chaperome pools.
MeSH term(s)	Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Drug Delivery Systems/methods ; Humans ; Molecular Chaperones/antagonists & inhibitors ; Molecular Chaperones/metabolism ; Neoplasm Proteins/antagonists & inhibitors ; Neoplasm Proteins/metabolism ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Protein Interaction Maps/drug effects
Chemical Substances	Antineoplastic Agents ; Molecular Chaperones ; Neoplasm Proteins
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.REV118.002811
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