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  1. Article ; Online: Response to letter to the Editor: comment on Corbett et al. entitled "Acupuncture and other physical treatments for the relief of pain due to osteoarthritis of the knee: network meta-analysis".

    Corbett, M S / Rice, S J C / Madurasinghe, V / Woolacott, N F

    Osteoarthritis and cartilage

    2014  Volume 22, Issue 5, Page(s) 712–713

    MeSH term(s) Acupuncture Analgesia/methods ; Arthralgia/therapy ; Humans ; Osteoarthritis, Knee/therapy ; Physical Therapy Modalities
    Language English
    Publishing date 2014-05
    Publishing country England
    Document type Comment ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 1167809-4
    ISSN 1522-9653 ; 1063-4584
    ISSN (online) 1522-9653
    ISSN 1063-4584
    DOI 10.1016/j.joca.2014.02.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3828: Show issues Location:
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  2. Article ; Online: Acupuncture and other physical treatments for the relief of pain due to osteoarthritis of the knee: network meta-analysis.

    Corbett, M S / Rice, S J C / Madurasinghe, V / Slack, R / Fayter, D A / Harden, M / Sutton, A J / Macpherson, H / Woolacott, N F

    Osteoarthritis and cartilage

    2013  Volume 21, Issue 9, Page(s) 1290–1298

    Abstract: Objective: To compare the effectiveness of acupuncture with other relevant physical treatments for alleviating pain due to knee osteoarthritis.: Design: Systematic review with network meta-analysis, to allow comparison of treatments within a coherent ...

    Abstract Objective: To compare the effectiveness of acupuncture with other relevant physical treatments for alleviating pain due to knee osteoarthritis.
    Design: Systematic review with network meta-analysis, to allow comparison of treatments within a coherent framework. Comprehensive searches were undertaken up to January 2013 to identify randomised controlled trials in patients with osteoarthritis of the knee, which reported pain.
    Results: Of 156 eligible studies, 114 trials (covering 22 treatments and 9,709 patients) provided data suitable for analysis. Most trials studied short-term effects and many were classed as being of poor quality with high risk of bias, commonly associated with lack of blinding (which was sometimes impossible to achieve). End of treatment results showed that eight interventions: interferential therapy, acupuncture, TENS, pulsed electrical stimulation, balneotherapy, aerobic exercise, sham acupuncture, and muscle-strengthening exercise produced a statistically significant reduction in pain when compared with standard care. In a sensitivity analysis of satisfactory and good quality studies, most studies were of acupuncture (11 trials) or muscle-strengthening exercise (9 trials); both interventions were statistically significantly better than standard care, with acupuncture being statistically significantly better than muscle-strengthening exercise (standardised mean difference: 0.49, 95% credible interval 0.00-0.98).
    Conclusions: As a summary of the current available research, the network meta-analysis results indicate that acupuncture can be considered as one of the more effective physical treatments for alleviating osteoarthritis knee pain in the short-term. However, much of the evidence in this area of research is of poor quality, meaning there is uncertainty about the efficacy of many physical treatments.
    MeSH term(s) Acupuncture Analgesia/methods ; Arthralgia/etiology ; Arthralgia/therapy ; Humans ; Osteoarthritis, Knee/complications ; Osteoarthritis, Knee/therapy ; Physical Therapy Modalities ; Randomized Controlled Trials as Topic
    Language English
    Publishing date 2013-08-21
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review ; Systematic Review
    ZDB-ID 1167809-4
    ISSN 1522-9653 ; 1063-4584
    ISSN (online) 1522-9653
    ISSN 1063-4584
    DOI 10.1016/j.joca.2013.05.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78).

    Corbett, M S / Schmitt, I / Riess, O / Walz, A

    Biochemical and biophysical research communications

    1994  Volume 205, Issue 1, Page(s) 612–617

    Abstract: The genomic DNA for ENA-78 has been obtained from a human chromosome 4 flow-sorted cosmid library. Three out of 25,000 screened single colonies yielded the same 2.2-kB EcoRI ENA-78 gene fragment. A similar size fragment was observed on genomic southern ... ...

    Abstract The genomic DNA for ENA-78 has been obtained from a human chromosome 4 flow-sorted cosmid library. Three out of 25,000 screened single colonies yielded the same 2.2-kB EcoRI ENA-78 gene fragment. A similar size fragment was observed on genomic southern blots, suggesting the presence of a single ENA-78 gene. The transcriptional start site was localized using a 5' RACE protocol on first strand cDNA prepared from stimulated alveolar type-II epithelial cell (A549) poly(A) mRNA. The ENA-78 gene contains four exons and three introns and the open reading frame of 342 nucleotides encodes for a protein of total 114 amino acids. The 5' flanking region contains potential binding sites for several nuclear factors such as AP-2, NF-kappa B, and interferon regulatory factor-1.
    MeSH term(s) Amino Acid Sequence ; Base Sequence ; Binding Sites ; Cell Line ; Chemokine CXCL5 ; Chemokines, CXC ; Chromosomes, Human, Pair 4 ; Cloning, Molecular ; DNA, Complementary ; Humans ; Interleukin-8/analogs & derivatives ; Interleukin-8/genetics ; Interleukin-8/metabolism ; Molecular Sequence Data ; Regulatory Sequences, Nucleic Acid ; Transcription Factors/metabolism
    Chemical Substances CXCL5 protein, human ; Chemokine CXCL5 ; Chemokines, CXC ; DNA, Complementary ; Interleukin-8 ; Transcription Factors
    Language English
    Publishing date 1994-11-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205723-2
    ISSN 0006-291X ; 0006-291X
    ISSN (online) 0006-291X
    ISSN 0006-291X
    DOI 10.1006/bbrc.1994.2709
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 116: Show issues Location:
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  4. Article: SnR31, snR32, and snR33: three novel, non-essential snRNAs from Saccharomcyes cerevisiae

    Balakin, A.G / Schneider, G.S / Corbett, M.S / Ni, J / Fournier, M.J

    Nucleic acids research. 1993 Nov. 25, v. 21, no. 23

    1993  

    Abstract: Genes for three novel yeast snRNAs have been identified and tested for essentiality. Partial sequence information was developed for RNA extracted from isolated nuclei and the respective gene sequences were discovered by screening a DNA sequence database. ...

    Abstract Genes for three novel yeast snRNAs have been identified and tested for essentiality. Partial sequence information was developed for RNA extracted from isolated nuclei and the respective gene sequences were discovered by screening a DNA sequence database. The three RNAs contain 222, 188 and 183 nucleotides and are designated snR31, snR32 and snR33, respectively. Each RNA is derived from a single copy gene. The SNR31 gene is adjacent to a gene for an unnamed protein associated with the cap-binding protein eIF-4E. The SNR32 gene is next to a gene for ribosomal protein L41 and the gene for SNR33 is on chromosome III, between two open reading frames with no known function. Genetic disruption analyses showed that none of the three snRNAs is required for growth. The new RNAs bring the number of nonspliceosomal snRNAs characterized thus far in S. cerevisiae to 14, of which only three are essential.
    Keywords Saccharomyces cerevisiae ; small nuclear RNA ; structural genes ; nucleotide sequences ; mutagenesis ; chromosome mapping ; ribosomal DNA
    Language English
    Dates of publication 1993-1125
    Size p. 5391-5397.
    Document type Article
    ZDB-ID 186809-3
    ISSN 0301-5610 ; 0305-1048
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/21.23.5391
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: SnR31, snR32, and snR33: three novel, non-essential snRNAs from Saccharomyces cerevisiae.

    Balakin, A G / Schneider, G S / Corbett, M S / Ni, J / Fournier, M J

    Nucleic acids research

    1993  Volume 21, Issue 23, Page(s) 5391–5397

    Abstract: Genes for three novel yeast snRNAs have been identified and tested for essentiality. Partial sequence information was developed for RNA extracted from isolated nuclei and the respective gene sequences were discovered by screening a DNA sequence database. ...

    Abstract Genes for three novel yeast snRNAs have been identified and tested for essentiality. Partial sequence information was developed for RNA extracted from isolated nuclei and the respective gene sequences were discovered by screening a DNA sequence database. The three RNAs contain 222, 188 and 183 nucleotides and are designated snR31, snR32 and snR33, respectively. Each RNA is derived from a single copy gene. The SNR31 gene is adjacent to a gene for an unnamed protein associated with the cap-binding protein eIF-4E. The SNR32 gene is next to a gene for ribosomal protein L41 and the gene for SNR33 is on chromosome III, between two open reading frames with no known function. Genetic disruption analyses showed that none of the three snRNAs is required for growth. The new RNAs bring the number of non-spliceosomal snRNAs characterized thus far in S. cerevisiae to 14, of which only three are essential.
    MeSH term(s) Base Sequence ; Cloning, Molecular ; DNA Primers/chemistry ; Gene Expression ; Genes, Fungal ; Molecular Sequence Data ; Mutagenesis, Insertional ; RNA, Fungal/genetics ; RNA, Small Nuclear/genetics ; Saccharomyces cerevisiae/genetics
    Chemical Substances DNA Primers ; RNA, Fungal ; RNA, Small Nuclear
    Language English
    Publishing date 1993-11-25
    Publishing country England
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 186809-3
    ISSN 0305-1048 ; 0301-5610
    ISSN 0305-1048 ; 0301-5610
    DOI 10.1093/nar/21.23.5391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1067: Show issues Location:
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  6. Article: Comparative effects of calcipotriol solution (50 micrograms/ml) and betamethasone 17-valerate solution (1 mg/ml) in the treatment of scalp psoriasis.

    Klaber, M R / Hutchinson, P E / Pedvis-Leftick, A / Kragballe, K / Reunala, T L / Van de Kerkhof, P C / Johnsson, M K / Molin, L / Corbett, M S / Downess, N

    The British journal of dermatology

    1994  Volume 131, Issue 5, Page(s) 678–683

    Abstract: The efficacy, tolerability and safety of calcipotriol solution and betamethasone 17-valerate solution were compared in a multicentre, prospective, randomized, double-blind, parallel group study. Four hundred and seventy-four patients with scalp psoriasis ...

    Abstract The efficacy, tolerability and safety of calcipotriol solution and betamethasone 17-valerate solution were compared in a multicentre, prospective, randomized, double-blind, parallel group study. Four hundred and seventy-four patients with scalp psoriasis were recruited from six European countries and Canada. Following a 2-week washout period, either calcipotriol solution (50 micrograms/ml) or betamethasone 17-valerate solution (1 mg/ml) was applied twice daily for 4 weeks. After this time, patients who required no further active treatment were observed for relapse. Retreatment with calcipotriol was offered to those patients who relapsed, and who were originally in the calcipotriol-treated group. The two treatment groups were well matched at baseline. At the end of treatment, the proportion of patients who had 'cleared' or 'markedly improved' was statistically significantly greater in the betamethasone group (75%) than in the calcipotriol group (58%) (P < 0.001) (95% confidence interval of difference 25.3-->8.6). The decrease in total sign score (sum of scores for erythema, thickness and scaliness) at the end of treatment was also statistically significantly greater in the betamethasone group (61%) than the calcipotriol group (45%) (P < 0.001) (95% confidence interval of difference 9.7-->23.1). Adverse events were reported by 87 patients in the calcipotriol group, and 31 patients in the betamethasone group; the most common was lesional or perilesional irritation, which occurred significantly more frequently with calcipotriol (26%) than with betamethasone (8%) (P < 0.001). Fifteen patients (6%) in the calcipotriol group and four (1%) in the betamethasone group withdrew from the study because of adverse events or unacceptable treatment response (P = 0.017).(ABSTRACT TRUNCATED AT 250 WORDS)
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betamethasone Valerate/administration & dosage ; Calcitriol/administration & dosage ; Calcitriol/analogs & derivatives ; Dermatologic Agents/administration & dosage ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Prospective Studies ; Psoriasis/drug therapy ; Scalp Dermatoses/drug therapy ; Solutions
    Chemical Substances Dermatologic Agents ; Solutions ; calcipotriene (143NQ3779B) ; Betamethasone Valerate (9IFA5XM7R2) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 1994-11
    Publishing country England
    Document type Clinical Trial ; Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1111/j.1365-2133.1994.tb04982.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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