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Article ; Online: Unveiling the intriguing role of FAP20 in tubulin recruitment at the doublet microtubule inner junctions.

Black, Corbin S / Bui, Khanh Huy

Structure (London, England : 1993)

2023 Volume 31, Issue 12, Page(s) 1518–1519

Abstract: In this issue of Structure, Bangera et al. investigate the role of the inner junction protein FAP20 in doublet microtubule assembly. Using cryo-EM and microtubule dynamic assays, they demonstrate that FAP20 recruits free tubulins to existing microtubule ... ...

Abstract	In this issue of Structure, Bangera et al. investigate the role of the inner junction protein FAP20 in doublet microtubule assembly. Using cryo-EM and microtubule dynamic assays, they demonstrate that FAP20 recruits free tubulins to existing microtubule lattices, shedding light on B-tubule closure during doublet microtubule formation.
MeSH term(s)	Axoneme/metabolism ; Cilia/metabolism ; Flagella/metabolism ; Microtubules/metabolism ; Tubulin/metabolism
Chemical Substances	Tubulin
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1213087-4
ISSN	1878-4186 ; 0969-2126
ISSN (online)	1878-4186
ISSN	0969-2126
DOI	10.1016/j.str.2023.11.004
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Article ; Online: Application d’une nouvelle méthodologie d’analyse de risques a priori dans un service de radiothérapie.

Thellier, S / Brusadin, G / Corbin, S / Deutsch, E

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2021 Volume 25, Issue 6-7, Page(s) 642–644

Abstract: Since 2017, IRSN has been developing a new proactive risk analysis method. The Work Complexity Sharing and Exploration Spaces (EPECT in French) were tested for the first time in 2020 in the radiotherapy department of the Gustave Roussy Institute. The ... ...

Title translation	Application of a new methodology of a priori risk analysis in a radiotherapy department.
Abstract	Since 2017, IRSN has been developing a new proactive risk analysis method. The Work Complexity Sharing and Exploration Spaces (EPECT in French) were tested for the first time in 2020 in the radiotherapy department of the Gustave Roussy Institute. The EPECT method makes it possible to anchor the analysis of risks incurred by patients in daily work situations and to involve the top management. The time required to involve the teams is comparable to or even less than that required for a conventional risk analysis. The cost/benefit ratio of the method seems to be advantageous because it provides access to numerous information on daily activities, which makes it possible to improve the safety of patient care in radiotherapy. The information gathered allows relevant actions to be envisaged at both the technical and organizational levels, and to be linked to departmental projects.
MeSH term(s)	Cost-Benefit Analysis ; France ; Humans ; Patient Safety ; Quality Improvement ; Radiation Oncology ; Radiology Department, Hospital ; Radiotherapy ; Risk Assessment/methods ; Time Factors
Language	French
Publishing date	2021-07-01
Publishing country	France
Document type	Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2021.06.007
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Article ; Online: Protocole de coopération et pratique avancée, une perspective d’évolution pour le manipulateur en radiothérapie français.

Le Tallec, P / Corbin, S / Ahado, S / Boisbouvier, S

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2021 Volume 25, Issue 6-7, Page(s) 638–641

Abstract: For several years, the profession of radiographer has been unattractive and is in search of professional recognition. Increasingly complex therapeutic and diagnostic evolutions forces professionals to develop their skills to ensure quality and safe care ... ...

Title translation	Cooperation protocol and advanced practice, an evolutionary perspective for the French radiation therapist.
Abstract	For several years, the profession of radiographer has been unattractive and is in search of professional recognition. Increasingly complex therapeutic and diagnostic evolutions forces professionals to develop their skills to ensure quality and safe care for all patients. The primary role of the radiographer is to support patients and to accompany them during their examination or treatment, combining caregiver and technician's roles. Transversal missions and delegation of tasks are inherent to the profession but are not widely recognized. Cooperation between radiotherapy professionals is a response to offer the therapeutic radiographer/radiation therapist (RTT) opportunities in terms of attractiveness, career prospects, and increased skills. In radiotherapy, advanced practice activities already exist in some departments but require regulatory adjustments, in particular regarding the redistribution of the roles of RTT but also the status of these professionals. The formalization of these practices can be largely inspired by the many feedbacks around the world. This article aims to reflect the evolution's perspectives in the career of an RTT and on the valorisation of this profession in the current context.
MeSH term(s)	Allied Health Personnel/standards ; Allied Health Personnel/trends ; Career Choice ; Career Mobility ; Delegation, Professional/standards ; Humans ; Interprofessional Relations ; Needs Assessment ; Professional Competence/standards ; Professional-Patient Relations ; Radiation Oncology ; Radiography ; Radiotherapy ; Technology, Radiologic/standards ; Technology, Radiologic/trends
Language	French
Publishing date	2021-07-17
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2021.06.022
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Article ; Online: Impact d’un test de diagnostic du coronavirus positif sur le parcours du patient en radiothérapie à l’institut Gustave-Roussy.

Chiesa, V / Sun, R / Brusadin, G / Bour, M-S / Corbin, S

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2022 Volume 26, Issue 4, Page(s) 563–569

Abstract: Purpose: The coronavirus disease 2019 (COVID-19) epidemic continues to spread exponentially around the world. Cancer patients have a higher risk of commorbidity than the rest of the population. Radiotherapy departments are actively involved in the ... ...

Title translation	Impact of a positive coronavirus diagnostic test on the radiotherapy patient journey at Gustave-Roussy institute.
Abstract	Purpose: The coronavirus disease 2019 (COVID-19) epidemic continues to spread exponentially around the world. Cancer patients have a higher risk of commorbidity than the rest of the population. Radiotherapy departments are actively involved in the management of these patients, whether they have COVID or not, and it is recognized that the time taken to take charge and the continuity of treatment have a prognostic impact. The main objective was to assess the impact of the coronavirus on the treatment times of patients undergoing radiotherapy. Material and methods: This retrospective study was conducted in the radiotherapy department of Gustave-Roussy institute (France) during the period from March 3, 2020 to January 12, 2021. Organizational changes, patient care times between the day of the scan and the last radiotherapy session as well as the time taken to take charge of patients between the first session and the last radiotherapy session has been studied. Results: A total of 1183 patients were included, among which 60 had COVID-19. Patients were divided into four categories. Treatment times of patients who did not have COVID-19 and those of patients who did were not statistically significantly different. Conclusion: The organization of the radiotherapy department at the Gustave-Roussy institute is based on several points: carrying out preventive screening tests, protecting staff and patients and reorganizing the patient circuit. Thanks to the performance of diagnostic tests and the implementation of a specific workflow for patients with COVID, we ensure the continuity of patient treatment in complete safety without impacting treatment times.
MeSH term(s)	COVID-19 ; Diagnostic Tests, Routine ; Humans ; Neoplasms/radiotherapy ; Radiation Oncology ; Retrospective Studies
Language	French
Publishing date	2022-01-24
Publishing country	France
Document type	Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2021.08.024
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Article ; Online: Les prémices de la pratique avancée pour le manipulateur en radiothérapie.

Boisbouvier, S / Corbin, S / Charpentier, M / Billaud, P / Dolpierre, B / Douir, N / De Oliveira, A / Sousa, F

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2023 Volume 27, Issue 6-7, Page(s) 583–587

Abstract: The implementation of advanced practice in RT requires evidence regarding the clinical practices of radiation therapists (RTT) in the field. In this context, the goal of this article is to report the roles assigned to RTT in order to meet the demands of ... ...

Title translation	The first steps towards advanced practice for radiation therapists.
Abstract	The implementation of advanced practice in RT requires evidence regarding the clinical practices of radiation therapists (RTT) in the field. In this context, the goal of this article is to report the roles assigned to RTT in order to meet the demands of patients, RT services, and/or healthcare professionals. As part of the French Society of Oncologic Radiotherapy's congress, the Radiotherapy Committee of the French Association of radiographers presented a scientific program encompassing three main themes: patient follow-up by a RTT, the expertise of an RTT in Image Guided Radiation Therapy (IGRT), Adaptive Radiotherapy (ART), and the involvement of a RTT in research. This article presents an overview of five oral presentations that highlight concrete examples of roles assigned to RTTs in these specific domains. The follow-up of patients has been assigned to RTT. Research and development have been recognized as activities in which RTT play a significant role. The establishment of RTT specializing in IGRT has been reported to facilitate decision-making and is essential in ensuring professional expertise. Lastly, there is a need to enhance RTT skills in adaptive RT to support the implementation of this technique. These roles described as advanced practice meet needs and require a specific organisational framework and appropriate education and training (master type). Activities such as post-RT follow-up, validation of positioning imaging, delineation, writing research protocols, and involvement in the development of technological innovations were identified as essential tasks that can be assigned to RTT.
MeSH term(s)	Humans ; Allied Health Personnel ; Medical Oncology ; Radiation Oncology ; Radiotherapy, Image-Guided
Language	French
Publishing date	2023-07-21
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2023.06.014
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Article ; Online: Effect of odor treatment systems on bioaerosol microbial concentration and diversity from wastewater treatment plants.

Ouradou, A / Veillette, M / Bélanger Cayouette, A / Corbin, S / Boulanger, C / Dorner, S / Duchaine, C / Bédard, E

The Science of the total environment

2023 Volume 874, Page(s) 162419

Abstract: Biofiltration, activated carbon and chemical scrubbing are technologies used for odor control in wastewater treatment plants. These systems may also influence the airborne microbial load in treated air. The study objectives were to 1) evaluate the ... ...

Abstract	Biofiltration, activated carbon and chemical scrubbing are technologies used for odor control in wastewater treatment plants. These systems may also influence the airborne microbial load in treated air. The study objectives were to 1) evaluate the capacity of three odor control system technologies to reduce the airborne concentration of total bacteria, Legionella, L. pneumophila, non-tuberculous mycobacteria (NTM) and Cladosporium in winter and summer seasons and 2) to describe the microbial ecology of the biofiltration system and evaluate its impact on treated air microbial diversity. A reduction of the total bacterial concentration up to 25 times was observed after odor treatment. Quantification by qPCR revealed the presence of Legionella spp. in all air samples ranging between 26 and 1140 GC/m
MeSH term(s)	Odorants ; Legionella ; Bacteria ; Water Purification/methods ; Air Pollutants ; Water Microbiology
Chemical Substances	Air Pollutants
Language	English
Publishing date	2023-02-28
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2023.162419
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Zs.A 949: Show issues

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Article ; Online: Étude rétrospective sur l’intensification des pratiques de radiothérapie hypofractionnée : le virage organisationnel.

Corbin, S / Brusadin, G / Rivera, S / Bossi, A / Deutsch, É

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2020 Volume 24, Issue 6-7, Page(s) 714–721

Abstract: Purpose: External radiotherapy process is a chain of steps in which each of them is carried out only if the previous one has been completed. The development of hypofractionation practices in recent years tends to increase the workload of the stages of ... ...

Title translation	Retrospective study on the intensification of hypofractionated radiotherapy: The organizational change.
Abstract	Purpose: External radiotherapy process is a chain of steps in which each of them is carried out only if the previous one has been completed. The development of hypofractionation practices in recent years tends to increase the workload of the stages of preparation for irradiation and to decrease the number of fractions per patient. The purpose of this retrospective study is to analyze the evolution of these practices in a single centre and to assess the organizational issues involved. Material and methods: All radiation therapy records management data were extracted from the Radiation Therapy Information System. Radiotherapy sessions were identified by patient and by ICD (International Classification of Diseases) code. The filling rate of the treatment equipment was calculated using actual data from the radiotherapy department. Results: From 2015 to 2019, there was an increase in the number of scans (+16%), the number of patients treated (+11.6%) and the volume of hours available for treatment (+12%). Also, there was a decrease in the total number of fractions (-5%), in the average number of fractions performed per treatment sequence (-19%), in the occupancy rate of the machines (-7%) and in the average number of fractions performed per patient treated for malignant tumours of the bronchi and lung (-38%), digestive organs (-37%), secondary (-19%) breast (-15%) and prostate (-15%). The number of fractions administered per treatment sequence between 2015 and 2019 decreased significantly for patients in age groups [20-69] (P<0.001) and [>70] (P<0.001). Conclusion: A paradox appears between the increase in the total number of patients treated and the decrease in the loading rate of linacs. This shift of workload has an impact on the quality and safety of care and on the organizational and investment strategies. It also has an economic impact where the model of reimbursement is based on per fraction pricing. A reorganization of radiotherapy services is inevitable.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Middle Aged ; Neoplasms/radiotherapy ; Organizational Innovation ; Radiation Dose Hypofractionation/standards ; Retrospective Studies ; Young Adult
Keywords	covid19
Language	French
Publishing date	2020-08-21
Publishing country	France
Document type	Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2020.06.009
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Article ; Online: Studying both patient and staff experience to investigate their perceptions and to target key interactions to improve: a scoping review.

Crubezy, Marion / Corbin, Sara / Hyvert, Sophie / Michel, Philippe / Haesebaert, Julie

BMJ open

2022 Volume 12, Issue 10, Page(s) e061155

Abstract: Objective: The improvement of patient experience (PE) is related to the experience of staff caring for them. Yet there is little evidence as to which interactions matter the most for both patients and staff, or how they are perceived by them. We aimed ... ...

Abstract	Objective: The improvement of patient experience (PE) is related to the experience of staff caring for them. Yet there is little evidence as to which interactions matter the most for both patients and staff, or how they are perceived by them. We aimed to summarise the interactions and the perceptions between patients and staff from studies by using both patient and staff experience data in healthcare institutions. Design: Scoping review. Methods: We conducted a scoping review, including studies dealing with PE and staff experience. Two authors independently reviewed each title/abstract and the selected full-text articles. A list of variables (objective, study design, data sources, tools used, results, interactions, perceptions and actions) was charted and summarised using a narrative approach including both qualitative and quantitative data. Studies were grouped according to their objective and the key interactions summarised according to this stratification. The perceptions of patients and staff were identified in the results of selected studies and were classified into four categories: commonalities and disagreements of perceptions, patients' perceptions not perceived by professionals and professional's perceptions not perceived by patients. Results: A total of 42 studies were included. The stratification of studies by type of objective resulted in six groups that allowed to classify the key interactions (n=154) identified in the results of the selected studies. A total of 128 perceptions related to interaction between patient and staff were reported with the following distribution: commonalities (n=35), disagreements (n=18), patients' perceptions not perceived by professionals (n=47) and professional's perceptions not perceived by patients (n=28). We separated positive and negative perceptions, which resulted in seven scenarios, each with actions that can be carried out for one or both populations to overcome barriers. Conclusion: The study of both patient and staff experience allowed the identification of actions that can be taken to change the perceptions of patients and staff.
MeSH term(s)	Delivery of Health Care ; Health Facilities ; Humans
Language	English
Publishing date	2022-10-10
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-061155
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Article ; Online: Bioinspired magnetoreception and navigation in nonorthogonal environments using magnetic signatures.

Taylor, Brian K / Corbin, Sabrina

Bioinspiration & biomimetics

2019 Volume 14, Issue 6, Page(s) 66009

Abstract: Diverse taxa use Earth's magnetic field in conjunction with other sensory modalities to accomplish navigation tasks ranging from local homing to long-distance migration across continents and ocean basins. However, despite extensive research, the ... ...

Abstract	Diverse taxa use Earth's magnetic field in conjunction with other sensory modalities to accomplish navigation tasks ranging from local homing to long-distance migration across continents and ocean basins. However, despite extensive research, the mechanisms that underlie animal magnetoreception are not clearly understood, and how animals use Earth's magnetic field to navigate is an active area of investigation. Concurrently, Earth's magnetic field offers a signal that engineered systems can leverage for navigation in environments where man-made systems such as GPS are unavailable or unreliable. Using a proxy for Earth's magnetic field, and inspired by migratory animal behavior, this work implements a behavioral strategy that uses combinations of magnetic field inclination and intensity as rare or unique signatures that mark specific locations. Specifically, to increase the realism of previous work, in this study, a simulated agent uses a magnetic signatures based strategy to migrate in magnetic environments where lines of constant inclination and intensity are not necessarily orthogonal. The results further support existing notions that some animals may use combinations of magnetic properties as navigational markers, and provide insights into features and constraints that could enable navigational success or failure in either a biological or engineered system.
MeSH term(s)	Algorithms ; Animals ; Behavior, Animal/physiology ; Geographic Information Systems ; Magnetic Fields ; Spatial Navigation/physiology
Language	English
Publishing date	2019-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2235670-8
ISSN	1748-3190 ; 1748-3182
ISSN (online)	1748-3190
ISSN	1748-3182
DOI	10.1088/1748-3190/ab40f8
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Article ; Online: Métier de manipulateur en radiothérapie en tension en France : conséquences organisationnelles et difficultés à déployer de nouvelles missions et/ou délégation de tâches.

Bourgier, C / Boisbouvier, S / Bayart, É / Chamois, J / Clavère, P / Corbin, S / De Oliveira, A / Hannoun-Lévi, J-M / Hasbini, A / Geffroy-Hulot, C / Le Tallec, P / Monpetit, É / Santini, J-J

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2023 Volume 27, Issue 6-7, Page(s) 577–582

Abstract: Purpose: Radiation therapists shortage has been evaluated at national level in France, specifically in oncology radiotherapy, in terms of: (i) organizational adaptations, (ii) impact on patients care, and (iii) difficulties in deploying new missions and/ ...

Title translation	Radiation therapists shortage in France: Organizational consequences and difficulties in deploying new missions and/or tasks delegation.
Abstract	Purpose: Radiation therapists shortage has been evaluated at national level in France, specifically in oncology radiotherapy, in terms of: (i) organizational adaptations, (ii) impact on patients care, and (iii) difficulties in deploying new missions and/or tasks delegation. Materials and methods: French professional organisations representing radiation therapists - SFRO, SNRO and AFPPE - sent their members a national survey (ten questions on 32 items). Results: From 18 November 2022 to 31 December 2022, 55 responses were received (response rate: 31%) from radiotherapy managers or department heads; 51% had a structure comprising three to five treatment rooms (receiving 500 to 1000 patients per year [36%], or 1500 to 2000 patients per year [33%]). Activities performed were intensity-modulated radiotherapy (100%), stereotaxic radiotherapy (85%), brachytherapy (40%), adaptive radiotherapy (34%). These structures described consequences in closing machine time for 25% of them (reduction of the hourly volume greater than 10% in 57%) with the following consequences in the last 6 months: (i) an extension of the period of medical care (78%), a closing of one or more accelerators (50%) and the development of moderate hypofractionation scheme or extreme hypofractionation (50%). In current functioning, linear accelerators can deliver treatments with a team of two radiation therapists per room for a short day (43%) or two to four radiation therapists per room teams for a long day (40%). During the last 6 months, there has been a 10% increase in linear accelerators operating with a single team. (ii) regarding treatment planning: 16.4% reported a decrease in the opening amplitude (less than 20% in 44% of cases, from 20 to 50% in 33 % of cases). The initial scheduling of appointments for radiotherapy sessions was carried out by radiation therapists in 84% of the departments in current functioning (0.1 to 1 FTE dedicated to this activity in 62% of the departments). Over the last 6 months, there has been a clear reduction in the number of dedicated FTEs: [FTE=0.1 to 1]=-8%; [FTE=0]=+7%. (ii) Regarding tasks delegation (excluding the decree on acts and activities carried out by the radiation therapist): organ at risk delineation is partially performed by radiation therapist in 26% of the centres; caregiver support time in 78% (56% totally or 22% partially). This activity has been reduced by 42%. Seventy-five percent of departments want to develop new techniques, patient-centered approaches (44%), implement task delegation (organ at risk delineation: 58%; weekly consultations: 67%; positioning imaging validation: 71%), and 78% of departments are interested in developing advanced radiotherapy practice. However, the number of radiation therapists is considered insufficient in their implementation in 76% of cases (one to two FTE missing for 72% of structures). Conclusion: This survey shows a significant impact of radiation therapist shortage in radiotherapy oncology care (treatment delays, access to caregiver support time, workload on treatment teams), and represents a major obstacle to the development of radiotherapy structures.
MeSH term(s)	Humans ; France ; Brachytherapy ; Radiation Oncology ; Allied Health Personnel ; Radiosurgery
Language	French
Publishing date	2023-08-16
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2023.07.007
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