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  1. Article: Musical experience influences socio-emotional functioning in behavioural variant frontotemporal dementia.

    Van't Hooft, Jochum J / Benhamou, Elia / Albero Herreros, Claudia / Jiang, Jessica / Levett, Benjamin / Core, Lucy B / Requena-Komuro, Mai-Carmen / Hardy, Chris J D / Tijms, Betty M / Pijnenburg, Yolande A L / Warren, Jason D

    Frontiers in neurology

    2024  Volume 15, Page(s) 1341661

    Abstract: Objectives: On phenotypic and neuroanatomical grounds, music exposure might potentially affect the clinical expression of behavioural variant frontotemporal dementia (bvFTD). However, this has not been clarified.: Methods: 14 consecutive patients ... ...

    Abstract Objectives: On phenotypic and neuroanatomical grounds, music exposure might potentially affect the clinical expression of behavioural variant frontotemporal dementia (bvFTD). However, this has not been clarified.
    Methods: 14 consecutive patients with bvFTD fulfilling consensus diagnostic criteria were recruited via a specialist cognitive clinic. Earlier life musical experience, current musical listening habits and general socio-emotional behaviours were scored using a bespoke semi-quantitative musical survey and standardised functional scales, completed with the assistance of patients' primary caregivers. Associations of musical scores with behavioural scales were assessed using a linear regression model adjusted for age, sex, educational attainment and level of executive and general cognitive impairment.
    Results: Greater earlier life musical experience was associated with significantly lower Cambridge Behavioural Inventory (Revised) scores (β ± SE = -17.2 ± 5.2;
    Discussion: Musical experience in earlier life and potentially ongoing regular music listening may ameliorate socio-emotional functioning in bvFTD. Future work in larger cohorts is required to substantiate the robustness of this association, establish its mechanism and evaluate its clinical potential.
    Language English
    Publishing date 2024-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1341661
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Binary reversals: a diagnostic sign in primary progressive aphasia.

    Mulroy, Eoin / Core, Lucy B / Chokesuwattanaskul, Anthipa / Johnson, Jeremy Cs / Fletcher, Phillip D / Marshall, Charles R / Volkmer, Anna / Rohrer, Jonathan D / Hardy, Chris Jd / Rossor, Martin N / Warren, Jason D

    Journal of neurology, neurosurgery, and psychiatry

    2024  Volume 95, Issue 5, Page(s) 477–480

    Abstract: Background: Binary reversals (exemplified by 'yes'/'no' confusions) have been described in patients with primary progressive aphasia (PPA) but their diagnostic value and phenotypic correlates have not been defined.: Methods: We conducted a ... ...

    Abstract Background: Binary reversals (exemplified by 'yes'/'no' confusions) have been described in patients with primary progressive aphasia (PPA) but their diagnostic value and phenotypic correlates have not been defined.
    Methods: We conducted a retrospective cohort study analysing demographic, clinical, neuropsychological, linguistic and behavioural data from patients representing all major PPA syndromes (non-fluent/agrammatic variant, nfvPPA; logopenic variant, lvPPA; semantic variant, svPPA) and behavioural variant frontotemporal dementia (bvFTD). The prevalence of binary reversals and behavioural abnormalities, illness duration, parkinsonian features and neuropsychological test scores were compared between neurodegenerative syndromes, and the diagnostic predictive value of binary reversals was assessed using logistic regression.
    Results: Data were obtained for 83 patients (21 nfvPPA, 13 lvPPA, 22 svPPA, 27 bvFTD). Binary reversals occurred in all patients with nfvPPA, but significantly less frequently and later in lvPPA (54%), svPPA (9%) and bvFTD (44%). Patients with bvFTD with binary reversals had significantly more severe language (but not general executive or behavioural) deficits than those without reversals. Controlling for potentially confounding variables, binary reversals strongly predicted a diagnosis of nfvPPA over other syndromes.
    Conclusions: Binary reversals are a sensitive (though not specific) neurolinguistic feature of nfvPPA, and should suggest this diagnosis if present as a prominent early symptom.
    MeSH term(s) Humans ; Retrospective Studies ; Frontotemporal Dementia/psychology ; Aphasia ; Language ; Aphasia, Primary Progressive/diagnosis
    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 3087-9
    ISSN 1468-330X ; 0022-3050
    ISSN (online) 1468-330X
    ISSN 0022-3050
    DOI 10.1136/jnnp-2023-331662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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