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  1. Article ; Online: Progression of myeloproliferative neoplasm with BCR::JAK2 fusion to acute leukemia of ambiguous lineage.

    Suárez, Edwin Uriel / Piris, Miguel Ángel / Rodríguez-Pinilla, Socorro María / García, Juan F / López-Lorenzo, José Luis / Cornago-Navascués, Javier / Salgado-Sánchez, Rocío / Castaño-Bonilla, Tamara / Mata-Serna, Raquel / Alonso-Domínguez, Juan M / Llamas, Pilar

    Annals of hematology

    2024  Volume 103, Issue 5, Page(s) 1797–1799

    MeSH term(s) Humans ; Bone Marrow Neoplasms/genetics ; Janus Kinase 2/genetics ; Leukemia ; Mutation ; Myeloproliferative Disorders/genetics ; Oncogene Proteins, Fusion/genetics ; Proto-Oncogene Proteins c-bcr/genetics
    Chemical Substances JAK2 protein, human (EC 2.7.10.2) ; Janus Kinase 2 (EC 2.7.10.2) ; Oncogene Proteins, Fusion ; Proto-Oncogene Proteins c-bcr (EC 2.7.11.1)
    Language English
    Publishing date 2024-02-03
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-024-05647-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Music Listening in Stem Cell Transplantation and Acute Myeloid Leukemia: A Randomized Clinical Trial.

    Lázaro-García, Alberto / Láinez-González, Daniel / González-Rodríguez, Marta / Cano Alsua, Santiago / Suárez M, Edwin Uriel / Solán-Blanco, Laura / Cornago-Navascués, Javier / López-Lorenzo, José Luis / Llamas-Sillero, Pilar / Alonso-Domínguez, Juan Manuel

    Journal of pain and symptom management

    2024  Volume 67, Issue 6, Page(s) 501–511.e12

    Abstract: Context: Music listening (ML) has been shown to have a beneficial effect on patients with cancer. However, novel intervention approaches are needed.: Objectives: We aimed to determine whether ML based on the iso-principle, conducted using a mobile ... ...

    Abstract Context: Music listening (ML) has been shown to have a beneficial effect on patients with cancer. However, novel intervention approaches are needed.
    Objectives: We aimed to determine whether ML based on the iso-principle, conducted using a mobile application (GloMus), improves symptom burden, quality of life (QoL), anxiety, and depression in patients undergoing stem cell transplantation (SCT) and intensive induction chemotherapy for acute myeloid leukemia (AML).
    Methods: In this randomized controlled clinical trial, we assigned 71 patients to the ML or standard care (SC) groups, stratified by the reason for admission (AML, allogeneic-SCT, or inpatient/outpatient autologous-SCT). Upon admission, participants in the ML groups were invited to undergo daily ML sessions designed to change negative moods into positive ones (iso-principle). The intervention consisted of listening to pre-recorded classical music ordered by beats per minute and tonality. Symptom burden (Edmonton Symptom Assessment System-Revised) was assessed in the ML groups before and after each session. Anxiety, depression (Hospital Anxiety and Depression Scale), and QoL (Functional Assessment of Cancer Therapy-Bone Marrow Transplantation/Leukemia) were measured weekly in the ML and SC groups.
    Results: Symptom burden in both allogeneic- and inpatient autologous-SCT ML groups reduced after the intervention. In all experimental groups, clinically important improvements were observed after ML sessions. No differences were found between the groups (ML vs. SC) at different weeks of admission regarding anxiety, depression, and QoL.
    Conclusions: ML based on our innovative iso-principle strategy, conducted using GloMus, reduced the symptom burden in patients undergoing allogeneic- and inpatient autologous-SCT (ClinicalTrials.gov number, NCT05696457).
    MeSH term(s) Humans ; Leukemia, Myeloid, Acute/therapy ; Male ; Female ; Middle Aged ; Quality of Life ; Anxiety/therapy ; Music Therapy/methods ; Adult ; Depression/therapy ; Stem Cell Transplantation ; Treatment Outcome ; Aged
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639142-4
    ISSN 1873-6513 ; 0885-3924
    ISSN (online) 1873-6513
    ISSN 0885-3924
    DOI 10.1016/j.jpainsymman.2024.02.567
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  3. Article ; Online: ZBTB16-RARα-Positive Atypical Promyelocytic Leukemia: A Case Report.

    Pardo Gambarte, Laura / Franganillo Suárez, Aída / Cornago Navascués, Javier / Soto de Ozaeta, Carlos / Blas López, Carlos / Atance Pasarisas, Mireia / Salgado Sánchez, Rocío Nieves / Serrano Del Castillo, Cristina / Mata Serna, Raquel / Velasco Rodríguez, Diego / López-Lorenzo, José Luis / Llamas-Sillero, Pilar / Solán Blanco, Laura

    Medicina (Kaunas, Lithuania)

    2022  Volume 58, Issue 4

    Abstract: Background: The majority of patients with acute promyelocytic leukemia (APL) manifest a specific chromosomal translocation t(15;17)(q22;q21), characterized by the fusion of RARA and PML genes. However, a proportion of APL cases are due to variant ... ...

    Abstract Background: The majority of patients with acute promyelocytic leukemia (APL) manifest a specific chromosomal translocation t(15;17)(q22;q21), characterized by the fusion of RARA and PML genes. However, a proportion of APL cases are due to variant translocations, being t(11;17) (q23;q21) the most common amongst them. With the major exception of ZBTB16-RARA t(11;17) APL, these variant APL cases present similar morphological features as classic APL and are characterized by a lack of differentiation response to retinoids.
    Case summary: We describe the case of variant APL with the ZBTB16-RARA fusion gene, showing a distinct morphology of classical APL, characterized by crystalline intracytoplasmic inclusions in both peripheral blood (PB) and bone marrow (BM) patients' blasts. Our patient was treated with two courses of intensive chemotherapy, initiating maintenance treatment with all-trans retinoic acid (ATRA) on day twenty-eight of the second course. Our patient achieved complete remission (CR) once the intensive chemotherapy was combined with ATRA.
    Conclusions: This is the second case described of APL with t(11;17) that showed crystalline intracytoplasmic inclusions. The finding of these morphological features may suggest the presence of a variant translocation with RARA, being that both cases described are related to the presence of t(11;17). Despite induction treatment with intensive chemotherapy that included a seven-day continuous treatment with cytarabine (200 mg/m
    MeSH term(s) Bone Marrow ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/genetics ; Oncogene Proteins, Fusion/genetics ; Promyelocytic Leukemia Zinc Finger Protein/genetics ; Translocation, Genetic/genetics ; Tretinoin/therapeutic use
    Chemical Substances Oncogene Proteins, Fusion ; Promyelocytic Leukemia Zinc Finger Protein ; ZBTB16 protein, human (147855-37-6) ; Tretinoin (5688UTC01R)
    Language English
    Publishing date 2022-04-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina58040520
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  4. Article: PLZF-RAR

    Sobas, Marta / Talarn-Forcadell, Maria Carme / Martínez-Cuadrón, David / Escoda, Lourdes / García-Pérez, María J / Mariz, Jose / Mela-Osorio, María J / Fernández, Isolda / Alonso-Domínguez, Juan M / Cornago-Navascués, Javier / Rodríguez-Macias, Gabriela / Amutio, María E / Rodríguez-Medina, Carlos / Esteve, Jordi / Sokół, Agnieszka / Murciano-Carrillo, Thais / Calasanz, María J / Barrios, Manuel / Barragán, Eva /
    Sanz, Miguel A / Montesinos, Pau

    Cancers

    2020  Volume 12, Issue 5

    Abstract: It has been suggested that 1-2% of acute promyelocytic leukemia (APL) patients present variant rearrangements of retinoic acid receptor alpha (RARα) fusion gene, with the promyelocytic leukaemia zinc finger (PLZF)/ ... ...

    Abstract It has been suggested that 1-2% of acute promyelocytic leukemia (APL) patients present variant rearrangements of retinoic acid receptor alpha (RARα) fusion gene, with the promyelocytic leukaemia zinc finger (PLZF)/RAR
    Language English
    Publishing date 2020-05-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers12051313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Characteristics and outcome of patients with acute myeloid leukemia and trisomy 4.

    Kayser, Sabine / Martínez-Cuadrón, David / Hanoun, Maher / Stölzel, Friedrich / Gil, Cristina / Reinhardt, H Christian / Aguiar, Eliana / Schäfer-Eckart, Kerstin / Burgues, Juan Miguel Bergua / Steffen, Björn / Bernal, Teresa / Krause, Stefan W / Riaza, Rosalía / Schliemann, Christoph / Cervera, Jose / Kaufmann, Martin / Torres-Miñana, Laura / Hänel, Mathias / Acuña-Cruz, Evelyn /
    Jost, Edgar / Algarra, Jesus Lorenzo / Crysandt, Martina / Fransecky, Lars / Cornago-Navascues, Javier / Kraus, Sabrina / Martinez-Lopez, Joaquin / Einsele, Hermann / Niemann, Dirk / Neubauer, Andreas / Seggewiß-Bernhardt, Ruth / Scholl, Sebastian / Klein, Stefan A / Schmid, Christoph / Schaich, Markus / Schmidt-Hieber, Martin / Zukunft, Sven / Ho, Anthony D / Platzbecker, Uwe / Baldus, Claudia D / Müller-Tidow, Carsten / Thiede, Christian / Bornhäuser, Martin / Serve, Hubert / Levis, Mark / Montesinos, Pau / Röllig, Christoph / Schlenk, Richard F

    Haematologica

    2023  Volume 108, Issue 1, Page(s) 34–41

    Abstract: We retrospectively studied 125 patients with acute myeloid leukemia and trisomy 4 (median age at diagnosis, 58 years; range, 16-77 years) treated between 2000 and 2019 within a multicenter study. Trisomy 4 was the sole abnormality in 28 (22%) patients ... ...

    Abstract We retrospectively studied 125 patients with acute myeloid leukemia and trisomy 4 (median age at diagnosis, 58 years; range, 16-77 years) treated between 2000 and 2019 within a multicenter study. Trisomy 4 was the sole abnormality in 28 (22%) patients and additional abnormalities were present in 97 (78%) patients. Twenty-two (22%) and 15 (15%) of 101 tested patients harbored NPM1 and FLT3-ITD mutations. Two (3%) of 72 tested patients had double CEBPA mutations. Data on response to intensive anthracycline-based induction therapy were available for 119 patients. Complete remission was achieved in 67% (n=80) and the early death rate was 5% (n=6). Notably, patients with trisomy 4 as sole abnormality had a complete remission rate of 89%. Allogeneic hematopoietic cell transplantation was performed in 40 (34%) patients, of whom 19 were transplanted in first complete remission. The median follow-up of the intensively treated cohort was 5.76 years (95% confidence interval [95% CI]: 2.99-7.61 years). The 5-year overall survival and relapse-free survival rates were 30% (95% CI: 22-41%) and 27% (95% CI: 18-41%), respectively. An Andersen-Gill regression model on overall survival revealed that favorable-risk according to the European LeukemiaNet classification (hazard ratio [HR]=0.34; P=0.006) and trisomy 4 as sole abnormality (HR=0.41; P=0.01) were favorable factors, whereas age with a difference of 10 years (HR=1.15; P=0.11), female gender (HR=0.74; P=0.20) and allogeneic hematopoietic cell transplantation (HR=0.64; P=0.14) did not have an significant impact. In our cohort, patients with trisomy 4 as their sole abnormality had a high complete remission rate and favorable clinical outcome. Allogeneic hematopoietic cell transplantation did not seem to improve overall survival.
    MeSH term(s) Female ; Humans ; Middle Aged ; Hematopoietic Stem Cell Transplantation ; Leukemia, Myeloid, Acute/diagnosis ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/therapy ; Mutation ; Nucleophosmin ; Prognosis ; Retrospective Studies ; Trisomy/genetics ; Male ; Adolescent ; Young Adult ; Adult ; Aged
    Chemical Substances Nucleophosmin (117896-08-9)
    Language English
    Publishing date 2023-01-01
    Publishing country Italy
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Characteristics, clinical outcomes, and risk factors of SARS-COV-2 infection in adult acute myeloid leukemia patients: experience of the PETHEMA group.

    Palanques-Pastor, Tomás / Megías-Vericat, Juan Eduardo / Martínez, Pilar / López Lorenzo, José Luis / Cornago Navascués, Javier / Rodriguez Macias, Gabriela / Cano, Isabel / Arnan Sangerman, Montserrat / Vidriales Vicente, María Belén / Algarra Algarra, Jesús Lorenzo / Foncillas, María Ángeles / Herrera, Pilar / Botella Prieto, Carmen / Vives, Susana / Figuera Álvarez, Ángela / Cuevas Palomares, Laida / Sobas, Marta / Contento Gonzalo, Alejandro / Cuello García, Rebeca /
    Amutio Diez, María Elena / De Miguel Llorente, Dunia / Navas Elorza, Begoña / Bergua Burgues, Juan Miguel / Bernal Del Castillo, Teresa / Mateos Rodríguez, María Carmen / de Cabo López, Erik / Franco Villegas, Ana Carolina / García Boyero, Raimundo / Escolano Escobar, Cristian / Seri Merino, Cristina / Cervero, Carlos / Roldán Pérez, Alicia / Hermosín Ramos, Lourdes / Cervera Calvo, Marta / Olave, María Telesa / Villafuerte Gutiérrez, Paola / de Laiglesiai, Almudena / Serrano, Josefina / Najera Irazu, María Josefa / Piñana, José Luis / Sanz, Miguel Ángel / Martínez-López, Joaquín / Montesinos, Pau

    Leukemia & lymphoma

    2021  Volume 62, Issue 12, Page(s) 2928–2938

    Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces higher morbidity and mortality in hematological malignancies, but evidence in acute myeloid leukemia (AML) is scarce. A multicenter observational study was conducted to ... ...

    Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection produces higher morbidity and mortality in hematological malignancies, but evidence in acute myeloid leukemia (AML) is scarce. A multicenter observational study was conducted to determine the clinical outcomes and assess the impact of therapeutic approaches in adult AML patients with SARS-CoV-2 infection in the first wave (March-May 2020). Overall, 108 patients were included: 51.9% with active leukemia and 70.4% under therapeutic schedules for AML. Signs and symptoms of SARS-CoV-2 were present in 96.3% of patients and 82.4% received specific treatment for SARS-CoV-2. The mortality rate was 43.5% and was correlated with age, gender, active leukemia, dyspnea, severe SARS-CoV-2, intensive care measures, neutrophil count, and D-dimer levels. A protective effect was found with azithromycin, lopinavir/ritonavir, and normal liver enzyme levels. During the SARS-CoV-2 first wave, our findings suggested an increased mortality in AML in a short period. SARS-CoV-2 management could be guided by risk factors in AML patients.
    MeSH term(s) Adult ; COVID-19 ; Humans ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/therapy ; Lopinavir ; Risk Factors ; SARS-CoV-2
    Chemical Substances Lopinavir (2494G1JF75)
    Language English
    Publishing date 2021-07-22
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Observational Study
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2021.1948031
    Database MEDical Literature Analysis and Retrieval System OnLINE

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