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  1. AU="Corrêa, Diogo G"
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  1. Artikel ; Online: Measuring head circumference using visual impressions or cross-sectional volumetric imaging: a comparison.

    Mourão, Rodrigo / Corrêa, Diogo G / Correia, Rafael / Amorim Fernandes, Talmas / Ventura, Nina

    Pediatric radiology

    2022  Band 53, Heft 1, Seite(n) 86–93

    Abstract: Background: Head circumference (HC) correlates with brain growth and development. However, radiologists typically use their visual impressions to evaluate head dimensions, which is a purely subjective assessment.: Objective: The first objective of ... ...

    Abstract Background: Head circumference (HC) correlates with brain growth and development. However, radiologists typically use their visual impressions to evaluate head dimensions, which is a purely subjective assessment.
    Objective: The first objective of this paper was to analyze whether it is possible to obtain HC measurements by CT and MRI cross-sectional volumetric imaging using parameters similar to the tape measurement method, which is considered the gold standard. The second objective was to determine the most accurate method for characterizing head size: visual impression or imaging measurement.
    Materials and methods: Children who underwent HC measurement by tape and with volumetric imaging exams were selected from the Paulo Niemeyer State Brain Institute, Brazil. Two radiologists classified the children's heads using their visual impressions and by direct measurement on imaging. We used anatomical parameters similar to the tape measurement method and appropriate head growth charts and compared the absolute values obtained.
    Results: The concordance between tape and imaging ranged 52.3-72.7% for visual impression (kappa 0.27-0.55), ≥ 95.5% for CT and ≥ 93.1% for MRI (kappa ≥ 0.92 and ≥ 0.88, respectively). Intraclass correlation coefficients ≥ 0.997 and ≥ 0.996, absolute technical error measurements of 0.20-0.31 cm and 0.24-0.29 cm, and relative technical error measurements of 0.49-0.73% and 0.58-0.70% were evidenced in the intra- and inter-rater evaluations, respectively. The means between the methods were not significantly different (P > 0.05), with high values of Pearson correlation coefficient (≥ 0.99) and Lin concordance correlation coefficient (≥ 0.99).
    Conclusion: Head circumference values obtained by cross-sectional volumetric imaging are similar to those obtained using the tape measurement method (gold standard), with high repeatability and reproducibility. Head size characterization by visual impression is less accurate than head circumference measurement by imaging and plotting the values obtained on World Health Organization normative charts.
    Mesh-Begriff(e) Child ; Humans ; Reproducibility of Results ; Cross-Sectional Studies ; Head/diagnostic imaging ; Head/anatomy & histology ; Cephalometry/methods ; Brain
    Sprache Englisch
    Erscheinungsdatum 2022-07-13
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 124459-0
    ISSN 1432-1998 ; 0301-0449
    ISSN (online) 1432-1998
    ISSN 0301-0449
    DOI 10.1007/s00247-022-05448-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Influence of natalizumab on resting-state connectivity in patients with multiple sclerosis.

    Corrêa, Diogo G / van Duinkerken, Eelco / Farinhas, João Gabriel D / Pereira, Valéria C / Gasparetto, Emerson L / Alves-Leon, Soniza V / Lopes, Fernanda Cristina R

    Journal of central nervous system disease

    2023  Band 15, Seite(n) 11795735231195775

    Abstract: Background: Changes in brain connectivity occur in patients with multiple sclerosis (MS), even in patients under disease-modifying therapies. Using magnetic resonance imaging (MRI) to asses patients treated with disease-modifying therapies, such as ... ...

    Abstract Background: Changes in brain connectivity occur in patients with multiple sclerosis (MS), even in patients under disease-modifying therapies. Using magnetic resonance imaging (MRI) to asses patients treated with disease-modifying therapies, such as natalizumab, can elucidate the mechanisms involved in clinical deterioration in MS.
    Objectives: To evaluate differences in resting-state functional connectivity among MS patients treated with natalizumab, MS patients not treated with natalizumab, and controls.
    Design: Single-center retrospective cross-sectional study.
    Methods: Twenty-three MS patients being treated with natalizumab were retrospectively compared with 23 MS patients who were naïve for natalizumab, and were using first-line medications (interferon-β and/or glatiramer acetate), and 17 gender- and age-matched control subjects. The MS patient groups were also matched for time since diagnosis and hyperintense lesion volume on FLAIR. All participants underwent brain MRI using a 3 Tesla scanner. Independent component analysis and dual regression were used to identify resting-state functional connectivity using the FMRIB Software Library.
    Results: In comparison to controls, the MS patients treated with natalizumab presented decreased connectivity in the left orbitofrontal cortex, in the anterior cingulate and orbitofrontal cortex network. The patients not treated with natalizumab presented increased connectivity in the secondary visual, sensorimotor, and ventral attention networks in comparison to controls.Compared to patients treated with natalizumab, the patients not using natalizumab presented increased connectivity in the left Heschl's gyrus and in the right superior frontal gyrus in the ventral attention network.
    Conclusion: Differences in brain connectivity between MS patients not treated with natalizumab, healthy controls, and patients treated with natalizumab may be secondary to suboptimal neuronal compensation due to prior less efficient treatments, or due to a compensation in response to maladaptive plasticity.
    Sprache Englisch
    Erscheinungsdatum 2023-08-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2586873-1
    ISSN 1179-5735
    ISSN 1179-5735
    DOI 10.1177/11795735231195775
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Posterior cingulate gyri metabolic alterations in HIV-positive patients with and without memory deficits.

    Corrêa, Diogo G / van Duinkerken, Eelco / Zimmermann, Nicolle / Fonseca, Rochele P / Gasparetto, Emerson L

    Radiologia brasileira

    2020  Band 53, Heft 6, Seite(n) 359–365

    Abstract: Objective: We aimed to evaluate whether human immunodeficiency virus (HIV)-positive patients with and without clinically significant memory deficits and healthy control participants differ on in vivo hydrogen-1 magnetic resonance spectroscopy (H-MRS) in ...

    Abstract Objective: We aimed to evaluate whether human immunodeficiency virus (HIV)-positive patients with and without clinically significant memory deficits and healthy control participants differ on in vivo hydrogen-1 magnetic resonance spectroscopy (H-MRS) in the posterior cingulate gyri.
    Materials and methods: In total, 21 HIV-positive patients with memory deficit (HIV+wMD) were compared with 15 HIV-positive patients without memory deficit (HIV+wOMD) and 22 sex-, age-, and education-matched control participants. Memory impairments were classified based on the participants' performance on the Rey Auditory Verbal Learning Test. Short echo time (30 ms), single-voxel H-MRS was performed using a 1.5-T magnetic resonance scanner.
    Results: The HIV+wMD and HIV+wOMD groups had higher choline/creatine ratio in the posterior cingulate gyri than the control group. There were no significant metabolite ratio differences between the HIV+wMD and HIV+wOMD groups.
    Conclusion: HIV-positive patients with and without memory deficits had significantly higher choline/creatine ratios than controls in the posterior cingulate gyri, which may reflect cerebral inflammation, altered cell membrane metabolism, microgliosis, and/or astrocytosis.
    Sprache Englisch
    Erscheinungsdatum 2020-12-10
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 2078806-X
    ISSN 1678-7099 ; 0100-3984
    ISSN (online) 1678-7099
    ISSN 0100-3984
    DOI 10.1590/0100-3984.2019.0093
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Increased posterior cingulate cortex efficiency may predict cognitive impairment in asymptomatic HIV patients.

    Ventura, Nina / Douw, Linda / Correa, Diogo G / Netto, Tania M / Cabral, Rafael F / Lopes, Fernanda Cristina Rueda / Gasparetto, Emerson L

    The neuroradiology journal

    2018  Band 31, Heft 4, Seite(n) 372–378

    Abstract: Purpose Despite antiretroviral therapy, approximately half of individuals with human immunodeficiency virus (HIV) will develop HIV-associated neurocognitive disorder (HAND). Efficiency of brain networks is of great importance for cognitive functioning, ... ...

    Abstract Purpose Despite antiretroviral therapy, approximately half of individuals with human immunodeficiency virus (HIV) will develop HIV-associated neurocognitive disorder (HAND). Efficiency of brain networks is of great importance for cognitive functioning, since functional networks may reorganize or compensate to preserve normal cognition. This study aims to compare efficiency of the posterior cingulate cortex (PCC) between patients with and without HAND and controls. We hypothesize HAND negative (HAND-) patients will show higher PCC efficiency than HAND positive (HAND+) patients. Methods A total of 10 HAND + patients were compared with 9 HAND- patients and 17 gender-, age-, and education-matched controls. Resting-state functional MRI was acquired with a 3 Tesla scanner. Local efficiency, a measure of network functioning, was investigated for PCC. Network differences among HAND + , HAND- patients and controls were tested as well as correlations between network parameters and cognitive test performance in different domains. Results HAND- patients showed significantly increased PCC efficiency compared with healthy controls ( p = 0.015). No differences were observed between HAND + patients and either controls ( p = 0.327) or HAND- patients ( p = 0.152). In HAND- patients, PCC efficiency was positively related with cognitive performance in the attention/working memory domain ( p = 0.003). Conversely, in HAND + patients, PCC efficiency was negatively correlated with performance in the abstraction/executive domain ( p = 0.002). Conclusion HAND- patients showed a higher level of PCC efficiency compared with healthy subjects, and PCC efficiency was positively related to cognitive performance. These results support the functional reorganization hypothesis, that increased PCC efficiency is a compensation technique to maintain cognitive functioning.
    Mesh-Begriff(e) Analysis of Variance ; Brain Mapping ; Cognition/physiology ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/etiology ; Cognitive Dysfunction/physiopathology ; Cohort Studies ; Cross-Sectional Studies ; Female ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/physiopathology ; HIV Infections/complications ; HIV Infections/diagnostic imaging ; HIV Infections/physiopathology ; HIV Infections/psychology ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology ; Neuropsychological Tests ; Rest
    Sprache Englisch
    Erscheinungsdatum 2018-06-13
    Erscheinungsland United States
    Dokumenttyp Comparative Study ; Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/1971400918782327
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: White-matter integrity in patients with systemic lupus erythematosus and memory deficits.

    Corrêa, Diogo G / Zimmermann, Nicolle / Borges, Rafael S / Pereira, Denis B / Doring, Thomas M / Tukamoto, Gustavo / Fonseca, Rochele P / Gasparetto, Emerson L

    The neuroradiology journal

    2018  Band 31, Heft 6, Seite(n) 587–595

    Abstract: Purpose: Cognitive dysfunction is common in neuropsychiatric systemic lupus erythematosus (SLE). Memory is a commonly affected cognitive domain. Clinically, however, it is difficult to detect memory deficits. The objective of this study is to evaluate ... ...

    Abstract Purpose: Cognitive dysfunction is common in neuropsychiatric systemic lupus erythematosus (SLE). Memory is a commonly affected cognitive domain. Clinically, however, it is difficult to detect memory deficits. The objective of this study is to evaluate whether normal controls and SLE patients with and without memory deficit differ in terms of white-matter integrity.
    Methods: Twenty SLE patients with memory deficit were compared to 47 SLE patients without memory deficit and 22 sex-, age-, and education-matched control individuals. Diffusion tensor imaging (DTI) was performed in a 1.5-Tesla scanner. For tract-based spatial statistics analysis, a white-matter skeleton was created. A permutation-based inference with 5000 permutations with a threshold of p < 0.05 was used to identify abnormalities in fractional anisotropy (FA). The mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD) were also projected onto the mean FA skeleton.
    Results: Compared to controls, SLE patients with and without memory deficit had decreased FA in: bilateral anterior thalamic radiation, inferior fronto-occipital fasciculus, superior longitudinal fasciculus, uncinate fasciculus, corticospinal tract, genu, and body of the corpus callosum. SLE patients with and without memory deficit also presented increased MD and RD values compared to controls in these areas. Comparison between SLE patients with and without memory deficit did not present significant differences in DTI parameters.
    Conclusion: DTI can detect extensive abnormalities in the normal-appearing white matter of SLE patients with and without memory deficit, compared to controls. However, there was no difference, in terms of white-matter integrity, between the groups of SLE patients.
    Mesh-Begriff(e) Adult ; Anisotropy ; Brain Mapping ; Case-Control Studies ; Cognition Disorders/diagnostic imaging ; Cognition Disorders/etiology ; Corpus Callosum/diagnostic imaging ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Lupus Erythematosus, Systemic/diagnostic imaging ; Lupus Erythematosus, Systemic/pathology ; Male ; Memory Disorders/diagnostic imaging ; Memory Disorders/pathology ; Middle Aged ; Nerve Fibers/pathology ; Neuropsychological Tests ; Retrospective Studies ; White Matter/diagnostic imaging
    Sprache Englisch
    Erscheinungsdatum 2018-08-09
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/1971400918793601
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Longitudinal evaluation of resting-state connectivity, white matter integrity and cortical thickness in stable HIV infection: Preliminary results.

    Corrêa, Diogo G / Zimmermann, Nicolle / Ventura, Nina / Tukamoto, Gustavo / Doring, Thomas / Leite, Sarah Cb / Fonseca, Rochele P / Bahia, Paulo Rv / Lopes, Fernanda Cr / Gasparetto, Emerson L

    The neuroradiology journal

    2017  Band 30, Heft 6, Seite(n) 535–545

    Abstract: Purpose The objectives of this study were to determine if HIV-infected patients treated with highly active antiretroviral therapy (HAART), without dementia, suffer from longitudinal gray matter (GM) volume loss, changes in white matter (WM) integrity and ...

    Abstract Purpose The objectives of this study were to determine if HIV-infected patients treated with highly active antiretroviral therapy (HAART), without dementia, suffer from longitudinal gray matter (GM) volume loss, changes in white matter (WM) integrity and deterioration in functional connectivity at rest, in an average interval of 30 months. Methods Clinically stable HIV-positive patients (on HAART, CD4 + T lymphocyte > 200 cells/μl, and viral loads <50 copies/μl) were recruited. None of them had HIV-associated dementia. Each patient underwent two scans, performed in a 1.5-T magnetic resonance imaging (MRI) scanner. FreeSurfer was used to perform cortical volumetric reconstruction and segmentation of GM structures. WM integrity was assessed using tract-based spatial statistics to post-process diffusion tensor imaging data, and FMRIB's Software Library tools were used to post-process resting-state functional magnetic resonance imaging (RS-fMRI). Results There were no significant differences in cortical thickness, deep GM volumes, or diffusivity parameters between the scans at the two time points. Five resting-state networks were identified in our patients. In the second MRI, HIV-positive patients presented increased areas of functional connectivity in visual pathways, frontoparietal and cerebellar networks, compared with the first MRI (considering p < 0.05). Conclusions RS-fMRI revealed potentially compensatory longitudinal alterations in the brains of HIV-positive patients, attempting to compensate for brain damage related to the infection.
    Sprache Englisch
    Erscheinungsdatum 2017-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2257770-1
    ISSN 2385-1996 ; 1971-4009 ; 1120-9976
    ISSN (online) 2385-1996
    ISSN 1971-4009 ; 1120-9976
    DOI 10.1177/1971400917739273
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Diffusion tensor MRI evaluation of the corona radiata, cingulate gyri, and corpus callosum in HIV patients.

    Leite, Sarah C B / Corrêa, Diogo G / Doring, Thomas M / Kubo, Tadeu T A / Netto, Tania M / Ferracini, Rafael / Ventura, Nina / Bahia, Paulo R V / Gasparetto, Emerson L

    Journal of magnetic resonance imaging : JMRI

    2013  Band 38, Heft 6, Seite(n) 1488–1493

    Abstract: Purpose: To evaluate the white matter integrity of the corona radiata, cingulate gyri, and corpus callosum in patients with human immunodeficiency virus (HIV) infection through diffusion tensor imaging (DTI).: Materials and methods: Thirty-four ... ...

    Abstract Purpose: To evaluate the white matter integrity of the corona radiata, cingulate gyri, and corpus callosum in patients with human immunodeficiency virus (HIV) infection through diffusion tensor imaging (DTI).
    Materials and methods: Thirty-four patients with at least 5 years of HIV infection and 27 healthy controls underwent magnetic resonance imaging (MRI) in a 1.5 T scanner. A voxelwise-based technique was used to analyze the DTI data.
    Results: We found that in the body of corpus callosum the fractional anisotropy (FA) was significantly reduced, whereas mean diffusivity (MD) and radial diffusivity (RD) were increased in HIV patients. Analyzing the corona radiata, axial diffusivity (AD) and MD were significantly increased in the left superior region, MD and RD were increased in the left posterior area, and, furthermore, MD was also increased in the right posterior region. No significant abnormalities were found on the cingulate gyri. The white matter damage, related to FA reduction, was associated with increased RD, indicating that demyelization might be the pathophysiological result of this damage.
    Conclusion: Since the DTI can detect abnormalities in the normal-appearing white matter, this technique may play a role as an early marker of HIV disease progression, including clinical manifestations such as cognitive impairment.
    Mesh-Begriff(e) Adult ; Aged ; Corpus Callosum/pathology ; Diffusion Tensor Imaging/methods ; Female ; Gyrus Cinguli/pathology ; HIV Infections/pathology ; Humans ; Image Interpretation, Computer-Assisted/methods ; Imaging, Three-Dimensional/methods ; Internal Capsule/pathology ; Male ; Middle Aged ; Nerve Fibers, Myelinated/pathology ; Reproducibility of Results ; Sensitivity and Specificity
    Sprache Englisch
    Erscheinungsdatum 2013-12
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1146614-5
    ISSN 1522-2586 ; 1053-1807
    ISSN (online) 1522-2586
    ISSN 1053-1807
    DOI 10.1002/jmri.24129
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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