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  1. AU="Corral, Esther"
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  1. Artikel ; Online: COVID-19 in Spain: Transplantation in the midst of the pandemic.

    Domínguez-Gil, Beatriz / Coll, Elisabeth / Fernández-Ruiz, Mario / Corral, Esther / Del Río, Francisco / Zaragoza, Rafael / Rubio, Juan J / Hernández, Domingo

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2020  Band 20, Heft 9, Seite(n) 2593–2598

    Abstract: Spain has been one of the most affected countries by the COVID-19 outbreak. As of April 28, 2020, the number of confirmed cases is 210 773, including 102 548 patients recovered, more than 10 300 admitted to the ICU, and 23 822 deaths, with a global case ... ...

    Abstract Spain has been one of the most affected countries by the COVID-19 outbreak. As of April 28, 2020, the number of confirmed cases is 210 773, including 102 548 patients recovered, more than 10 300 admitted to the ICU, and 23 822 deaths, with a global case fatality rate of 11.3%. From the perspective of donation and transplantation, the Spanish system first focused on safety issues, providing recommendations for donor evaluation and testing, and to rule out SARS-CoV-2 infection in potential recipients prior to transplantation. Since the country entered into an epidemiological scenario of sustained community transmission and saturation of intensive care, developing donation and transplantation procedures has become highly complex. Since the national state of alarm was declared in Spain on March 13, 2020, the mean number of donors has declined from 7.2 to 1.2 per day, and the mean number of transplants from 16.1 to 2.1 per day. Increased mortality on the waiting list may become a collateral damage of this terrible pandemic.
    Mesh-Begriff(e) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Organ Transplantation ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Spain/epidemiology ; Tissue Donors/supply & distribution ; Tissue and Organ Procurement/organization & administration ; Waiting Lists
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-27
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15983
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  2. Artikel ; Online: Antibiotic susceptibility trend before and after long-term use of selective digestive decontamination: a 16 year ecological study.

    Lloréns-Villar, Yanire / Tusell, Fernando / Canut, Andrés / Barrasa, Helena / Corral, Esther / Martín, Alejandro / Rodríguez-Gascón, Alicia

    The Journal of antimicrobial chemotherapy

    2019  Band 74, Heft 8, Seite(n) 2289–2294

    Abstract: Objectives: The aim of this study was to compare antimicrobial susceptibility rates in a Spanish ICU before and after the introduction of selective digestive decontamination (SDD) and also to compare these with susceptibility data from other Spanish ... ...

    Abstract Objectives: The aim of this study was to compare antimicrobial susceptibility rates in a Spanish ICU before and after the introduction of selective digestive decontamination (SDD) and also to compare these with susceptibility data from other Spanish ICUs without SDD.
    Methods: We performed a retrospective study in the ICU of the University Hospital of Alava, where SDD was implemented in 2002. The SDD protocol consisted of a 2% mixture of gentamicin, colistin and amphotericin B applied on the buccal mucosa and a suspension of the same drugs in the gastrointestinal tract; additionally, for the first 3 days, systemic ceftriaxone was administered. From 1998 to 2013 we analysed the susceptibility rates for 48 antimicrobial/organism combinations. Interrupted time series using a linear dynamic model with SDD as an intervention was used. Data from other ICUs were obtained from the ENVIN-HELICS national registry.
    Results: Only amoxicillin/clavulanic acid against Escherichia coli and Proteus mirabilis, and a high concentration of gentamicin against Enterococcus faecalis, resulted in a significant decrease in the susceptibility rate after the implementation of SDD, with a drop of 20%, 27% and 32%, respectively. Compared with other Spanish ICUs without SDD, the susceptibility rate was higher in the ICU of our hospital in most cases. When it was lower, differences were <10%, except for a high concentration of streptomycin against Enterococcus faecium, for which the difference was 19%.
    Conclusions: No relevant changes in the overall susceptibility rate after the implementation of SDD were detected. Susceptibility rates were not lower than those in the Spanish ICUs without SDD.
    Mesh-Begriff(e) Anti-Bacterial Agents/administration & dosage ; Antifungal Agents/administration & dosage ; Decontamination/methods ; Drug Resistance, Bacterial ; Enterobacteriaceae/drug effects ; Enterobacteriaceae/isolation & purification ; Enterococcus/drug effects ; Enterococcus/isolation & purification ; Hospitals, University ; Humans ; Intensive Care Units ; Interrupted Time Series Analysis ; Microbial Sensitivity Tests ; Retrospective Studies ; Spain
    Chemische Substanzen Anti-Bacterial Agents ; Antifungal Agents
    Sprache Englisch
    Erscheinungsdatum 2019-05-07
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkz186
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  3. Artikel: COVID-19 in Spain: Transplantation in the midst of the pandemic

    Domínguez-Gil, Beatriz / Coll, Elisabeth / Fernández-Ruiz, Mario / Corral, Esther / Del Río, Francisco / Zaragoza, Rafael / Rubio, Juan J / Hernández, Domingo

    Am. j. transplant

    Abstract: Spain has been one of the most affected countries by the COVID-19 outbreak. As of April 28, 2020, the number of confirmed cases is 210 773, including 102 548 patients recovered, more than 10 300 admitted to the ICU, and 23 822 deaths, with a global case ... ...

    Abstract Spain has been one of the most affected countries by the COVID-19 outbreak. As of April 28, 2020, the number of confirmed cases is 210 773, including 102 548 patients recovered, more than 10 300 admitted to the ICU, and 23 822 deaths, with a global case fatality rate of 11.3%. From the perspective of donation and transplantation, the Spanish system first focused on safety issues, providing recommendations for donor evaluation and testing, and to rule out SARS-CoV-2 infection in potential recipients prior to transplantation. Since the country entered into an epidemiological scenario of sustained community transmission and saturation of intensive care, developing donation and transplantation procedures has become highly complex. Since the national state of alarm was declared in Spain on March 13, 2020, the mean number of donors has declined from 7.2 to 1.2 per day, and the mean number of transplants from 16.1 to 2.1 per day. Increased mortality on the waiting list may become a collateral damage of this terrible pandemic.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #32359194
    Datenquelle COVID19

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  4. Artikel ; Online: COVID‐19 in Spain

    Domínguez‐Gil, Beatriz / Coll, Elisabeth / Fernández‐Ruiz, Mario / Corral, Esther / Río, Francisco / Zaragoza, Rafael / Rubio, Juan J. / Hernández, Domingo

    American Journal of Transplantation

    Transplantation in the midst of the pandemic

    2020  Band 20, Heft 9, Seite(n) 2593–2598

    Schlagwörter Immunology and Allergy ; Pharmacology (medical) ; Transplantation ; covid19
    Sprache Englisch
    Verlag Wiley
    Erscheinungsland us
    Dokumenttyp Artikel ; Online
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.15983
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  5. Artikel ; Online: The key decision: forgoing treatment or maintaining care.

    Saralegui, Iñaki / Manzano, Alberto / Corral, Esther

    Journal of critical care

    2010  Band 25, Heft 4, Seite(n) 651; author reply 652

    Mesh-Begriff(e) Clinical Protocols ; Decision Making ; Humans ; Intensive Care Units ; Life Support Care/ethics ; Life Support Care/legislation & jurisprudence ; Respiration, Artificial/ethics ; Spain ; Withholding Treatment/ethics ; Withholding Treatment/legislation & jurisprudence
    Sprache Englisch
    Erscheinungsdatum 2010-12
    Erscheinungsland United States
    Dokumenttyp Comment ; Letter
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2010.06.014
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  6. Artikel ; Online: Descontaminación digestiva selectiva: repercusión en la carga de trabajo y el coste del laboratorio de microbiología y tendencias en la resistencia bacteriana.

    García-San Vicente, Blanca / Canut, Andrés / Labora, Alicia / Otazua, Maritxu / Corral, Esther

    Enfermedades infecciosas y microbiologia clinica

    2010  Band 28, Heft 2, Seite(n) 75–81

    Abstract: Introduction: This study determines the workload and cost of implementing selective digestive decontamination in the microbiology laboratory, and reports the impact on microbial flora and bacterial resistance trends in the intensive care unit (ICU).: ... ...

    Titelübersetzung Selective decontamination of the digestive tract: repercussions on microbiology laboratory workload and costs, and antibiotic resistance trends.
    Abstract Introduction: This study determines the workload and cost of implementing selective digestive decontamination in the microbiology laboratory, and reports the impact on microbial flora and bacterial resistance trends in the intensive care unit (ICU).
    Methods: The total microbiological workload and cost were quantified, as well as the part charged to the petitioning service, in the year before and the year after introducing the procedure. Changes in microbial flora were evaluated and bacterial resistance trends were analyzed over 12 years in 21 sentinel antimicrobial/microorganism combinations.
    Results: The workload ascribed to the ICU increased by 10% and cost increased by 1.8% in the period after introduction of the procedure (non-significant differences). The increased workload resulting from epidemiological surveillance cultures was compensated by significant reductions in quantitative endotracheal aspirate cultures, blood cultures, exudate cultures, identification tests with antibiograms, and serologies. The procedure has been associated with a significant decrease in Acinetobacter isolates and a significant increase in Enterococcus. Three significant trends of increased resistance were detected, all of them in Pseudomonas aeruginosa (imipenem, tobramycin, and ciprofloxacin).
    Conclusions: In our hospital, implementation of selective digestive decontamination did not cause a significant increase in the workload or costs in the microbiology laboratory. Selective digestive decontamination was associated with a significant decrease in Acinetobacter, an increase in Enterococcus, and higher resistance to imipenem, tobramycin and ciprofloxacin in P. aeruginosa.
    Mesh-Begriff(e) Amphotericin B/administration & dosage ; Amphotericin B/pharmacology ; Amphotericin B/therapeutic use ; Anti-Infective Agents/administration & dosage ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/therapeutic use ; Bacteria, Aerobic/drug effects ; Bacteria, Aerobic/isolation & purification ; Bacteriological Techniques/economics ; Bacteriological Techniques/statistics & numerical data ; Ceftriaxone/administration & dosage ; Ceftriaxone/pharmacology ; Ceftriaxone/therapeutic use ; Colistin/administration & dosage ; Colistin/pharmacology ; Colistin/therapeutic use ; Critical Care/methods ; Decontamination/economics ; Decontamination/methods ; Drug Resistance, Fungal ; Drug Resistance, Microbial ; Fungi/drug effects ; Fungi/isolation & purification ; Gastrointestinal Tract/microbiology ; Gentamicins/administration & dosage ; Gentamicins/pharmacology ; Gentamicins/therapeutic use ; Hospital Costs ; Hospitals, General/economics ; Hospitals, Public/economics ; Humans ; Intensive Care Units/economics ; Intensive Care Units/statistics & numerical data ; Laboratories, Hospital/economics ; Respiration, Artificial ; Retrospective Studies ; Spain ; Workload/economics ; Workload/statistics & numerical data
    Chemische Substanzen Anti-Infective Agents ; Gentamicins ; Ceftriaxone (75J73V1629) ; Amphotericin B (7XU7A7DROE) ; Colistin (Z67X93HJG1)
    Sprache Spanisch
    Erscheinungsdatum 2010-02
    Erscheinungsland Spain
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 1070941-1
    ISSN 1578-1852 ; 0213-005X
    ISSN (online) 1578-1852
    ISSN 0213-005X
    DOI 10.1016/j.eimc.2009.03.005
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Association between -T786C NOS3 polymorphism and resistant hypertension

    Martín-Luengo Cándido / Sánchez-Rodríguez Angel / Sánchez-Ledesma María / Corral Esther / Cruz-González Ignacio / González-Sarmiento Rogelio

    BMC Cardiovascular Disorders, Vol 9, Iss 1, p

    a prospective cohort study

    2009  Band 35

    Abstract: Abstract Background It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but ... ...

    Abstract Abstract Background It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not with resistant hypertension. The aim of the present study was to investigate if the -786T>C and G894T (Glu298Asp) polymorphisms of the NOS3 gene were associated with resistant hypertension. Methods A prospective case-control observational study was performed. From a series of 950 consecutive patients followed up during 42 months, 48 patients with resistant hypertension were detected. 232 patients with controlled high blood pressure were also included. Results No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients. However, genotype -786CC was more frequent in the group of patients with resistant hypertension (33.3%) than in the group of patients with controlled high blood pressure (17.7%) (p 0.03). Furthermore carriers of allele T (-786TC and -786TT) were more frequent in patients with controlled hypertension (82.3%) than those with resistant hypertension (66.7%) (Multivariate analysis; RR 2.09; 95% CI 1.03–4.24; p 0.004). Conclusion Our results indicate that genotype -786CC of the NOS3 gene increase the susceptibility to suffer resistant hypertension, which suggest that resistance to conventional therapy could be determined at the endothelial level.
    Schlagwörter Diseases of the circulatory (Cardiovascular) system ; RC666-701 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Cardiovascular ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Thema/Rubrik (Code) 610 ; 616
    Sprache Englisch
    Erscheinungsdatum 2009-08-01T00:00:00Z
    Verlag BioMed Central
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Utility of Real-Time 3-Dimensional Transesophageal Echocardiography in the Assessment of Mitral Paravalvular Leak.

    Arribas-Jimenez, Antonio / Rama-Merchan, Juan C / Barreiro-Pérez, Manuel / Merchan-Gómez, Soraya / Iscar-Galán, Alberto / Martín-García, Ana / Nieto-Ballestero, Felix / Sánchez-Corral, Esther / Rodriguez-Collado, Javier / Cruz-González, Ignacio / Sanchez, Pedro L

    Circulation journal : official journal of the Japanese Circulation Society

    2016  Band 80, Heft 3, Seite(n) 738–744

    Abstract: Background: Mitral paravalvular leak (PVL) is a potential complication of surgical valve replacement procedures. Real-time 3D transesophageal echocardiography (RT-3DTEE) has emerged as an efficient tool for providing essential information about the ... ...

    Abstract Background: Mitral paravalvular leak (PVL) is a potential complication of surgical valve replacement procedures. Real-time 3D transesophageal echocardiography (RT-3DTEE) has emerged as an efficient tool for providing essential information about the anatomy of mitral PVLs compared with 2DTEE findings. The purpose of this study was to evaluate the utility of RT-3DTEE in the assessment of mitral PVLs.
    Methods and results: The 3D characteristics of PVLs were recorded and compared with 2D findings. We included 34 consecutive patients with clinical suspicion of mitral PVL in the study. Mitral PVLs were detected in 26 patients (76%); 26 PVLs were identified by 2DTEE and 37 by RT-3DTEE. Moderate or severe mitral regurgitation was present in 23 patients (88%). The most common PVL locations were the septal and posterior regions. The median PVL size measured by RT-3DTEE was 7 mm long×4 mm wide. The median vena contracta of defect measured by 2DTEE and RT-3DTEE was 5 mm and 4 mm, respectively. The median effective regurgitant orifice area of defect measured by RT-3DTEE was 0.36 cm(2). The defect types were "oval" (54%), "round" (35%), "crescentic" (8%) and highly irregular (3%).
    Conclusions: Compared with 2DTEE, RT-3DTEE provided detailed descriptions of the number, location, size and morphology of PVLs, which is essential for planning and guiding the potential corrective techniques. (Circ J 2016; 80: 738-744).
    Mesh-Begriff(e) Aged ; Echocardiography, Transesophageal/methods ; Female ; Heart Valve Prosthesis Implantation/adverse effects ; Humans ; Male ; Middle Aged ; Mitral Valve/diagnostic imaging ; Mitral Valve/surgery ; Postoperative Complications/diagnostic imaging ; Postoperative Complications/therapy
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-15-0802
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  9. Artikel ; Online: Association between -T786C NOS3 polymorphism and resistant hypertension: a prospective cohort study.

    Cruz-González, Ignacio / Corral, Esther / Sánchez-Ledesma, María / Sánchez-Rodríguez, Angel / Martín-Luengo, Cándido / González-Sarmiento, Rogelio

    BMC cardiovascular disorders

    2009  Band 9, Seite(n) 35

    Abstract: Background: It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not ... ...

    Abstract Background: It is estimated that 5% of the hypertensive patients are resistant to conventional antihypertensive therapy. Polymorphisms in the endothelial nitric oxide synthase (NOS3) gene have been associated with high blood pressure levels, but not with resistant hypertension. The aim of the present study was to investigate if the -786T>C and G894T (Glu298Asp) polymorphisms of the NOS3 gene were associated with resistant hypertension.
    Methods: A prospective case-control observational study was performed. From a series of 950 consecutive patients followed up during 42 months, 48 patients with resistant hypertension were detected. 232 patients with controlled high blood pressure were also included.
    Results: No differences were observed in the distribution of G894T (Glu298Asp) NOS3 genotypes between the resistant hypertension group and the controlled hypertension patients. However, genotype -786CC was more frequent in the group of patients with resistant hypertension (33.3%) than in the group of patients with controlled high blood pressure (17.7%) (p 0.03). Furthermore carriers of allele T (-786TC and -786TT) were more frequent in patients with controlled hypertension (82.3%) than those with resistant hypertension (66.7%) (Multivariate analysis; RR 2.09; 95% CI 1.03-4.24; p 0.004).
    Conclusion: Our results indicate that genotype -786CC of the NOS3 gene increase the susceptibility to suffer resistant hypertension, which suggest that resistance to conventional therapy could be determined at the endothelial level.
    Mesh-Begriff(e) Aged ; Aged, 80 and over ; Antihypertensive Agents/therapeutic use ; Blood Pressure/drug effects ; Blood Pressure/genetics ; Case-Control Studies ; Drug Resistance/genetics ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Humans ; Hypertension/drug therapy ; Hypertension/enzymology ; Hypertension/genetics ; Male ; Middle Aged ; Nitric Oxide Synthase Type III/genetics ; Odds Ratio ; Phenotype ; Polymorphism, Genetic ; Prospective Studies ; Risk Assessment
    Chemische Substanzen Antihypertensive Agents ; NOS3 protein, human (EC 1.14.13.39) ; Nitric Oxide Synthase Type III (EC 1.14.13.39)
    Sprache Englisch
    Erscheinungsdatum 2009-08-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2059859-2
    ISSN 1471-2261 ; 1471-2261
    ISSN (online) 1471-2261
    ISSN 1471-2261
    DOI 10.1186/1471-2261-9-35
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: A randomized trial of intravenous glutamine supplementation in trauma ICU patients.

    Pérez-Bárcena, Jon / Marsé, Pedro / Zabalegui-Pérez, Arturo / Corral, Esther / Herrán-Monge, Rubén / Gero-Escapa, María / Cervera, Mercedes / Llompart-Pou, Juan Antonio / Ayestarán, Ignacio / Raurich, Joan Maria / Oliver, Antonio / Buño, Antonio / García de Lorenzo, Abelardo / Frontera, Guiem

    Intensive care medicine

    2014  Band 40, Heft 4, Seite(n) 539–547

    Abstract: Purpose: To evaluate the effect of the intravenous (i.v.) L-alanyl-L-glutamine dipeptide supplementation during 5 days on clinical outcome in trauma patients admitted to the intensive care unit (ICU).: Methods: This was a prospective, randomized, ... ...

    Abstract Purpose: To evaluate the effect of the intravenous (i.v.) L-alanyl-L-glutamine dipeptide supplementation during 5 days on clinical outcome in trauma patients admitted to the intensive care unit (ICU).
    Methods: This was a prospective, randomized, double-blind, multicenter trial. Glutamine was not given as a component of nutrition but as an extra infusion. The primary outcome variable was the number of new infections within the first 14 days.
    Results: We included 142 patients. There were no differences between groups in baseline characteristics. Up to 62 % of the patients in the placebo group and 63 % in the treatment group presented confirmed infections (p = 0.86). ICU length of stay was 14 days in both groups (p = 0.54). Hospital length of stay was 27 days in the placebo group and 29 in the treatment group (p = 0.88). ICU mortality was 4.2 % in both groups (p = 1). Sixty percent of the patients presented low glutamine levels before randomization. At the end of the treatment (6th day), 48 % of the patients maintained low glutamine levels (39 % of treated patients vs. 57 % in the placebo group). Patients with low glutamine levels at day 6 had more number of infections (58.8 vs. 80.9 %; p = 0.032) and longer ICU (9 vs. 20 days; p < 0.01) and hospital length of stay (24 vs. 41 days; p = 0.01).
    Conclusions: There was no benefit with i.v. L-alanyl-L-glutamine dipeptide supplementation (0.5 g/kg body weight/day of the dipeptide) during 5 days in trauma patients admitted to the ICU. The i.v. glutamine supplementation was not enough to normalize the plasma glutamine levels in all patients. Low plasma glutamine levels at day 6 were associated with a worse outcome.
    Mesh-Begriff(e) Adult ; Dietary Supplements ; Double-Blind Method ; Female ; Glutamine/administration & dosage ; Glutamine/blood ; Humans ; Infections/complications ; Infusions, Intravenous ; Intensive Care Units ; Length of Stay ; Male ; Middle Aged ; Prospective Studies ; Wounds and Injuries/blood ; Wounds and Injuries/drug therapy ; Wounds and Injuries/mortality
    Chemische Substanzen Glutamine (0RH81L854J)
    Sprache Englisch
    Erscheinungsdatum 2014-02-21
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-014-3230-y
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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