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  1. Article ; Online: The Role of Voltage-Gated Calcium Channels in Basal Ganglia Neurodegenerative Disorders.

    Correa, Bernardo H M / Moreira, Carlos Roberto / Hildebrand, Michael E / Vieira, Luciene Bruno

    Current neuropharmacology

    2022  Volume 21, Issue 2, Page(s) 183–201

    Abstract: ... Calcium ( ... ...

    Abstract Calcium (Ca
    MeSH term(s) Humans ; Calcium Channels/metabolism ; Basal Ganglia Diseases/metabolism ; Basal Ganglia Diseases/pathology ; Neurons/metabolism ; Basal Ganglia/metabolism ; Parkinson Disease/metabolism ; Calcium/metabolism
    Chemical Substances Calcium Channels ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-04-01
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X20666220327211156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Involvement of the Renin-Angiotensin System in Stress: State of the Art and Research Perspectives.

    Correa, Bernardo H M / Becari, Luca / Fontes, Marco Antônio Peliky / Simões-E-Silva, Ana Cristina / Kangussu, Lucas M

    Current neuropharmacology

    2021  Volume 20, Issue 6, Page(s) 1212–1228

    Abstract: Background: Along with other canonical systems, the renin-angiotensin system (RAS) has shown important roles in stress. This system is a complex regulatory proteolytic cascade composed of various enzymes, peptides, and receptors. Besides the classical ( ... ...

    Abstract Background: Along with other canonical systems, the renin-angiotensin system (RAS) has shown important roles in stress. This system is a complex regulatory proteolytic cascade composed of various enzymes, peptides, and receptors. Besides the classical (ACE/Ang II/AT1 receptor) and the counter-regulatory (ACE2/Ang-(1-7)/Mas receptor) RAS axes, evidence indicates that nonclassical components, including Ang III, Ang IV, AT
    Objective and methods: This comprehensive review summarizes the current knowledge on the participation of RAS components in different adverse environmental stimuli stressors, including air jet stress, cage switch stress, restraint stress, chronic unpredictable stress, neonatal isolation stress, and post-traumatic stress disorder.
    Results and conclusion: In general, activation of the classical RAS axis potentiates stress-related cardiovascular, endocrine, and behavioral responses, while the stimulation of the counter-regulatory axis attenuates these effects. Pharmacological modulation in both axes is optimistic, offering promising perspectives for stress-related disorders treatment. In this regard, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers are potential candidates already available since they block the classical axis, activate the counter-regulatory axis, and are safe and efficient drugs.
    MeSH term(s) Angiotensin II/metabolism ; Angiotensin II/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Angiotensin-Converting Enzyme Inhibitors/therapeutic use ; Humans ; Infant, Newborn ; Peptide Fragments/metabolism ; Peptidyl-Dipeptidase A/metabolism ; Peptidyl-Dipeptidase A/pharmacology ; Renin-Angiotensin System/physiology ; Signal Transduction
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Peptide Fragments ; Angiotensin II (11128-99-7) ; Peptidyl-Dipeptidase A (EC 3.4.15.1)
    Language English
    Publishing date 2021-12-01
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2192352-8
    ISSN 1875-6190 ; 1570-159X
    ISSN (online) 1875-6190
    ISSN 1570-159X
    DOI 10.2174/1570159X19666210719142300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6150: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Telomere Shortening and Psychiatric Disorders: A Systematic Review.

    Pousa, Pedro A / Souza, Raquel M / Melo, Paulo Henrique M / Correa, Bernardo H M / Mendonça, Tamires S C / Simões-E-Silva, Ana Cristina / Miranda, Débora M

    Cells

    2021  Volume 10, Issue 6

    Abstract: Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis ... ...

    Abstract Telomeres are aging biomarkers, as they shorten while cells undergo mitosis. The aim of this study was to evaluate whether psychiatric disorders marked by psychological distress lead to alterations to telomere length (TL), corroborating the hypothesis that mental disorders might have a deeper impact on our physiology and aging than it was previously thought. A systematic search of the literature using MeSH descriptors of psychological distress ("Traumatic Stress Disorder" or "Anxiety Disorder" or "depression") and telomere length ("cellular senescence", "oxidative stress" and "telomere") was conducted on PubMed, Cochrane Library and ScienceDirect databases. A total of 56 studies (113,699 patients) measured the TL from individuals diagnosed with anxiety, depression and posttraumatic disorders and compared them with those from healthy subjects. Overall, TL negatively associates with distress-related mental disorders. The possible underlying molecular mechanisms that underly psychiatric diseases to telomere shortening include oxidative stress, inflammation and mitochondrial dysfunction linking. It is still unclear whether psychological distress is either a cause or a consequence of telomere shortening.
    MeSH term(s) Humans ; Mental Disorders/genetics ; Mental Disorders/metabolism ; Mitochondria/genetics ; Mitochondria/metabolism ; Oxidative Stress ; Telomere/genetics ; Telomere/metabolism ; Telomere Shortening
    Language English
    Publishing date 2021-06-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells10061423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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