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  1. Article ; Online: Reduction in the Number of Patients with Suspected and Confirmed Acute Coronary Syndrome during the early months of the Covid-19 Pandemic: Analysis of a Brazilian Network.

    Silva, Pedro Gabriel Melo de Barros E / Dutra, Ana Amaral Ferreira / Manfredi, Adriana Bertolami / Sampaio, Pedro Paulo Nogueres / Correa, Celso Musa / Griz, Hemilo Borba / Setta, Daniel / Furlan, Valter

    Arquivos brasileiros de cardiologia

    2021  Volume 116, Issue 5, Page(s) 1003–1006

    Title translation Redução no Número de Pacientes com Síndrome Coronariana Aguda Suspeita e Confirmada nos Primeiros Meses da Pandemia da Covid-19: Análise de uma Rede Brasileira.
    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/epidemiology ; Brazil/epidemiology ; COVID-19 ; Humans ; Pandemics ; SARS-CoV-2
    Language Portuguese
    Publishing date 2021-05-17
    Publishing country Brazil
    Document type Letter
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.36660/abc.20200873
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  2. Article ; Online: Potential performance of a 0 h/1 h algorithm and a single cut-off measure of high-sensitivity troponin T in a diverse population: main results of the IN-HOPE study.

    de Barros E Silva, Pedro G M / Ferreira, Ana Amaral / Malafaia, Felipe / Tavares Reis, Antonielle Figueiredo Macedo / Sznejder, Henry / Lopes Junior, Augusto Celso De Araujo / Agostinho, Camila Anacleto / Fonseca, Luiz Henrique de Oliveira / Okitoi, Débora Vieira Donini / Correa, Celso Musa / Zincone, Eduardo / Cury, Marcelo Paiva / Rosa, Gustavo Augusto Lopes / Ribeiro, Henrique Barbosa / Soeiro, Alexandre de Matos / de Oliveira, Carlos Alexandre Lemes / Kuusberg, Guilherme Capelli / Ohe, Louis Nakayama / Souza, Douglas de Oliveira /
    Manfredi, Adriana Bertolami / Martins, Amanda Francisco / Sampaio, Pedro Paulo Nogueres / Vaz, Thiago Baganha / Franco, Luciana Ferreira / Ferreira, Carlos Eduardo Dos Santos / Lopes, Renato Delascio

    European heart journal. Acute cardiovascular care

    2023  Volume 12, Issue 11, Page(s) 755–764

    Abstract: Aims: Chest pain is a major cause of medical evaluation at emergency department (ED) and demands observation to exclude the diagnosis of acute myocardial infarction (AMI). High-sensitivity cardiac troponin assays used as isolated measure and by 0- and 1- ...

    Abstract Aims: Chest pain is a major cause of medical evaluation at emergency department (ED) and demands observation to exclude the diagnosis of acute myocardial infarction (AMI). High-sensitivity cardiac troponin assays used as isolated measure and by 0- and 1-h algorithms are accepted as a rule-in/rule-out strategy, but there is a lack of validation in specific populations.
    Methods and results: The IN-HOspital Program to systematizE Chest Pain Protocol (IN-HOPE study) is a multicentre study that prospectively included patients admitted to the ED due to suspected symptoms of AMI at 16 sites in Brazil. Medical decisions of all patients followed the standard approach of 0 h/3 h protocol, but, in addition, blood samples were also collected at 0 and 1 h and sent to a central laboratory (core lab) to measure high-sensitivity cardiac troponin T (hs-cTnT). To assess the theoretical performance of 0 h/1 h algorithm, troponin < 12 ng/L with a delta < 3 was considered rule-out while a value ≥ 52 or a delta ≥ 5 was considered a rule-in criterion (the remaining were considered as observation group). The main objective of the study was to assess, in a population managed by the 0 h/3 h protocol, the accuracy of 0 h/1 h algorithm overall and in groups with a higher probability of AMI. All patients were followed up for 30 days, and potential events were adjudicated. In addition to the prospective cohort, a retrospective analysis was performed assessing all patients with hs-cTnT measured during the year of 2021 but not included in the prospective cohort, regardless of the indication of the test. A total of 5.497 patients were included (583 in the prospective and 4.914 in the retrospective analysis). The prospective cohort had a mean age of 57.3 (± 14.8) and 45.6% of females with a mean HEART score of 4.0 ± 2.2. By the core lab analysis, 74.4% would be eligible for a rule-out approach (45.3% of them with a HEART score > 3) while 7.3% would fit the rule-in criteria. In this rule-out group, the negative predictive value for index AMI was 100% (99.1-100) overall and regardless of clinical scores. At 30 days, no death or AMI occurred in the rule-out group of both 0/1 and 0/3 h algorithms while 52.4% of the patients in the rule-in group (0 h/1 h) were considered as AMI by adjudication. In the observation group (grey zone) of 0 h/1 h algorithm, GRACE discriminated the risk of these patients better than HEART score. In the retrospective analysis, 1.091 patients had a troponin value of <5 ng/L and there were no cardiovascular deaths at 30 days in this group. Among all 4.914 patients, the 30-day risk of AMI or cardiovascular death increased according to the level of troponin: 0% in the group < 5 ng/L, 0.6% between 5 and 14 ng/L, 2.2% between 14 and 42 ng/L, 6.3% between 42 and 90 ng/L, and 7.7% in the level ≥ 90 ng/L.
    Conclusion: In this large multicentre study, a 0 h/1 h algorithm had the potential to classify as rule-in or rule-out in almost 80% of the patients. The rule-out protocol had high negative predictive value regardless of clinical risk scores. Categories of levels of hs-cTn T also showed good accuracy in discriminating risk of the patients with a very favourable prognosis for cardiovascular death in the group with value < 5 ng/L.
    Clinicaltrials.gov: NCT04756362.
    MeSH term(s) Female ; Humans ; Middle Aged ; Algorithms ; Biomarkers ; Chest Pain/diagnosis ; Chest Pain/etiology ; Emergency Service, Hospital ; Myocardial Infarction/diagnosis ; Myocardial Infarction/epidemiology ; Prospective Studies ; Retrospective Studies ; Troponin I ; Troponin T ; Male ; Adult ; Aged
    Chemical Substances Biomarkers ; Troponin I ; Troponin T
    Language English
    Publishing date 2023-07-14
    Publishing country England
    Document type Multicenter Study ; Journal Article
    ZDB-ID 2663340-1
    ISSN 2048-8734 ; 2048-8726
    ISSN (online) 2048-8734
    ISSN 2048-8726
    DOI 10.1093/ehjacc/zuad082
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Use of mechanical circulatory support in cases of end-stage acute heart failure.

    Colafranceschi, Alexandre Siciliano / Monteiro, Andrey José de Oliveira / Barbosa, Rodrigo Minati / Côrtes, Denise Castro de Souza / Correa, Celso Musa / Canale, Leonardo Secchin / Fernandes, Marcelo Ramalho / Botelho, Eduardo / Campos, Luiz Antonio de Almeida

    Arquivos brasileiros de cardiologia

    2007  Volume 89, Issue 5, Page(s) 311–4, 343–5

    MeSH term(s) Adult ; Fatal Outcome ; Heart Failure/surgery ; Heart Failure/therapy ; Heart Transplantation ; Heart-Assist Devices ; Humans ; Male ; Middle Aged ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Waiting Lists
    Language Portuguese
    Publishing date 2007-12-17
    Publishing country Brazil
    Document type Case Reports ; Journal Article
    ZDB-ID 730261-7
    ISSN 1678-4170 ; 0066-782X
    ISSN (online) 1678-4170
    ISSN 0066-782X
    DOI 10.1590/s0066-782x2007001700011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 548: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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