Article: Association between calcium intake and colorectal neoplasia in Puerto Rican Hispanics.
Archivos latinoamericanos de nutricion
2011 Volume 60, Issue 4, Page(s) 348–354
Abstract: Epidemiological studies show that a high calcium intake reduces the risk of colon cancer. The objective was to study the association between calcium intake and colorectal neoplasia in a clinic-based sample of Hispanics adults from Puerto Rico. As part of ...
| Abstract | Epidemiological studies show that a high calcium intake reduces the risk of colon cancer. The objective was to study the association between calcium intake and colorectal neoplasia in a clinic-based sample of Hispanics adults from Puerto Rico. As part of this cross-sectional study, a total of 433 subjects were recruited from surgery and gastroenterology clinics at the University of Puerto Rico. Calcium intake was estimated using a food frequency questionnaire (FFQ) of calcium rich foods. Socio-demographics, health history and colonoscopy results were obtained from the primary study. Chi square and odds ratios (OR) for colorectal neoplasia (adenomas and/ or adenocarcinoma) were calculated for total calcium, dietary calcium and for calcium supplement use. In total, 312 (72%) from 433 participants completed the FFQ and had available colonoscopy results; from these, 196 (62.5%) were free of neoplasia and 117 (37.5%) had colorectal neoplasia. Colorectal neoplasia subjects were older, a lower proportion were females and less educated than those without neoplasia (p < 0.01). Total calcium intake (median 1180 mg/d) was greater in those free of neoplasia compared to colorectal neoplasia subjects (median 1036 mg/d; p<0.05). A high total calcium intake and the use of calcium supplements significantly reduced the OR (crude and age adjusted) for colorectal neoplasia; although these associations lost statistical significance after additionally adjusting for gender and educational level. In conclusion, a high calcium intake and the use of calcium supplements may be protective against colorectal neoplasia, although a greater sample may be required to observe significant associations in a multivariate model. |
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| MeSH term(s) | Aged ; Calcium, Dietary/administration & dosage ; Colonoscopy ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/prevention & control ; Cross-Sectional Studies ; Diet Records ; Dietary Supplements ; Female ; Humans ; Male ; Middle Aged ; Puerto Rico/epidemiology |
| Chemical Substances | Calcium, Dietary |
| Language | English |
| Publishing date | 2011-08-22 |
| Publishing country | Venezuela |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ZDB-ID | 194741-2 |
| ISSN | 0004-0622 |
| ISSN | 0004-0622 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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