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  1. Article ; Online: New and emerging therapies for diabetic kidney disease.

    Correa-Rotter, Ricardo / Maple-Brown, Louise J / Sahay, Rakesh / Tuttle, Katherine R / Ulasi, Ifeoma I

    Nature reviews. Nephrology

    2024  Volume 20, Issue 3, Page(s) 156–160

    MeSH term(s) Humans ; Diabetic Nephropathies/drug therapy ; Kidney ; Diabetes Mellitus
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-023-00782-1
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  2. Article: Advances in Hemodialysis in the Last Decade in Latin America.

    González-Bedat, María C / Rosa-Diez, Guillermo / Correa-Rotter, Ricardo

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2023  Volume 75, Issue 6, Page(s) 300–308

    Abstract: Unassigned: Kidney replacement therapy (KRT) initiated in Latin America towards the second half of the 20th century, starting with dialytic therapies and, shortly thereafter, with kidney transplant. By the end of 2021, close to half a million Latin ... ...

    Abstract Unassigned: Kidney replacement therapy (KRT) initiated in Latin America towards the second half of the 20th century, starting with dialytic therapies and, shortly thereafter, with kidney transplant. By the end of 2021, close to half a million Latin Americans were under KRT, with an overall unadjusted prevalence of 872 per million persons (pmp), yet with significant heterogeneity between nations. By treatment modality, 68% of prevalent patients were treated with hemodialysis (HD), 9% with peritoneal dialysis (PD), and 23% were living with a functioning kidney graft (LFG). In the last decade, HD is the KRT that has had the largest growth, and it also has incorporated newer and better technologies. Nevertheless, Latin America shows heterogeneity between countries, and as a region we are far from achieving full accessibility to all in need of KRT. While there has been growth and improvement in existing renal dialysis registries, and several countries that did not previously have these registries have implemented them, there are still some nations with limited or absent registry implementation. The number of nephrologists in the region is heterogeneous, with only four countries having an appropriate group of specialists. The remaining nations have an important need to expand nephrology training programs. SLANH is a major regional player in addressing these topics and supporting the expansion of appropriate nephrology programs to improve inequalities and patient care. (Rev Invest Clin. 2023;75(6):300-8).
    MeSH term(s) Humans ; Latin America/epidemiology ; Kidney Failure, Chronic/epidemiology ; Kidney Failure, Chronic/therapy ; Renal Dialysis ; Kidney Transplantation ; Registries
    Language English
    Publishing date 2023-12-28
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    DOI 10.24875/RIC.23000224
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  3. Article: Sodium-Glucose Cotransporter 2 Inhibitors Mechanisms of Action: A Review.

    Fonseca-Correa, Jorge I / Correa-Rotter, Ricardo

    Frontiers in medicine

    2021  Volume 8, Page(s) 777861

    Abstract: Sodium-Glucose Cotransporter 2 inhibitors (SGLT2i), or gliflozins, are a group of antidiabetic drugs that have shown improvement in renal and cardiovascular outcomes in patients with kidney disease, with and without diabetes. In this review, we will ... ...

    Abstract Sodium-Glucose Cotransporter 2 inhibitors (SGLT2i), or gliflozins, are a group of antidiabetic drugs that have shown improvement in renal and cardiovascular outcomes in patients with kidney disease, with and without diabetes. In this review, we will describe the different proposed mechanisms of action of SGLT2i. Gliflozins inhibit renal glucose reabsorption by blocking the SGLT2 cotransporters in the proximal tubules and causing glucosuria. This reduces glycemia and lowers HbA
    Language English
    Publishing date 2021-12-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.777861
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  4. Article: Dapagliflozin in chronic kidney disease: cost-effectiveness beyond the DAPA-CKD trial.

    McEwan, Phil / Davis, Jason A / Gabb, Peter D / Wheeler, David C / Rossing, Peter / Chertow, Glenn M / Correa-Rotter, Ricardo / Tamura, Kouichi / Barone, Salvatore / Garcia Sanchez, Juan Jose

    Clinical kidney journal

    2024  Volume 17, Issue 2, Page(s) sfae025

    Abstract: Background: The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial enrolled patients with estimated glomerular filtration rate 25-75 mL/min/1.73 m: Methods: We adapted a published Markov model based on the DAPA-CKD trial but to ... ...

    Abstract Background: The Dapagliflozin and Prevention of Adverse Outcomes in CKD (DAPA-CKD) trial enrolled patients with estimated glomerular filtration rate 25-75 mL/min/1.73 m
    Methods: We adapted a published Markov model based on the DAPA-CKD trial but to a broader population, irrespective of urine albumin-to-creatinine ratio, using patient-level data from the DAPA-CKD and DECLARE-TIMI 58 trials. We sourced cost and utility inputs from literature and the DAPA-CKD trial. The analysis considered healthcare system perspectives over a lifetime horizon.
    Results: Treatment with dapagliflozin was predicted to attenuate disease progression and extend projected life expectancy by 0.64 years (12.5 versus 11.9 years, undiscounted) in the UK, with similar estimates in other settings. Clinical benefits translated to mean quality-adjusted life year (QALY; discounted) gains between 0.45 and 0.68 years across countries. Incremental cost-effectiveness ratios in the UK, Spain, Italy and Japan ($10 676/QALY, $14 479/QALY, $7771/QALY and $13 723/QALY, respectively) were cost-effective at country-specific willingness-to-pay thresholds. Subgroup analyses suggest dapagliflozin is cost-effective irrespective of urinary albumin-to-creatine ratio and type 2 diabetes status.
    Conclusion: Treatment with dapagliflozin may be cost-effective for patients across a wider spectrum of estimated glomerular filtration rates and albuminuria than previously demonstrated, with or without type 2 diabetes, in the UK, Spanish, Italian and Japanese healthcare systems.
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfae025
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  5. Article ; Online: Mesoamerican Nephropathy.

    Correa-Rotter, Ricardo / García-Trabanino, Ramón

    Seminars in nephrology

    2019  Volume 39, Issue 3, Page(s) 263–271

    Abstract: Mesoamerican endemic nephropathy is a type of chronic kidney disease of unknown origin, present in pockets of high prevalence along the Pacific Ocean coast of the Mesoamerican region, from southwest Mexico to Costa Rica. The disease is common in young ... ...

    Abstract Mesoamerican endemic nephropathy is a type of chronic kidney disease of unknown origin, present in pockets of high prevalence along the Pacific Ocean coast of the Mesoamerican region, from southwest Mexico to Costa Rica. The disease is common in young adult men, most often yet not exclusively from agricultural communities, and with a high mortality rate. Kidney biopsy specimens show primarily tubular atrophy and interstitial fibrosis with some glomerular changes attributed to ischemia. Exposure to agrochemicals, heavy metals or metalloids, intense physical activity under heat stress with dehydration, infections, among other possible causes have been hypothesized as the culprit of the disease. Hypokalemia and hyperuricemia are frequent clinical features. Early diagnosis is key to initiate timely treatment and slow down the progression to end-stage kidney disease. At present, our knowledge about the magnitude of the disease burden imposed by Mesoamerican endemic nephropathy is clearly incomplete and its cause has not been determined. There is a need to implement epidemiologic and mechanistic research projects as well as formal chronic kidney disease and end-stage kidney disease registries in the Mesoamerican region to better understand the real extent of the epidemic, delimit risk populations, and to construct sound public health policy decisions.
    MeSH term(s) Agrochemicals/adverse effects ; Central America/epidemiology ; Dehydration/complications ; Geography ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Failure, Chronic/etiology ; Kidney Failure, Chronic/therapy ; Metals, Heavy/adverse effects ; Mexico/epidemiology ; Risk Factors
    Chemical Substances Agrochemicals ; Metals, Heavy
    Language English
    Publishing date 2019-05-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2019.02.004
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  6. Article ; Online: Effects of canagliflozin on major adverse cardiovascular events by baseline estimated glomerular filtration rate: Pooled Hispanic subgroup analyses from the CANVAS Program and CREDENCE trial.

    Weir, Matthew R / Gogate, Jagadish / Damaraju, C V / Correa-Rotter, Ricardo / Mahaffey, Kenneth W

    Diabetes, obesity & metabolism

    2021  Volume 24, Issue 1, Page(s) 12–20

    Abstract: Aim: To assess the risk of major adverse cardiovascular events (MACE) of canagliflozin in Hispanic patients with type 2 diabetes (T2D) and high cardiovascular risk or nephropathy with varying levels of kidney function.: Materials and methods: This ... ...

    Abstract Aim: To assess the risk of major adverse cardiovascular events (MACE) of canagliflozin in Hispanic patients with type 2 diabetes (T2D) and high cardiovascular risk or nephropathy with varying levels of kidney function.
    Materials and methods: This post hoc analysis included integrated, pooled data from the CANVAS Program and CREDENCE trial. The effects of canagliflozin versus placebo on major adverse cardiovascular events (MACE; i.e. cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke) were assessed in subgroups by baseline estimated glomerular filtration rate (eGFR; <45, 45-60, and >60 mL/min/1.73 m
    Results: A total of 14 543 participants were included; 3029 (20.8%) self-identified as Hispanic. In the overall population, canagliflozin reduced the risk of MACE compared with placebo (HR, 0.83; 95% CI, 0.75, 0.92), with no heterogeneity observed across eGFR subgroups (interaction P = .22). In the Hispanic cohort, canagliflozin also reduced the risk of MACE (HR, 0.71; 95% CI, 0.55, 0.92), with no heterogeneity by baseline eGFR (interaction P = .25), including among the Hispanic participants at highest risk with a baseline eGFR of less than 45 mL/min/1.73 m
    Conclusion: Canagliflozin reduced the risk of MACE overall, and among Hispanic participants with T2D and high cardiovascular risk or nephropathy in the CANVAS Program and CREDENCE trial, without heterogeneity by baseline eGFR.
    MeSH term(s) Canagliflozin/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/prevention & control ; Clinical Trials as Topic ; Diabetes Mellitus, Type 2/chemically induced ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Glomerular Filtration Rate ; Hispanic or Latino ; Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Stroke/chemically induced
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors ; Canagliflozin (0SAC974Z85)
    Language English
    Publishing date 2021-09-23
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
    ZDB-ID 1454944-x
    ISSN 1463-1326 ; 1462-8902
    ISSN (online) 1463-1326
    ISSN 1462-8902
    DOI 10.1111/dom.14539
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  7. Article ; Online: Effects of Dapagliflozin in People without Diabetes and with Microalbuminuria.

    Heerspink, Hiddo J L / Chertow, Glenn M / Jongs, Niels / Correa-Rotter, Ricardo / Rossing, Peter / Sjöström, C David / Langkilde, Anna Maria / Wheeler, David C

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Volume 17, Issue 11, Page(s) 1665–1668

    MeSH term(s) Humans ; Glucosides/therapeutic use ; Glucosides/pharmacology ; Benzhydryl Compounds/therapeutic use ; Benzhydryl Compounds/pharmacology ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy
    Chemical Substances dapagliflozin (1ULL0QJ8UC) ; Glucosides ; Benzhydryl Compounds
    Language English
    Publishing date 2022-09-09
    Publishing country United States
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.07290622
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  8. Article ; Online: Dapagliflozin and Blood Pressure in Patients with Chronic Kidney Disease and Albuminuria.

    Heerspink, Hiddo Jl / Provenzano, Michele / Vart, Priya / Jongs, Niels / Correa-Rotter, Ricardo / Rossing, Peter / Mark, Patrick B / Pecoits-Filho, Roberto / McMurray, John Jv / Langkilde, Anna Maria / Wheeler, David C / Toto, Robert B / Chertow, Glenn M

    American heart journal

    2024  Volume 270, Page(s) 125–135

    Abstract: Background and aims: Sodium-glucose cotransporter 2 inhibitors decrease blood pressure in patients with type 2 diabetes, but the consistency and magnitude of blood pressure lowering with dapagliflozin in patients with chronic kidney disease (CKD) is ... ...

    Abstract Background and aims: Sodium-glucose cotransporter 2 inhibitors decrease blood pressure in patients with type 2 diabetes, but the consistency and magnitude of blood pressure lowering with dapagliflozin in patients with chronic kidney disease (CKD) is unknown. We conducted a prespecified analysis of the DAPA-CKD trial to investigate the effect of dapagliflozin on systolic blood pressure (SBP) in patients with CKD, with and without type 2 diabetes.
    Methods: A total of 4304 adults with baseline estimated glomerular filtration rate (eGFR) 25-75 mL/min/1.73m
    Results: Baseline mean (SD) SBP was 137.1 mmHg (17.4). By Week 2, dapagliflozin compared to placebo reduced SBP by 3.6 mmHg (95% CI 2.8-4.4 mmHg), an effect maintained over the duration of the trial (2.9 mmHg, 2.3-3.6 mmHg). Time-averaged reductions in SBP were 3.2 mmHg (2.5-4.0 mmHg) in patients with diabetes and 2.3 mmHg (1.2-3.4 mmHg) in patients without diabetes. The time-averaged effect of dapagliflozin on diastolic blood pressure (DBP) was 1.0 mmHg (0.6-1.4 mmHg); 0.8 mmHg (0.4-1.3 mmHg) in patients with diabetes and 1.4 mmHg (0.7-2.1 mmHg) in patients without diabetes. Benefits of dapagliflozin on the primary composite and secondary endpoints were evident across the spectrum of baseline SBP and DBP.
    Conclusion: In patients with CKD and albuminuria, randomization to dapagliflozin was associated with modest reductions in systolic and diastolic BP.
    MeSH term(s) Adult ; Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/drug therapy ; Blood Pressure ; Albuminuria/etiology ; Albuminuria/complications ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Glomerular Filtration Rate ; Benzhydryl Compounds ; Glucosides
    Chemical Substances dapagliflozin (1ULL0QJ8UC) ; Sodium-Glucose Transporter 2 Inhibitors ; Benzhydryl Compounds ; Glucosides
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2024.02.006
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  9. Article ; Online: Association between soft drinks intake and low glomerular filtration rate in Mexican adults: Results from RenMex.

    Rivera-Paredez, Berenice / Morales, Mariluz / Velázquez-Cruz, Rafael / Salmerón, Jorge / Jiménez-Corona, Aida / Balderas-Arteaga, Nydia / González-Villalpando, Clicerio / Tamayo, Juan / Lajous, Martin / Catzin-Kuhlmann, Andrés / Nelson, Robert / Correa-Rotter, Ricardo / Denova-Gutierréz, Edgar

    Clinical nutrition (Edinburgh, Scotland)

    2024  Volume 43, Issue 4, Page(s) 1062–1069

    Abstract: Background & aims: To evaluate the association between soft drinks (SDs) consumption and estimated glomerular filtration rate (eGFR) in a Mexican adult population.: Methods: We used data from the RenMex consortium (n = 2095) that included the Mexican ...

    Abstract Background & aims: To evaluate the association between soft drinks (SDs) consumption and estimated glomerular filtration rate (eGFR) in a Mexican adult population.
    Methods: We used data from the RenMex consortium (n = 2095) that included the Mexican Teachers Cohort Study (34-65 years), the Health Workers Cohort Study (18-90 years), and the Comitán Study (19-91 years). In this cross-sectional study, we assessed SDs consumption (cola and flavored soda) using a food frequency questionnaire (FFQ) and estimated eGFR using the CKD Epidemiology Collaboration equation. Quantile regression was used to assess the association between SDs consumption and eGFR with eGFR as a continuous variable. Multinomial logistic regression models were used for eGFR categories derived from quantile regression (mildly decreased eGFR, ≥72.9-87.9 mL/min/1.73 m
    Results: Mean age of study participants was 47.2 years, 67.5% were women, and 12.2% had diabetes. eGFR was <60 mL/min/1.73 m
    Conclusion: Our results suggest that higher SDs consumption is associated with lower eGFR. Encouraging healthy dietary choices should be part of the management and prevention of CKD.
    MeSH term(s) Adult ; Humans ; Female ; Middle Aged ; Male ; Glomerular Filtration Rate ; Cohort Studies ; Cross-Sectional Studies ; Renal Insufficiency, Chronic/epidemiology ; Carbonated Beverages ; Risk Factors
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2024.03.002
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  10. Article ; Online: Ambient heat exposure and kidney function in patients with chronic kidney disease: a post-hoc analysis of the DAPA-CKD trial.

    Zhang, Zhiyan / Heerspink, Hiddo J L / Chertow, Glenn M / Correa-Rotter, Ricardo / Gasparrini, Antonio / Jongs, Niels / Langkilde, Anna Maria / McMurray, John J V / Mistry, Malcolm N / Rossing, Peter / Toto, Robert D / Vart, Priya / Nitsch, Dorothea / Wheeler, David C / Caplin, Ben

    The Lancet. Planetary health

    2024  Volume 8, Issue 4, Page(s) e225–e233

    Abstract: Background: Higher temperatures are associated with higher rates of hospital admissions for nephrolithiasis and acute kidney injury. Occupational heat stress is also a risk factor for kidney dysfunction in resource-poor settings. It is unclear whether ... ...

    Abstract Background: Higher temperatures are associated with higher rates of hospital admissions for nephrolithiasis and acute kidney injury. Occupational heat stress is also a risk factor for kidney dysfunction in resource-poor settings. It is unclear whether ambient heat exposure is associated with loss of kidney function in patients with established chronic kidney disease. We assessed the association between heat index and change in estimated glomerular filtration rate (eGFR) in participants from the DAPA-CKD trial in a post-hoc analysis.
    Methods: DAPA-CKD was a randomised controlled trial of oral dapagliflozin 10 mg once daily or placebo that enrolled participants aged 18 years or older, with or without type 2 diabetes, with a urinary albumin-to-creatinine ratio of 200-5000 mg/g, and an eGFR of 25-75 mL/min per 1·73 m
    Findings: Climate and eGFR data were available for 4017 (93·3%) of 4304 participants in 21 countries (mean age: 61·9 years; mean eGFR: 43·3 mL per 1·73 m
    Interpretation: Higher ambient heat exposure is associated with more rapid eGFR decline in those with established chronic kidney disease. Efforts to mitigate heat exposure should be tested as part of strategies to attenuate chronic kidney disease progression.
    Funding: None.
    MeSH term(s) Humans ; Middle Aged ; Diabetes Mellitus, Type 2 ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/drug therapy ; Glomerular Filtration Rate ; Risk Factors ; Kidney
    Language English
    Publishing date 2024-04-05
    Publishing country Netherlands
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2542-5196
    ISSN (online) 2542-5196
    DOI 10.1016/S2542-5196(24)00026-3
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