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  1. Article: Glycation and Glycosylation in Cardiovascular Remodeling: Focus on Advanced Glycation End Products and O-Linked Glycosylations as Glucose-Related Pathogenetic Factors and Disease Markers.

    Dozio, Elena / Massaccesi, Luca / Corsi Romanelli, Massimiliano Marco

    Journal of clinical medicine

    2021  Volume 10, Issue 20

    Abstract: Glycation and glycosylation are non-enzymatic and enzymatic reactions, respectively, of glucose, glucose metabolites, and other reducing sugars with different substrates, such as proteins, lipids, and nucleic acids. Increased availability of glucose is a ...

    Abstract Glycation and glycosylation are non-enzymatic and enzymatic reactions, respectively, of glucose, glucose metabolites, and other reducing sugars with different substrates, such as proteins, lipids, and nucleic acids. Increased availability of glucose is a recognized risk factor for the onset and progression of diabetes-mellitus-associated disorders, among which cardiovascular diseases have a great impact on patient mortality. Both advanced glycation end products, the result of non-enzymatic glycation of substrates, and O-linked-N-Acetylglucosaminylation, a glycosylation reaction that is controlled by O-N-AcetylGlucosamine (GlcNAc) transferase (OGT) and O-GlcNAcase (OGA), have been shown to play a role in cardiovascular remodeling. In this review, we aim (1) to summarize the most recent data regarding the role of glycation and O-linked-N-Acetylglucosaminylation as glucose-related pathogenetic factors and disease markers in cardiovascular remodeling, and (2) to discuss potential common mechanisms linking these pathways to the dysregulation and/or loss of function of different biomolecules involved in this field.
    Language English
    Publishing date 2021-10-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10204792
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Osteomyelitis, Oxidative Stress and Related Biomarkers

    Massaccesi, Luca / Galliera, Emanuela / Pellegrini, Antonio / Banfi, Giuseppe / Corsi Romanelli, Massimiliano Marco

    Antioxidants. 2022 May 27, v. 11, no. 6

    2022  

    Abstract: Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and ... ...

    Abstract Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being Staphylococcus aureus, affecting bone or bone marrow, and severely impairing bone homeostasis, resulting in osteolysis. One of the characteristic features of OM is a strong state of oxidative stress (OS) with severe consequences on the delicate balance between osteoblastogenesis and osteoclastogenesis. Here we describe this, analyzing the effects of OS in bone remodeling and discussing the need for new, easy-to-measure and widely available OS biomarkers that will provide valid support in the management of the disease.
    Keywords Staphylococcus aureus ; biomarkers ; bone formation ; bone marrow ; bone resorption ; homeostasis ; osteoblasts ; osteoclasts ; osteomyelitis ; oxidative stress
    Language English
    Dates of publication 2022-0527
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11061061
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: Erythrocytes as markers of oxidative stress related pathologies.

    Massaccesi, Luca / Galliera, Emanuela / Corsi Romanelli, Massimiliano Marco

    Mechanisms of ageing and development

    2020  Volume 191, Page(s) 111333

    Abstract: Erythrocytes are deeply sensitive cells and important health indicators. During inflammatory response RBC, as a part of haematological system, are exposed to circulating inflammatory mediators and related oxidative stress. They present a highly ... ...

    Abstract Erythrocytes are deeply sensitive cells and important health indicators. During inflammatory response RBC, as a part of haematological system, are exposed to circulating inflammatory mediators and related oxidative stress. They present a highly specialized and organized cell membrane that interacts with inflammatory mediators and oxidative agents, leading to a variety of structural changes that promptly signal an abnormal situation. This review is aimed to provide an overview on erythrocyte involvement in physiological and pathological processes related to oxidative stress, such as aging, Down syndrome, neurodegenerative diseases, for instance Alzheimer Disease, erectile dysfunction and cardiovascular diseases. In particular this review will focus on the effects of oxidative stress on structural changes in the cell membrane and also on in the activity of erythrocyte enzymes such as membrane-bound, cytosolic glycohydrolases and RBC-eNOS. This review also underlines the potential clinical application of erythrocyte specific related parameters, which can be important tools not only for the study but also for the monitoring of several oxidative stress related diseases.
    MeSH term(s) Alzheimer Disease/blood ; Animals ; Biomarkers/blood ; Down Syndrome/blood ; Erectile Dysfunction/blood ; Erythrocyte Membrane/metabolism ; Female ; Humans ; Male ; Oxidative Stress
    Chemical Substances Biomarkers
    Language English
    Publishing date 2020-08-16
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 183915-9
    ISSN 1872-6216 ; 0047-6374
    ISSN (online) 1872-6216
    ISSN 0047-6374
    DOI 10.1016/j.mad.2020.111333
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  4. Article: Osteomyelitis, Oxidative Stress and Related Biomarkers.

    Massaccesi, Luca / Galliera, Emanuela / Pellegrini, Antonio / Banfi, Giuseppe / Corsi Romanelli, Massimiliano Marco

    Antioxidants (Basel, Switzerland)

    2022  Volume 11, Issue 6

    Abstract: Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and ... ...

    Abstract Bone is a very dynamic tissue, subject to continuous renewal to maintain homeostasis through bone remodeling, a process promoted by two cell types: osteoblasts, of mesenchymal derivation, are responsible for the deposition of new material, and osteoclasts, which are hematopoietic cells, responsible for bone resorption. Osteomyelitis (OM) is an invasive infectious process, with several etiological agents, the most common being
    Language English
    Publishing date 2022-05-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox11061061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting the Adipose Tissue in COVID-19.

    Malavazos, Alexis Elias / Corsi Romanelli, Massimiliano Marco / Bandera, Francesco / Iacobellis, Gianluca

    Obesity (Silver Spring, Md.)

    2020  Volume 28, Issue 7, Page(s) 1178–1179

    MeSH term(s) Adipose Tissue ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Obesity ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-21
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2230457-5
    ISSN 1930-739X ; 1071-7323 ; 1930-7381
    ISSN (online) 1930-739X
    ISSN 1071-7323 ; 1930-7381
    DOI 10.1002/oby.22844
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4061: Show issues Location:
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    Zs.MG 87: Show issues

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  6. Article ; Online: Creatine kinase elevation: a neglected clue to the diagnosis of polymyositis. A case report.

    Sitzia, Clementina / Sansone, Valeria Ada / Corsi Romanelli, Massimiliano Marco

    Clinical chemistry and laboratory medicine

    2018  Volume 57, Issue 7, Page(s) e149–e151

    MeSH term(s) Creatine Kinase/blood ; Electromyography ; Humans ; Immunoglobulins, Intravenous/therapeutic use ; Male ; Middle Aged ; Muscle Strength ; Muscle, Skeletal/pathology ; Myoglobin/blood ; Polymyositis/diagnosis ; Polymyositis/drug therapy ; Steroids/therapeutic use
    Chemical Substances Immunoglobulins, Intravenous ; Myoglobin ; Steroids ; Creatine Kinase (EC 2.7.3.2)
    Language English
    Publishing date 2018-11-23
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 1418007-8
    ISSN 1437-4331 ; 1434-6621 ; 1437-8523
    ISSN (online) 1437-4331
    ISSN 1434-6621 ; 1437-8523
    DOI 10.1515/cclm-2018-0928
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 121: Show issues Location:
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  7. Article ; Online: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.

    Sitzia, Clementina / Vianello, Elena / Dozio, Elena / Kalousová, Marta / Zima, Tomáš / Brizzola, Stefano / Roccabianca, Paola / Tedeschi, Gabriella / Lamont, John / Tacchini, Lorenza / Corsi-Romanelli, Massimiliano Marco

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Obesity is an epidemic condition linked to cardiovascular disease severity and mortality. Fat localization and type represent cardiovascular risk estimators. Importantly, visceral fat secretes adipokines known to promote low-grade inflammation that, in ... ...

    Abstract Obesity is an epidemic condition linked to cardiovascular disease severity and mortality. Fat localization and type represent cardiovascular risk estimators. Importantly, visceral fat secretes adipokines known to promote low-grade inflammation that, in turn, modulate its secretome and cardiac metabolism. In this regard, IL-33 regulates the functions of various immune cells through ST2 binding and-following its role as an immune sensor to infection and stress-is involved in the pro-fibrotic remodeling of the myocardium. Here we further investigated the IL-33/ST2 effects on cardiac remodeling in obesity, focusing on molecular pathways linking adipose-derived IL-33 to the development of fibrosis or hypertrophy. We analyzed the Zucker Fatty rat model, and we developed in vitro models to mimic the adipose and myocardial relationship. We demonstrated a dysregulation of IL-33/ST2 signaling in both adipose and cardiac tissue, where they affected Epac proteins and myocardial gene expression, linked to pro-fibrotic signatures. In Zucker rats, pro-fibrotic effects were counteracted by ghrelin-induced IL-33 secretion, whose release influenced transcription factor expression and ST2 isoforms balance regulation. Finally, the effect of IL-33 signaling is dependent on several factors, such as cell types' origin and the balancing of ST2 isoforms. Noteworthy, it is reasonable to state that considering IL-33 to have a unique protective role should be considered over-simplistic.
    MeSH term(s) Animals ; Rats ; Cardiomegaly/genetics ; Cardiomegaly/metabolism ; Disease Models, Animal ; Fibrosis/genetics ; Fibrosis/metabolism ; Ghrelin/genetics ; Ghrelin/metabolism ; Guanine Nucleotide Exchange Factors/genetics ; Guanine Nucleotide Exchange Factors/metabolism ; Interleukin-1 Receptor-Like 1 Protein/genetics ; Interleukin-1 Receptor-Like 1 Protein/metabolism ; Interleukin-33/genetics ; Interleukin-33/metabolism ; Myocardium/metabolism ; Obesity/complications ; Obesity/genetics ; Obesity/metabolism ; Rats, Zucker ; Receptors, Interleukin-1/genetics ; Receptors, Interleukin-1/metabolism ; Ventricular Remodeling/genetics ; Ventricular Remodeling/physiology
    Chemical Substances Ghrelin ; Guanine Nucleotide Exchange Factors ; Il33 protein, rat ; Interleukin-1 Receptor-Like 1 Protein ; Interleukin-33 ; obestatin, rat ; Rapgef3 protein, rat ; Receptors, Interleukin-1 ; ST2 protein, rat
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24031991
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Osteopontin: The Molecular Bridge between Fat and Cardiac-Renal Disorders.

    Vianello, Elena / Kalousová, Marta / Dozio, Elena / Tacchini, Lorenza / Zima, Tomáš / Corsi Romanelli, Massimiliano Marco

    International journal of molecular sciences

    2020  Volume 21, Issue 15

    Abstract: Osteopontin (OPN) is a multifaceted matricellular protein, with well-recognized roles in both the physiological and pathological processes in the body. OPN is expressed in the main organs and cell types, in which it induces different biological actions. ... ...

    Abstract Osteopontin (OPN) is a multifaceted matricellular protein, with well-recognized roles in both the physiological and pathological processes in the body. OPN is expressed in the main organs and cell types, in which it induces different biological actions. During physiological conditioning, OPN acts as both an intracellular protein and soluble excreted cytokine, regulating tissue remodeling and immune-infiltrate in adipose tissue the heart and the kidney. In contrast, the increased expression of OPN has been correlated with the severity of the cardiovascular and renal outcomes associated with obesity. Indeed, OPN expression is at the "cross roads" of visceral fat extension, cardiovascular diseases (CVDs) and renal disorders, in which OPN orchestrates the molecular interactions, leading to chronic low-grade inflammation. The common factor associated with OPN overexpression in adipose, cardiac and renal tissues seems attributable to the concomitant increase in visceral fat size and the increase in infiltrated OPN
    MeSH term(s) Adipose Tissue/metabolism ; Heart Diseases/genetics ; Heart Diseases/metabolism ; Heart Diseases/pathology ; Humans ; Inflammation/genetics ; Inflammation/pathology ; Insulin Resistance/genetics ; Intra-Abdominal Fat/metabolism ; Kidney/metabolism ; Kidney/pathology ; Kidney Diseases/genetics ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Myocardium/metabolism ; Myocardium/pathology ; Obesity/genetics ; Obesity/metabolism ; Obesity/pathology ; Osteopontin/genetics ; Osteopontin/metabolism
    Chemical Substances Osteopontin (106441-73-0)
    Language English
    Publishing date 2020-08-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms21155568
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  9. Article ; Online: Intra-erythrocytes magnesium deficiency could reflect cognitive impairment status due to vascular disease: a pilot study.

    Sitzia, Clementina / Sterlicchio, Michele / Crapanzano, Calogero / Dozio, Elena / Vianello, Elena / Corsi Romanelli, Massimiliano Marco

    Journal of translational medicine

    2020  Volume 18, Issue 1, Page(s) 458

    Abstract: Background and aims: Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremors, seizure and ... ...

    Abstract Background and aims: Magnesium is a fundamental cation that regulates neuronal transmission, protein synthesis, energy metabolism. Magnesium deficiency mostly affects nervous and cardiovascular systems determining weakness, tremors, seizure and arrhythmias. This condition retains also a role in memory function and neuronal plasticity. Importantly magnesium deficiency could remain latent and asymptomatic resulting a risk factor for cardiovascular disease. In this sense we aim to determine magnesium status in patient presenting cognitive impairment of vascular origin.
    Methods: 21 healthy subjects and 27 patients presenting vascular cognitive impairment were included in this study. Both plasma and intraerythrocitary magnesium level were measured to detect magnesium deficiency and cognitive performance was evaluated trough Mini Mental State Evaluation (MMSE).
    Results: Here we showed that patients presenting vascular cognitive impairment present intraerythrocitary magnesium level lower than age-matched healthy subjects. To note their plasma magnesium resulted within reference limit.
    Conclusion: We suggest that intracellular magnesium laboratory measurement is needed to detect occult magnesium deficiency in population at risk. Magnesium supplementation could represent an adjuvant for healthy aging in high risk population.
    MeSH term(s) Cognitive Dysfunction/complications ; Erythrocytes ; Humans ; Magnesium Deficiency/complications ; Pilot Projects ; Vascular Diseases
    Language English
    Publishing date 2020-12-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1479-5876
    ISSN (online) 1479-5876
    DOI 10.1186/s12967-020-02645-w
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  10. Article: ST2/IL-33 signaling in cardiac fibrosis

    Vianello, Elena / Corsi Romanelli, Massimiliano Marco / Dozio, Elena / Frati, Luigi / Tacchini, Lorenza

    international journal of biochemistry & cell biology. 2019 Sept. 23,

    2019  

    Abstract: Cardiac fibrosis is a significant global health problem associated with nearly all forms of heart disease. In the heart interstitial fibrosis may be reparative, replacing areas damaged by myocyte loss after acute infarction, or compensative, responding ... ...

    Abstract Cardiac fibrosis is a significant global health problem associated with nearly all forms of heart disease. In the heart interstitial fibrosis may be reparative, replacing areas damaged by myocyte loss after acute infarction, or compensative, responding to cardiac overload. However, after injury in chronic cases activated myofibroblasts contribute to the tissue imbalance of the newer molecules associated with cardiac fibrosis, interleukin (IL-33), and suppression of tumorigenicity 2 (ST2). Physiological stretching causes myofibroblasts to release IL-33 which binds the ST2 receptor (ST2L) on the cardiomyocyte membrane, promoting cell survival and integrity. But in chronic conditions, local and neighboring cells can increase the release of IL-33’s decoy, soluble ST2 (sST2), which blocks IL-33/ST2L binding, promoting tissue fibrosis. We review recent studies that have illustrated novel aspects of ST2/IL-33 signaling mediating cardiac fibrosis, and some newer biomolecular targets for the prevention and treatment of maladaptive remodeling.
    Keywords cardiomyocytes ; cell viability ; fibrosis ; heart diseases ; infarction ; interleukins
    Language English
    Dates of publication 2019-0923
    Publishing place Elsevier Ltd
    Document type Article
    Note Pre-press version
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2019.105619
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