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  1. Article ; Online: Microscopy Research and Technique virtual issue: "Correlative light and electron microscopy".

    Cortese, Katia / Verkade, Paul

    Microscopy research and technique

    2023  Volume 87, Issue 1, Page(s) 3–4

    Language English
    Publishing date 2023-03-14
    Publishing country United States
    Document type Editorial
    ZDB-ID 1099714-3
    ISSN 1097-0029 ; 1059-910X
    ISSN (online) 1097-0029
    ISSN 1059-910X
    DOI 10.1002/jemt.24305
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2251: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Imaging Endocytosis Dynamics in Health and Disease.

    Tagliatti, Erica / Cortese, Katia

    Membranes

    2022  Volume 12, Issue 4

    Abstract: Endocytosis is a critical process for cell growth and viability. It mediates nutrient uptake, guarantees plasma membrane homeostasis, and generates intracellular signaling cascades. Moreover, it plays an important role in dead cell clearance and defense ... ...

    Abstract Endocytosis is a critical process for cell growth and viability. It mediates nutrient uptake, guarantees plasma membrane homeostasis, and generates intracellular signaling cascades. Moreover, it plays an important role in dead cell clearance and defense against external microbes. Finally, endocytosis is an important cellular route for the delivery of nanomedicines for therapeutic treatments. Thus, it is not surprising that both environmental and genetic perturbation of endocytosis have been associated with several human conditions such as cancer, neurological disorders, and virus infections, among others. Over the last decades, a lot of research has been focused on developing advanced imaging methods to monitor endocytosis events with high resolution in living cells and tissues. These include fluorescence imaging, electron microscopy, and correlative and super-resolution microscopy. In this review, we outline the major endocytic pathways and briefly discuss how defects in the molecular machinery of these pathways lead to disease. We then discuss the current imaging methodologies used to study endocytosis in different contexts, highlighting strengths and weaknesses.
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2614641-1
    ISSN 2077-0375
    ISSN 2077-0375
    DOI 10.3390/membranes12040393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Interactions between Glycine and Glutamate through Activation of Their Transporters in Hippocampal Nerve Terminals.

    Cortese, Katia / Gagliani, Maria Cristina / Raiteri, Luca

    Biomedicines

    2023  Volume 11, Issue 12

    Abstract: Evidence supports the pathophysiological relevance of crosstalk between the neurotransmitters Glycine and Glutamate and their close interactions; some reports even support the possibility of Glycine-Glutamate cotransmission in central nervous system (CNS) ...

    Abstract Evidence supports the pathophysiological relevance of crosstalk between the neurotransmitters Glycine and Glutamate and their close interactions; some reports even support the possibility of Glycine-Glutamate cotransmission in central nervous system (CNS) areas, including the hippocampus. Functional studies with isolated nerve terminals (synaptosomes) permit us to study transporter-mediated interactions between neurotransmitters that lead to the regulation of transmitter release. Our main aims here were: (i) to investigate release-regulating, transporter-mediated interactions between Glycine and Glutamate in hippocampal nerve terminals and (ii) to determine the coexistence of transporters for Glycine and Glutamate in these terminals. Purified synaptosomes, analyzed at the ultrastructural level via electron microscopy, were used as the experimental model. Mouse hippocampal synaptosomes were prelabeled with [
    Language English
    Publishing date 2023-11-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines11123152
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  4. Article ; Online: Bridging the gap between basic science and clinical curricula: lessons from SARS-COV-2 pandemic.

    Cortese, Katia / Frascio, Marco

    Surgical and radiologic anatomy : SRA

    2021  Volume 44, Issue 1, Page(s) 81–82

    MeSH term(s) COVID-19 ; Curriculum ; Humans ; Pandemics ; SARS-CoV-2
    Language English
    Publishing date 2021-04-24
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 632839-8
    ISSN 1279-8517 ; 0930-312X ; 0930-1038
    ISSN (online) 1279-8517
    ISSN 0930-312X ; 0930-1038
    DOI 10.1007/s00276-021-02755-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1456: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: New Settings in Anatomy and Surgery Teaching During the Covid-19 Pandemic.

    Cortese, Katia / Frascio, Marco

    Anatomical sciences education

    2021  Volume 14, Issue 4, Page(s) 430–431

    MeSH term(s) Anatomy/education ; COVID-19 ; General Surgery/education ; Humans ; Teaching
    Language English
    Publishing date 2021-04-30
    Publishing country United States
    Document type Letter
    ZDB-ID 2483491-9
    ISSN 1935-9780 ; 1935-9772
    ISSN (online) 1935-9780
    ISSN 1935-9772
    DOI 10.1002/ase.2077
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    Zs.A 6787: Show issues Location:
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  6. Article ; Online: An easy and reliable way to preoperatively identify the auriculo-temporal nerve in migraine surgery.

    Raposio, Giorgio / Cortese, Katia / Raposio, Edoardo

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2022  Volume 75, Issue 7, Page(s) 2387–2440

    Abstract: In this paper, we describe a simple and reliable way to preoperatively localize the auriculotemporal nerve in migraine surgery. We measured the correspondence of this cutaneous landmark and the ATN in twelve migraine patients operated at Site V. Our ... ...

    Abstract In this paper, we describe a simple and reliable way to preoperatively localize the auriculotemporal nerve in migraine surgery. We measured the correspondence of this cutaneous landmark and the ATN in twelve migraine patients operated at Site V. Our findings demonstrated a very high concordance between the described point and the underlying auriculotemporal nerve. This method might be of some utility in the preoperative planning of Site V Migraine surgery, in the strive of reducing the length of cutaneous incision and the invasiveness of the procedure.
    MeSH term(s) Humans ; Mandibular Nerve/surgery ; Migraine Disorders/surgery
    Language English
    Publishing date 2022-04-25
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2022.04.029
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    Uk I Zs.157: Show issues Location:
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  7. Article ; Online: Complement tunes glutamate release and supports synaptic impairments in an animal model of multiple sclerosis.

    Olivero, Guendalina / Taddeucci, Alice / Vallarino, Giulia / Trebesova, Hanna / Roggeri, Alessandra / Gagliani, Maria Cristina / Cortese, Katia / Grilli, Massimo / Pittaluga, Anna

    British journal of pharmacology

    2024  

    Abstract: Background and purpose: To deepen our knowledge of the role of complement in synaptic impairment in experimental autoimmune encephalomyelitis (EAE) mice, we investigated the distribution of C1q and C3 proteins and the role of complement as a promoter of ...

    Abstract Background and purpose: To deepen our knowledge of the role of complement in synaptic impairment in experimental autoimmune encephalomyelitis (EAE) mice, we investigated the distribution of C1q and C3 proteins and the role of complement as a promoter of glutamate release in purified nerve endings (synaptosomes) and astrocytic processes (gliosomes) isolated from the cortex of EAE mice at the acute stage of the disease (21 ± 1 day post-immunization).
    Experimental approach: EAE cortical synaptosomes and gliosomes were analysed for glutamate release efficiency (measured as release of preloaded [
    Key results: In healthy mice, complement releases [
    Conclusion and implications: Our results unveil a new noncanonical role of complement in the CNS of EAE mice relevant to disease progression and central synaptopathy that suggests new therapeutic targets for the management of MS.
    Language English
    Publishing date 2024-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 80081-8
    ISSN 1476-5381 ; 0007-1188
    ISSN (online) 1476-5381
    ISSN 0007-1188
    DOI 10.1111/bph.16328
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uf I Zs.146: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Development of Biotinylated Liposomes Encapsulating Metformin for Therapeutic Targeting of Inflammation-Based Diseases.

    Ailuno, Giorgia / Baldassari, Sara / Balboni, Alice / Pastorino, Sara / Zuccari, Guendalina / Cortese, Katia / Barbieri, Federica / Drava, Giuliana / Florio, Tullio / Caviglioli, Gabriele

    Pharmaceutics

    2024  Volume 16, Issue 2

    Abstract: Inflammation is a physiological response to a damaging stimulus but sometimes can be the cause of the onset of neurodegenerative diseases, atherosclerosis, and cancer. These pathologies are characterized by the overexpression of inflammatory markers like ...

    Abstract Inflammation is a physiological response to a damaging stimulus but sometimes can be the cause of the onset of neurodegenerative diseases, atherosclerosis, and cancer. These pathologies are characterized by the overexpression of inflammatory markers like endothelial adhesion molecules, such as Vascular Cell Adhesion Molecule-1 (VCAM-1). In the present work, the development of liposomes for therapeutic targeted delivery to inflamed endothelia is described. The idea is to exploit a three-step pretargeting system based on the biotin-avidin high-affinity interaction: the first step involves a previously described biotin derivative bearing a VCAM-1 binding peptide; in the second step, the avidin derivative NeutrAvidin
    Language English
    Publishing date 2024-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16020235
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  9. Article: Electrophysiological and morphological modulation of neuronal-glial network by breast cancer and nontumorigenic mammary cell conditioned medium.

    Di Lisa, Donatella / Cortese, Katia / Chiappalone, Michela / Arnaldi, Pietro / Martinoia, Sergio / Castagnola, Patrizio / Pastorino, Laura

    Frontiers in bioengineering and biotechnology

    2024  Volume 12, Page(s) 1368851

    Abstract: Breast cancer is a significant global health concern, with the overexpression of human epidermal growth factor receptor 2 (HER2/ERBB2) being a driver oncogene in 20%-30% of cases. Indeed, HER2/ERBB2 plays a crucial role in regulating cell growth, ... ...

    Abstract Breast cancer is a significant global health concern, with the overexpression of human epidermal growth factor receptor 2 (HER2/ERBB2) being a driver oncogene in 20%-30% of cases. Indeed, HER2/ERBB2 plays a crucial role in regulating cell growth, differentiation, and survival via a complex signaling network. Overexpression of HER2/ERBB2 is associated with more aggressive behavior and increased risk of brain metastases, which remains a significant clinical challenge for treatment. Recent research has highlighted the role of breast cancer secretomes in promoting tumor progression, including excessive proliferation, immune invasion, and resistance to anti-cancer therapy, and their potential as cancer biomarkers. In this study, we investigated the impact of ERBB2+ breast cancer
    Language English
    Publishing date 2024-04-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1368851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Morphologic vascular anomalies detected during migraine surgery.

    Raposio, Edoardo / Raposio, Giorgio / Del Duchetto, Denise / Tagliatti, Erica / Cortese, Katia

    Journal of plastic, reconstructive & aesthetic surgery : JPRAS

    2022  Volume 75, Issue 11, Page(s) 4069–4073

    Abstract: Although there is increasing evidence of migraine headaches having extracranial origins, the exact mechanisms underlying the pathogenesis of surgically treated migraines continue to be poorly investigated and described. We studied the microscopic and ... ...

    Abstract Although there is increasing evidence of migraine headaches having extracranial origins, the exact mechanisms underlying the pathogenesis of surgically treated migraines continue to be poorly investigated and described. We studied the microscopic and ultrastructural characteristics of superficial temporal artery (STA) and occipital (OA) artery in the auriculotemporal and great occipital trigger points of migraine patients to determine their possible role in migraine etiopathogenesis. Fifteen biopsies, 10 of STA and 5 from OAs, were collected intraoperatively during migraine surgery and immediately processed for optical and ultramicroscopic analysis. We detected the following anomalies in all the specimens: (a) endothelial damage with internal elastic lamina fragmentation and intimal thickening; (b) marked irregularity in the shape and metachromasia of the vascular smooth muscle cells (VSMCs), separation of cells by abundant extracellular matrix and vacuoles. The electron microscopy analysis confirmed that presumed VSMCs infiltrated the intima layer revealing a consistent shift of VSMCs from contractile to synthetically active phenotypes, endosome-like organelles, multilamellar structures, abundant extracellular vacuoles filled with fine granular material and membranes, and extracellular vesicles in the matrix space surrounding synthetically active cells. Our study revealed specific alterations in the vasculature at the neurovascular bundles of the temporal and occipital trigger sites. These findings are indicative of an active involvement of the arteries in the auriculotemporal and great occipital trigger sites in evoking migraine.
    MeSH term(s) Humans ; Migraine Disorders/etiology ; Migraine Disorders/surgery ; Temporal Arteries/anatomy & histology ; Arteries
    Language English
    Publishing date 2022-08-22
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2217750-4
    ISSN 1878-0539 ; 1748-6815 ; 0007-1226
    ISSN (online) 1878-0539
    ISSN 1748-6815 ; 0007-1226
    DOI 10.1016/j.bjps.2022.08.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.157: Show issues Location:
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