Article ; Online: Inflammation, mitochondrial dysfunction and physical performance: a possible association in older patients with persistent atrial fibrillation-the results of a preliminary study.
Aging clinical and experimental research
2023 Volume 35, Issue 11, Page(s) 2831–2837
Abstract: Background: Atrial fibrillation (AF) is associated with chronic inflammation, a hallmark of ageing process. The aim of this study was to determine interleukin-6 (IL-6)-associated variables, also exploring acylcarnitines, expression of mitochondrial ... ...
| Abstract | Background: Atrial fibrillation (AF) is associated with chronic inflammation, a hallmark of ageing process. The aim of this study was to determine interleukin-6 (IL-6)-associated variables, also exploring acylcarnitines, expression of mitochondrial abnormalities. Methods: We evaluated 22 controls and 50 patients with persistent AF. IL-6 and acylcarnitines were measured with ELISA kits and mass spectrometry techniques. Results: IL-6 concentration (mean: 3.9 ± 3.1 pg/mL) was lower in controls and increased in AF patients, especially with heart failure. The CHA Conclusions: In older AF patients, IL-6 correlated with acylcarnitines and lower physical performance. Alterations in energy production, reduced physical function and inflammation could contribute to frailty development. |
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| MeSH term(s) | Humans ; Aged ; Atrial Fibrillation/complications ; Stroke/complications ; Risk Assessment/methods ; Interleukin-6 ; Inflammation/complications ; Mitochondria ; Risk Factors | |||||
| Chemical Substances | Interleukin-6 | |||||
| Language | English | |||||
| Publishing date | 2023-09-21 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2104785-6 | |||||
| ISSN | 1720-8319 ; 1594-0667 | |||||
| ISSN (online) | 1720-8319 | |||||
| ISSN | 1594-0667 | |||||
| DOI | 10.1007/s40520-023-02558-w | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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