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  1. Article ; Online: Complicated acute appendicitis with compromised appendiceal base: A review of surgical strategies.

    Caballero-Alvarado, Jose / Lau Torres, Victor / Peralta, Katherine Lozano / Zavaleta-Corvera, Carlos

    Polski przeglad chirurgiczny

    2024  Volume 96, Page(s) 65–70

    Abstract: ... Introduction: ... Acute appendicitis is one of the most frequent emergencies in hospitals around the world; it requires early surgical treatment in complicated cases. One of the challenges that the surgeon faces during appendectomy is when the ... ...

    Abstract
    Introduction:     Acute appendicitis is one of the most frequent emergencies in hospitals around the world; it requires early surgical treatment in complicated cases. One of the challenges that the surgeon faces during appendectomy is when the base of the appendix is compromised by either a perforation or gangrene. To show the surgical strategies that have been reported, as well as the complications associated with a compromised appendicular base in a complicated acute appendicitis.

    Methods:     A bibliographic search was carried out in the databases of Pubmed, Embase, Web of Science, and Google Scholar. The search expression ("appendiceal stump closure" OR "Closure of the appendiceal stump" OR "Management of appendiceal stump") was used to search for articles. The inclusion criteria were observational studies (case reports, case series, or cross-sectional, case-control, or cohort studies).

    Discussion:     Different techniques have been reported for the treatment of a compromised appendicular base. Among the most used are primary closure, partial resection of the cecum, cecostomy tube, ileocecectomy, and right hemicolectomy. The most frequent complications are surgical site infection, intra-abdominal abscess, postoperative ileus, intestinal obstruction, and others.

    Conclusions:     The appendicular base, compromised by necrosis or perforation, requires adequate treatment in order to prevent dehiscence of the appendicular stump sutures and fecal peritonitis. A number of surgical options have been reported.
    .
    MeSH term(s) Humans ; Appendicitis/complications ; Appendicitis/surgery ; Cross-Sectional Studies ; Laparoscopy/methods ; Appendix/surgery ; Appendectomy/methods ; Postoperative Complications/etiology ; Postoperative Complications/surgery
    Language English
    Publishing date 2024-02-13
    Publishing country Poland
    Document type Review ; Journal Article
    ZDB-ID 128732-1
    ISSN 2299-2847 ; 0032-373X
    ISSN (online) 2299-2847
    ISSN 0032-373X
    DOI 10.5604/01.3001.0053.6868
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  2. Article: Laparoskopicheskoe i otkrytoe khirurgicheskoe lechenie kist kholedokha: sistematicheskii obzor i metaanaliz.

    Plasencia, G / Alvarado, J C / Corvera, C Z / Angulo, W P

    Khirurgiia

    2023  , Issue 3, Page(s) 54–62

    Abstract: Objective: To determine if laparoscopic excision is more effective than open excision in the treatment of choledochal cysts.: Material and methods: A systematic review of randomized clinical trials in 3 databases measuring the efficacy of ... ...

    Title translation Laparoscopic excision versus open excision for the treatment of choledochal cysts: a systematic review and meta-analysis.
    Abstract Objective: To determine if laparoscopic excision is more effective than open excision in the treatment of choledochal cysts.
    Material and methods: A systematic review of randomized clinical trials in 3 databases measuring the efficacy of laparoscopic and open excision of choledochal cysts was performed. The authors considered international and national reports, whose results were analyzed in detail.
    Results: Mean duration of laparoscopic excision was 51 min, open excision - 35.4 min. Length of hospital-stay after laparoscopic excision ranged between 5 and 74 days, after open excision - between 7 and 146 days. Bile leakage rate was 1-2% and 4%, respectively. Laparoscopic excision was followed by lower complication rate. Morbidity and mortality in laparoscopic excision was 20% and 0%, in open excision - 60% and 3.3%, respectively.
    Conclusion: Laparoscopic excision is more effective than open excision in the treatment of choledochal cysts.
    MeSH term(s) Humans ; Choledochal Cyst/surgery ; Treatment Outcome ; Retrospective Studies ; Laparoscopy/methods ; Biliary Tract Surgical Procedures/methods
    Language Russian
    Publishing date 2023-12-05
    Publishing country Russia (Federation)
    Document type Meta-Analysis ; Systematic Review ; English Abstract ; Journal Article
    ZDB-ID 419230-8
    ISSN 2309-5628 ; 0023-1207
    ISSN (online) 2309-5628
    ISSN 0023-1207
    DOI 10.17116/hirurgia202403154
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  3. Article: Multifocal pancreatic PPoma in the setting of MEN1: Case report and review of literature.

    Mosenia, Arman / Ward, Casey / Yee, Alisa / Qorbani, Amir / Corvera, Carlos

    International journal of surgery case reports

    2021  Volume 83, Page(s) 106008

    Abstract: Introduction and importance: Functioning pancreatic neuroendocrine tumors (pNETs) that express pancreatic polypeptide-PPomas-do not yet have a pathognomonic clinical syndrome associated with them due to their overall rarity and diverse symptoms. ... ...

    Abstract Introduction and importance: Functioning pancreatic neuroendocrine tumors (pNETs) that express pancreatic polypeptide-PPomas-do not yet have a pathognomonic clinical syndrome associated with them due to their overall rarity and diverse symptoms. Moreover, in patients with MEN1, the often multifocal nature of pNETs presents a unique clinical issue.
    Case presentation: We report a case of a 22-year-old man with a known MEN1 gene mutation who was suffering from severe diarrhea (7-8 bowel movements per day) and was found to have only elevated PP levels on biochemical work-up. Ga68-DOTATATE PET/CT showed multifocal tumors in the body and tail of the pancreas that were not evident on contrast-enhanced CT. The patient underwent a successful laparoscopic radical antegrade modular pancreatosplenectomy (RAMP) and recovered well post-operatively with complete resolution of his diarrhea. Immunohistochemistry showed multiple pure PPomas.
    Clinical discussion: This case highlights the unique propensity for multifocal disease in patients with MEN1 mutations and the utility of functional imaging by somatostatin analogs, i.e., Ga68-DOTATATE PET/CT, in order to perform oncologic laparoscopic pancreatic resections.
    Conclusion: PPomas in the setting of MEN1 mutations are a unique clinical entity due to their diverse associated clinical syndromes and propensity for multifocal disease.
    Language English
    Publishing date 2021-05-23
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2021.106008
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  4. Article ; Online: LAPAROSCOPIC SLEEVE GASTRECTOMY VERSUS LAPAROSCOPIC ROUX-EN-Y GASTRIC BYPASS FOR WEIGHT LOSS IN OBESE PATIENTS: WHICH IS MORE EFFECTIVE? A SYSTEMATIC REVIEW AND META-ANALYSIS.

    García-Honores, Laura / Caballero-Alvarado, Jose / Bustamante-Cabrejos, Alexander / Lozano-Peralta, Katherine / Zavaleta-Corvera, Carlos

    Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery

    2023  Volume 36, Page(s) e1782

    Abstract: Background: Bariatric surgery is the most effective option to reduce weight in morbid obesity patients. The techniques most employed are the restrictive surgery laparoscopic sleeve gastrectomy (LSG), surgical procedures of intestinal malabsorption, and ... ...

    Abstract Background: Bariatric surgery is the most effective option to reduce weight in morbid obesity patients. The techniques most employed are the restrictive surgery laparoscopic sleeve gastrectomy (LSG), surgical procedures of intestinal malabsorption, and both types (restrictive and intestinal malabsorption) such as the Roux-en-Y laparoscopic gastric bypass (RYLGB).
    Aims: To determine if LSG is more effective than RYLGB for weight loss.
    Methods: A systematic review and meta-analysis was carried out, including five clinical trials and sixteen cohorts comparing LSG versus RYLGB in weight loss and secondary outcomes: resolution of comorbidities, postoperative complications, operative time, hospital stay, and improvement in quality of life.
    Results: Excess weight loss was 10.2% (mean difference [MD] 10.2; 95%CI -10.14; -9.90) higher in patients undergoing LSG than in patients submitted to RYLGB. Diabetes mellitus type 2 was resolved in 17% (relative risk [RR] 0.83; 95%CI 0.77-0.90) of cases, more significantly after LSG, arterial hypertension in 23% (RR 0.77; 95%CI 0.69-0.84), and dyslipidemia in 17% (RR 0.83; 95%CI 0.77-0.90). Postoperative complications were 73% higher in patients undergoing RYLGB (MD 0.73; 95%CI 0.63-0.83). The operative time was 35.76 minutes shorter in the LSG (MD -35.76; 95%CI -37.28; -34.24). Finally, the quality of life improved more in patients operated by LSG (MD 0.37; 95%CI -0.48; -0.26).
    Conclusions: The study demonstrated that LSG could be more effective than RYLGB in reducing the percentage of excess weight, comorbidities, postoperative complications, operative time, hospital stay, and in improving quality of life.
    MeSH term(s) Humans ; Gastric Bypass/methods ; Quality of Life ; Obesity, Morbid/surgery ; Obesity, Morbid/complications ; Laparoscopy/methods ; Gastrectomy/methods ; Weight Loss ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Treatment Outcome
    Language English
    Publishing date 2023-12-08
    Publishing country Brazil
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ISSN 2317-6326
    ISSN (online) 2317-6326
    DOI 10.1590/0102-672020230064e1782
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  5. Article ; Online: Improved survival of patients receiving immunotherapy and chemotherapy following curative-intent resection of colorectal liver metastases.

    Pollini, Tommaso / Tran, Thuy / Wong, Paul / Adam, Mohamed A / Alseidi, Adnan / Corvera, Carlos / Hirose, Kenzo / Nakakura, Eric / Warren, Robert / Maker, Vijay K / Maker, Ajay V

    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract

    2024  Volume 28, Issue 3, Page(s) 246–251

    Abstract: Background: Despite significant advancements in the treatment of patients with colorectal liver metastases (CRLMs), only a minority will experience long-term survival. This study aimed to determine the effect of chemotherapy (CT) and immunotherapy (IT) ... ...

    Abstract Background: Despite significant advancements in the treatment of patients with colorectal liver metastases (CRLMs), only a minority will experience long-term survival. This study aimed to determine the effect of chemotherapy (CT) and immunotherapy (IT) compared with that of CT alone on patient survival after surgical resection.
    Methods: Patients undergoing curative-intent liver resection followed by adjuvant systemic therapy for stage IV colon cancer were identified using the National Cancer Database. Patients were stratified into type of therapy (CT alone vs CT + IT) and microsatellite status. Propensity score-weighted analysis was performed through 1:1 matching based on the nearest neighbor method.
    Results: Of 9943 patients who underwent resection of CRLMs, 7971 (80%) received systemic adjuvant therapy. Of 7971 patients, 1432 (18%) received a combination of CT and IT. Microsatellite status was not associated with overall survival (OS). Adjuvant CT + IT was associated with increased 3-year OS compared with that of CT alone in both the unmatched cohort (55% vs 48%, respectively; P < .001) and matched cohort (52% vs 48%, respectively; P = .050). On multivariate analysis, older age, positive resection margins, and KRAS mutation were independent predictors of poor survival, whereas the administration of adjuvant CT + IT was an independent predictor of improved survival.
    Conclusion: IT combined with CT was associated with improved survival compared with that of CT alone after curative-intent resection of CRLMs, regardless of microsatellite instability status. Clinical trials to determine optimal patient selection, IT regimen, and long-term efficacy to improve outcomes of patients with CRLMs are warranted.
    MeSH term(s) Humans ; Immunotherapy ; Liver Neoplasms/therapy ; Chemotherapy, Adjuvant ; Hepatectomy ; Colonic Neoplasms/therapy
    Language English
    Publishing date 2024-01-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2012365-6
    ISSN 1873-4626 ; 1934-3213 ; 1091-255X
    ISSN (online) 1873-4626 ; 1934-3213
    ISSN 1091-255X
    DOI 10.1016/j.gassur.2023.12.026
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  6. Article: Post-COVID cholangiopathy: A narrative review.

    Caballero-Alvarado, José / Zavaleta Corvera, Carlos / Merino Bacilio, Bryan / Ruiz Caballero, Clara / Lozano-Peralta, Katherine

    Gastroenterologia y hepatologia

    2022  Volume 46, Issue 6, Page(s) 474–482

    Abstract: Since the spread of the first cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection much progress has been made in understanding the disease process. However, we are still facing the complications of coronavirus disease 19 ( ... ...

    Abstract Since the spread of the first cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection much progress has been made in understanding the disease process. However, we are still facing the complications of coronavirus disease 19 (COVID-19). Multiple sequelae may appear as a consequence of acute infection. This set of entities called post-COVID-19 syndrome involves a wide variety of new, recurrent or persistent symptoms grouped together as a consequence of the acute disease process. One of those that has attracted the most attention is the liver and bile duct involvement called post-COVID-19 cholangiopathy. This is characterized by elevation of liver markers such as alkaline phosphatase, bilirubin and transaminases as well as alterations in the bile ducts in imaging studies. Thus, a narrative review of the cases reported until the end of 2021 was carried out. From the findings found, we concluded that patients who have had COVID-19 or during the process have required hospitalization should remain under follow-up for at least 6 months by a multidisciplinary team.
    MeSH term(s) Humans ; Cholangitis, Sclerosing/diagnosis ; Post-Acute COVID-19 Syndrome ; COVID-19/complications ; SARS-CoV-2 ; Bile Ducts
    Language Spanish
    Publishing date 2022-09-27
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 632502-6
    ISSN 0210-5705
    ISSN 0210-5705
    DOI 10.1016/j.gastrohep.2022.09.004
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  7. Article: ERICVA Risk Scale simplified as a predictor of amputation in critical limb ischemia.

    Mantilla Ibañez, María Luisa / Sánchez Bardales, Fernando / Zavaleta Corvera, Carlos / Caballero Alvarado, Jose / Pozzuoli, Gabriela / Muente Alva, Liz Stephanie

    Journal de medecine vasculaire

    2022  Volume 47, Issue 3, Page(s) 116–124

    Abstract: Objective: Demonstrate that simplified ERICVA (Valladolid Critical Limb Ischaemia Risk Scale) is useful in predicting amputation in chronic limb-threatening ischemia (CLI) after one year of revascularization.: Methods: A retrospective cohort study ... ...

    Abstract Objective: Demonstrate that simplified ERICVA (Valladolid Critical Limb Ischaemia Risk Scale) is useful in predicting amputation in chronic limb-threatening ischemia (CLI) after one year of revascularization.
    Methods: A retrospective cohort study was performed. We analyzed the medical records of 93 patients over the age of 35 with the diagnosis of CLI who were treated in the Department of Internal Medicine, Orthopedics or in the Cardiovascular Surgery Unit of the Víctor Lazarte Echegaray Hospital and the High Complexity Virgen de La Puerta Hospital during the period 2015-2018. The simplified ERICVA score was determined in patients before surgical and endovascular revascularization. We included 31 patients who scored 2 or more points in the exposed group and 62 patients who scored less than 2 points in the group not exposed to amputation risk. The collected data was analyzed with the statistical program SPSS where the Relative Risk and significance was obtained with Pearson's Chi-square. The multivariate analysis was also carried out in order to obtain the adjusted relative risk.
    Results: It was identified that the simplified ERICVA score greater than or equal to 2 points was more frequent in those who underwent amputation (90.3%) compared to patients who did not undergo amputation (4.8%), increasing the risk of amputation in those patients with CLI who underwent revascularization (RR: 18.67, P<0.001). It was also possible to identify that within the group of patients that showed a high risk of amputation according to the ERICVA scale, they had a higher risk of major amputation (RR: 9.32, P<0.001) as opposed to the risk of minor amputation (RR: 1, 89, P=0.193). Among the items of the simplified ERICVA scale, the preoperative neutrophil-lymphocyte ratio and hematocrit were significantly higher in the group of amputated patients (P<0.001). In addition, it was possible to identify that the score greater than or equal to 2 was independently associated with the risk of amputation in patients revascularized with CLI (RR: 13.5, P<0.001).
    Conclusion: In our patient population, the simplified ERICVA scale is useful in predicting major and minor amputation in critical limb ischemia after revascularization. The present data showed that the patients who had a simplified ERICVA score greater than or equal to 2 had a higher risk of major amputation compared to the risk of minor amputation. However, it is important to highlight that the impact on the prediction of minor amputation is greater because in some circumstances major amputation can appear as a complication of CLI.
    MeSH term(s) Amputation ; Chronic Limb-Threatening Ischemia ; Endovascular Procedures/adverse effects ; Humans ; Ischemia/diagnosis ; Ischemia/surgery ; Limb Salvage ; Peripheral Arterial Disease/diagnosis ; Peripheral Arterial Disease/surgery ; Retrospective Studies ; Risk Factors ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2022-08-02
    Publishing country France
    Document type Journal Article
    ISSN 2542-4513
    ISSN 2542-4513
    DOI 10.1016/j.jdmv.2022.07.002
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  8. Article: A rare presentation of hepatolithiasis in an adolescent patient: A case report.

    Freise, Jonathan / Mena, Jorge / Wen, Kwun Wah / Stoller, Marshall / Ho, Sunita / Corvera, Carlos

    International journal of surgery case reports

    2020  Volume 72, Page(s) 343–345

    Abstract: Introduction: Hepatolithiasis (intrahepatic stones) is rare in adolescent patients and requires complex management strategies to prevent recurrent infections and progression to hepatic fibrosis. Surgical management is often required. In cases of unclear ...

    Abstract Introduction: Hepatolithiasis (intrahepatic stones) is rare in adolescent patients and requires complex management strategies to prevent recurrent infections and progression to hepatic fibrosis. Surgical management is often required. In cases of unclear etiology, further work-up is indicated to provide insight into future management. In this report we describe an extensive stone analysis.
    Presentation of case: A 20-year-old Caucasian female presented with known hepatolithiasis and multiple prior recurrent bouts of abdominal pain requiring hospitalization. Magnetic resonance cholangiopancreatography (MRCP) demonstrated an abnormal left-sided hepatic biliary ductal system dilatation. She was treated surgically with a formal left hepatectomy and preservation of the caudate lobe. The right ductal system had no stones or evidence of inflammation, and her bile and stones cultures were negative for organism growth. An extensive analysis demonstrated stone composition primarily of cholesterol.
    Discussion: Adolescent presentations of hepatolithiasis are rare and considerations in the differential diagnosis include primary sclerosing cholangitis, bile acid transporter defects, and other known genetic diseases. This case is unique because only the left half of the intrahepatic ductal system had evidence of stone disease and the bile was sterile. A detailed stone analysis demonstrating cholesterol supersaturation provides additional context though the etiology remains unclear in this case and will require lifelong follow-up.
    Conclusion: Early-onset hepatolithiasis is rare and requires expert management, and in some cases definitive surgical management with life-long follow-up. Extensive stone analysis and genetic testing can be performed to help identify disease etiology in unique cases.
    Language English
    Publishing date 2020-06-12
    Publishing country Netherlands
    Document type Case Reports
    ISSN 2210-2612
    ISSN 2210-2612
    DOI 10.1016/j.ijscr.2020.06.017
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  9. Article ; Online: Metastatic colorectal adenocarcinoma tumor purity assessment from whole exome sequencing data.

    Tbeileh, Noura / Timmerman, Luika / Mattis, Aras N / Toriguchi, Kan / Kasai, Yosuke / Corvera, Carlos / Nakakura, Eric / Hirose, Kenzo / Donner, David B / Warren, Robert S / Karelehto, Eveliina

    PloS one

    2023  Volume 18, Issue 4, Page(s) e0271354

    Abstract: Tumors rich in stroma are associated with advanced stage and poor prognosis in colorectal adenocarcinoma (CRC). Abundance of stromal cells also has implications for genomic analysis of patient tumors as it may prevent detection of somatic mutations. As ... ...

    Abstract Tumors rich in stroma are associated with advanced stage and poor prognosis in colorectal adenocarcinoma (CRC). Abundance of stromal cells also has implications for genomic analysis of patient tumors as it may prevent detection of somatic mutations. As part of our efforts to interrogate stroma-cancer cell interactions and to identify actionable therapeutic targets in metastatic CRC, we aimed to determine the proportion of stroma embedded in hepatic CRC metastases by performing computational tumor purity analysis based on whole exome sequencing data (WES). Unlike previous studies focusing on histopathologically prescreened samples, we used an unbiased in-house collection of tumor specimens. WES from CRC liver metastasis samples were utilized to evaluate stromal content and to assess the performance of three in silico tumor purity tools, ABSOLUTE, Sequenza and PureCN. Matching tumor derived organoids were analyzed as a high purity control as they are enriched in cancer cells. Computational purity estimates were compared to those from a histopathological assessment conducted by a board-certified pathologist. According to all computational methods, metastatic specimens had a median tumor purity of 30% whereas the organoids were enriched for cancer cells with a median purity estimate of 94%. In line with this, variant allele frequencies (VAFs) of oncogenes and tumor suppressor genes were undetectable or low in most patient tumors, but higher in matching organoid cultures. Positive correlation was observed between VAFs and in silico tumor purity estimates. Sequenza and PureCN produced concordant results whereas ABSOLUTE yielded lower purity estimates for all samples. Our data shows that unbiased sample selection combined with molecular, computational, and histopathological tumor purity assessment is critical to determine the level of stroma embedded in metastatic colorectal adenocarcinoma.
    MeSH term(s) Humans ; Exome Sequencing ; Mutation ; Exome/genetics ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Adenocarcinoma/genetics ; Liver Neoplasms/genetics
    Language English
    Publishing date 2023-04-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0271354
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  10. Article ; Online: National Practice Patterns in Malignant Peritoneal Mesothelioma: Updates in Management and Survival.

    Calthorpe, Lucia / Romero-Hernandez, Fernanda / Casey, Megan / Nunez, Miguel / Conroy, Patricia C / Hirose, Kenzo / Kim, Alex / Kirkwood, Kimberly / Maker, Ajay V / Corvera, Carlos / Nakakura, Eric / Alseidi, Adnan / Adam, Mohamed Abdelgadir

    Annals of surgical oncology

    2023  Volume 30, Issue 8, Page(s) 5119–5129

    Abstract: Background: Malignant peritoneal mesothelioma (MPM) is a rare malignancy with a historically poor prognosis. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as an effective therapy for patients with ... ...

    Abstract Background: Malignant peritoneal mesothelioma (MPM) is a rare malignancy with a historically poor prognosis. Cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has emerged as an effective therapy for patients with peritoneal malignancies. A contemporary analysis of trends in management of and survival from MPM is warranted.
    Methods: Patients with MPM were identified from the National Cancer Database (2004-2018). Patients were categorized by treatment (CRS-HIPEC, CRS-chemotherapy, CRS only, chemotherapy only, no treatment), and joinpoint regression was employed to compute the annual percent change (APC) in treatment over time. Multivariable Cox proportional hazards models were used to analyze factors associated with survival.
    Results: Of 2683 patients with MPM, 19.1% underwent CRS-HIPEC, and 21.1% received no treatment. Joinpoint regression revealed a statistically significant increase in the proportion of patients undergoing CRS-HIPEC over time (APC 3.21, p = 0.01), and a concurrent decrease in the proportion of patients who underwent no treatment (APC - 2.21, p = 0.02). Median overall survival was 19.5 months. Factors independently associated with survival included CRS-HIPEC, CRS, histology, sex, age, race, Charlson Comorbidity Index, insurance, and hospital type. Although there was a strong association between year of diagnosis and survival on univariate analysis (2016-2018 HR 0.67, p < 0.001), this association was attenuated after adjustment for treatment.
    Conclusions: CRS-HIPEC is increasingly employed as a treatment for MPM. In parallel, there has been a decrease in patients receiving no treatment with an increase in overall survival. These findings suggest that patients with MPM may be receiving more appropriate therapy; however, a substantial proportion of patients may remain undertreated.
    MeSH term(s) Humans ; Mesothelioma/pathology ; Peritoneal Neoplasms/pathology ; Lung Neoplasms/pathology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Prognosis ; Hyperthermia, Induced ; Mesothelioma, Malignant ; Combined Modality Therapy ; Cytoreduction Surgical Procedures ; Survival Rate ; Retrospective Studies
    Language English
    Publishing date 2023-05-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1200469-8
    ISSN 1534-4681 ; 1068-9265
    ISSN (online) 1534-4681
    ISSN 1068-9265
    DOI 10.1245/s10434-023-13528-x
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    ab Jg. 2022: Lesesaal (EG)

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