Article ; Online: Global frequency and distribution of head and neck sarcomas in adulthood: a systematic review.
2024 Volume 281, Issue 5, Page(s) 2553–2567
Abstract: Purpose: Head and neck sarcomas (HNS) constitute a rare and heterogeneous cancer entity. Management remains a challenge due their rarity and different biological behaviour among tens of subtypes. This systematic review aimed to describe HNS global ... ...
| Abstract | Purpose: Head and neck sarcomas (HNS) constitute a rare and heterogeneous cancer entity. Management remains a challenge due their rarity and different biological behaviour among tens of subtypes. This systematic review aimed to describe HNS global frequency and distribution in adulthood. Methods: A systematic review was performed using PICOTS search strategies for qualitative question and it was written in accordance with PRISMA 2020 Statement. 70,653 publications were identified, and 15 variables were evaluated for a total of 2428 patients. Results: We identified 47 studies from 21 different countries from 5 different continents. Most of studies (83.3%) were performed in single institutions and America and Asia overruled for number of papers included (21 and 10, respectivelly). Osteosarcoma was more frequent, followed by chondrosarcoma, angiosarcoma and malignant fibrous histiocytoma. Early stage accounted for almost 80% of cases; advanced stage prevailed in developing countries. 1783 patients (90.1%) underwent surgery and 780 (39.4%) had adjuvant therapy. 50.8% of patients experienced tumour recurrence and the lowest mortality rate was reported in Europe (29.9%). Conclusions: HNS holds a relative poor prognosis possibly explained by the heterogeneity of the disease. Treatment of HNS has shown to be highly diverse among different countries, underlining the importance of uniformed treatment guidelines to achieve better patient management and to improve survival outcomes. |
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| MeSH term(s) | Humans ; Neoplasm Recurrence, Local ; Sarcoma/epidemiology ; Sarcoma/therapy ; Osteosarcoma ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/therapy ; Bone Neoplasms | |||||
| Language | English | |||||
| Publishing date | 2024-02-21 | |||||
| Publishing country | Germany | |||||
| Document type | Systematic Review ; Journal Article | |||||
| ZDB-ID | 1017359-6 | |||||
| ISSN | 1434-4726 ; 0937-4477 | |||||
| ISSN (online) | 1434-4726 | |||||
| ISSN | 0937-4477 | |||||
| DOI | 10.1007/s00405-024-08477-4 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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