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  1. Article: Metastatic congenital neuroblastoma associated with in situ neuroblastoma: case report and review of literature.

    Costa, Andressa Dias / Zerbini, Maria Claudia Nogueira / Cristofani, Lilian

    Autopsy & case reports

    2014  Volume 4, Issue 2, Page(s) 27–33

    Abstract: Although neonatal tumors are rare, neuroblastoma is the most common neoplasia among them. These tumors, which usually involve children in early infancy, are derived from neural crest cells of adrenal gland medulla or sympathetic ganglia. Even though ... ...

    Abstract Although neonatal tumors are rare, neuroblastoma is the most common neoplasia among them. These tumors, which usually involve children in early infancy, are derived from neural crest cells of adrenal gland medulla or sympathetic ganglia. Even though congenital metastatic neuroblastoma presents a favorable prognosis, it may lead to death if not recognized and treated early on. The authors report the case of a 2-month-old child who was born from in vitro fertilization, and whose diagnosis was made after birth. The form of presentation of this case as a metastatic disease concerning this age group is noteworthy.
    Language English
    Publishing date 2014-06-30
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2014.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Alobar holoprosencephaly and Trisomy 13 (Patau syndrome).

    Costa, Andressa Dias / Schultz, Regina / Rosemberg, Sérgio

    Autopsy & case reports

    2013  Volume 3, Issue 2, Page(s) 5–10

    Abstract: Holoprosencephaly (HPE) is a congenital defect of the brain, median structures, and face resulting from an incomplete cleavage of the primitive brain during early embryogenesis. The authors report a case of trisomy 13 syndrome diagnosed at prenatal ... ...

    Abstract Holoprosencephaly (HPE) is a congenital defect of the brain, median structures, and face resulting from an incomplete cleavage of the primitive brain during early embryogenesis. The authors report a case of trisomy 13 syndrome diagnosed at prenatal follow up. The preterm newborn lived only 5 hours, and died because of severe respiratory failure. The autopsy findings disclosed facial, skull, limbs, cardiac, and cerebral malformations. Among the latter, the presence of alobar HPE, the central theme of this report, was evident. The most common nonrandom chromosomal abnormality in patients with HPE is trisomy 13. The most severe variant, namely alobar HPE, is shown in this case report. Discussion on this severe anomaly, along with the case report with details of Patau's syndrome, is the goal of this report.
    Language English
    Publishing date 2013-06-30
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2013.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.

    Raghavan, Srivatsan / Winter, Peter S / Navia, Andrew W / Williams, Hannah L / DenAdel, Alan / Lowder, Kristen E / Galvez-Reyes, Jennyfer / Kalekar, Radha L / Mulugeta, Nolawit / Kapner, Kevin S / Raghavan, Manisha S / Borah, Ashir A / Liu, Nuo / Väyrynen, Sara A / Costa, Andressa Dias / Ng, Raymond W S / Wang, Junning / Hill, Emma K / Ragon, Dorisanne Y /
    Brais, Lauren K / Jaeger, Alex M / Spurr, Liam F / Li, Yvonne Y / Cherniack, Andrew D / Booker, Matthew A / Cohen, Elizabeth F / Tolstorukov, Michael Y / Wakiro, Isaac / Rotem, Asaf / Johnson, Bruce E / McFarland, James M / Sicinska, Ewa T / Jacks, Tyler E / Sullivan, Ryan J / Shapiro, Geoffrey I / Clancy, Thomas E / Perez, Kimberly / Rubinson, Douglas A / Ng, Kimmie / Cleary, James M / Crawford, Lorin / Manalis, Scott R / Nowak, Jonathan A / Wolpin, Brian M / Hahn, William C / Aguirre, Andrew J / Shalek, Alex K

    Cell

    2021  Volume 184, Issue 25, Page(s) 6119–6137.e26

    Abstract: Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and relationship to therapeutic response is limited. To examine these attributes systematically, we ... ...

    Abstract Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and relationship to therapeutic response is limited. To examine these attributes systematically, we profiled metastatic biopsies and matched organoid models at single-cell resolution. In vivo, we identify a new intermediate PDAC transcriptional cell state and uncover distinct site- and state-specific tumor microenvironments (TMEs). Benchmarking models against this reference map, we reveal strong culture-specific biases in cancer cell transcriptional state representation driven by altered TME signals. We restore expression state heterogeneity by adding back in vivo-relevant factors and show plasticity in culture models. Further, we prove that non-genetic modulation of cell state can strongly influence drug responses, uncovering state-specific vulnerabilities. This work provides a broadly applicable framework for aligning cell states across in vivo and ex vivo settings, identifying drivers of transcriptional plasticity and manipulating cell state to target associated vulnerabilities.
    MeSH term(s) Adult ; Aged ; Biomarkers, Tumor/metabolism ; Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Pancreatic Neoplasms/metabolism ; Single-Cell Analysis ; Tumor Microenvironment
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2021-12-07
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.11.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1167: Show issues Location:
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  4. Article: Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer

    Raghavan, Srivatsan / Winter, Peter S. / Navia, Andrew W. / Williams, Hannah L. / DenAdel, Alan / Lowder, Kristen E. / Galvez-Reyes, Jennyfer / Kalekar, Radha L. / Mulugeta, Nolawit / Kapner, Kevin S. / Raghavan, Manisha S. / Borah, Ashir A. / Liu, Nuo / Väyrynen, Sara A. / Costa, Andressa Dias / Ng, Raymond W.S. / Wang, Junning / Hill, Emma K. / Ragon, Dorisanne Y. /
    Brais, Lauren K. / Jaeger, Alex M. / Spurr, Liam F. / Li, Yvonne Y. / Cherniack, Andrew D. / Booker, Matthew A. / Cohen, Elizabeth F. / Tolstorukov, Michael Y. / Wakiro, Isaac / Rotem, Asaf / Johnson, Bruce E. / McFarland, James M. / Sicinska, Ewa T. / Jacks, Tyler E. / Sullivan, Ryan J. / Shapiro, Geoffrey I. / Clancy, Thomas E. / Perez, Kimberly / Rubinson, Douglas A. / Ng, Kimmie / Cleary, James M. / Crawford, Lorin / Manalis, Scott R. / Nowak, Jonathan A. / Wolpin, Brian M. / Hahn, William C. / Aguirre, Andrew J. / Shalek, Alex K.

    Cell. 2021 Dec. 09, v. 184, no. 25

    2021  

    Abstract: Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and relationship to therapeutic response is limited. To examine these attributes systematically, we ... ...

    Abstract Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and relationship to therapeutic response is limited. To examine these attributes systematically, we profiled metastatic biopsies and matched organoid models at single-cell resolution. In vivo, we identify a new intermediate PDAC transcriptional cell state and uncover distinct site- and state-specific tumor microenvironments (TMEs). Benchmarking models against this reference map, we reveal strong culture-specific biases in cancer cell transcriptional state representation driven by altered TME signals. We restore expression state heterogeneity by adding back in vivo-relevant factors and show plasticity in culture models. Further, we prove that non-genetic modulation of cell state can strongly influence drug responses, uncovering state-specific vulnerabilities. This work provides a broadly applicable framework for aligning cell states across in vivo and ex vivo settings, identifying drivers of transcriptional plasticity and manipulating cell state to target associated vulnerabilities.
    Keywords RNA ; adenocarcinoma ; drugs ; metastasis ; neoplasm cells ; organoids ; pancreatic neoplasms ; plasticity ; transcription (genetics)
    Language English
    Dates of publication 2021-1209
    Size p. 6119-6137.e26.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.11.017
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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