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  1. AU="Costa, Bruno Buranello"
  2. AU="Kohler, Beatriz"
  3. AU="Tabata, Toshinori"
  4. AU="Sun, Shijing"
  5. AU="Kufeji D."
  6. AU="Kohani, Sayeh"
  7. AU="Wong, John Cm"
  8. AU="Hua LI"
  9. AU="Özkan, Yasemin"
  10. AU=Quirmbach Diana
  11. AU="Corpstein, Clairissa D"
  12. AU="Motel-Klingebiel, Andreas"
  13. AU="Brown, Randy A"
  14. AU="Feng, Yaying"
  15. AU="Lussi, A"
  16. AU="Yeon Susan B"
  17. AU="Abaci, Irem"
  18. AU="Lin, Xiaode"
  19. AU="Mendez, Luis"
  20. AU=Alzahrani Faisal A AU=Alzahrani Faisal A
  21. AU="Heidi G Standke"
  22. AU="Banville, Isabelle"
  23. AU=Morrow Lee E
  24. AU="Cuss, Chad W."
  25. AU="Carter, Paul (Interviewpartner)"
  26. AU=Lubozynski M F
  27. AU="Yves, Ville"
  28. AU="Bayer, Emily A"
  29. AU=Roesch Saskia
  30. AU="Tam, Benjamin"
  31. AU="Mori, Kousuke"
  32. AU="Steuer, Melanie"
  33. AU="Sood Hemant"
  34. AU="Jennifer Schaff"
  35. AU="Maji, Manideepa"
  36. AU=Evans Heather L
  37. AU="Cheng, Shuai"
  38. AU="Zalis, Joshua"

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  1. Artikel ; Online: Outbreak of endemic carbapenem-resistant

    Shinohara, Danielle Rosani / Dos Santos Saalfeld, Silvia Maria / Martinez, Hilton Vizzi / Altafini, Daniela Dambroso / Costa, Bruno Buranello / Fedrigo, Nayara Helisandra / Tognim, Maria Cristina Bronharo

    Infection control and hospital epidemiology

    2021  Band 43, Heft 6, Seite(n) 815–817

    Mesh-Begriff(e) Acinetobacter baumannii ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; COVID-19 ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Cross Infection/drug therapy ; Cross Infection/epidemiology ; Disease Outbreaks ; Humans ; Intensive Care Units ; Microbial Sensitivity Tests
    Chemische Substanzen Anti-Bacterial Agents ; Carbapenems
    Sprache Englisch
    Erscheinungsdatum 2021-03-09
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2021.98
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1714: Hefte anzeigen Standort:
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  2. Artikel ; Online: Overuse of empirical antibiotics in a COVID-19 intensive care unit led to the spread of carbapenem-resistant Gram-negative bacteria in a teaching hospital.

    Dambroso-Altafini, Daniela / Dos Santos Saalfeld, Silvia Maria / de Souza Ferreira de Mattos, Monica / Martinez, Hilton Vizzi / Shinohara, Danielle Rosani / Zarpellon, Mirian Nicéa / Costa, Bruno Buranello / Bronharo Tognim, Maria Cristina

    Journal of global antimicrobial resistance

    2022  Band 30, Seite(n) 100–102

    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; COVID-19 ; Carbapenems/pharmacology ; Gram-Negative Bacteria ; Hospitals, Teaching ; Humans ; Intensive Care Units
    Chemische Substanzen Anti-Bacterial Agents ; Carbapenems
    Sprache Englisch
    Erscheinungsdatum 2022-06-13
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2710046-7
    ISSN 2213-7173 ; 2213-7173
    ISSN (online) 2213-7173
    ISSN 2213-7173
    DOI 10.1016/j.jgar.2022.06.006
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Epidemiologic surveillance of multidrug-resistant bacteria in a teaching hospital: A 3-year experience.

    Zarpellon, Mirian Nicéa / Viana, Giselle Fukita / Mitsugui, Cecília Saori / Costa, Bruno Buranello / Tamura, Nathalie Kira / Aoki, Elisabeth Eyko / Helbel, Cesar / Nishiyama, Sheila Alexandra Belini / Saalfeld, Silvia Maria Dos Santos / Tognim, Maria Cristina Bronharo

    American journal of infection control

    2017  Band 46, Heft 4, Seite(n) 387–392

    Abstract: Background: The objective of this prospective study was to verify the effectiveness of a multidisciplinary surveillance program that was implemented in a teaching hospital in southern Brazil, to prevent and control the spread of multidrug-resistant ... ...

    Abstract Background: The objective of this prospective study was to verify the effectiveness of a multidisciplinary surveillance program that was implemented in a teaching hospital in southern Brazil, to prevent and control the spread of multidrug-resistant organisms.
    Methods: The program implemented involved establishment of prevention guidelines, hand-hygiene promotion, isolation of patients colonized or infected by such organisms, enforced contact precautions, and terminal cleaning and disinfection of isolation rooms. A microbiology service, previously provided by an external laboratory, was established in the hospital. Detection of bacteria-resistant genes and molecular typing were performed also.
    Results: Statistically significant differences were observed between the pre- and post-intervention periods (P = .00198). Control measures were effective in blocking the dissemination of a previously endemic clone of Acinetobacter baumannii. Changes were observed in the dissemination pattern, from a monoclonal to a polyclonal mode. The incidence of vancomycin-resistant Enterococcus during the surveillance period was low. Only 2 isolates of BLA
    Conclusions: These results indicate that the surveillance program implemented was effective in preventing the spread of multidrug-resistant organisms in the hospital.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/genetics ; Bacteria/isolation & purification ; Bacterial Typing Techniques ; Drug Resistance, Multiple, Bacterial ; Epidemiological Monitoring ; Hospitals, Teaching ; Humans ; Infection Control ; Microbial Sensitivity Tests ; Phylogeny
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2017-12-06
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 392362-9
    ISSN 1527-3296 ; 0196-6553
    ISSN (online) 1527-3296
    ISSN 0196-6553
    DOI 10.1016/j.ajic.2017.10.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1773: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Artikel ; Online: Pharmacodynamic Evaluation of the Potential Clinical Utility of Fosfomycin and Meropenem in Combination Therapy against KPC-2-Producing Klebsiella pneumoniae.

    Albiero, James / Sy, Sherwin K B / Mazucheli, Josmar / Caparroz-Assef, Silvana Martins / Costa, Bruno Buranello / Alves, Janio Leal Borges / Gales, Ana Cristina / Tognim, Maria Cristina Bronharo

    Antimicrobial agents and chemotherapy

    2016  Band 60, Heft 7, Seite(n) 4128–4139

    Abstract: KPC-producing Klebsiella pneumoniae causes serious infections associated with high death rates worldwide. Combination therapy consisting of fosfomycin and a carbapenem is better than monotherapy to combat multidrug-resistant microorganisms, but no ... ...

    Abstract KPC-producing Klebsiella pneumoniae causes serious infections associated with high death rates worldwide. Combination therapy consisting of fosfomycin and a carbapenem is better than monotherapy to combat multidrug-resistant microorganisms, but no dosages for the combination have been defined. The MICs of meropenem and fosfomycin were evaluated against 18 clinical isolates of KPC-2-producing K. pneumoniae The activities of combination antimicrobials were also determined by the checkerboard method. The MIC50 and MIC90 of each agent alone and in combination were challenged against short (1.5-h) or prolonged (3-h) infusion regimens of meropenem (1 g every 8 h [q8h], 1.5 g q6h, 2 g q8h) and fosfomycin (4 g q8h, 6 g q6h, 8 g q8h) by Monte Carlo simulation to evaluate the time above the MIC of the free drug concentration as a percentage of the dosing interval (fT>MIC). The monotherapy MIC50s and MIC90s were 32 and 256 mg/liter for meropenem and 64 and 512 mg/liter for fosfomycin, respectively. Antimicrobial combination increased bacterial susceptibility to 1/4 the MIC50s and to 1/8 to 1/16 the MIC90s of monotherapy. The antimicrobial combination demonstrated a synergistic effect for at least two-thirds of the isolates. In combination therapy, fosfomycin regimens of 6 g q6h and 8 g q8h as a 3-h infusion against the MIC50 and MIC90 had better chances of achieving ≥90% probability of target attainment (PTA) of 70% fT>MIC. Meropenem regimens of 1.5 g q6h and 2 g q8h in prolonged infusion can achieve close to 90% PTA of 40% fT>MIC for MIC50 but not MIC90 The significant reduction in the MIC values and the achievement of appropriate PTA demonstrated that regimens containing fosfomycin with meropenem can be effective against KPC-2-producing K. pneumoniae.
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Fosfomycin/pharmacology ; Klebsiella pneumoniae/drug effects ; Klebsiella pneumoniae/enzymology ; Microbial Sensitivity Tests ; Monte Carlo Method ; Thienamycins/pharmacology ; beta-Lactamases/genetics ; beta-Lactamases/metabolism
    Chemische Substanzen Anti-Bacterial Agents ; Thienamycins ; Fosfomycin (2N81MY12TE) ; beta-Lactamases (EC 3.5.2.6) ; meropenem (FV9J3JU8B1)
    Sprache Englisch
    Erscheinungsdatum 2016-07
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 217602-6
    ISSN 1098-6596 ; 0066-4804
    ISSN (online) 1098-6596
    ISSN 0066-4804
    DOI 10.1128/AAC.03099-15
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 809: Hefte anzeigen Standort:
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