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  1. Article ; Online: Pyrrolidine dithiocarbamate reduces alloxan-induced kidney damage by decreasing nox4, inducible nitric oxide synthase, and metalloproteinase-2.

    Pereira, Bruna Pinheiro / do Valle, Gabriel Tavares / Salles, Bruno César Côrrea / Costa, Karla Cristinne Mancini / Ângelo, Marilene Lopes / Torres, Larissa Helena Lobo / Novaes, Rômulo Dias / Ruginsk, Sílvia Graciela / Tirapelli, Carlos Renato / de Araújo Paula, Fernanda Borges / Ceron, Carla Speroni

    Naunyn-Schmiedeberg's archives of pharmacology

    2020  Volume 393, Issue 10, Page(s) 1899–1910

    Abstract: We examined the effect of the NFκB inhibitor pyrrolidine-1-carbodithioic acid (PDTC) on inducible nitric oxide synthase (iNOS), matrix metalloproteinase-2 (MMP-2) activity, and oxidative and inflammatory kidney damage in alloxan-induced diabetes. Two ... ...

    Abstract We examined the effect of the NFκB inhibitor pyrrolidine-1-carbodithioic acid (PDTC) on inducible nitric oxide synthase (iNOS), matrix metalloproteinase-2 (MMP-2) activity, and oxidative and inflammatory kidney damage in alloxan-induced diabetes. Two weeks after diabetes induction (alloxan-130 mg/kg), control and diabetic rats received PDTC (100 mg/kg) or vehicle for 8 weeks. Body weight, glycemia, urea, and creatinine were measured. Kidney changes were measured in hematoxylin/eosin sections and ED1 by immunohistochemistry. Kidney thiobarbituric acid reactive substances (TBARS), superoxide anion (O2-), and nitrate/nitrite (NOx) levels, and catalase and superoxide dismutase (SOD) activities were analyzed. Also, kidney nox4 and iNOS expression, and NFkB nuclear translocation were measured by western blot, and MMP-2 by zymography. Glycemia and urea increased in alloxan rats, which were not modified by PDTC treatment. However, PDTC attenuated kidney structural alterations and macrophage infiltration in diabetic rats. While diabetes increased both TBARS and O
    MeSH term(s) Alloxan/toxicity ; Animals ; Antioxidants/pharmacology ; Antioxidants/therapeutic use ; Kidney Diseases/chemically induced ; Kidney Diseases/drug therapy ; Kidney Diseases/enzymology ; Male ; Matrix Metalloproteinase 2/metabolism ; Matrix Metalloproteinase Inhibitors/pharmacology ; Matrix Metalloproteinase Inhibitors/therapeutic use ; NADPH Oxidase 4/antagonists & inhibitors ; NADPH Oxidase 4/metabolism ; Nitric Oxide Synthase Type II/antagonists & inhibitors ; Nitric Oxide Synthase Type II/metabolism ; Pyrrolidines/pharmacology ; Pyrrolidines/therapeutic use ; Rats ; Rats, Wistar ; Thiocarbamates/pharmacology ; Thiocarbamates/therapeutic use
    Chemical Substances Antioxidants ; Matrix Metalloproteinase Inhibitors ; Pyrrolidines ; Thiocarbamates ; pyrrolidine dithiocarbamic acid (25769-03-3) ; Alloxan (6SW5YHA5NG) ; Nitric Oxide Synthase Type II (EC 1.14.13.39) ; Nos2 protein, rat (EC 1.14.13.39) ; NADPH Oxidase 4 (EC 1.6.3.-) ; Nox4 protein, rat (EC 1.6.3.-) ; Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Mmp2 protein, rat (EC 3.4.24.24)
    Language English
    Publishing date 2020-05-21
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-020-01906-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.5: Show issues Location:
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  2. Article ; Online: Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice.

    Almeida, Carolina Aparecida Faria / Pereira-Junior, Antonio Alves / Rangel, Jéssica Gonçalves / Pereira, Bruna Pinheiro / Costa, Karla Cristinne Mancini / Bruno, Vitor / Silveira, Gabriela Oliveira / Ceron, Carla Speroni / Yonamine, Mauricio / Camarini, Rosana / Garcia, Raphael Caio Tamborelli / Marcourakis, Tania / Torres, Larissa Helena

    Behavioural brain research

    2021  Volume 416, Page(s) 113546

    Abstract: Alcohol use disorder needs more effective treatments because relapse rates remain high. Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our study aimed to evaluate the effects of ayahuasca on ethanol-induced behavioral ... ...

    Abstract Alcohol use disorder needs more effective treatments because relapse rates remain high. Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our study aimed to evaluate the effects of ayahuasca on ethanol-induced behavioral sensitization (EIBS). Swiss mice received 2.2 g/kg ethanol or saline IP injections every other day across nine days (D1, D3, D5, D7, and D9), and locomotor activity was evaluated 10 min after each injection. Then, animals were treated daily with ayahuasca (corresponding to 1.76 mg/kg of N,N-dimethyltryptamine, DMT) or water by oral gavage for eight consecutive days. On the seventh day, mice were evaluated in the elevated plus maze. Then, mice were challenged with a single dose of ethanol to measure their locomotor activity. Dopamine receptors, serotonin receptors, dynorphin, and prodynorphin levels were quantified in the striatum and hippocampus by blot analysis. Repeated ethanol administration resulted in EIBS. However, those animals treated with ayahuasca had an attenuated EIBS. Moreover, ayahuasca reduced the anxiogenic response to ethanol withdrawal and prevented the ethanol-induced changes on 5-HT1a receptor and prodynorphin levels in the hippocampus and reduced ethanol effects in the dynorphin/prodynorphin ratio levels in the striatum. These results suggest a potential application of ayahuasca to modulate the neuroplastic changes induced by ethanol.
    MeSH term(s) Animals ; Banisteriopsis/drug effects ; Behavior, Animal/drug effects ; Beverages ; Ethanol/pharmacology ; Hallucinogens/administration & dosage ; Hallucinogens/pharmacology ; Male ; Mice ; Neuronal Plasticity/drug effects
    Chemical Substances Hallucinogens ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2021-08-23
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2021.113546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1599: Show issues Location:
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  3. Article: Maintained anxiolytic effects of cannabidiol after treatment discontinuation in healthcare workers during the COVID-19 pandemic.

    Souza, José Diogo S / Zuardi, Antonio W / Guimarães, Francisco S / Osório, Flávia de Lima / Loureiro, Sonia Regina / Campos, Alline Cristina / Hallak, Jaime E C / Dos Santos, Rafael G / Machado Silveira, Isabella Lara / Pereira-Lima, Karina / Pacheco, Julia Cozar / Ushirohira, Juliana Mayumi / Ferreira, Rafael Rinaldi / Costa, Karla Cristinne Mancini / Scomparin, Davi Silveira / Scarante, Franciele Franco / Pires-Dos-Santos, Isabela / Mechoulam, Raphael / Kapczinski, Flávio /
    Fonseca, Benedito A L / Esposito, Danillo L A / Andraus, Maristela Haddad / Crippa, José Alexandre S

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 856846

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-10-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.856846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: No effect of prior Dengue virus 1 infection in mouse dams on long-term behavioral profiles in offspring infected with Zika virus during gestation.

    Costa, Karla Cristinne Mancini / Brancaglion, Gustavo Andrade / Almeida, Carolina Aparecida de Faria / de Amorim, Gabriel Estevam Santos / Veloso, Luciana Lopes / Lião, Lucas da Silva / de Souza, Gabriel Augusto Pires / Pinheiro, Bruna Pereira / Ângelo, Marilene Lopes / Ruginsk, Silvia Graciela / Brandão, Wesley Nogueira / Marcourakis, Tania / Ceron, Carla Speroni / Coelho, Luiz Felipe Leomil / Torres, Larissa Helena

    Neuroscience letters

    2020  Volume 739, Page(s) 135448

    Abstract: Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study ... ...

    Abstract Zika virus (ZIKV) is a mosquito-borne Flavivirus structurally and antigenically related to Dengue virus (DENV). Zika virus has been associated with congenital anomalies and most ZIKV outbreaks have occurred in endemic areas of DENV. The present study investigated the effects of prior DENV serotype 1 (DENV1) immunity in immunocompetent female Swiss mice on gestational ZIKV infection in offspring. Physical/reflex development, locomotor activity, anxiety, visual acuity, and brain-derived neurotrophic factor (BDNF) levels were evaluated in offspring during infancy and adolescence. Anti-DENV1 and anti-ZIKV antibodies were detected in sera of the progenitors, whereas no ZIKV genomes were detected in the offspring brain. Pups from dams with only DENV1 immunity presented alterations of physical/reflex development. Pups from all infected dams exhibited time-related impairments in locomotor activity and anxiolytic-like behavior. Offspring from DENV/ZIKV-infected dams exhibited impairments in visual acuity during infancy but not during adolescence, which was consistent with morphometric analysis of the optic nerve. Pups from DENV1-, ZIKV-, and DENV/ZIKV-infected dams exhibited a decrease in BDNF levels during infancy and an increase during adolescence in distinct brain regions. In summary, we found no influence of prior DENV1 immunity on gestational ZIKV infection in offspring, with the exception of alterations of early visual parameters, and an increase in BDNF levels in the hippocampus during adolescence.
    MeSH term(s) Animals ; Behavior, Animal ; Brain/immunology ; Brain/virology ; Brain-Derived Neurotrophic Factor/immunology ; Brain-Derived Neurotrophic Factor/metabolism ; Dengue/immunology ; Female ; Male ; Maze Learning ; Mice ; Pregnancy ; Pregnancy Complications, Infectious/immunology ; Pregnancy Complications, Infectious/psychology ; Zika Virus Infection/immunology ; Zika Virus Infection/psychology
    Chemical Substances Bdnf protein, mouse ; Brain-Derived Neurotrophic Factor
    Language English
    Publishing date 2020-10-28
    Publishing country Ireland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2020.135448
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1166: Show issues Location:
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