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  1. Article ; Online: Perception of butenolides by Bacillus subtilis via the α/β hydrolase RsbQ.

    Melville, Kim T / Kamran, Muhammad / Yao, Jiaren / Costa, Marianne / Holland, Madeleine / Taylor, Nicolas L / Fritz, Georg / Flematti, Gavin R / Waters, Mark T

    Current biology : CB

    2024  Volume 34, Issue 3, Page(s) 623–631.e6

    Abstract: The regulation of behavioral and developmental decisions by small molecules is common to all domains of life. In plants, strigolactones and karrikins are butenolide growth regulators that influence several aspects of plant growth and development, as well ...

    Abstract The regulation of behavioral and developmental decisions by small molecules is common to all domains of life. In plants, strigolactones and karrikins are butenolide growth regulators that influence several aspects of plant growth and development, as well as interactions with symbiotic fungi.
    MeSH term(s) Hydrolases/genetics ; Bacillus subtilis ; 4-Butyrolactone ; Lactones/chemistry ; Perception ; Arabidopsis Proteins/genetics ; Plant Growth Regulators
    Chemical Substances butenolide (8KXK25H388) ; Hydrolases (EC 3.-) ; 4-Butyrolactone (OL659KIY4X) ; Lactones ; Arabidopsis Proteins ; Plant Growth Regulators
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.12.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Development and validation of a logic model for comprehensive medication management services.

    Sousa, Samuel R A E / Shoemaker, Sarah Joyce / do Nascimento, Mariana M G / Costa, Marianne S / Ramalho de Oliveira, Djenane

    The International journal of pharmacy practice

    2017  Volume 26, Issue 3, Page(s) 250–257

    Abstract: Objectives: To develop and validate a theoretical logic model for comprehensive medication management (CMM) services.: Methods: The components of a logic model were constructed after a literature review and interviews with 4 CMM professionals. To ... ...

    Abstract Objectives: To develop and validate a theoretical logic model for comprehensive medication management (CMM) services.
    Methods: The components of a logic model were constructed after a literature review and interviews with 4 CMM professionals. To validate the logic model, a panel of 17 CMM experts participated in three online Delphi method rounds to achieve consensus on the model. The consensus between the experts on each component of the logic model was evaluated using the Content Validity Index and Inter-rater Agreement in each of the rounds.
    Key findings: A logic model for CMM services containing 51 items was constructed and validated. Both the items of each component of the model and the linkage between the main components were agreed upon among the experts.
    Conclusions: A logic model for CMM services was developed and validated. It is an innovative tool that, if used as a theoretical framework for the implementation of CMM, can ensure greater reproducibility of CMM services in different scenarios of practice and levels of care.
    MeSH term(s) Delphi Technique ; Drug-Related Side Effects and Adverse Reactions/prevention & control ; Humans ; Logic ; Medication Therapy Management/organization & administration ; Models, Theoretical ; Observer Variation ; Reproducibility of Results
    Language English
    Publishing date 2017-08-10
    Publishing country England
    Document type Journal Article ; Validation Studies
    ZDB-ID 1087040-4
    ISSN 2042-7174 ; 0961-7671
    ISSN (online) 2042-7174
    ISSN 0961-7671
    DOI 10.1111/ijpp.12392
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  3. Article ; Online: Enzyme-responsive cell-penetrating peptide conjugated mesoporous silica quantum dot nanocarriers for controlled release of nucleus-targeted drug molecules and real-time intracellular fluorescence imaging of tumor cells.

    Li, Jinming / Liu, Fang / Shao, Qing / Min, Yuanzeng / Costa, Marianne / Yeow, Edwin K L / Xing, Bengang

    Advanced healthcare materials

    2014  Volume 3, Issue 8, Page(s) 1230–1239

    Abstract: Here, a set of novel and personalized nanocarriers are presented for controlled nucleus-targeted antitumor drug delivery and real-time imaging of intracellular drug molecule trafficking by integrating an enzyme activatable cell penetrating peptide (CPP) ... ...

    Abstract Here, a set of novel and personalized nanocarriers are presented for controlled nucleus-targeted antitumor drug delivery and real-time imaging of intracellular drug molecule trafficking by integrating an enzyme activatable cell penetrating peptide (CPP) with mesoporous silica coated quantum dots nanoparticles. Upon loading of antitumor drug, doxorubicin (DOX) and further exposure to proteases in tumor cell environment, the enzymatic cleavage of peptide sequence activates oligocationic TAT residues on the QDs@mSiO2 surface and direct the DOX delivery into cellular nucleus. The systematic cell imaging and cytotoxicity studies confirm that the enzyme responsive DOX-loaded CPP-QDs@mSiO2 nanoparticles can selectively release DOX in the tumor cells with high cathepsin B enzyme expression and greatly facilitate DOX accumulation in targeted nucleus, thus exhibiting enhanced antitumor activity in these cells. As contrast, there is limited nuclear-targeted drug accumulation and lower tumor cytotoxicity observed in the cells without enzyme expression. More importantly, significant antitumor DOX accumulation and higher tumor inactivation is also found in the drug resistant tumor cells with targeted enzyme expression. Such simple and specific enzyme responsive mesoporous silica-QDs nanoconjugates provide great promise for rational design of targeted drug delivery into biological system, and may thus greatly facilitate the medical theranostics in the near future.
    MeSH term(s) Amino Acid Sequence ; Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/toxicity ; Cathepsin B/metabolism ; Cell Line, Tumor ; Cell Nucleus/metabolism ; Cell Survival/drug effects ; Cell-Penetrating Peptides/chemistry ; Cell-Penetrating Peptides/metabolism ; Delayed-Action Preparations ; Doxorubicin/chemistry ; Doxorubicin/toxicity ; Drug Carriers/chemistry ; Humans ; Mice ; Microscopy, Confocal ; NIH 3T3 Cells ; Porosity ; Quantum Dots/chemistry ; Silicon Dioxide/chemistry
    Chemical Substances Antineoplastic Agents ; Cell-Penetrating Peptides ; Delayed-Action Preparations ; Drug Carriers ; Silicon Dioxide (7631-86-9) ; Doxorubicin (80168379AG) ; Cathepsin B (EC 3.4.22.1)
    Language English
    Publishing date 2014-08
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201300613
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6966: Show issues Location:
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