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  1. Book ; Online: Local Labor Market Effects of Mergers and Acquisitions in Developing Countries

    Costa, Vitor

    Evidence from Brazil

    2023  

    Abstract: I use matched employer-employee records merged with corporate tax information from 2003 to 2017 to estimate labor market-wide effects of mergers and acquisitions in Brazil. Labor markets are defined by pairs of commuting zone and industry sector. In the ... ...

    Abstract I use matched employer-employee records merged with corporate tax information from 2003 to 2017 to estimate labor market-wide effects of mergers and acquisitions in Brazil. Labor markets are defined by pairs of commuting zone and industry sector. In the following year of a merger, market size falls by 10.8%. The employment adjustment is concentrated in merging firms. For the firms not involved in M&As, I estimate a 1.07% decline in workers earnings and a positive, although not significant, increase in their size. Most mergers have a predicted impact of zero points in concentration, measured by the Herfindahl-Hirschman Index (HHI). I spillover firms, earnings decline similarly for mergers with high and low predicted changes in HHI. Contrary to the recent literature on market concentration in developed economies, I find no evidence of oligopsonistic behavior in Brazilian labor markets.
    Keywords Economics - General Economics
    Subject code 331
    Publishing date 2023-06-14
    Publishing country us
    Document type Book ; Online
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  2. Article ; Online: Vacuolar ATPase-mediated regulation of neutral lipid dynamics: Insights into lipid droplet homeostasis and stress response mechanisms.

    Costa, Vítor / Teixeira, Vitor

    Biochimica et biophysica acta. Molecular and cell biology of lipids

    2024  Volume 1869, Issue 3, Page(s) 159465

    Abstract: This study explores the intricate relationship between the yeast vacuolar ... ...

    Abstract This study explores the intricate relationship between the yeast vacuolar H
    MeSH term(s) Saccharomyces cerevisiae Proteins/metabolism ; Vacuolar Proton-Translocating ATPases/metabolism ; Lipid Droplets/metabolism ; Saccharomyces cerevisiae/metabolism ; Homeostasis ; Lipids
    Chemical Substances Saccharomyces cerevisiae Proteins ; Vacuolar Proton-Translocating ATPases (EC 3.6.1.-) ; Lipids
    Language English
    Publishing date 2024-02-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 60-7
    ISSN 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    ISSN (online) 1879-2618 ; 1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2650
    ISSN 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
    DOI 10.1016/j.bbalip.2024.159465
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  3. Article: Oxidative stress in N88S seipinopathy: novel insights into the mechanisms of neurodegeneration and therapeutic avenues.

    Costa, Vítor / Teixeira, Vitor

    Neural regeneration research

    2023  Volume 18, Issue 8, Page(s) 1719–1720

    Language English
    Publishing date 2023-02-23
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.363196
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  4. Article ; Online: Prediction and biological analysis of yeast VDAC1 phosphorylation.

    Sousa, André D / Costa, Ana Luisa / Costa, Vítor / Pereira, Clara

    Archives of biochemistry and biophysics

    2024  Volume 753, Page(s) 109914

    Abstract: The mitochondrial outer membrane protein porin 1 (Por1), the yeast orthologue of mammalian voltage-dependent anion channel (VDAC), is the major permeability pathway for the flux of metabolites and ions between cytosol and mitochondria. In yeast, several ... ...

    Abstract The mitochondrial outer membrane protein porin 1 (Por1), the yeast orthologue of mammalian voltage-dependent anion channel (VDAC), is the major permeability pathway for the flux of metabolites and ions between cytosol and mitochondria. In yeast, several Por1 phosphorylation sites have been identified. Protein phosphorylation is a major modification regulating a variety of biological activities, but the potential biological roles of Por1 phosphorylation remains unaddressed. In this work, we analysed 10 experimentally observed phosphorylation sites in yeast Por1 using bioinformatics tools. Two of the residues, T100 and S133, predicted to reduce and increase pore permeability, respectively, were validated using biological assays. In accordance, Por1
    MeSH term(s) Animals ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Phosphorylation ; Voltage-Dependent Anion Channels/metabolism ; Mitochondria/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Mammals/metabolism
    Chemical Substances Voltage-Dependent Anion Channels ; Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2024-01-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2024.109914
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  5. Article ; Online: Mitochondria and the cell cycle in budding yeast

    Leite, Ana Cláudia / Costa, Vítor / Pereira, Clara

    International Journal of Biochemistry and Cell Biology. 2023 Aug., v. 161 p.106444-

    2023  

    Abstract: As centers for energy production and essential biosynthetic activities, mitochondria are vital for cell growth and proliferation. Accumulating evidence suggests an integrated regulation of these organelles and the nuclear cell cycle in distinct organisms. ...

    Abstract As centers for energy production and essential biosynthetic activities, mitochondria are vital for cell growth and proliferation. Accumulating evidence suggests an integrated regulation of these organelles and the nuclear cell cycle in distinct organisms. In budding yeast, a well-established example of this coregulation is the coordinated movement and positional control of mitochondria during the different phases of the cell cycle. The molecular determinants involved in the inheritance of the fittest mitochondria by the bud also seem to be cell cycle-regulated. In turn, loss of mtDNA or defects in mitochondrial structure or inheritance often lead to a cell cycle delay or arrest, indicating that mitochondrial function can also regulate cell cycle progression, possibly through the activation of cell cycle checkpoints. The up-regulation of mitochondrial respiration at G2/M, presumably to fulfil energetic requirements for progression at this phase, also supports a mitochondria-cell cycle interplay. Cell cycle-linked mitochondrial regulation is accomplished at the transcription level and through post-translational modifications, predominantly protein phosphorylation. Here, we address mitochondria-cell cycle interactions in the yeast Saccharomyces cerevisiae and discuss future challenges in the field.
    Keywords Saccharomyces cerevisiae ; biosynthesis ; cell cycle ; cell growth ; energy ; mitochondria ; protein phosphorylation ; yeasts ; Bioenergetics ; Quality control ; Inheritance ; Signaling
    Language English
    Dates of publication 2023-08
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2023.106444
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  6. Article ; Online: Mitochondria and the cell cycle in budding yeast.

    Leite, Ana Cláudia / Costa, Vítor / Pereira, Clara

    The international journal of biochemistry & cell biology

    2023  Volume 161, Page(s) 106444

    Abstract: As centers for energy production and essential biosynthetic activities, mitochondria are vital for cell growth and proliferation. Accumulating evidence suggests an integrated regulation of these organelles and the nuclear cell cycle in distinct organisms. ...

    Abstract As centers for energy production and essential biosynthetic activities, mitochondria are vital for cell growth and proliferation. Accumulating evidence suggests an integrated regulation of these organelles and the nuclear cell cycle in distinct organisms. In budding yeast, a well-established example of this coregulation is the coordinated movement and positional control of mitochondria during the different phases of the cell cycle. The molecular determinants involved in the inheritance of the fittest mitochondria by the bud also seem to be cell cycle-regulated. In turn, loss of mtDNA or defects in mitochondrial structure or inheritance often lead to a cell cycle delay or arrest, indicating that mitochondrial function can also regulate cell cycle progression, possibly through the activation of cell cycle checkpoints. The up-regulation of mitochondrial respiration at G2/M, presumably to fulfil energetic requirements for progression at this phase, also supports a mitochondria-cell cycle interplay. Cell cycle-linked mitochondrial regulation is accomplished at the transcription level and through post-translational modifications, predominantly protein phosphorylation. Here, we address mitochondria-cell cycle interactions in the yeast Saccharomyces cerevisiae and discuss future challenges in the field.
    MeSH term(s) Saccharomycetales/genetics ; Saccharomycetales/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism ; Mitochondria/metabolism ; Cell Division ; Cell Cycle/genetics ; Saccharomyces cerevisiae/metabolism
    Chemical Substances Saccharomyces cerevisiae Proteins
    Language English
    Publishing date 2023-07-06
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 1228429-4
    ISSN 1878-5875 ; 1357-2725
    ISSN (online) 1878-5875
    ISSN 1357-2725
    DOI 10.1016/j.biocel.2023.106444
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  7. Article ; Online: Is the 5-Minute Time-Trial Cycling Test a Valid Predictor of Maximal Oxygen Uptake? An External Cross-Validation Study.

    Borszcz, Fernando Klitzke / Ferreira Tramontin, Artur / de Lucas, Ricardo Dantas / Pereira Costa, Vitor

    International journal of sports physiology and performance

    2024  , Page(s) 1–11

    Abstract: Purpose: This study aimed to cross-validate a recently proposed equation for the prediction of maximal oxygen uptake (V˙O2max) in cycling exercise by using the average power output normalized by the body mass from a 5-minute time trial (RPO5-min) as the ...

    Abstract Purpose: This study aimed to cross-validate a recently proposed equation for the prediction of maximal oxygen uptake (V˙O2max) in cycling exercise by using the average power output normalized by the body mass from a 5-minute time trial (RPO5-min) as the independent variable. Further, the study aimed to update the predictive equation using Bayesian informative prior distributions and meta-analysis.
    Methods: On different days, 49 male cyclists performed an incremental graded exercise test until exhaustion and a 5-minute time trial on a stationary cycle ergometer. We compared the actual V˙O2max with the predicted value obtained from the RPO5-min, using a modified Bayesian Bland-Altman agreement analysis. In addition, this study updated the data on the linear regression between V˙O2max and RPO5-min, by incorporating information from a previous study as a Bayesian informative prior distribution or via meta-analysis.
    Results: On average, the predicted V˙O2max using RPO5-min underestimated the actual V˙O2max by -6.6 mL·kg-1·min-1 (95% credible interval, -8.6 to -4.7 mL·kg-1·min-1). The lower and upper 95% limits of agreement were -17.2 (-22.7 to -12.3) and 3.8 (-1.0 to 9.5) mL·kg-1·min-1, respectively. When the current study's data were analyzed using the previously published data as a Bayesian informative prior distribution, the accuracy of predicting sample means was found to be better when compared with the data combined via meta-analyses.
    Conclusions: The proposed equation presented systematic bias in our sample, in which the prediction underestimated the actual V˙O2max. We provide an updated equation using the previous one as the prior distribution, which could be generalized to a greater audience of cyclists.
    Language English
    Publishing date 2024-04-03
    Publishing country United States
    Document type Journal Article
    ISSN 1555-0273
    ISSN (online) 1555-0273
    DOI 10.1123/ijspp.2023-0330
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  8. Article ; Online: The APC/C Activator Cdh1p Plays a Role in Mitochondrial Metabolic Remodelling in Yeast.

    Leite, Ana Cláudia / Barbedo, Maria / Costa, Vítor / Pereira, Clara

    International journal of molecular sciences

    2023  Volume 24, Issue 4

    Abstract: Cdh1p is one of the two substrate adaptor proteins of the anaphase promoting complex/cyclosome (APC/C), a ubiquitin ligase that regulates proteolysis during cell cycle. In this work, using a proteomic approach, we found 135 mitochondrial proteins whose ... ...

    Abstract Cdh1p is one of the two substrate adaptor proteins of the anaphase promoting complex/cyclosome (APC/C), a ubiquitin ligase that regulates proteolysis during cell cycle. In this work, using a proteomic approach, we found 135 mitochondrial proteins whose abundance was significantly altered in the
    MeSH term(s) Proteomics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Cdh1 Proteins/metabolism
    Chemical Substances Saccharomyces cerevisiae Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; CDH1 protein, S cerevisiae ; Cdh1 Proteins
    Language English
    Publishing date 2023-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24044111
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  9. Book ; Online: NeuralLog

    Guimarães, Victor / Costa, Vítor Santos

    a Neural Logic Language

    2021  

    Abstract: Application domains that require considering relationships among objects which have real-valued attributes are becoming even more important. In this paper we propose NeuralLog, a first-order logic language that is compiled to a neural network. The main ... ...

    Abstract Application domains that require considering relationships among objects which have real-valued attributes are becoming even more important. In this paper we propose NeuralLog, a first-order logic language that is compiled to a neural network. The main goal of NeuralLog is to bridge logic programming and deep learning, allowing advances in both fields to be combined in order to obtain better machine learning models. The main advantages of NeuralLog are: to allow neural networks to be defined as logic programs; and to be able to handle numeric attributes and functions. We compared NeuralLog with two distinct systems that use first-order logic to build neural networks. We have also shown that NeuralLog can learn link prediction and classification tasks, using the same theory as the compared systems, achieving better results for the area under the ROC curve in four datasets: Cora and UWCSE for link prediction; and Yelp and PAKDD15 for classification; and comparable results for link prediction in the WordNet dataset.

    Comment: 14 pages
    Keywords Computer Science - Machine Learning
    Subject code 006
    Publishing date 2021-05-04
    Publishing country us
    Document type Book ; Online
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  10. Article: Leading the way in the nervous system: Lipid Droplets as new players in health and disease

    Teixeira, Vitor / Maciel, Patrícia / Costa, Vítor

    Biochimica et biophysica acta. 2021 Jan., v. 1866, no. 1

    2021  

    Abstract: Lipid droplets (LDs) are ubiquitous fat storage organelles composed of a neutral lipid core, comprising triacylglycerols (TAG) and sterol esters (SEs), surrounded by a phospholipid monolayer membrane with several decorating proteins. Recently, LD biology ...

    Abstract Lipid droplets (LDs) are ubiquitous fat storage organelles composed of a neutral lipid core, comprising triacylglycerols (TAG) and sterol esters (SEs), surrounded by a phospholipid monolayer membrane with several decorating proteins. Recently, LD biology has come to the foreground of research due to their importance for energy homeostasis and cellular stress response. As aberrant LD accumulation and lipid depletion are hallmarks of numerous diseases, addressing LD biogenesis and turnover provides a new framework for understanding disease-related mechanisms. Here we discuss the potential role of LDs in neurodegeneration, while making some predictions on how LD imbalance can contribute to pathophysiology in the brain.
    Keywords biogenesis ; brain ; energy ; homeostasis ; neurodegenerative diseases ; organelles ; pathophysiology ; phospholipids ; sterols ; stress response ; triacylglycerols
    Language English
    Dates of publication 2021-01
    Publishing place Elsevier B.V.
    Document type Article
    Note NAL-AP-2-clean
    ISSN 1388-1981
    DOI 10.1016/j.bbalip.2020.158820
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