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  1. Article ; Online: Impact of the COVID-19 Outbreak on Anesthesiologist Assistance for Endoscopic Procedures

    Calcedonio Calcara / Camilla Ciscato / Arnaldo Amato / Emanuele Sinagra / Costanza Alvisi / Sandro Ardizzone / Andrea Anderloni / Pietro Gambitta

    Clinical Endoscopy, Vol 55, Iss 1, Pp 49-

    2022  Volume 57

    Abstract: Background/Aims: The coronavirus disease 2019 (COVID-19) outbreak has modified the activities of endoscopy units worldwide. Herein, we investigated the impact of the COVID-19 outbreak on anesthesiologist assistance for endoscopic procedures in Lombardy, ... ...

    Abstract Background/Aims: The coronavirus disease 2019 (COVID-19) outbreak has modified the activities of endoscopy units worldwide. Herein, we investigated the impact of the COVID-19 outbreak on anesthesiologist assistance for endoscopic procedures in Lombardy, Italy. Methods: A questionnaire concerning anesthesiologist assistance provided from October 26 to December 6, 2020, in comparison with the same period in 2019, was sent to endoscopic units in Lombardy. Results: Approximately 54% (34/63) of the units responded. A reduction in the number of all endoscopies (-33.5%; 18792 in 2020 vs. 28264 in 2019) and anesthesiologist-assisted endoscopies (-15.3%; 2652 in 2020 vs. 3132 in 2019) was reported. A greater reduction in anesthesiologist assistance was observed in government community units (-29.5%) than in academic (-14%) and private community units (-4.6%). Among all units, 85% reported a reduction in anesthesiologist assistance; 65% observed a delay/cancellation of procedures; 59%, a restricted patient selection; 17%, the need to transfer some patients to other hospitals; and 32%, a related worsening of procedure quality. Conclusion: The COVID-19 pandemic compromised the anesthesiologist assistance for endoscopic procedures in Lombardy, which worsened the procedure quality mainly in government community units. The COVID-19 “stress test” suggests a more balanced allocation of anesthesiologic resources in the future.
    Keywords anesthesiologist assistance ; covid-19 ; endoscopic quality ; Internal medicine ; RC31-1245 ; Diseases of the digestive system. Gastroenterology ; RC799-869
    Subject code 600
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Korean Society of Gastrointestinal Endoscopy
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Pathologic substrate of gastropathy in Anderson-Fabry disease

    Alessandro Di Toro / Nupoor Narula / Lorenzo Giuliani / Monica Concardi / Alexandra Smirnova / Valentina Favalli / Mario Urtis / Costanza Alvisi / Elena Antoniazzi / Eloisa Arbustini

    Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-

    2020  Volume 4

    Abstract: Abstract In both classic and late-onset AFD, mutations of the GLA gene cause deficient activity of the alpha-galactosidase enzyme resulting in intracellular accumulation of the undigested substrate. Gastrointestinal symptoms (GI) are common but non- ... ...

    Abstract Abstract In both classic and late-onset AFD, mutations of the GLA gene cause deficient activity of the alpha-galactosidase enzyme resulting in intracellular accumulation of the undigested substrate. Gastrointestinal symptoms (GI) are common but non-specific and imputed to the AFD, irrespective of the demonstration of substrate accumulation in GI cells. We demonstrate substrate accumulation in gastric epithelial, vascular, and nerve cells of patients with classic AFD and, vice versa, absence of accumulation in late-onset AFD and controls.
    Keywords Anderson Fabry disease (AFD) ; Gastropathy ; Esophagogastroduodenoscopy (EGD) ; Globotriaosylceramide (GB3) ; Medicine ; R
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Intestinal expression of genes implicated in iron absorption and their regulation by hepcidin

    Bergamaschi, Gaetano / Antonio Di Sabatino / Alessandra Pasini / Cristina Ubezio / Filippo Costanzo / Davide Grataroli / Michela Masotti / Costanza Alvisi / Gino R. Corazza

    Clinical nutrition. 2017 Oct., v. 36

    2017  

    Abstract: Through inhibition of iron absorption and iron mobilization from tissue stores, hepcidin exerts a negative control on iron homeostasis. Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the ... ...

    Abstract Through inhibition of iron absorption and iron mobilization from tissue stores, hepcidin exerts a negative control on iron homeostasis. Hepcidin, in fact, promotes the degradation of ferroportin (Fpn1), the iron exporter molecule expressed on the membrane of hepatocytes and macrophages, thus preventing iron release from cells to plasma. Hepcidin effects on enterocytes, however, are less clear. Aim of the present study was to further investigate the regulation of iron absorption by hepcidin.The transcriptional response of human duodenal mucosa to hepcidin was investigated using organ cultures of duodenal biopsies perendoscopically collected from healthy controls. Biopsies were cultured for 4 h with or without hepcidin-25 and were then assayed for the expression of iron-related genes.In samples that had not been exposed to hepcidin, correlations were found between the expression of genes involved in iron absorption: DMT1, Fpn1, Dcytb and HCP1. In ex vivo experiments hepcidin down-regulated mRNA levels of the iron transporters Fpn1, and DMT1, of the ferric reductase Dcytb, of the ferroxidase hephaestin, and of the putative heme carrier protein HCP1.Through the reported transcriptional changes hepcidin can modulate several steps of the iron absorption process, including the reduction of dietary iron by Dcytb, its uptake by enterocytes through DMT1, the mucosal uptake of heme iron by HCP1, and enterocyte iron release to plasma by Fpn1 in conjunction with hephaestin.
    Keywords biopsy ; enterocytes ; ferroxidase ; gene expression ; heme ; heme iron ; hepatocytes ; hepcidin ; homeostasis ; humans ; iron absorption ; macrophages ; messenger RNA ; transcription (genetics) ; transporters
    Language English
    Dates of publication 2017-10
    Size p. 1427-1433.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 604812-2
    ISSN 1532-1983 ; 0261-5614
    ISSN (online) 1532-1983
    ISSN 0261-5614
    DOI 10.1016/j.clnu.2016.09.021
    Database NAL-Catalogue (AGRICOLA)

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