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Article ; Online: Grandpa Is Getting Incubated.

Costanzo, Elizabeth

2020 Volume 38, Issue 2, Page(s) 116

MeSH term(s)	Advance Directives ; Aged ; Family Relations ; Grandparents ; Humans ; Intubation, Intratracheal ; Male
Language	English
Publishing date	2020-03-05
Publishing country	United States
Document type	Journal Article ; Personal Narrative
ZDB-ID	2814267-6
ISSN	2374-4537 ; 2374-4529
ISSN (online)	2374-4537
ISSN	2374-4529
DOI	10.1097/NHH.0000000000000850
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Article ; Online: A retrospective observational study on cases of anaplastic brain tumors treated with the Di Bella Method: A rationale and effectiveness.

Di Bella, Giuseppe / Borghetto, Vittoria / Costanzo, Elena

Neuro endocrinology letters

2022 Volume 42, Issue 7, Page(s) 464–483

Abstract: Despite all the new developments in cancer therapy, the life expectancy of patients with malignant anaplastic brain tumors and glioblastoma multiform (GBM) remains short. Since the establishment of the Di Bella Method (DBM) in cancer therapy, DBM was ... ...

Abstract	Despite all the new developments in cancer therapy, the life expectancy of patients with malignant anaplastic brain tumors and glioblastoma multiform (GBM) remains short. Since the establishment of the Di Bella Method (DBM) in cancer therapy, DBM was able to increase the survival rate and life quality, without overt toxicity, in comparison to what is described in the literature related to the analogous brain tumors, with the same immunohistochemical, histologic and clinical features. Therefore, we treated seven patients with malignant anaplastic brain tumors using the DBM protocol. DBM therapy consists of somatostatin and analogous (octreotide) all trans-retinoic acid (ATRA), β-Carotene, axerophthol dissolved in vitamin E, vitamin D, vitamin C, melatonin (MLT), proteoglycans-glycosaminoglycans, valproic acid, acetazolamide, diethyldithiocarbamate, hydroxyurea, and temozolomide. These molecules have either antiproliferative, antiangiogenic, cytostatic, antioxidant, antimetastatic (differentiative), and immunomodulating features. Moreover, the inclusion of ATRA, MLT, and glucosamine with sodium valproate, diethyldithiocarbamate and acetazolamide has reinforced antitumor properties of the therapy by extending them to cancer stem cells. Furthermore, the non-cytolytic and non-cytotoxic metronomic dosage of hydroxyurea and temozolomide had increased the DBM therapy outcome by strengthening anti-tumor capability. The results of such treatment revealed that all seven patients were still alive after 5 to 8 years of starting DBM. In conclusion, the multi-strategic objectives of DBM are inhibiting the proliferative-invasiveness and neoplastic angiogenesis, silencing the survival system of cancer stem cells, enhancing the immunomodulatory and antioxidant activities, improving vitality and efficiency of normal cells, and depressing the efficiency and vitality of neoplastic ones.
MeSH term(s)	Acetazolamide/therapeutic use ; Antioxidants/therapeutic use ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Ditiocarb/therapeutic use ; Glioblastoma/drug therapy ; Humans ; Hydroxyurea/therapeutic use ; Melatonin/therapeutic use ; Temozolomide/therapeutic use ; Vitamins
Chemical Substances	Antioxidants ; Vitamins ; Ditiocarb (99Z2744345) ; Melatonin (JL5DK93RCL) ; Acetazolamide (O3FX965V0I) ; Hydroxyurea (X6Q56QN5QC) ; Temozolomide (YF1K15M17Y)
Language	English
Publishing date	2022-05-01
Publishing country	Sweden
Document type	Journal Article ; Observational Study
ZDB-ID	135951-4
ISSN	2354-4716 ; 0172-780X
ISSN (online)	2354-4716
ISSN	0172-780X
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Article ; Online: Deep learning for automatic prediction of early activation of treatment naïve non-exudative MNVs in AMD.

Crincoli, Emanuele / Catania, Fiammetta / Sacconi, Riccardo / Ribarich, Nicolò / Ferrara, Silvia / Parravano, Mariacristina / Costanzo, Eliana / Querques, Giuseppe

Retina (Philadelphia, Pa.)

2024

Abstract: Background: Around 30% of non-exudative macular neovascularizations(NE-MNVs) exudate within 2 years from diagnosis in patients with age-related macular degeneration(AMD).The aim of the study is to develop a deep learning classifier based on optical ... ...

Abstract	Background: Around 30% of non-exudative macular neovascularizations(NE-MNVs) exudate within 2 years from diagnosis in patients with age-related macular degeneration(AMD).The aim of the study is to develop a deep learning classifier based on optical coherence tomography(OCT) and OCT angiography(OCTA) to identify NE-MNVs at risk of exudation. Methods: AMD patients showing OCTA and fluorescein angiography (FA) documented NE-MNV with a 2-years minimum imaging follow-up were retrospectively selected. Patients showing OCT B-scan-documented MNV exudation within the first 2 years formed the EX-GROUP while the others formed QU-GROUP.ResNet-101, Inception-ResNet-v2 and DenseNet-201 were independently trained on OCTA and OCT B-scan images. Combinations of the 6 models were evaluated with major and soft voting techniques. Results: Eighty-nine (89) eyes of 89 patients with a follow-up of 5.7 ± 1.5 years were recruited(35 EX GROUP and 54 QU GROUP). Inception-ResNet-v2 was the best performing among the 3 single convolutional neural networks(CNNs).The major voting model resulting from the association of the 3 different CNNs resulted in improvement of performance both for OCTA and OCT B-scan (both significantly higher than human graders' performance). Soft voting model resulting from the combination of OCTA and OCT B-scan based major voting models showed a testing accuracy of 94.4%. Peripheral arcades and large vessels on OCTA enface imaging were more prevalent in QU GROUP. Conclusions: Artificial intelligence shows high performances in identifications of NE-MNVs at risk for exudation within the first 2 years of follow up, allowing better customization of follow up timing and avoiding treatment delay. Better results are obtained with the combination of OCTA and OCT B-scan image analysis.
Language	English
Publishing date	2024-03-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	603192-4
ISSN	1539-2864 ; 0275-004X
ISSN (online)	1539-2864
ISSN	0275-004X
DOI	10.1097/IAE.0000000000004106
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Article ; Online: Author Response: Relationship of Choroidal Vasculature and Choriocapillaris Flow With Alterations of Salivary α-Amylase Patterns in Central Serous Chorioretinopathy.

Scarinci, Fabio / Patacchioli, Francesca Romana / Costanzo, Eliana / Parravano, Mariacristina

Investigative ophthalmology & visual science

2022 Volume 63, Issue 6, Page(s) 10

MeSH term(s)	Central Serous Chorioretinopathy/diagnosis ; Choroid/blood supply ; Fluorescein Angiography ; Humans ; Retrospective Studies ; Salivary alpha-Amylases ; Tomography, Optical Coherence
Chemical Substances	Salivary alpha-Amylases (EC 3.2.1.1)
Language	English
Publishing date	2022-06-09
Publishing country	United States
Document type	Research Support, Non-U.S. Gov't ; Letter ; Comment
ZDB-ID	391794-0
ISSN	1552-5783 ; 0146-0404
ISSN (online)	1552-5783
ISSN	0146-0404
DOI	10.1167/iovs.63.6.10
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Article ; Online: Impact of intravitreal anti-VEGF therapy on intraretinal microvascular abnormalities in proliferative diabetic retinopathy.

De Geronimo, Daniele / Parravano, Mariacristina / Sacconi, Riccardo / Fragiotta, Serena / Giannini, Daniela / Costanzo, Eliana / Varano, Monica / Querques, Giuseppe

Acta diabetologica

2024 Volume 61, Issue 4, Page(s) 525–528

MeSH term(s)	Humans ; Diabetic Retinopathy/drug therapy ; Retinal Vessels ; Fluorescein Angiography ; Intravitreal Injections ; Angiogenesis Inhibitors/therapeutic use ; Tomography, Optical Coherence ; Diabetes Mellitus/drug therapy
Chemical Substances	Angiogenesis Inhibitors
Language	English
Publishing date	2024-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-023-02227-4
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Article: Prognostic Imaging Biomarkers in Diabetic Macular Edema Eyes Treated with Intravitreal Dexamethasone Implant.

Costanzo, Eliana / Giannini, Daniela / De Geronimo, Daniele / Fragiotta, Serena / Varano, Monica / Parravano, Mariacristina

Journal of clinical medicine

2023 Volume 12, Issue 4

Abstract: Background: The aim was to evaluate predictive value of baseline optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in diabetic macular edema (DME) treated with dexamethasone implant (DEXi).: Methods: OCT and OCTA parameters ... ...

Abstract	Background: The aim was to evaluate predictive value of baseline optical coherence tomography (OCT) and OCT angiography (OCTA) parameters in diabetic macular edema (DME) treated with dexamethasone implant (DEXi). Methods: OCT and OCTA parameters were collected: central macular thickness (CMT), vitreomacular abnormalities (VMIAs), intraretinal and subretinal fluid (mixed DME pattern), hyper-reflective foci (HRF), microaneurysms (MAs) reflectivity, ellipsoid zone disruption, suspended scattering particles in motion (SSPiM), perfusion density (PD), vessel length density, and foveal avascular zone. Responders' (RES) and non-responders' (n-RES) eyes were classified considering morphological (CMT reduction ≥ 10%) and functional (BCVA change ≥ 5 ETDRS letters) changes after DEXi. Binary logistic regression OCT, OCTA, and OCT/OCTA-based models were developed. Results: Thirty-four DME eyes were enrolled (18 treatment-naïve). OCT-based model combining DME mixed pattern + MAs + HRF and OCTA-based model combining SSPiM and PD showed the best performance to correctly classify the morphological RES eyes. In the treatment-naïve eyes, VMIAs were included with a perfect fit for n-RES eyes. Conclusion: The presence of DME mixed pattern, a high number of parafoveal HRF, hyper-reflective MAs, SSPiM in the outer nuclear layers, and high PD represent baseline predictive biomarkers for DEXi treatment responsiveness. The application of these models to treatment-naïve patients allowed a good identification of n-RES eyes.
Language	English
Publishing date	2023-02-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12041303
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Article: Il Mezzogiorno nella stampa e nei convegni

Costanzo, Elisa

Rivista economica del Mezzogiorno : trimestrale della SVIMEZ, Associazione per lo Sviluppo dell'Industria nel Mezzogiorno Bd. XXIX.2015, 1/2, S. 303-331

2015

Author's details	rassegna a cura di Elisa Costanzo
Language	Italian
Publisher	Il Mulino
Publishing place	Bologna
Document type	Article
Note	Zsfassung in engl. Sprache
ZDB-ID	1131530-1
ISSN	1120-9534
Database	ECONomics Information System

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Article: Extracorporeal Membrane Oxygenation as Treatment of Severe COVID-19 Infection: A Case Report.

Douedi, Steven / Alshami, Abbas / Costanzo, Eric

Cureus

2020 Volume 12, Issue 4, Page(s) e7714

Abstract: Novel coronavirus 2019 (COVID-19) is a severe respiratory infection leading to acute respiratory distress syndrome (ARDS) accounting for thousands of cases and deaths across the world. Several alternatives in treatment options have been assessed and used ...

Abstract	Novel coronavirus 2019 (COVID-19) is a severe respiratory infection leading to acute respiratory distress syndrome (ARDS) accounting for thousands of cases and deaths across the world. Several alternatives in treatment options have been assessed and used in this patient population. However, when mechanical ventilation and prone positioning are unsuccessful, venovenous extracorporeal membrane oxygenation (VV-ECMO) may be used. We present a case of a 41-year-old female, with no significant medical history and no recent history of exposure to sick contacts, presented to the emergency department (ED) with fever, severe shortness of breath, and flu-like symptoms with a positive COVID-19 test. Ultimately, she worsened on mechanical ventilation and prone positioning and required VV-ECMO. The use of VV-ECMO in COVID-19 infected patients is still controversial. While some studies have shown a high mortality rate despite aggressive treatment, such as in our case, the lack of large sample size studies and treatment alternatives places healthcare providers against a wall without options in patients with severe refractory ARDS due to COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-04-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.7714
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Article ; Online: Profile of non-responder and late responder patients treated for diabetic macular edema: systemic and ocular factors.

Parravano, Mariacristina / Costanzo, Eliana / Querques, Giuseppe

Acta diabetologica

2020 Volume 57, Issue 8, Page(s) 911–921

Abstract: Diabetic macular edema (DME) treatment represents a challenge for the ophthalmologists, and several aspects of real treatment expectancy are still being discussed and not yet fully elucidated. A univocal definition of responsiveness to treatment has not ... ...

Abstract	Diabetic macular edema (DME) treatment represents a challenge for the ophthalmologists, and several aspects of real treatment expectancy are still being discussed and not yet fully elucidated. A univocal definition of responsiveness to treatment has not been reached. How the clinicians can evaluate the therapeutic success? The evaluation of systemic and ocular factors should help in this complex management. The age influences the long-term outcomes, and the role of glycemic control is confounded by contrasting correlations between hemoglobin glycated A1c and DME. Long-term treatment success is influenced by baseline best-corrected visual acuity (BCVA), central macular thickness (CMT) and early BCVA response. Also baseline diabetic retinopathy severity scale score is useful to evaluate the chances of improvement before and during treatments. The time-switching was influenced by early BCVA response, however considering a delayed response in a percentage of patients. Several structural optical coherence tomography (OCT) findings could predict long-term success, as the presence of serous retinal detachment, hyperreflective retinal spots, the disruption of external limiting membrane and ellipsoid zone, the disorganization of inner retinal layers and continued increase in CMT were considered predictors of poor response to treatment. Foveal avascular zone enlargement, high number of microaneurysms (Mas), lower vessel density (VD) in deep capillary plexus and lower parafoveal VD in superficial capillary plexus were considered as OCT angiography biomarkers of poor responsiveness. The aim of this review is to report the factors that could influence the response to treatment of DME patients.
MeSH term(s)	Age Factors ; Blood Glucose/metabolism ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Diabetic Retinopathy/pathology ; Diabetic Retinopathy/therapy ; Fluorescein Angiography/methods ; Humans ; Macular Edema/diagnosis ; Macular Edema/epidemiology ; Macular Edema/pathology ; Macular Edema/therapy ; Risk Factors ; Time Factors ; Tomography, Optical Coherence/methods ; Treatment Failure ; Visual Acuity/physiology
Chemical Substances	Blood Glucose
Language	English
Publishing date	2020-02-29
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1097676-0
ISSN	1432-5233 ; 0940-5429
ISSN (online)	1432-5233
ISSN	0940-5429
DOI	10.1007/s00592-020-01496-7
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Article ; Online: Influence of extremely low-frequency electric fields on the growth of Vigna radiata seedlings.

Costanzo, Evelina

Bioelectromagnetics

2011 Volume 32, Issue 7, Page(s) 589–592

Abstract: The biological effects of extremely low-frequency electric fields (ELF) on living organisms have been explored in many studies, but the results are controversial and only a few studies investigated the influence of the intensity of the applied field on ... ...

Abstract	The biological effects of extremely low-frequency electric fields (ELF) on living organisms have been explored in many studies, but the results are controversial and only a few studies investigated the influence of the intensity of the applied field on seedling growth. Here we assess the effects of a 50 Hz sinusoidal electric field on the early growth of Vigna radiata seedlings while varying the field intensity. Experiments performed in a dark, constant-climate chamber on several thousands of seedlings show that the field produces an inhibitory effect at a low field intensity and an enhancing one at a higher intensity. The maximum negative effect occurs at about 450 V/m, which is an intensity much lower than the exposure limits currently in force in the safety regulations.
MeSH term(s)	Electricity ; Electromagnetic Fields ; Fabaceae/growth & development ; Fabaceae/radiation effects ; Seedlings/growth & development ; Seedlings/radiation effects
Language	English
Publishing date	2011-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	760683-7
ISSN	1521-186X ; 0197-8462
ISSN (online)	1521-186X
ISSN	0197-8462
DOI	10.1002/bem.20666
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