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  1. Article ; Online: Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR.

    Kokalaki, Evangelia / Ma, Biao / Ferrari, Mathieu / Grothier, Thomas / Hazelton, Warren / Manzoor, Somayya / Costu, Eren / Taylor, Julia / Bulek, Anna / Srivastava, Saket / Gannon, Isaac / Jha, Ram / Gealy, Rosalind / Stanczuk, Lukas / Rizou, Tatiana / Robson, Mathew / El-Kholy, Mohamed / Baldan, Vania / Righi, Matteo /
    Sillibourne, James / Thomas, Simon / Onuoha, Shimobi / Cordoba, Shaun / Pule, Martin

    Molecular therapy : the journal of the American Society of Gene Therapy

    2023  Volume 32, Issue 2, Page(s) 556–558

    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2023.12.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Dual targeting of CD19 and CD22 against B-ALL using a novel high-sensitivity aCD22 CAR.

    Kokalaki, Evangelia / Ma, Biao / Ferrari, Mathieu / Grothier, Thomas / Hazelton, Warren / Manzoor, Somayya / Costu, Eren / Taylor, Julia / Bulek, Anna / Srivastava, Saket / Gannon, Isaac / Jha, Ram / Gealy, Rosalind / Stanczuk, Lukas / Rizou, Tatiana / Robson, Mathew / El-Kholy, Mohamed / Baldan, Vania / Righi, Matteo /
    Sillibourne, James / Thomas, Simon / Onuoha, Shimobi / Cordoba, Shaun / Pule, Martin

    Molecular therapy : the journal of the American Society of Gene Therapy

    2023  Volume 31, Issue 7, Page(s) 2089–2104

    Abstract: CAR T cells recognizing CD19 effectively treat relapsed and refractory B-ALL and DLBCL. However, CD19 loss is a frequent cause of relapse. Simultaneously targeting a second antigen, CD22, may decrease antigen escape, but is challenging: its density is ... ...

    Abstract CAR T cells recognizing CD19 effectively treat relapsed and refractory B-ALL and DLBCL. However, CD19 loss is a frequent cause of relapse. Simultaneously targeting a second antigen, CD22, may decrease antigen escape, but is challenging: its density is approximately 10-fold less than CD19, and its large structure may hamper immune synapse formation. The characteristics of the optimal CD22 CAR are underexplored. We generated 12 distinct CD22 antibodies and tested CARs derived from them to identify a CAR based on the novel 9A8 antibody, which was sensitive to low CD22 density and lacked tonic signaling. We found no correlation between affinity or membrane proximity of recognition epitope within Ig domains 3-6 of CD22 with CART function. The optimal strategy for CD19/CD22 CART co-targeting is undetermined. Co-administration of CD19 and CD22 CARs is costly; single CARs targeting CD19 and CD22 are challenging to construct. The co-expression of two CARs has previously been achieved using bicistronic vectors. Here, we generated a dual CART product by co-transduction with 9A8-41BBζ and CAT-41BBζ (obe-cel), the previously described CD19 CAR. CAT/9A8 CART eliminated single- and double-positive target cells in vitro and eliminated CD19
    MeSH term(s) Humans ; Receptors, Chimeric Antigen/metabolism ; T-Lymphocytes ; Neoplasm Recurrence, Local ; Burkitt Lymphoma ; Immunotherapy, Adoptive ; Adaptor Proteins, Signal Transducing ; Antigens, CD19 ; Antibodies ; Sialic Acid Binding Ig-like Lectin 2
    Chemical Substances Receptors, Chimeric Antigen ; Adaptor Proteins, Signal Transducing ; Antigens, CD19 ; Antibodies ; CD22 protein, human ; Sialic Acid Binding Ig-like Lectin 2
    Language English
    Publishing date 2023-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2023.03.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5640: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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