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  1. Article ; Online: Discordance between Documented Criteria and Documented Diagnosis of Traumatic Brain Injury in the Emergency Department.

    Cota, Martin R / Moses, Anita D / Jikaria, Neekita R / Bittner, Katie C / Diaz-Arrastia, Ramon R / Latour, Lawrence L / Turtzo, L Christine

    Journal of neurotrauma

    2018  Volume 36, Issue 8, Page(s) 1335–1342

    Abstract: Accurate diagnosis of traumatic brain injury (TBI) is critical to ensure that patients receive appropriate follow-up care, avoid risk of subsequent injury, and are aware of possible long-term consequences. However, diagnosis of TBI, particularly in the ... ...

    Abstract Accurate diagnosis of traumatic brain injury (TBI) is critical to ensure that patients receive appropriate follow-up care, avoid risk of subsequent injury, and are aware of possible long-term consequences. However, diagnosis of TBI, particularly in the emergency department (ED), can be difficult because the symptoms of TBI are vague and nonspecific, and patients with suspected TBI may present with additional injuries that require immediate medical attention. We performed a retrospective chart review to evaluate accuracy of TBI diagnosis in the ED. Records of 1641 patients presenting to the ED with suspected TBI and a head computed tomography (CT) were reviewed. We found only 47% of patients meeting the American Congress of Rehabilitation Medicine criteria for TBI received a documented ED diagnosis of TBI in medical records. After controlling for demographic and clinical factors, patients presenting at a level I trauma center, with cause of injury other than fall, without CT findings of TBI, and without loss of consciousness were more likely to lack documented diagnosis despite meeting diagnostic criteria for TBI. A greater proportion of patients without documented ED diagnosis of TBI were discharged home compared to those with a documented diagnosis of TBI (58% vs. 40%; p < 0.001). Together, these data suggest that many patients who have sustained a TBI are discharged home from the ED without a documented diagnosis of TBI, and that improved awareness and implementation of diagnostic criteria for TBI is important in the ED and for in- and outpatient providers.
    MeSH term(s) Adolescent ; Adult ; Aged ; Brain Injuries, Traumatic/diagnosis ; Emergency Service, Hospital/standards ; Female ; Humans ; Male ; Middle Aged ; Neurology/standards ; Retrospective Studies ; Young Adult
    Language English
    Publishing date 2018-12-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2018.5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Meningeal blood-brain barrier disruption in acute traumatic brain injury.

    Turtzo, Lisa Christine / Jikaria, Neekita / Cota, Martin R / Williford, Joshua P / Uche, Victoria / Davis, Tara / MacLaren, Judy / Moses, Anita D / Parikh, Gunjan / Castro, Marcelo A / Pham, Dzung L / Butman, John A / Latour, Lawrence L

    Brain communications

    2020  Volume 2, Issue 2, Page(s) fcaa143

    Abstract: The meninges serve as a functional barrier surrounding the brain, critical to the immune response, and can be compromised following head trauma. Meningeal enhancement can be detected on contrast-enhanced MRI in patients presenting with acute traumatic ... ...

    Abstract The meninges serve as a functional barrier surrounding the brain, critical to the immune response, and can be compromised following head trauma. Meningeal enhancement can be detected on contrast-enhanced MRI in patients presenting with acute traumatic brain injury, even when head CT is negative. Following head trauma, gadolinium-based contrast appears to extravasate from the vasculature, enhancing the dura within minutes, and later permeates the subarachnoid space. The aims of this study were to characterize the initial kinetics of the uptake of contrast agent after injury and the delayed redistribution of contrast enhancement in the subarachnoid space in hyperacute patients. Neuroimaging was obtained prospectively in two large ongoing observational studies of patients aged 18 years or older presenting to the emergency department with suspected acute head injury. Dynamic contrast-enhanced MRI studies in a cohort of consecutively enrolling patients with mild traumatic brain injury (
    Language English
    Publishing date 2020-09-09
    Publishing country England
    Document type Journal Article
    ISSN 2632-1297
    ISSN (online) 2632-1297
    DOI 10.1093/braincomms/fcaa143
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Changes in Plasma von Willebrand Factor and Cellular Fibronectin in MRI-Defined Traumatic Microvascular Injury.

    Sandsmark, Danielle K / Bogoslovsky, Tanya / Qu, Bao-Xi / Haber, Margalit / Cota, Martin R / Davis, Cora / Butman, John A / Latour, Lawrence L / Diaz-Arrastia, Ramon

    Frontiers in neurology

    2019  Volume 10, Page(s) 246

    Abstract: The neuropathology of traumatic brain injury (TB) is diverse, including primary injury to neurons, axons, glial cells, vascular structures, and secondary processes, such as edema and inflammation that vary between individual patients. Traumatic ... ...

    Abstract The neuropathology of traumatic brain injury (TB) is diverse, including primary injury to neurons, axons, glial cells, vascular structures, and secondary processes, such as edema and inflammation that vary between individual patients. Traumatic microvascular injury is an important endophenotype of TBI-related injury. We studied patients who sustained a TBI requiring ER evaluation and had an MRI performed within 48 h of injury. We classified patients into 3 groups based on their MRI findings: (1) those that had evidence of traumatic microvascular injury on susceptibility or diffusion weighted MRI sequences without frank hemorrhage [Traumatic Vascular Injury (TVI) group; 20 subjects]. (2) those who had evidence of intraparenchymal, subdural, epidural, or subarachnoid hemorrhage [Traumatic Hemorrhage (TH) group; 26 subjects], and (3) those who had no traumatic injuries detected by MRI [MRI-negative group; 30 subjects]. We then measured plasma protein biomarkers of vascular injury [von Willebrand Factor (vWF) or cellular fibronectin (cFn)] and axonal injury (phosphorylated neurofilament heavy chain; pNF-H). We found that the TVI group was characterized by decreased expression of plasma vWF (
    Language English
    Publishing date 2019-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2019.00246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Differential Gene Expression Associated with Meningeal Injury in Acute Mild Traumatic Brain Injury.

    Livingston, Whitney S / Gill, Jessica M / Cota, Martin R / Olivera, Anlys / O'Keefe, Jessica L / Martin, Christiana / Latour, Lawrence L

    Journal of neurotrauma

    2016  Volume 34, Issue 4, Page(s) 853–860

    Abstract: Injury to the meninges is not uncommon after traumatic brain injury (TBI), yet minimal research has been directed toward understanding the relevant biology. After a concussive event, the meninges are observed to abnormally enhance on post-contrast ... ...

    Abstract Injury to the meninges is not uncommon after traumatic brain injury (TBI), yet minimal research has been directed toward understanding the relevant biology. After a concussive event, the meninges are observed to abnormally enhance on post-contrast magnetic resonance imaging (MRI) in some patients, but not all. The aim of this work is to identify genes differentially expressed in patients with meningeal injury. Patients presenting to the emergency room with suspected TBI received a standard research MRI and blood draw within 48 h of injury. Two groups of patients were included: those with and without abnormal enhancement of the meninges on post-contrast MRI, both without other imaging findings. Groups were compared on microarray gene expression in peripheral blood samples using Affymetrix (Santa Clara, CA) and Partek Genomics Suite (Partek, Inc., St. Louis, MO) software (false discovery rate, <0.05). Forty patients were enrolled with a time from injury to MRI/blood draw of 16.8 h (interquartile range, 7.5-24.1). We observed 76 genes to be differentially expressed in patients with meningeal injury compared to those without, such as receptor for Fc fragment of IgA, multiple C2 domains, transmembrane 2, and G-protein-coupled receptor 27, which have been previously associated with initiating inflammatory mediators, phagocytosis, and other regulatory mechanisms. Post-contrast MRI is able to detect meningeal injury and has a unique biological signature observed through gene expression. These findings suggest that an acute inflammatory response occurs in response to injury to the meninges following a concussion.
    MeSH term(s) Adult ; Brain Concussion/diagnostic imaging ; Brain Concussion/genetics ; Female ; Gene Expression/genetics ; Humans ; Magnetic Resonance Imaging ; Male ; Meninges/diagnostic imaging ; Meninges/injuries ; Middle Aged ; Young Adult
    Language English
    Publishing date 2016-08-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 645092-1
    ISSN 1557-9042 ; 0897-7151
    ISSN (online) 1557-9042
    ISSN 0897-7151
    DOI 10.1089/neu.2016.4479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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