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Article: Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma.

Bernatsky, Sasha / Velásquez García, Héctor A / Spinelli, John J / Gaffney, Patrick / Smedby, Karin E / Ramsey-Goldman, Rosalind / Wang, Sophia S / Adami, Hans-Olov / Albanes, Demetrius / Angelucci, Emanuele / Ansell, Stephen M / Asmann, Yan W / Becker, Nikolaus / Benavente, Yolanda / Berndt, Sonja I / Bertrand, Kimberly A / Birmann, Brenda M / Boeing, Heiner / Boffetta, Paolo /
Bracci, Paige M / Brennan, Paul / Brooks-Wilson, Angela R / Cerhan, James R / Chanock, Stephen J / Clavel, Jacqueline / Conde, Lucia / Cotenbader, Karen H / Cox, David G / Cozen, Wendy / Crouch, Simon / De Roos, Anneclaire J / de Sanjose, Silvia / Di Lollo, Simonetta / Diver, W Ryan / Dogan, Ahmet / Foretova, Lenka / Ghesquières, Hervé / Giles, Graham G / Glimelius, Bengt / Habermann, Thomas M / Haioun, Corinne / Hartge, Patricia / Hjalgrim, Henrik / Holford, Theodore R / Holly, Elizabeth A / Jackson, Rebecca D / Kaaks, Rudolph / Kane, Eleanor / Kelly, Rachel S / Klein, Robert J / Kraft, Peter / Kricker, Anne / Lan, Qing / Lawrence, Charles / Liebow, Mark / Lightfoot, Tracy / Link, Brian K / Maynadie, Marc / McKay, James / Melbye, Mads / Molina, Thierry J / Monnereau, Alain / Morton, Lindsay M / Nieters, Alexandra / North, Kari E / Novak, Anne J / Offit, Kenneth / Purdue, Mark P / Rais, Marco / Riby, Jacques / Roman, Eve / Rothman, Nathaniel / Salles, Gilles / Severi, Gianluca / Severson, Richard K / Skibola, Christine F / Slager, Susan L / Smith, Alex / Smith, Martyn T / Southey, Melissa C / Staines, Anthony / Teras, Lauren R / Thompson, Carrie A / Tilly, Hervé / Tinker, Lesley F / Tjonneland, Anne / Turner, Jenny / Vajdic, Claire M / Vermeulen, Roel C H / Vijai, Joseph / Vineis, Paolo / Virtamo, Jarmo / Wang, Zhaoming / Weinstein, Stephanie / Witzig, Thomas E / Zelenetz, Andrew / Zeleniuch-Jacquotte, Anne / Zhang, Yawei / Zheng, Tongzhang / Zucca, Mariagrazia / Clarke, Ann E

Lupus science & medicine

2017  Volume 4, Issue 1, Page(s) e000187

Abstract: Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms ( ...

Abstract Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL.
Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis.
Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765.
Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.
Language English
Publishing date 2017-11-12
Publishing country England
Document type Journal Article
ZDB-ID 2779620-6
ISSN 2053-8790
ISSN 2053-8790
DOI 10.1136/lupus-2016-000187
Database MEDical Literature Analysis and Retrieval System OnLINE

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