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  1. AU="Couceiro, Carlos"
  2. AU="Mahjoubi, Linda"
  3. AU="van Den Bergh, Annelies"
  4. AU="Le Sourd, Anne-Marie"
  5. AU="Pillai, Renuka Kandhaya"
  6. AU="Jawaid Iqbal"
  7. AU="Wallet, Shannon M"
  8. AU="Ribatti, Domenico"
  9. AU="N Neigh, Gretchen"
  10. AU=Miyamoto David T. AU=Miyamoto David T.
  11. AU="Choi, Sangil"
  12. AU="Brahimi, Sandra"
  13. AU="Sidell, K R"
  14. AU=Zhang Qiao
  15. AU="Desai, Pankaja"
  16. AU="Lilius, Lena"
  17. AU="Nasser, Hesham"
  18. AU="Schwarz, Falko"
  19. AU="Björkström, Jenny"
  20. AU="Puecher, A"
  21. AU="Vachha, Behroze Adi"
  22. AU="Gangjun Liu"
  23. AU="Anne-Sophie Tietz"
  24. AU="Koleva, Antoniya"
  25. AU="Gray, Elaine"
  26. AU="Granum, Stine"
  27. AU="Mazzei, Lorenzo"

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  1. Artikel ; Online: Immunosuppressive drug combinations after kidney transplantation and post-transplant diabetes: A systematic review and meta-analysis.

    Oliveras, Laia / Coloma, Ana / Lloberas, Nuria / Lino, Luis / Favà, Alexandre / Manonelles, Anna / Codina, Sergi / Couceiro, Carlos / Melilli, Edoardo / Sharif, Adnan / Hecking, Manfred / Guthoff, Martina / Cruzado, Josep M / Pascual, Julio / Montero, Nuria

    Transplantation reviews (Orlando, Fla.)

    2024  Band 38, Heft 3, Seite(n) 100856

    Abstract: Post-transplant diabetes mellitus (PTDM) is a frequent complication after kidney transplantation (KT). This systematic review investigated the effect of different immunosuppressive regimens on the risk of PTDM. We performed a systematic literature search ...

    Abstract Post-transplant diabetes mellitus (PTDM) is a frequent complication after kidney transplantation (KT). This systematic review investigated the effect of different immunosuppressive regimens on the risk of PTDM. We performed a systematic literature search in MEDLINE and CENTRAL for randomized controlled trials (RCTs) that included KT recipients with any immunosuppression and reported PTDM outcomes up to 1 October 2023. The analysis included 125 RCTs. We found no differences in PTDM risk within induction therapies. In de novo KT, there was an increased risk of developing PTDM with tacrolimus versus cyclosporin (RR 1.71, 95%CI [1.38-2.11]). No differences were observed between tacrolimus+mammalian target of rapamycin inhibitor (mTORi) and tacrolimus+MMF/MPA, but there was a tendency towards a higher risk of PTDM in the cyclosporin+mTORi group (RR 1.42, 95%CI [0.99-2.04]). Conversion from cyclosporin to an mTORi increased PTDM risk (RR 1.89, 95%CI [1.18-3.03]). De novo belatacept compared with a calcineurin inhibitor resulted in 50% lower risk of PTDM (RR 0.50, 95%CI [0.32-0.79]). Steroid avoidance resulted in 31% lower PTDM risk (RR 0.69, 95%CI [0.57-0.83]), whereas steroid withdrawal resulted in no differences. Immunosuppression should be decided on an individual basis, carefully weighing the risk of future PTDM and rejection.
    Sprache Englisch
    Erscheinungsdatum 2024-05-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Review
    ZDB-ID 639400-0
    ISSN 1557-9816 ; 0955-470X
    ISSN (online) 1557-9816
    ISSN 0955-470X
    DOI 10.1016/j.trre.2024.100856
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

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  2. Artikel ; Online: Obesity in Renal Transplantation.

    Quero, Maria / Montero, Nuria / Rama, Inés / Codina, Sergi / Couceiro, Carlos / Cruzado, Josep M

    Nephron

    2021  Band 145, Heft 6, Seite(n) 614–623

    Abstract: Background: Data from the WHO show an increasing rate of overweight and obesity in general population in the last decades. This increase in obesity also affects population with end-stage renal disease (ESRD) and kidney transplant (KT) candidates.: ... ...

    Abstract Background: Data from the WHO show an increasing rate of overweight and obesity in general population in the last decades. This increase in obesity also affects population with end-stage renal disease (ESRD) and kidney transplant (KT) candidates.
    Summary: In this review, we focused on how obesity impacts on KT stages: access to KT and outcomes of KT candidates; how to reduce weight and its consequences; short and long-term outcomes in obese recipients and the impact of weight variations; and the implications of obesity in living donor KT. We searched MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials until November 30, 2020. We selected systematic reviews and meta-analyses and randomized clinical trials. When no such reports were found for a topic, observational studies were included in the assessment. Key Messages: Although obesity is a risk factor to present worst outcomes after KT, several studies have demonstrated a survival benefit compared to patients who continue on dialysis. There is a need for a public health campaign to raise awareness in KT candidates and to highlight the importance of self-care, increasing exercise, healthy diet, and weight loss.
    Mesh-Begriff(e) Anti-Obesity Agents/therapeutic use ; Bariatric Surgery ; Humans ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Obesity/complications ; Obesity/drug therapy ; Obesity/surgery ; Tissue Donors ; Treatment Outcome ; Weight Loss
    Chemische Substanzen Anti-Obesity Agents
    Sprache Englisch
    Erscheinungsdatum 2021-05-11
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Review
    ZDB-ID 207121-6
    ISSN 2235-3186 ; 1423-0186 ; 1660-8151 ; 0028-2766
    ISSN (online) 2235-3186 ; 1423-0186
    ISSN 1660-8151 ; 0028-2766
    DOI 10.1159/000515786
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 169: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Artikel ; Online: Colony stimulating factor-1 receptor drives glomerular parietal epithelial cell activation in focal segmental glomerulosclerosis.

    Cruzado, Josep M / Manonelles, Anna / Rayego-Mateos, Sandra / Doladé, Núria / Amaya-Garrido, Ana / Varela, Cristian / Guiteras, Roser / Mosquera, Jose Luis / Jung, Michaela / Codina, Sergi / Martínez-Valenzuela, Laura / Draibe, Juliana / Couceiro, Carlos / Vigués, Francesc / Madrid, Álvaro / Florian, M Carolina / Ruíz-Ortega, Marta / Sola, Anna

    Kidney international

    2024  

    Abstract: Parietal epithelial cells (PECs) are kidney progenitor cells with similarities to a bone marrow stem cell niche. In focal segmental glomerulosclerosis (FSGS) PECs become activated and contribute to extracellular matrix deposition. Colony stimulating ... ...

    Abstract Parietal epithelial cells (PECs) are kidney progenitor cells with similarities to a bone marrow stem cell niche. In focal segmental glomerulosclerosis (FSGS) PECs become activated and contribute to extracellular matrix deposition. Colony stimulating factor-1 (CSF-1), a hematopoietic growth factor, acts via its specific receptor, CSF-1R, and has been implicated in several glomerular diseases, although its role on PEC activation is unknown. Here, we found that CSF-1R was upregulated in PECs and podocytes in biopsies from patients with FSGS. Through in vitro studies, PECs were found to constitutively express CSF-1R. Incubation with CSF-1 induced CSF-1R upregulation and significant transcriptional regulation of genes involved in pathways associated with PEC activation. Specifically, CSF-1/CSF-1R activated the ERK1/2 signaling pathway and upregulated CD44 in PECs, while both ERK and CSF-1R inhibitors reduced CD44 expression. Functional studies showed that CSF-1 induced PEC proliferation and migration, while reducing the differentiation of PECs into podocytes. These results were validated in the Adriamycin-induced FSGS experimental mouse model. Importantly, treatment with either the CSF-1R-specific inhibitor GW2580 or Ki20227 provided a robust therapeutic effect. Thus, we provide evidence of the role of the CSF-1/CSF-1R pathway in PEC activation in FSGS, paving the way for future clinical studies investigating the therapeutic effect of CSF-1R inhibitors on patients with FSGS.
    Sprache Englisch
    Erscheinungsdatum 2024-02-28
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2024.02.010
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 797: Hefte anzeigen Standort:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Artikel: Effect of kidney replacement therapy modality after first kidney graft failure on second kidney transplantation outcomes.

    Couceiro, Carlos / Rama, Inés / Comas, Jordi / Montero, Núria / Manonelles, Anna / Codina, Sergi / Favà, Alexandre / Melilli, Edoardo / Coloma, Ana / Quero, Maria / Tort, Jaume / Cruzado, Josep M

    Clinical kidney journal

    2022  Band 15, Heft 11, Seite(n) 2046–2055

    Abstract: Background: There is a lack of information regarding which is the best dialysis technique after kidney transplant (KT) failure. The aim of this study is to compare the effect of kidney replacement therapy modality-peritoneal dialysis (TX-PD-TX), ... ...

    Abstract Background: There is a lack of information regarding which is the best dialysis technique after kidney transplant (KT) failure. The aim of this study is to compare the effect of kidney replacement therapy modality-peritoneal dialysis (TX-PD-TX), haemodialysis (TX-HD-TX) and preemptive deceased donor retransplantation (TX-TX) on patient survival and second KT outcomes.
    Methods: A retrospective observational study from the Catalan Renal Registry was carried out. We included adult patients with failing of their first KT from 2000 to 2018.
    Results: Among 2045 patients, 1829 started on HD (89.4%), 168 on PD (8.2%) and 48 (2.4%) received a preemptive KT. Non-inclusion on the KT waiting list and HD were associated with worse patient survival. For patients included on the waiting list, the probability of human leucocyte antigens (HLA) sensitization and to receive a second KT was similar in HD and PD. A total of 776 patients received a second KT (38%), 656 in TX-HD-TX, 72 in TX-PD-TX and 48 in TX-TX groups. Adjusted mortality after second KT was higher in TX-HD-TX patients compared with TX-TX and TX-PD-TX groups, without differences between TX-TX and TX-PD-TX groups. Death-censored second graft survival was similar in all three groups.
    Conclusions: Our results suggest that after first KT failure, PD is superior to HD in reducing mortality in candidates for a second KT without options for preemptive retransplantation.
    Sprache Englisch
    Erscheinungsdatum 2022-06-14
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2655800-2
    ISSN 2048-8513 ; 2048-8505
    ISSN (online) 2048-8513
    ISSN 2048-8505
    DOI 10.1093/ckj/sfac155
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Tuberculosis prevention in patients undergoing kidney transplantation: A nurse-led program for screening and treatment.

    Grijota-Camino, Maria D / Montero, Núria / Luque, Maria J / Díaz-Jurado, Maria / Sabé, Núria / Pérez-Recio, Sandra / Couceiro, Carlos / Muñoz, Laura / Cruzado, Josep M / Santin, Miguel

    Transplant infectious disease : an official journal of the Transplantation Society

    2021  Band 23, Heft 4, Seite(n) e13603

    Abstract: Background: Systematic screening for, and treatment of, latent tuberculosis (TB) infection is recommended prior to kidney transplant. However, little is known about patient compliance with, or the safety profile of, preventive therapies used in clinical ...

    Abstract Background: Systematic screening for, and treatment of, latent tuberculosis (TB) infection is recommended prior to kidney transplant. However, little is known about patient compliance with, or the safety profile of, preventive therapies used in clinical practice.
    Methods: This was a retrospective observational study of patients who were eligible for kidney transplant and were evaluated for TB infection between January 2013 and June 2019 at the TB clinic of a tertiary care teaching hospital. All patient data were registered prospectively as part of our nurse-led program before kidney transplant. We assessed completion rates, tolerance with therapy, development of TB, and associated workload.
    Results: In total, 1568 patients were referred to our TB clinic for evaluation. Preventive therapy was given to 385 patients and completed by 340 (88.3%). Of these, 89 (23.1%) experienced some intolerance, with 27 requiring full discontinuation. After a median follow-up of 45 months (1426 patient-years), 206 (53.5%) of the treated patients received a kidney transplant; only one patient, who failed to complete treatment, developed post-transplant TB (7.01 cases per 10 000 patient-years; 95% confidence interval, 0.35-34.59). Extra nurse or medical visits were required by 268 (69.6%) patients.
    Conclusion: Despite the complexity and workload generated by patients with ESRD awaiting kidney transplant, preventive therapy for TB is effective in most cases. Our experience provides important evidence on the feasibility of preventive therapy for TB before kidney transplant when delivered as part of a comprehensive nurse-led program.
    Mesh-Begriff(e) Humans ; Kidney Transplantation/adverse effects ; Latent Tuberculosis/diagnosis ; Latent Tuberculosis/drug therapy ; Latent Tuberculosis/prevention & control ; Nurse's Role ; Retrospective Studies ; Tuberculosis/diagnosis ; Tuberculosis/prevention & control
    Sprache Englisch
    Erscheinungsdatum 2021-03-31
    Erscheinungsland Denmark
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 1476094-0
    ISSN 1399-3062 ; 1398-2273
    ISSN (online) 1399-3062
    ISSN 1398-2273
    DOI 10.1111/tid.13603
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5100: Hefte anzeigen Standort:
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  6. Artikel ; Online: A comprehensive assessment of long-term SARS-CoV-2-specific adaptive immune memory in convalescent COVID-19 Solid Organ Transplant recipients.

    Favà, Alexandre / Donadeu, Laura / Jouve, Thomas / Gonzalez-Costello, José / Lladó, Laura / Santana, Carolina / Toapanta, Néstor / Lopez, Manuel / Pernin, Vincent / Facundo, Carme / Cabañas, Nuria Serra / Thaunat, Olivier / Crespo, Marta / Llinàs-Mallol, Laura / Revuelta, Ignacio / Sabé, Nuria / Rombauts, Alexander / Calatayud, Laura / Ardanuy, Carmen /
    Esperalba, Juliana / Fernandez, Candela / Lozano, Juan J / Preyer, Rosemarie / Strecker, Kevin / Couceiro, Carlos / García-Romero, Elena / Cachero, Alba / Meneghini, Maria / Torija, Alba / Le Quintrec, Moglie / Melilli, Edoardo / Cruzado, Josep Maria / Polo, Carolina / Moreso, Francesc / Crespo, Elena / Bestard, Oriol

    Kidney international

    2022  Band 101, Heft 5, Seite(n) 1027–1038

    Abstract: Long-term adaptive immune memory has been reported among immunocompetent individuals up to eight months following SARS-CoV-2 infection. However, limited data is available in convalescent patients with a solid organ transplant. To investigate this, we ... ...

    Abstract Long-term adaptive immune memory has been reported among immunocompetent individuals up to eight months following SARS-CoV-2 infection. However, limited data is available in convalescent patients with a solid organ transplant. To investigate this, we performed a thorough evaluation of adaptive immune memory at different compartments (serological, memory B cells and cytokine [IFN-γ, IL-2, IFN-γ/IL12 and IL-21] producing T cells) specific to SARS-CoV-2 by ELISA and FluoroSpot-based assays in 102 convalescent patients (53 with a solid organ transplants (38 kidney, 5 liver, 5 lung and 5 heart transplant) and 49 immunocompetent controls) with different clinical COVID-19 severity (severe, mild and asymptomatic) beyond six months after infection. While similar detectable memory responses at different immune compartments were detected between those with a solid organ transplant and immunocompetent individuals, these responses were predominantly driven by distinct COVID-19 clinical severities (97.6%, 80.5% and 42.1%, all significantly different, were seropositive; 84% vs 75% vs 35.7%, all significantly different, showed IgG-producing memory B cells and 82.5%, 86.9% and 31.6%, displayed IFN-γ producing T cells; in severe, mild and asymptomatic convalescent patients, respectively). Notably, patients with a solid organ transplant with longer time after transplantation did more likely show detectable long-lasting immune memory, regardless of COVID-19 severity. Thus, our study shows that patients with a solid organ transplant are capable of maintaining long-lasting peripheral immune memory after COVID-19 infection; mainly determined by the degree of infection severity.
    Mesh-Begriff(e) Antibodies, Viral ; COVID-19 ; Humans ; Immunologic Memory ; Organ Transplantation/adverse effects ; SARS-CoV-2 ; Transplant Recipients
    Chemische Substanzen Antibodies, Viral
    Sprache Englisch
    Erscheinungsdatum 2022-02-04
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2021.12.029
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Buch: Capim

    Couceiro, Carlos

    [e poemas supérfluos]

    1984  

    Verfasserangabe [Carlos Couceiro]
    Sprache Portugiesisch
    Umfang 185 S
    Erscheinungsort S.l.
    Dokumenttyp Buch
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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